Strain Name:
C57BL/6J-MtgxR3721Btlr/Mmmh
Stock Number:
040712-MU
Citation ID:
RRID:MMRRC_040712-MU
Other Names:
R3721 (G1), C57BL/6J-MtgxR3721Btlr
Major Collection:

Gene Information

Rab6b
Name: RAB6B, member RAS oncogene family
Synonyms: C330006L04Rik, D9Bwg0185e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 270192
Homologene: 39749
Acvr2a
Name: activin receptor IIA
Synonyms: ActRIIa, tActRII, Acvr2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 11480
HGNC: HGNC:173
Homologene: 20391
Ranbp17
Name: RAN binding protein 17
Synonyms: 4932704E15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 66011
Homologene: 36409
Ash2l
Name: ASH2 like histone lysine methyltransferase complex subunit
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 23808
HGNC: HGNC:744
Homologene: 3436
Myh10
Name: myosin, heavy polypeptide 10, non-muscle
Synonyms: nonmuscle myosin heavy chain II-B, NMHC-B, SMemb, nonmuscle myosin heavy chain IIB, 9330167F11Rik, 5730504C04Rik, Myhn2, Myosin IIB, NMHC II-B, Myhn-2, myosin IIB, Fltn, Fltn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 77579
HGNC: HGNC:7568
Homologene: 55941
Naa25
Name: N(alpha)-acetyltransferase 25, NatB auxiliary subunit
Synonyms: 4833422K13Rik, C330023M02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231713
Homologene: 6891
Nol9
Name: nucleolar protein 9
Synonyms: 6030462G04Rik, 4632412I24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 74035
Homologene: 32589
Srrm2
Name: serine/arginine repetitive matrix 2
Synonyms: 5033413A03Rik, SRm300
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 75956
Cdc73
Name: cell division cycle 73, Paf1/RNA polymerase II complex component
Synonyms: C130030P16Rik, 8430414L16Rik, Hrpt2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 214498
Homologene: 11571
Slc44a1
Name: solute carrier family 44, member 1
Synonyms: CHTL1, CTL1, 4833416H08Rik, Cdw92, 2210409B22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 100434
Homologene: 11137
Ubn1
Name: ubinuclein 1
Synonyms: 1110029L11Rik, 2610108L02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 170644
VEGA: 16
Homologene: 9656
Myo9a
Name: myosin IXa
Synonyms: 4732465J09Rik, C130068I12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 270163
HGNC: HGNC:7608
Homologene: 21371
Smc5
Name: structural maintenance of chromosomes 5
Synonyms: Smc5l1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 226026
VEGA: 19
Homologene: 41009
Rcc1
Name: regulator of chromosome condensation 1
Synonyms: 4931417M11Rik, Chc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 100088
HGNC: HGNC:1913
Homologene: 55567
Dars2
Name: aspartyl-tRNA synthetase 2 (mitochondrial)
Synonyms: 5830468K18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226539
Homologene: 7093
Rad1
Name: RAD1 checkpoint DNA exonuclease
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 19355
HGNC: HGNC:9806
Homologene: 37695
Mei1
Name: meiotic double-stranded break formation protein 1
Synonyms: mei1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 74369
Homologene: 46535
Enpp6
Name: ectonucleotide pyrophosphatase/phosphodiesterase 6
Synonyms: B830047L21Rik, D8Ertd514e, 4833421B01Rik, Npp6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 320981
Homologene: 62657
Lypd4
Name: Ly6/Plaur domain containing 4
Synonyms: 4933400F01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 232973
Homologene: 45458
Larp7
Name: La ribonucleoprotein 7, transcriptional regulator
Synonyms: D3Wsu161e, C330027G06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 28036
Homologene: 88843
Hp1bp3
Name: heterochromatin protein 1, binding protein 3
Synonyms: Hp1bp74
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 15441
Homologene: 7774
Kirrel
Name: kirre like nephrin family adhesion molecule 1
Synonyms: Neph1, Kirrel1, 6720469N11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 170643
Homologene: 10089
Hectd3
Name: HECT domain E3 ubiquitin protein ligase 3
Synonyms: 1700064K09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 76608
Homologene: 18426
Pomgnt1
Name: protein O-linked mannose beta 1,2-N-acetylglucosaminyltransferase
Synonyms: 0610016I07Rik, 4930467B06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 68273
Homologene: 9806
Spink4
Name: serine peptidase inhibitor, Kazal type 4
Synonyms: MPGC60
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 20731
Homologene: 7954
Pkhd1
Name: polycystic kidney and hepatic disease 1
Synonyms: tigmin, FPC
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 241035
HGNC: HGNC:9016
Homologene: 16336
Pde10a
Name: phosphodiesterase 10A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 23984
HGNC: HGNC:8772
Homologene: 4852
Emilin2
Name: elastin microfibril interfacer 2
Synonyms: basilin, FOAP-10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 246707
VEGA: 17
Homologene: 36483
Slc7a1
Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
Synonyms: Rev-1, Rec-1, Atrc-1, Atrc1, 4831426K01Rik, mCAT-1, Cat1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 11987
Homologene: 20658
Irs1
Name: insulin receptor substrate 1
Synonyms: IRS-1, G972R
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 16367
HGNC: HGNC:6125
Homologene: 4049
Rnf135
Name: ring finger protein 135
Synonyms: U 2-3-0, MGC13061, 0610037N03Rik, 2410006N06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 71956
Homologene: 12427
Adamts2
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 2
Synonyms: ADAM-TS2, hPCPNI, a disintegrin and metalloproteinase with thrombospondin repeats, procollagen N-proteinase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216725
HGNC: HGNC:218
Homologene: 8597
Catsperg2
Name: cation channel sperm associated auxiliary subunit gamma 2
Synonyms: 1700067C01Rik, CATSPERG
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 76718
Homologene: 10915
Slc2a2
Name: solute carrier family 2 (facilitated glucose transporter), member 2
Synonyms: liver-type glucose transporter, Glut-2, Glut2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 20526
Homologene: 68047
Gm5155
Name: predicted gene 5155
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 381852
Homologene: 115938
Clec2e
Name: C-type lectin domain family 2, member e
Synonyms: Clra
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232409
Homologene: 131164
Dnai1
Name: dynein axonemal intermediate chain 1
Synonyms: 1110066F04Rik, Dnaic1, b2b1526Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 68922
HGNC: HGNC:2954
Homologene: 8122
Sntb1
Name: syntrophin, basic 1
Synonyms: beta1-Syntrophin, 59-1 DAP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 20649
Homologene: 9618
Sh3bp4
Name: SH3-domain binding protein 4
Synonyms: BOG25
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 98402
Homologene: 8726
Il18rap
Name: interleukin 18 receptor accessory protein
Synonyms: AcPL accessory protein-like)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 16174
HGNC: HGNC:5989
Homologene: 2859
Tufm
Name: Tu translation elongation factor, mitochondrial
Synonyms: EF-TuMT, 2300002G02Rik, C76308
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233870
Homologene: 2490
Cers5
Name: ceramide synthase 5
Synonyms: 2310081H14Rik, Trh4, CerS5, Lass5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 71949
Homologene: 23634
Cyp3a59
Name: cytochrome P450, family 3, subfamily a, polypeptide 59
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 100041449
Homologene: 135775
F11
Name: coagulation factor XI
Synonyms: plasma thromboplastin antecedent, FXI, Cf11, 1600027G01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 109821
HGNC: HGNC:3529
Homologene: 86654
Rars2
Name: arginyl-tRNA synthetase 2, mitochondrial
Synonyms: PRO1992, 1500002I10Rik, Rarsl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 109093
Homologene: 5707
Arhgap9
Name: Rho GTPase activating protein 9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 216445
VEGA: 10
Homologene: 13041
Ric8a
Name: RIC8 guanine nucleotide exchange factor A
Synonyms: RIC-8, synembryn, Ric8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 101489
Homologene: 23331
Or4k2
Name: olfactory receptor family 4 subfamily K member 2
Synonyms: GA_x6K02T2PMLR-5881670-5880717, MOR247-1, Olfr730
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 258486
Homologene: 17269
Poll
Name: polymerase (DNA directed), lambda
Synonyms: 1110003P06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 56626
VEGA: 19
HGNC: HGNC:9184
Homologene: 40863
Gsta3
Name: glutathione S-transferase, alpha 3
Synonyms: Gst2-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 14859
HGNC: HGNC:4628
Homologene: 37355
Ccrl2
Name: chemokine (C-C motif) receptor-like 2
Synonyms: 1810047I05Rik, L-CCR, Cmkbr1l2, CCR11, Ackr5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 54199
HGNC: HGNC:1612
Homologene: 2948
Fam102b
Name: family with sequence similarity 102, member B
Synonyms: 1600010D10Rik, B430201A12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 329739
Homologene: 46568
Lair1
Name: leukocyte-associated Ig-like receptor 1
Synonyms: 5133400O11Rik, mLair-1, Lair-1, D7Bwg0421e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 52855
Homologene: 48097
Rps6ka4
Name: ribosomal protein S6 kinase, polypeptide 4
Synonyms: MSK2, 1110069D02Rik, 90kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 56613
VEGA: 19
Homologene: 69288
Or5p72
Name: olfactory receptor family 5 subfamily P member 72
Synonyms: GA_x6K02T2PBJ9-10752603-10753547, MOR204-9, Olfr497
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258733
Homologene: 133602
Dlg2
Name: discs large MAGUK scaffold protein 2
Synonyms: PSD93, Chapsyn-110, A330103J02Rik, B330007M19Rik, LOC382816, Dlgh2, B230218P12Rik, Gm21505
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 23859
HGNC: HGNC:2901
Homologene: 1046
Lhx1
Name: LIM homeobox protein 1
Synonyms: Lim1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 16869
HGNC: HGNC:6593
Homologene: 4068
Gpr171
Name: G protein-coupled receptor 171
Synonyms: F730001G15Rik, H963
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229323
Homologene: 36330
Ggnbp1
Name: gametogenetin binding protein 1
Synonyms: 0610031G08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 70772
Homologene: 79568
Diras2
Name: DIRAS family, GTP-binding RAS-like 2
Synonyms: 2900052J15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 68203
VEGA: 13
Homologene: 56777
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 20,585,655 bp
  • T to C, chromosome 1 at 21,260,089 bp
  • T to A, chromosome 1 at 40,537,088 bp
  • C to T, chromosome 1 at 82,290,085 bp
  • A to G, chromosome 1 at 89,145,328 bp
  • T to C, chromosome 1 at 143,695,453 bp
  • A to T, chromosome 1 at 161,063,308 bp
  • T to C, chromosome 2 at 48,892,138 bp
  • T to A, chromosome 3 at 28,727,152 bp
  • A to G, chromosome 3 at 59,097,670 bp
  • C to T, chromosome 3 at 87,089,151 bp
  • C to T, chromosome 3 at 108,979,767 bp
  • A to G, chromosome 3 at 127,546,811 bp
  • T to A, chromosome 4 at 34,659,970 bp
  • T to A, chromosome 4 at 40,929,136 bp
  • G to A, chromosome 4 at 41,602,615 bp
  • T to C, chromosome 4 at 53,491,445 bp
  • T to G, chromosome 4 at 116,153,543 bp
  • T to A, chromosome 4 at 116,999,745 bp
  • T to C, chromosome 4 at 132,337,814 bp
  • T to G, chromosome 4 at 138,239,608 bp
  • A to G, chromosome 4 at 152,039,706 bp
  • T to A, chromosome 5 at 121,431,556 bp
  • T to A, chromosome 5 at 146,096,597 bp
  • G to A, chromosome 5 at 148,335,533 bp
  • C to A, chromosome 6 at 129,094,410 bp
  • A to C, chromosome 7 at 4,010,783 bp
  • A to G, chromosome 7 at 17,902,738 bp
  • C to A, chromosome 7 at 24,865,459 bp
  • A to G, chromosome 7 at 29,705,102 bp
  • T to A, chromosome 7 at 91,711,800 bp
  • G to T, chromosome 7 at 108,423,119 bp
  • T to C, chromosome 7 at 126,490,460 bp
  • T to C, chromosome 7 at 140,861,961 bp
  • C to G, chromosome 8 at 25,818,625 bp
  • A to G, chromosome 8 at 45,248,638 bp
  • C to T, chromosome 8 at 47,082,861 bp
  • G to A, chromosome 9 at 59,868,180 bp
  • T to C, chromosome 9 at 103,167,174 bp
  • T to C, chromosome 9 at 111,056,364 bp
  • A to G, chromosome 10 at 127,328,971 bp
  • GCCTGGATACTGACC to GCC, chromosome 11 at 33,219,203 bp
  • C to T, chromosome 11 at 50,773,211 bp
  • G to T, chromosome 11 at 68,813,052 bp
  • G to T, chromosome 11 at 80,196,917 bp
  • G to A, chromosome 11 at 84,521,828 bp
  • T to A, chromosome 13 at 52,508,023 bp
  • C to T, chromosome 14 at 50,186,680 bp
  • T to C, chromosome 15 at 10,488,026 bp
  • C to A, chromosome 15 at 55,642,818 bp
  • A to G, chromosome 15 at 82,103,204 bp
  • C to A, chromosome 15 at 99,772,663 bp
  • A to G, chromosome 16 at 5,073,378 bp
  • T to A, chromosome 17 at 8,969,589 bp
  • CTCCTCTTCTTCCTCTTCTTCCTC to CTCCTCTTCTTCCTC, chromosome 17 at 23,822,575 bp
  • T to C, chromosome 17 at 27,029,613 bp
  • T to C, chromosome 17 at 71,273,454 bp
  • A to G, chromosome 19 at 6,839,277 bp
  • T to C, chromosome 19 at 23,210,492 bp
  • A to G, chromosome 19 at 45,553,577 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3721 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040712-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.