Strain Name:
C57BL/6J-MtgxR3707Btlr/Mmmh
Stock Number:
040700-MU
Citation ID:
RRID:MMRRC_040700-MU
Other Names:
R3707 (G1), C57BL/6J-MtgxR3707Btlr
Major Collection:

Strain Information

Zfx
Name: zinc finger protein X-linked
Synonyms: Zfx5,6, Zfx6, Zfx5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 22764
Homologene: 2561
Resf1
Name: retroelement silencing factor 1
Synonyms: GET, 2810474O19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 67246
Homologene: 19251
Top2a
Name: topoisomerase (DNA) II alpha
Synonyms: DNA Topoisomerase II alpha, Top-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 21973
Homologene: 830
Lgr4
Name: leucine-rich repeat-containing G protein-coupled receptor 4
Synonyms: A930009A08Rik, Gpr48, A330106J01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 107515
Homologene: 10226
Rif1
Name: replication timing regulatory factor 1
Synonyms: 5730435J01Rik, 6530403D07Rik, D2Ertd145e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 51869
Homologene: 41231
Zbtb40
Name: zinc finger and BTB domain containing 40
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230848
Homologene: 8912
Arfgap1
Name: ADP-ribosylation factor GTPase activating protein 1
Synonyms: ARF1 GAP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228998
Homologene: 5517
Rab3ip
Name: RAB3A interacting protein
Synonyms: Gtpat12, SSX2 interacting protein, Rabin3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 216363
VEGA: 10
Homologene: 32340
Mtg1
Name: mitochondrial ribosome-associated GTPase 1
Synonyms: LOC212508, Gtpbp7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 212508
Homologene: 44527
Macrod2
Name: mono-ADP ribosylhydrolase 2
Synonyms: 2610107G07Rik, 1110033L15Rik, 2900006F19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 72899
Homologene: 85987
Pdhb
Name: pyruvate dehydrogenase (lipoamide) beta
Synonyms: 2610103L06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 68263
VEGA: 14
HGNC: HGNC:8808
Homologene: 712
Avpr1a
Name: arginine vasopressin receptor 1A
Synonyms: V1aR
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 54140
HGNC: HGNC:895
Homologene: 568
Rrbp1
Name: ribosome binding protein 1
Synonyms: mRRp0, ES/130, p180, mRRp1.8, mRRp2, mRRp5.4, mRRp10, mRRp16.8, mRRp15b, mRRp15a, mRRp41, mRRp47, 1700087N07Rik, 5730465C04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 81910
Homologene: 68138
Dennd6a
Name: DENN domain containing 6A
Synonyms: A630054L15Rik, Fam116a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 211922
Homologene: 13503
Lrch1
Name: leucine-rich repeats and calponin homology (CH) domain containing 1
Synonyms: 4832412D13Rik, Chdc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 380916
VEGA: 14
Homologene: 32244
Nr4a3
Name: nuclear receptor subfamily 4, group A, member 3
Synonyms: TEC, NOR-1, Nor1, MINOR
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 18124
HGNC: HGNC:7982
Homologene: 5074
Eci3
Name: enoyl-Coenzyme A delta isomerase 3
Synonyms: 1810022C23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 69123
Homologene: 74357
Cplane1
Name: ciliogenesis and planar polarity effector 1
Synonyms: b2b012Clo, Jbts17, Hug, 2410089E03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 73692
Homologene: 11315
Ppfia4
Name: protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4
Synonyms: 1110008G13Rik, LOC100042382, Liprin-alpha4, Gm3812
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 68507
HGNC: HGNC:9248
Homologene: 66200
Tdrd1
Name: tudor domain containing 1
Synonyms: MTR-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 83561
Homologene: 12850
Top2b
Name: topoisomerase (DNA) II beta
Synonyms: Top-2, D230016L12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 21974
Homologene: 134711
Cyp2d10
Name: cytochrome P450, family 2, subfamily d, polypeptide 10
Synonyms: P450-2D, Cyp2d
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 13101
VEGA: 15
HGNC: HGNC:2625
Homologene: 86099
Gm10033
Name: predicted gene 10033
Synonyms: E230024E03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 378466
Pappa2
Name: pappalysin 2
Synonyms: placenta-specific 3, pregnancy-associated plasma preproprotein-A2, pregnancy-associated plasma protein-E, PAPP-A2, PLAC3, Pappe
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 23850
Homologene: 10661
Vmn2r53
Name: vomeronasal 2, receptor 53
Synonyms: EG637908
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 637908
Homologene: 104040
Or6c8
Name: olfactory receptor family 6 subfamily C member 8
Synonyms: GA_x6K02T2PULF-10765431-10764502, MOR115-1, Olfr767
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 258315
Homologene: 105186
Vmn2r4
Name: vomeronasal 2, receptor 4
Synonyms: EG637053
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 637053
Homologene: 129754
Pigc
Name: phosphatidylinositol glycan anchor biosynthesis, class C
Synonyms: 3110030E07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 67292
HGNC: HGNC:8960
Homologene: 7109
Slc22a22
Name: solute carrier family 22 (organic cation transporter), member 22
Synonyms: OAT-PG, BC026439
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 210463
Homologene: 18166
Zfp715
Name: zinc finger protein 715
Synonyms: 2610041B18Rik, mszf15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 69930
Homologene: 74591
Hmbox1
Name: homeobox containing 1
Synonyms: F830020C16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 219150
Homologene: 11589
Eef2k
Name: eukaryotic elongation factor-2 kinase
Synonyms: eEF-2K
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 13631
Homologene: 7299
Bcs1l
Name: BCS1-like (yeast)
Synonyms: 9130022O19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 66821
HGNC: HGNC:1020
Homologene: 3193
1700012B07Rik
Name: RIKEN cDNA 1700012B07 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 69324
Homologene: 78000
Chrng
Name: cholinergic receptor, nicotinic, gamma polypeptide
Synonyms: Achr-3, Acrg
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 11449
HGNC: HGNC:1967
Homologene: 3810
Nkain3
Name: Na+/K+ transporting ATPase interacting 3
Synonyms: E130310K16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 269513
Homologene: 18265
Pimreg
Name: PICALM interacting mitotic regulator
Synonyms: 2610008F03Rik, CATS, 6720460F02Rik, Fam64a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 109212
Homologene: 10378
Or12e10
Name: olfactory receptor family 12 subfamily E member 10
Synonyms: GA_x6K02T2Q125-49311440-49312384, MOR264-19, Olfr1145
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258317
Homologene: 27123
Herpud1
Name: homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
Synonyms: Herp, Mifl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 64209
Homologene: 40973
Tapbpl
Name: TAP binding protein-like
Synonyms: TAPBPL-R
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 213233
Homologene: 9958
Gm11545
Name: predicted gene 11545
Synonyms: C86086
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217122
Homologene: 135925
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 74,590,105 bp
  • C to T, chromosome 1 at 87,210,611 bp
  • T to C, chromosome 1 at 134,309,660 bp
  • A to T, chromosome 1 at 158,834,918 bp
  • T to A, chromosome 1 at 161,971,094 bp
  • T to A, chromosome 2 at 52,093,580 bp
  • T to C, chromosome 2 at 87,810,176 bp
  • T to C, chromosome 2 at 109,970,754 bp
  • C to A, chromosome 2 at 141,810,629 bp
  • G to T, chromosome 2 at 143,953,277 bp
  • T to C, chromosome 2 at 180,980,485 bp
  • A to T, chromosome 3 at 64,389,474 bp
  • A to T, chromosome 4 at 20,484,920 bp
  • A to T, chromosome 4 at 48,056,699 bp
  • A to G, chromosome 4 at 136,999,568 bp
  • A to G, chromosome 6 at 125,224,695 bp
  • C to T, chromosome 6 at 149,329,113 bp
  • T to C, chromosome 7 at 12,582,054 bp
  • T to C, chromosome 7 at 43,311,129 bp
  • C to A, chromosome 7 at 120,884,712 bp
  • A to T, chromosome 7 at 140,149,804 bp
  • G to C, chromosome 8 at 69,372,416 bp
  • T to A, chromosome 8 at 94,392,239 bp
  • A to G, chromosome 10 at 116,937,666 bp
  • T to A, chromosome 10 at 122,449,109 bp
  • T to A, chromosome 10 at 129,079,385 bp
  • G to A, chromosome 11 at 72,046,332 bp
  • T to C, chromosome 11 at 94,757,559 bp
  • T to C, chromosome 11 at 98,996,825 bp
  • G to T, chromosome 11 at 109,794,154 bp
  • C to A, chromosome 13 at 34,947,100 bp
  • T to C, chromosome 14 at 8,170,409 bp
  • T to C, chromosome 14 at 16,388,447 bp
  • T to C, chromosome 14 at 26,592,391 bp
  • T to C, chromosome 14 at 64,896,836 bp
  • C to T, chromosome 14 at 74,857,997 bp
  • T to C, chromosome 15 at 8,259,816 bp
  • C to A, chromosome 15 at 57,250,973 bp
  • A to G, chromosome 15 at 82,403,016 bp
  • T to C, chromosome 19 at 56,865,993 bp
  • A to G, chromosome X at 94,098,807 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3707 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040700-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.