Strain Name:
C57BL/6J-MtgxR3701Btlr/Mmmh
Stock Number:
040694-MU
Citation ID:
RRID:MMRRC_040694-MU
Other Names:
R3701 (G1), C57BL/6J-MtgxR3701Btlr
Major Collection:

Strain Information

Tnfsf4
Name: tumor necrosis factor (ligand) superfamily, member 4
Synonyms: OX40L, gp34, Txgp1l, Ath-1, TXGP1, CD134L, Ath1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 22164
Homologene: 2495
Efnb1
Name: ephrin B1
Synonyms: Stra1, LERK-2, Cek5 ligand, Epl2, Cek5-L, EFL-3, Elk-L, Eplg2, Lerk2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 13641
HGNC: HGNC:3226
Homologene: 3263
Kcnj5
Name: potassium inwardly-rectifying channel, subfamily J, member 5
Synonyms: Kir3.4, GIRK4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 16521
VEGA: 9
HGNC: HGNC:6266
Homologene: 20248
Kpnb1
Name: karyopherin (importin) beta 1
Synonyms: Impnb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 16211
HGNC: HGNC:6400
Homologene: 1707
Cstf1
Name: cleavage stimulation factor, 3' pre-RNA, subunit 1
Synonyms: 1700057K18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 67337
HGNC: HGNC:2483
Homologene: 1012
Asxl1
Name: ASXL transcriptional regulator 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228790
Homologene: 9098
Acvr1b
Name: activin A receptor, type 1B
Synonyms: ActR-IB, Acvrlk4, SKR2, ActRIB, Alk4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 11479
HGNC: HGNC:172
Homologene: 20906
Ttc37
Name: tetratricopeptide repeat domain 37
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218343
VEGA: 13
Homologene: 40966
Phka2
Name: phosphorylase kinase alpha 2
Synonyms: k, Phk, 6330505C01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 110094
HGNC: HGNC:8926
Homologene: 246
Lrrc28
Name: leucine rich repeat containing 28
Synonyms: 2310058O11Rik, 2210012C09Rik, 1300004K21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 67867
Homologene: 16944
Cul5
Name: cullin 5
Synonyms: 4921514I20Rik, C330021I08Rik, C030032G03Rik, VACM-1, 8430423K24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 75717
HGNC: HGNC:2556
Homologene: 2597
Zfp740
Name: zinc finger protein 740
Synonyms: 1110034O07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 68744
Homologene: 129530
Zfp592
Name: zinc finger protein 592
Synonyms: A730014M16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233410
Homologene: 8759
Triml2
Name: tripartite motif family-like 2
Synonyms: EG622117
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 622117
Homologene: 18316
Lyn
Name: LYN proto-oncogene, Src family tyrosine kinase
Synonyms: Hck-2, Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 17096
HGNC: HGNC:6735
Homologene: 55649
Nbeal1
Name: neurobeachin like 1
Synonyms: A530050O19Rik, ALS2CR17, A530083I02Rik, 2310076G13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 269198
Homologene: 16453
Dnph1
Name: 2'-deoxynucleoside 5'-phosphate N-hydrolase 1
Synonyms: Rcl, c-Myc-responsive, BC048355
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 381101
VEGA: 17
Homologene: 4704
Pdgfra
Name: platelet derived growth factor receptor, alpha polypeptide
Synonyms: CD140a, Pdgfr-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 18595
HGNC: HGNC:8803
Homologene: 31361
Chchd2l
Name: coiled-coil-helix-coiled-coil-helix domain containing 2-like
Synonyms: 2410018M08Rik, Zbed5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 71970
Homologene: 84838
Tex15
Name: testis expressed gene 15
Synonyms: 2210014E14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 104271
Homologene: 12837
Hivep2
Name: human immunodeficiency virus type I enhancer binding protein 2
Synonyms: MIBP1, Schnurri-2, Shn-2, Gm20114
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 15273
HGNC: HGNC:4921
Homologene: 4900
Ces2a
Name: carboxylesterase 2A
Synonyms: 9130231C15Rik, Ces6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 102022
HGNC: HGNC:1864
Homologene: 136396
Psmb9
Name: proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)
Synonyms: Lmp-2, Lmp2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 16912
HGNC: HGNC:9546
Homologene: 2094
Hivep1
Name: human immunodeficiency virus type I enhancer binding protein 1
Synonyms: Cryabp1, alphaA-CRYBP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 110521
VEGA: 13
HGNC: HGNC:4920
Homologene: 1596
Cacna1i
Name: calcium channel, voltage-dependent, alpha 1I subunit
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 239556
HGNC: HGNC:1396
Homologene: 69331
Vmn2r104
Name: vomeronasal 2, receptor 104
Synonyms: V2r7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 22313
Homologene: 129751
Cyld
Name: CYLD lysine 63 deubiquitinase
Synonyms: CYLD1, 2010013M14Rik, C130039D01Rik, 2900009M21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 74256
HGNC: HGNC:2584
Homologene: 9069
Or14j3
Name: olfactory receptor family 14 subfamily J member 3
Synonyms: MOR218-10, GA_x6K02T2PSCP-2049802-2048870, Olfr114
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 258284
Homologene: 133642
Tmf1
Name: TATA element modulatory factor 1
Synonyms: LOC232286, 7030402D04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232286
Homologene: 133801
Snx14
Name: sorting nexin 14
Synonyms: YR-14, C330035N22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 244962
Homologene: 17823
Adgrb1
Name: adhesion G protein-coupled receptor B1
Synonyms: B830018M07Rik, Bai1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 107831
HGNC: HGNC:943
Homologene: 1287
Or9i14
Name: olfactory receptor family 9 subfamily I member 14
Synonyms: GA_x6K02T2RE5P-4147744-4146800, MOR211-2, Olfr1499
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 258792
Homologene: 17393
Zfp983
Name: zinc finger protein 983
Synonyms: 3110052M02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 73229
VEGA: 17
Entrep1
Name: endosomal transmembrane epsin interactor 1
Synonyms: LOC381217, Fam189a2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 381217
VEGA: 19
Homologene: 3540
Nmur2
Name: neuromedin U receptor 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216749
Homologene: 49618
Fdxr
Name: ferredoxin reductase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 14149
HGNC: HGNC:3642
Homologene: 3033
Or6c5c
Name: olfactory receptor family 6 subfamily C member 5C
Synonyms: GA_x6K02T2PULF-11141498-11142436, MOR111-10, Olfr787
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 258069
Homologene: 105326
Zfp647
Name: zinc finger protein 647
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 239546
VEGA: 15
Homologene: 27805
Trdn
Name: triadin
Synonyms: 2310045H21Rik, triadin-3, triadin-2, triadin-1, triadin 3, triadin 2, triadin 1, EG432451
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 76757
VEGA: 10
Homologene: 38137
Itgb1bp2
Name: integrin beta 1 binding protein 2
Synonyms: melusin, Chordc3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 26549
HGNC: HGNC:6154
Homologene: 22708
Akr1c19
Name: aldo-keto reductase family 1, member C19
Synonyms: 1810010N06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 432720
Homologene: 134145
Clip4
Name: CAP-GLY domain containing linker protein family, member 4
Synonyms: 1700074B05Rik, 5830409B12Rik, 4833417L20Rik, 1700024K14Rik, Rsnl2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 78785
VEGA: 17
Homologene: 11662
Pkd2l1
Name: polycystic kidney disease 2-like 1
Synonyms: polycystin-L, Pkdl, PCL, TRPP3, PKD2L
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 329064
HGNC: HGNC:9011
Homologene: 22946
Ttc34
Name: tetratricopeptide repeat domain 34
Synonyms: B230396O12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242800
Homologene: 130480
AC188608.2
Name:
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 60,251,413 bp
  • G to A, chromosome 1 at 161,417,207 bp
  • A to G, chromosome 2 at 153,399,344 bp
  • A to G, chromosome 2 at 172,380,392 bp
  • A to G, chromosome 4 at 3,742,455 bp
  • T to C, chromosome 4 at 154,865,482 bp
  • T to A, chromosome 5 at 75,180,220 bp
  • G to A, chromosome 5 at 129,903,159 bp
  • A to G, chromosome 6 at 97,172,331 bp
  • A to T, chromosome 7 at 67,531,605 bp
  • C to T, chromosome 7 at 81,037,411 bp
  • T to C, chromosome 8 at 33,574,166 bp
  • T to C, chromosome 8 at 43,185,471 bp
  • T to A, chromosome 8 at 88,729,551 bp
  • T to G, chromosome 8 at 104,739,761 bp
  • T to C, chromosome 9 at 32,317,828 bp
  • T to C, chromosome 9 at 53,629,216 bp
  • T to C, chromosome 9 at 88,420,243 bp
  • C to A, chromosome 10 at 14,128,969 bp
  • C to A, chromosome 10 at 33,334,984 bp
  • A to T, chromosome 10 at 129,462,952 bp
  • A to G, chromosome 11 at 56,040,777 bp
  • C to T, chromosome 11 at 97,171,723 bp
  • A to T, chromosome 11 at 115,269,701 bp
  • C to T, chromosome 13 at 4,243,033 bp
  • T to C, chromosome 13 at 42,157,727 bp
  • T to C, chromosome 13 at 76,113,679 bp
  • A to C, chromosome 15 at 74,545,015 bp
  • G to A, chromosome 15 at 76,910,910 bp
  • A to T, chromosome 15 at 80,381,071 bp
  • G to A, chromosome 15 at 101,193,923 bp
  • T to C, chromosome 15 at 102,212,585 bp
  • A to G, chromosome 17 at 20,029,556 bp
  • G to C, chromosome 17 at 21,661,539 bp
  • C to A, chromosome 17 at 34,185,720 bp
  • G to A, chromosome 17 at 37,589,826 bp
  • A to T, chromosome 17 at 39,955,221 bp
  • G to A, chromosome 17 at 46,498,711 bp
  • A to G, chromosome 17 at 71,799,008 bp
  • T to G, chromosome 19 at 13,815,348 bp
  • T to C, chromosome 19 at 23,979,467 bp
  • A to G, chromosome 19 at 44,157,227 bp
  • T to C, chromosome X at 99,147,101 bp
  • T to C, chromosome X at 101,451,687 bp
  • T to C, chromosome X at 160,533,049 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3701 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040694-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.