Strain Name:
C57BL/6J-MtgxR3725Btlr/Mmmh
Stock Number:
040716-MU
Citation ID:
RRID:MMRRC_040716-MU
Other Names:
R3725 (G1), C57BL/6J-MtgxR3725Btlr
Major Collection:

Gene Information

Lamb1
Name: laminin B1
Synonyms: Lamb-1, C81607, C80098, D130003D08Rik, Lamb1-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 16777
HGNC: HGNC:6486
Homologene: 1722
Tmem59l
Name: transmembrane protein 59-like
Synonyms: 5330410G16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 67937
Homologene: 8104
Camsap3
Name: calmodulin regulated spectrin-associated protein family, member 3
Synonyms: Nezha, 2310057J16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 69697
Homologene: 18966
Vpreb3
Name: pre-B lymphocyte gene 3
Synonyms: Vpreb-3, 8HS-20
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 22364
Homologene: 7598
Rxra
Name: retinoid X receptor alpha
Synonyms: RXRalpha1, RXR alpha 1, 9530071D11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 20181
Homologene: 2220
Cdk5rap2
Name: CDK5 regulatory subunit associated protein 2
Synonyms: 2900018K03Rik, an
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 214444
Homologene: 49533
Atp6v1a
Name: ATPase, H+ transporting, lysosomal V1 subunit A
Synonyms: VPP2, VA68, Atp6a1, lysosomal 70kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 11964
HGNC: HGNC:851
Homologene: 123934
Adam8
Name: a disintegrin and metallopeptidase domain 8
Synonyms: CD156, MS2, E430039A18Rik, CD156a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 11501
HGNC: HGNC:215
Homologene: 74384
Zkscan5
Name: zinc finger with KRAB and SCAN domains 5
Synonyms: hKraba1, Zfp95
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 22757
Homologene: 8734
Samd7
Name: sterile alpha motif domain containing 7
Synonyms: 4930597A01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 75953
Homologene: 18802
Tasor2
Name: transcription activation suppressor family member 2
Synonyms: BC016423, Fam208b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 105203
VEGA: 13
Homologene: 26435
Dmxl2
Name: Dmx-like 2
Synonyms: E130119P06Rik, 6430411K14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235380
HGNC: HGNC:2938
Homologene: 41022
Gja8
Name: gap junction protein, alpha 8
Synonyms: Cnx50, connexin 50, alpha 8 connexin, Cx50, Aey5, Lop10, dcm
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 14616
HGNC: HGNC:4281
Homologene: 3857
Dsp
Name: desmoplakin
Synonyms: DP, 2300002E22Rik, 5730453H04Rik, rul
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 109620
HGNC: HGNC:3052
Homologene: 37922
Vps13d
Name: vacuolar protein sorting 13D
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230895
Homologene: 15583
Epg5
Name: ectopic P-granules autophagy protein 5 homolog (C. elegans)
Synonyms: 5430411K18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 100502841
VEGA: 18
Homologene: 14575
Smarcb1
Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
Synonyms: SNF5/INI1, integrase interactor 1, Baf47, Ini1, Snf5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 20587
Homologene: 2310
Ddx24
Name: DEAD box helicase 24
Synonyms: 2510027P10Rik, 1700055J08Rik, DEAD (Asp-Glu-Ala-Asp) box polypeptide 24
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 27225
VEGA: 12
Homologene: 10702
Nipbl
Name: NIPBL cohesin loading factor
Synonyms: 4921518A06Rik, 4933421G18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 71175
VEGA: 15
Homologene: 15850
Polr3g
Name: polymerase (RNA) III (DNA directed) polypeptide G
Synonyms: RPC32, 2310047G20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 67486
Homologene: 38184
Fam135a
Name: family with sequence similarity 135, member A
Synonyms: 4921533L14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 68187
Homologene: 32665
Slmap
Name: sarcolemma associated protein
Synonyms: Slap, D330001L02Rik, Miranda
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 83997
Homologene: 31428
Uggt1
Name: UDP-glucose glycoprotein glucosyltransferase 1
Synonyms: C820010P03Rik, 0910001L17Rik, A930007H10Rik, Ugcgl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 320011
Homologene: 10586
Tnrc6c
Name: trinucleotide repeat containing 6C
Synonyms: 9930033H14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217351
Homologene: 23137
Fzd5
Name: frizzled class receptor 5
Synonyms: Fz5, 5330434N09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 14367
HGNC: HGNC:4043
Homologene: 2590
Galnt12
Name: polypeptide N-acetylgalactosaminyltransferase 12
Synonyms: A630062B03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230145
Homologene: 11637
Adamtsl3
Name: ADAMTS-like 3
Synonyms: punctin-2, 9230119C12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 269959
Homologene: 18912
Dhx36
Name: DEAH (Asp-Glu-Ala-His) box polypeptide 36
Synonyms: Ddx36, 2810407E23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 72162
Homologene: 6356
Slc22a29
Name: solute carrier family 22. member 29
Synonyms: D630002G06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 236293
Homologene: 77136
Rapgef5
Name: Rap guanine nucleotide exchange factor (GEF) 5
Synonyms: mr-gef, D030051B22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217944
VEGA: 12
Homologene: 56563
Ppfia4
Name: protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4
Synonyms: 1110008G13Rik, LOC100042382, Liprin-alpha4, Gm3812
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 68507
HGNC: HGNC:9248
Homologene: 66200
Stpg2
Name: sperm tail PG rich repeat containing 2
Synonyms: LOC381476, B930007M17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 381476
Homologene: 52167
Rbbp8
Name: retinoblastoma binding protein 8, endonuclease
Synonyms: 9930104E21Rik, CtIP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 225182
VEGA: 18
HGNC: HGNC:9891
Homologene: 28546
Col9a1
Name: collagen, type IX, alpha 1
Synonyms: Col9a-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12839
HGNC: HGNC:2217
Homologene: 1393
Ccdc81
Name: coiled-coil domain containing 81
Synonyms: 4921513D09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 70884
Homologene: 128447
Olfr805
Name: olfactory receptor 805
Synonyms: GA_x6K02T2PULF-11402237-11401278, MOR110-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 258548
Smarcal1
Name: SWI/SNF related matrix associated, actin dependent regulator of chromatin, subfamily a-like 1
Synonyms: Mharp, 6030401P21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 54380
Homologene: 8558
Pcdhb9
Name: protocadherin beta 9
Synonyms: Pcdhb4C, PcdhbI
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 93880
Homologene: 87124
Fam209
Name: family with sequence similarity 209
Synonyms: 1700029J11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 76426
Homologene: 19218
Fbxo11
Name: F-box protein 11
Synonyms: GENA 104, Jf
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 225055
Homologene: 11843
Vmn2r7
Name: vomeronasal 2, receptor 7
Synonyms: 4933425M15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 319217
Homologene: 129754
Vmn2r54
Name: vomeronasal 2, receptor 54
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 666085
Homologene: 104040
Cfh
Name: complement component factor h
Synonyms: Sas-1, Mud-1, Sas1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12628
HGNC: HGNC:4883
Homologene: 20086
Pigc
Name: phosphatidylinositol glycan anchor biosynthesis, class C
Synonyms: 3110030E07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 67292
HGNC: HGNC:8960
Homologene: 7109
Psg18
Name: pregnancy specific glycoprotein 18
Synonyms: mmCGM6, Cea-3, Cea3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 26438
Homologene: 110989
Cyp3a11
Name: cytochrome P450, family 3, subfamily a, polypeptide 11
Synonyms: IIIAm1, Cyp3a, Pcn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 13112
HGNC: HGNC:2638
Homologene: 133568
Mlip
Name: muscular LMNA-interacting protein
Synonyms: 2310046A06Rik, CIP, cardiac ISL1-interacting protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 69642
Homologene: 90445
Nfxl1
Name: nuclear transcription factor, X-box binding-like 1
Synonyms: TCF9, LOC381696, D430033A06Rik, 1700012H24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 100978
Homologene: 26752
Tmem19
Name: transmembrane protein 19
Synonyms: 2810428F02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 67226
VEGA: 10
Homologene: 10107
Rad9a
Name: RAD9 checkpoint clamp component A
Synonyms: Rad9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 19367
VEGA: 19
HGNC: HGNC:9827
Homologene: 32118
Gsdmd
Name: gasdermin D
Synonyms: M2-4, DF5L, 1810036L03Rik, Dfna5l, Gsdmdc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 69146
VEGA: 15
Homologene: 12299
Vmn1r205
Name: vomeronasal 1 receptor 205
Synonyms: V1rh8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 171251
Homologene: 110880
Olfr1355
Name: olfactory receptor 1355
Synonyms: GA_x6K02T2QGN0-2932609-2931677, MOR139-6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 257734
Homologene: 136441
Gm7173
Name: predicted gene 7173
Synonyms:
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
Tmod1
Name: tropomodulin 1
Synonyms: E-Tmod, erythrocyte tropomodulin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 21916
Homologene: 20701
Ac174597.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Slc11a1
Name: solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1
Synonyms: host resistance locus Bcg/Ity/Lsh, Bcg, Ity, Nramp, Lsh, ity, Nramp1, Ity1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 18173
Homologene: 73884
Sptssa
Name: serine palmitoyltransferase, small subunit A
Synonyms: 1110002B05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 104725
VEGA: 12
Homologene: 15889
Gm8730
Name: predicted pseudogene 8730
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 667618
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 24,057,434 bp
  • A to G, chromosome 1 at 24,195,460 bp
  • A to T, chromosome 1 at 36,182,507 bp
  • A to G, chromosome 1 at 64,736,339 bp
  • T to C, chromosome 1 at 72,626,596 bp
  • C to A, chromosome 1 at 74,376,784 bp
  • T to C, chromosome 1 at 134,313,711 bp
  • T to C, chromosome 1 at 140,086,496 bp
  • G to A, chromosome 1 at 161,971,291 bp
  • A to G, chromosome 2 at 27,754,277 bp
  • T to C, chromosome 2 at 172,473,995 bp
  • T to C, chromosome 3 at 30,751,134 bp
  • A to T, chromosome 3 at 62,488,222 bp
  • A to T, chromosome 3 at 64,724,991 bp
  • A to G, chromosome 3 at 96,919,845 bp
  • A to G, chromosome 3 at 139,317,477 bp
  • T to C, chromosome 4 at 46,097,026 bp
  • A to T, chromosome 4 at 47,104,140 bp
  • C to A, chromosome 4 at 70,235,437 bp
  • T to A, chromosome 4 at 145,115,648 bp
  • A to T, chromosome 5 at 72,517,062 bp
  • A to T, chromosome 5 at 145,220,913 bp
  • A to G, chromosome 5 at 145,866,000 bp
  • C to A, chromosome 6 at 68,632,274 bp
  • G to A, chromosome 7 at 12,632,296 bp
  • T to A, chromosome 7 at 18,354,823 bp
  • A to C, chromosome 7 at 82,612,404 bp
  • A to T, chromosome 7 at 89,866,630 bp
  • T to A, chromosome 7 at 139,983,868 bp
  • T to C, chromosome 8 at 3,603,785 bp
  • A to G, chromosome 8 at 70,487,301 bp
  • T to C, chromosome 8 at 102,865,032 bp
  • T to A, chromosome 9 at 54,393,769 bp
  • A to G, chromosome 9 at 77,190,380 bp
  • T to A, chromosome 10 at 75,916,786 bp
  • G to A, chromosome 10 at 75,943,291 bp
  • T to A, chromosome 10 at 78,879,932 bp
  • A to G, chromosome 10 at 115,359,770 bp
  • A to T, chromosome 10 at 129,723,115 bp
  • C to T, chromosome 11 at 117,723,529 bp
  • C to T, chromosome 12 at 31,321,075 bp
  • T to C, chromosome 12 at 54,656,395 bp
  • A to G, chromosome 12 at 103,417,605 bp
  • T to A, chromosome 12 at 117,755,950 bp
  • T to C, chromosome 13 at 3,590,538 bp
  • A to T, chromosome 13 at 22,592,501 bp
  • A to G, chromosome 13 at 38,194,689 bp
  • A to G, chromosome 13 at 38,197,618 bp
  • C to T, chromosome 13 at 81,694,635 bp
  • C to A, chromosome 14 at 26,427,242 bp
  • T to C, chromosome 15 at 8,295,661 bp
  • A to G, chromosome 15 at 75,866,090 bp
  • A to G, chromosome 16 at 44,101,757 bp
  • A to G, chromosome 17 at 88,009,286 bp
  • G to T, chromosome 18 at 11,732,176 bp
  • T to C, chromosome 18 at 37,401,601 bp
  • T to C, chromosome 18 at 78,017,679 bp
  • G to A, chromosome 19 at 4,197,695 bp
  • A to T, chromosome 19 at 8,218,609 bp
  • T to A, chromosome X at 79,510,015 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3725 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040716-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.