Strain Name:
C57BL/6J-MtgxR3710Btlr/Mmmh
Stock Number:
040703-MU
Citation ID:
RRID:MMRRC_040703-MU
Other Names:
R3710 (G1), C57BL/6J-MtgxR3710Btlr
Major Collection:

Gene Information

Col2a1
Name: collagen, type II, alpha 1
Synonyms: Del1, Lpk, M100856, Col2, Rgsc856, Col2a, Col2a-1, M100413, Rgsc413
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 12824
HGNC: HGNC:2200
Homologene: 55607
Myh9
Name: myosin, heavy polypeptide 9, non-muscle
Synonyms: NMHC II-A, Myhn1, E030044M24Rik, Fltn, D0Jmb2, Myhn-1, myosin IIA
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 17886
HGNC: HGNC:7579
Homologene: 129835
Pdpk1
Name: 3-phosphoinositide dependent protein kinase 1
Synonyms: Pkb kinase, Pdk1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 18607
HGNC: HGNC:8816
Homologene: 37643
Diaph1
Name: diaphanous related formin 1
Synonyms: Diap1, D18Wsu154e, mDia1, Drf1, p140mDia, Dia1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 13367
HGNC: HGNC:2876
Homologene: 129567
Ipo8
Name: importin 8
Synonyms: Om1, C130009K11Rik, OM-1, Ranbp8, 6230418K12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 320727
HGNC: HGNC:9853
Homologene: 48430
Tomm22
Name: translocase of outer mitochondrial membrane 22
Synonyms: Tom22
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 223696
Homologene: 10638
Ankrd28
Name: ankyrin repeat domain 28
Synonyms: E430019N21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 105522
VEGA: 14
Homologene: 35374
Otof
Name: otoferlin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 83762
HGNC: HGNC:8515
Homologene: 12892
Cic
Name: capicua transcriptional repressor
Synonyms: 1200010B10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 71722
Homologene: 87637
Car12
Name: carbonic anhydrase 12
Synonyms: 2310047E01Rik, CA XII
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 76459
HGNC: HGNC:1371
Homologene: 20327
Il15ra
Name: interleukin 15 receptor, alpha chain
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 16169
HGNC: HGNC:5978
Homologene: 1650
Rbms2
Name: RNA binding motif, single stranded interacting protein 2
Synonyms: Scr3, 2610315E04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 56516
VEGA: 10
HGNC: HGNC:9909
Homologene: 37706
Rps17
Name: ribosomal protein S17
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 20068
Homologene: 110867
Tph2
Name: tryptophan hydroxylase 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 216343
Homologene: 27831
Aak1
Name: AP2 associated kinase 1
Synonyms: D6Ertd245e, 5530400K14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 269774
Homologene: 128746
Dsg2
Name: desmoglein 2
Synonyms: D18Ertd293e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 13511
HGNC: HGNC:3049
Homologene: 1464
Rps3
Name: ribosomal protein S3
Synonyms: D7Ertd795e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 27050
Homologene: 779
Lsm14a
Name: LSM14A mRNA processing body assembly factor
Synonyms: 2700023B17Rik, Tral
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 67070
Homologene: 40537
Osbpl10
Name: oxysterol binding protein-like 10
Synonyms: C820004B04Rik, 4933433D06Rik, OPR-10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 74486
Homologene: 69240
Eif5b
Name: eukaryotic translation initiation factor 5B
Synonyms: A030003E17Rik, IF2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 226982
Homologene: 134613
March6
Name: membrane-associated ring finger (C3HC4) 6
Synonyms: F830029L24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 223455
VEGA: 15
Homologene: 4301
Ank1
Name: ankyrin 1, erythroid
Synonyms: pale, Ank-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 11733
HGNC: HGNC:492
Homologene: 55427
Col9a2
Name: collagen, type IX, alpha 2
Synonyms: Col9a-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 12840
HGNC: HGNC:2218
Homologene: 37535
Cdc42bpa
Name: CDC42 binding protein kinase alpha
Synonyms: A930014J19Rik, DMPK-like
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 226751
HGNC: HGNC:1737
Homologene: 55765
Zc3hav1
Name: zinc finger CCCH type, antiviral 1
Synonyms: ZAP, 9830115L13Rik, 2900058M19Rik, 9130009D18Rik, 1200014N16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 78781
Homologene: 10585
Gm1965
Name: predicted gene 1965
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 434065
B4galt3
Name: UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 3
Synonyms: ESTM26, R74981, beta4GalT-III, 9530061M23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 57370
HGNC: HGNC:926
Homologene: 48241
Adcy8
Name: adenylate cyclase 8
Synonyms: AC8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 11514
VEGA: 15
HGNC: HGNC:239
Homologene: 37443
Gprc6a
Name: G protein-coupled receptor, family C, group 6, member A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 210198
VEGA: 10
Homologene: 17529
Ap3b2
Name: adaptor-related protein complex 3, beta 2 subunit
Synonyms: beta3B, Naptb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 11775
HGNC: HGNC:567
Homologene: 55837
Ros1
Name: Ros1 proto-oncogene
Synonyms: c-ros, Ros-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 19886
Homologene: 2207
Atrnl1
Name: attractin like 1
Synonyms: Alp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 226255
VEGA: 19
Homologene: 45809
Vmn2r108
Name: vomeronasal 2, receptor 108
Synonyms: EG627805
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 627805
Homologene: 129678
D130040H23Rik
Name: RIKEN cDNA D130040H23 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 211135
Homologene: 138403
Agbl2
Name: ATP/GTP binding protein-like 2
Synonyms: Ccp2, Ccp2, A430081C19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 271813
Homologene: 11715
Smarca2
Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
Synonyms: brm, Snf2l2, 2610209L14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 67155
Homologene: 2308
Rimbp2
Name: RIMS binding protein 2
Synonyms: A930033C01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 231760
Homologene: 14672
Mael
Name: maelstrom spermatogenic transposon silencer
Synonyms: 4933405K18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 98558
Homologene: 13143
Tgm1
Name: transglutaminase 1, K polypeptide
Synonyms: protein-glutamine-gamma-glutamyltransferase, K polypeptide, TGase1, 2310004J08Rik, TG K, TGase 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 21816
VEGA: 14
Homologene: 306
Gsto1
Name: glutathione S-transferase omega 1
Synonyms: p28, GSTX
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 14873
Homologene: 37971
Mtmr10
Name: myotubularin related protein 10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 233315
Homologene: 9822
Nlrp4c
Name: NLR family, pyrin domain containing 4C
Synonyms: Nalp-alpha, Rnh2, Nalp4c
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 83564
Homologene: 75315
Ogfod1
Name: 2-oxoglutarate and iron-dependent oxygenase domain containing 1
Synonyms: 4930415J21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 270086
Homologene: 41238
Olfr1434
Name: olfactory receptor 1434
Synonyms: Olfr1433, MOR214-4, GA_x6K02T2RE5P-2610001-2610414, GA_x6K02T2RE5P-2618516-2619454, MOR214-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 258680
Homologene: 45029
Syne3
Name: spectrin repeat containing, nuclear envelope family member 3
Synonyms: nesprin-3, nesprin-3beta, nesprin-3alpha, 4831426I19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 212073
VEGA: 12
Homologene: 17625
Vmn2r69
Name: vomeronasal 2, receptor 69
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 330581
Homologene: 115466
Csn3
Name: casein kappa
Synonyms: CSN10, Csnk
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 12994
HGNC: HGNC:2446
Homologene: 3818
Bud23
Name: BUD23, rRNA methyltransferase and ribosome maturation factor
Synonyms: 1110003N24Rik, Wbscr22
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 66138
Homologene: 5486
Cav3
Name: caveolin 3
Synonyms: Cav-3, M-caveolin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 12391
HGNC: HGNC:1529
Homologene: 7255
Spz1
Name: spermatogenic leucine zipper 1
Synonyms: 1700027M20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 79401
VEGA: 13
Homologene: 49934
E130304F04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
Aida
Name: axin interactor, dorsalization associated
Synonyms: 2610208M17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 108909
Homologene: 11268
Samd11
Name: sterile alpha motif domain containing 11
Synonyms: mr-s
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 231004
VEGA: 4
Homologene: 34983
Matn4
Name: matrilin 4
Synonyms: matrilin-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 17183
HGNC: HGNC:6910
Homologene: 2844
Was
Name: Wiskott-Aldrich syndrome
Synonyms: U42471, Wasp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
Alteration at locus: Chemically Induced
NCBI: 22376
Homologene: 30970
Sprr2g
Name: small proline-rich protein 2G
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 20761
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 38,050,172 bp
  • T to C, chromosome 1 at 166,238,566 bp
  • C to A, chromosome 1 at 171,274,043 bp
  • A to G, chromosome 1 at 180,065,063 bp
  • C to A, chromosome 1 at 183,304,675 bp
  • G to T, chromosome 2 at 11,730,647 bp
  • G to A, chromosome 2 at 90,805,808 bp
  • A to G, chromosome 2 at 164,393,008 bp
  • C to A, chromosome 3 at 92,374,729 bp
  • C to G, chromosome 4 at 121,054,258 bp
  • G to A, chromosome 4 at 156,250,495 bp
  • A to T, chromosome 5 at 30,385,266 bp
  • C to A, chromosome 5 at 87,930,023 bp
  • G to A, chromosome 5 at 128,789,731 bp
  • A to C, chromosome 5 at 135,056,350 bp
  • A to C, chromosome 6 at 38,332,162 bp
  • C to A, chromosome 6 at 86,950,875 bp
  • A to T, chromosome 6 at 89,145,425 bp
  • T to A, chromosome 6 at 112,459,813 bp
  • A to T, chromosome 6 at 148,806,344 bp
  • T to A, chromosome 7 at 6,065,628 bp
  • A to G, chromosome 7 at 25,286,981 bp
  • T to A, chromosome 7 at 34,353,779 bp
  • C to A, chromosome 7 at 64,326,685 bp
  • T to A, chromosome 7 at 81,344,924 bp
  • C to T, chromosome 7 at 81,473,850 bp
  • T to A, chromosome 7 at 85,406,393 bp
  • T to C, chromosome 7 at 99,479,419 bp
  • A to G, chromosome 8 at 23,087,079 bp
  • T to G, chromosome 8 at 69,300,834 bp
  • A to T, chromosome 8 at 94,057,752 bp
  • G to T, chromosome 9 at 66,750,978 bp
  • C to A, chromosome 9 at 115,207,587 bp
  • CAAA to CA, chromosome 10 at 51,615,680 bp
  • A to T, chromosome 10 at 52,161,895 bp
  • T to A, chromosome 10 at 115,174,058 bp
  • C to T, chromosome 10 at 128,143,443 bp
  • A to G, chromosome 12 at 104,943,438 bp
  • G to A, chromosome 13 at 92,575,123 bp
  • A to G, chromosome 13 at 119,712,099 bp
  • A to G, chromosome 14 at 31,748,851 bp
  • C to A, chromosome 14 at 55,712,595 bp
  • A to T, chromosome 15 at 31,509,826 bp
  • T to C, chromosome 15 at 64,725,535 bp
  • T to C, chromosome 15 at 77,773,347 bp
  • T to C, chromosome 15 at 79,671,218 bp
  • A to G, chromosome 15 at 97,990,907 bp
  • A to T, chromosome 17 at 20,462,670 bp
  • A to G, chromosome 17 at 24,091,603 bp
  • A to G, chromosome 18 at 20,602,117 bp
  • C to A, chromosome 18 at 37,845,484 bp
  • T to G, chromosome 19 at 12,283,086 bp
  • T to G, chromosome 19 at 26,668,890 bp
  • T to C, chromosome 19 at 47,859,532 bp
  • C to A, chromosome 19 at 57,657,114 bp
  • G to T, chromosome X at 8,086,688 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3710 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040703-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.