Strain Name:
C57BL/6J-MtgxR3700Btlr/Mmmh
Stock Number:
040693-MU
Citation ID:
RRID:MMRRC_040693-MU
Other Names:
R3700 (G1), C57BL/6J-MtgxR3700Btlr
Major Collection:

Gene Information

Cnnm2
Name: cyclin M2
Synonyms: Acdp2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 94219
VEGA: 19
HGNC: HGNC:103
Homologene: 9761
Sort1
Name: sortilin 1
Synonyms: sortilin, neurotensin receptor 3, Ntsr3, Ntr3, 2900053A11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 20661
Homologene: 136097
Tlr9
Name: toll-like receptor 9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 81897
Homologene: 68126
Tgfa
Name: transforming growth factor alpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 21802
Homologene: 2431
Hsp90ab1
Name: heat shock protein 90 alpha (cytosolic), class B member 1
Synonyms: Hsp84, Hsp90, Hsp84-1, C81438, Hspcb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 15516
HGNC: HGNC:5258
Homologene: 74306
Txn2
Name: thioredoxin 2
Synonyms: 2510006J11Rik, Trx2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 56551
Homologene: 40849
Mysm1
Name: myb-like, SWIRM and MPN domains 1
Synonyms: C530050H10Rik, C130067A03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 320713
Homologene: 66204
Rlf
Name: rearranged L-myc fusion sequence
Synonyms: 9230110M18Rik, MommeD8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 109263
Homologene: 8243
Tasp1
Name: taspase, threonine aspartase 1
Synonyms: 4930485D02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 75812
Homologene: 9795
Prdx6
Name: peroxiredoxin 6
Synonyms: acidic calcium-independent phospholipase A2, aiPLA2, GPx, Brp-12, Ltw4, Lvtw-4, Ltw-4, 1-Cys Prx, CP-3, Aop2, 1-cysPrx, 9430088D19Rik, NSGP, CC26
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 11758
Homologene: 3606
Stk39
Name: serine/threonine kinase 39
Synonyms: DCHT, SPAK, RF005, Rnl5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 53416
Homologene: 22739
Zzef1
Name: zinc finger, ZZ-type with EF hand domain 1
Synonyms: 8430405D05Rik, C130099L13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 195018
Homologene: 9027
Lss
Name: lanosterol synthase
Synonyms: 2810025N20Rik, D10Ertd116e, Osc
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 16987
HGNC: HGNC:6708
Homologene: 37408
Mmp14
Name: matrix metallopeptidase 14 (membrane-inserted)
Synonyms: Membrane type 1-MMP, MT1-MMP, sabe
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 17387
HGNC: HGNC:7160
Homologene: 21040
Lhx2
Name: LIM homeobox protein 2
Synonyms: Lh-2, LH2A, apterous, ap
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 16870
HGNC: HGNC:6594
Homologene: 55848
Pi4kb
Name: phosphatidylinositol 4-kinase beta
Synonyms: ESTM41, Pik4cb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 107650
HGNC: HGNC:8984
Homologene: 6741
Ddah1
Name: dimethylarginine dimethylaminohydrolase 1
Synonyms: 2410006N07Rik, 2510015N06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 69219
HGNC: HGNC:2715
Homologene: 8120
Ppp1r21
Name: protein phosphatase 1, regulatory subunit 21
Synonyms: 1110018J12Rik, Ccdc128, Klraq1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 73825
Homologene: 44811
Ttf2
Name: transcription termination factor, RNA polymerase II
Synonyms: 4632434F22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 74044
Homologene: 37826
Tepsin
Name: TEPSIN, adaptor related protein complex 4 accessory protein
Synonyms: 2410002I01Rik, Enthd2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 78777
Homologene: 35359
Arhgap28
Name: Rho GTPase activating protein 28
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 268970
Homologene: 18264
Dync2i1
Name: dynein 2 intermediate chain 1
Synonyms: D430033N04Rik, Wdr60, Dync2l1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217935
VEGA: 12
Homologene: 23067
Piezo1
Name: piezo-type mechanosensitive ion channel component 1
Synonyms: Piezo1, Fam38a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234839
Homologene: 124356
Skiv2l
Name: superkiller viralicidic activity 2-like (S. cerevisiae)
Synonyms: Ski2w, 4930534J06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 108077
Homologene: 123971
Cdh23
Name: cadherin 23 (otocadherin)
Synonyms: 4930542A03Rik, USH1D, mdfw, ahl, bob, nmf112, nmf181, nmf252, sals
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 22295
Homologene: 11142
Idh2
Name: isocitrate dehydrogenase 2 (NADP+), mitochondrial
Synonyms: Idh-2, IDPm
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 269951
HGNC: HGNC:5383
Homologene: 37590
Dnah5
Name: dynein, axonemal, heavy chain 5
Synonyms: Mdnah5, b2b1537Clo, b2b1565Clo, b2b1154Clo, b2b1134Clo, Dnahc5, b2b3491Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 110082
HGNC: HGNC:2950
Homologene: 1048
Gabra5
Name: gamma-aminobutyric acid (GABA) A receptor, subunit alpha 5
Synonyms: A230018I05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 110886
HGNC: HGNC:4079
Homologene: 20219
Eif3f
Name: eukaryotic translation initiation factor 3, subunit F
Synonyms: 0610037M02Rik, Eif3s5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 66085
HGNC: HGNC:3275
Homologene: 2783
Or6d13
Name: olfactory receptor family 6 subfamily D member 13
Synonyms: GA_x54KRFPKN04-58174409-58175392, MOR119-3, Olfr213
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 258020
Homologene: 74186
Muc5b
Name: mucin 5, subtype B, tracheobronchial
Synonyms: MUC9, MUC5, 2300002I04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 74180
HGNC: HGNC:7516
Homologene: 136756
Vmn2r111
Name: vomeronasal 2, receptor 111
Synonyms: EG210876
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 210876
Homologene: 86604
Plce1
Name: phospholipase C, epsilon 1
Synonyms: 4933403A21Rik, PLCepsilon
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 74055
Homologene: 9478
Kcnj6
Name: potassium inwardly-rectifying channel, subfamily J, member 6
Synonyms: Kir3.2, GIRK2, KCNJ7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 16522
VEGA: 16
HGNC: HGNC:6267
Homologene: 1688
Fbxw10
Name: F-box and WD-40 domain protein 10
Synonyms: SM2SH2, SM25H2, Fbw10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 213980
Homologene: 32757
Alpk2
Name: alpha-kinase 2
Synonyms: Hak
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 225638
Homologene: 50475
Pcolce
Name: procollagen C-endopeptidase enhancer protein
Synonyms: Astt-2, Astt2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 18542
HGNC: HGNC:8738
Homologene: 1946
Arhgap26
Name: Rho GTPase activating protein 26
Synonyms: 1810044B20Rik, 2610010G17Rik, 4933432P15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 71302
Homologene: 36349
Vmn2r118
Name: vomeronasal 2, receptor 118
Synonyms: EG668547, Vmn2r119, EG383258
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 383258
Homologene: 129687
Vmn1r10
Name: vomeronasal 1 receptor 10
Synonyms: V1rc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 113858
Homologene: 76459
Lrrc71
Name: leucine rich repeat containing 71
Synonyms: 4933430H15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 74485
Homologene: 83646
Sstr4
Name: somatostatin receptor 4
Synonyms: sst4, Smstr4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 20608
Homologene: 20286
Ankrd29
Name: ankyrin repeat domain 29
Synonyms: G630054C21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 225187
Homologene: 17839
Or6f2
Name: olfactory receptor family 6 subfamily F member 2
Synonyms: GA_x6K02T2PBJ9-42327937-42328872, MOR104-4, Olfr523
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258511
Homologene: 27191
Snapin
Name: SNAP-associated protein
Synonyms: Snap25bp, Snapap, Bloc1s7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 20615
Homologene: 8251
Zgpat
Name: zinc finger, CCCH-type with G patch domain
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 229007
Homologene: 41874
Bcl11a
Name: B cell CLL/lymphoma 11A (zinc finger protein)
Synonyms: mouse myeloid leukemia gene, COUP-TF interacting protein 1, CTIP1, Evi9, 2810047E18Rik, D930021L15Rik, Evi9c, Evi9b, Evi9a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 14025
Homologene: 11284
Vmn1r232
Name: vomeronasal 1 receptor 232
Synonyms: V1re4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 171227
Homologene: 121611
Klk5
Name: kallikrein related-peptidase 5
Synonyms: 1110030O19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 68668
HGNC: HGNC:6366
Homologene: 75000
Phc3
Name: polyhomeotic 3
Synonyms: EDR3, HPH3, E030046K01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 241915
Homologene: 69390
Esp1
Name: exocrine gland secreted peptide 1
Synonyms: ESP1, Gm6084
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 619517
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 161,247,288 bp
  • T to A, chromosome 2 at 38,360,099 bp
  • T to A, chromosome 2 at 68,392,118 bp
  • T to C, chromosome 2 at 139,910,554 bp
  • A to G, chromosome 2 at 148,396,353 bp
  • T to A, chromosome 2 at 181,365,646 bp
  • C to A, chromosome 3 at 30,914,128 bp
  • T to A, chromosome 3 at 87,745,878 bp
  • G to A, chromosome 3 at 90,490,192 bp
  • T to C, chromosome 3 at 94,994,288 bp
  • A to G, chromosome 3 at 100,951,008 bp
  • T to A, chromosome 3 at 108,356,639 bp
  • G to A, chromosome 3 at 145,891,495 bp
  • T to C, chromosome 4 at 94,970,652 bp
  • A to G, chromosome 4 at 121,150,863 bp
  • T to C, chromosome 5 at 137,609,047 bp
  • A to G, chromosome 6 at 57,114,302 bp
  • T to C, chromosome 6 at 86,269,918 bp
  • T to A, chromosome 6 at 116,540,528 bp
  • T to A, chromosome 7 at 43,850,827 bp
  • C to T, chromosome 7 at 57,490,731 bp
  • T to C, chromosome 7 at 80,099,147 bp
  • A to T, chromosome 7 at 108,940,275 bp
  • C to G, chromosome 7 at 140,176,214 bp
  • A to G, chromosome 7 at 141,847,249 bp
  • C to T, chromosome 8 at 122,494,903 bp
  • G to A, chromosome 9 at 106,224,079 bp
  • C to A, chromosome 10 at 60,327,370 bp
  • T to A, chromosome 10 at 76,546,192 bp
  • A to G, chromosome 11 at 24,163,890 bp
  • A to T, chromosome 11 at 62,869,157 bp
  • G to T, chromosome 11 at 72,886,772 bp
  • C to T, chromosome 11 at 120,091,753 bp
  • C to T, chromosome 12 at 116,211,842 bp
  • G to A, chromosome 14 at 54,431,932 bp
  • T to C, chromosome 15 at 28,387,791 bp
  • G to A, chromosome 15 at 77,927,776 bp
  • A to G, chromosome 16 at 94,833,006 bp
  • A to G, chromosome 17 at 20,914,203 bp
  • C to T, chromosome 17 at 22,571,161 bp
  • T to C, chromosome 17 at 34,849,903 bp
  • T to C, chromosome 17 at 40,731,107 bp
  • T to C, chromosome 17 at 45,571,514 bp
  • T to C, chromosome 17 at 55,608,421 bp
  • T to C, chromosome 17 at 67,901,366 bp
  • T to C, chromosome 17 at 88,582,454 bp
  • G to A, chromosome 18 at 12,254,700 bp
  • T to A, chromosome 18 at 39,120,184 bp
  • G to A, chromosome 18 at 65,305,151 bp
  • T to A, chromosome 19 at 38,705,337 bp
  • T to A, chromosome 19 at 46,762,551 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3700 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040693-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.