Strain Name:
C57BL/6J-MtgxR3726Btlr/Mmmh
Stock Number:
040717-MU
Citation ID:
RRID:MMRRC_040717-MU
Other Names:
R3726 (G1), C57BL/6J-MtgxR3726Btlr
Major Collection:

Gene Information

Lamb1
Name: laminin B1
Synonyms: Lamb-1, C81607, C80098, D130003D08Rik, Lamb1-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 16777
HGNC: HGNC:6486
Homologene: 1722
Itga8
Name: integrin alpha 8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241226
HGNC: HGNC:6144
Homologene: 37396
Gsr
Name: glutathione reductase
Synonyms: Gr-1, Gr1, D8Ertd238e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 14782
HGNC: HGNC:4623
Homologene: 531
Sptan1
Name: spectrin alpha, non-erythrocytic 1
Synonyms: alpha-fodrin, Spna-2, 2610027H02Rik, Spna2, alphaII-spectrin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 20740
Homologene: 2353
Tmem59l
Name: transmembrane protein 59-like
Synonyms: 5330410G16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 67937
Homologene: 8104
Hdgf
Name: heparin binding growth factor
Synonyms: D3Ertd299e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 15191
HGNC: HGNC:4856
Homologene: 3306
Camsap3
Name: calmodulin regulated spectrin-associated protein family, member 3
Synonyms: Nezha, 2310057J16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 69697
Homologene: 18966
Vpreb3
Name: pre-B lymphocyte gene 3
Synonyms: Vpreb-3, 8HS-20
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 22364
Homologene: 7598
Ggnbp2
Name: gametogenetin binding protein 2
Synonyms: DIF-3, Zfp403, D330017P12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217039
Homologene: 11750
Fbxo31
Name: F-box protein 31
Synonyms: 2310046N15Rik, Fbx14, Fbxo14, 1110003O08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 76454
Homologene: 11684
Cdk5rap2
Name: CDK5 regulatory subunit associated protein 2
Synonyms: 2900018K03Rik, an
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 214444
Homologene: 49533
Rnf216
Name: ring finger protein 216
Synonyms: UIP83, F830018F18Rik, 2810055G22Rik, Ubce7ip1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 108086
Homologene: 19442
Gas8
Name: growth arrest specific 8
Synonyms: Gas11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 104346
HGNC: HGNC:4166
Homologene: 1135
Slc43a2
Name: solute carrier family 43, member 2
Synonyms: 7630402D21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 215113
Homologene: 17555
Thbs1
Name: thrombospondin 1
Synonyms: TSP1, TSP-1, Thbs-1, tbsp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 21825
Homologene: 31142
Zfp980
Name: zinc finger protein 980
Synonyms: Gm13242
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 100041379
Homologene: 133076
Taf1c
Name: TATA-box binding protein associated factor, RNA polymerase I, C
Synonyms: mTAFI95
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 21341
Homologene: 21163
Ppp3cb
Name: protein phosphatase 3, catalytic subunit, beta isoform
Synonyms: PP2BA beta, Calnb, CnAbeta, 1110063J16Rik, Cnab
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 19056
HGNC: HGNC:9315
Homologene: 56429
Caap1
Name: caspase activity and apoptosis inhibitor 1
Synonyms: 5830433M19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 67770
Homologene: 32607
Slmap
Name: sarcolemma associated protein
Synonyms: Slap, D330001L02Rik, Miranda
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 83997
Homologene: 31428
Lct
Name: lactase
Synonyms: LOC226413, Lphl, LPH
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226413
HGNC: HGNC:6530
Homologene: 124204
Lonp1
Name: lon peptidase 1, mitochondrial
Synonyms: LON, 1200017E13Rik, Prss15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 74142
VEGA: 17
HGNC: HGNC:9479
Homologene: 3521
Fsip2
Name: fibrous sheath-interacting protein 2
Synonyms: OTTMUSG00000013335
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241516
Homologene: 110349
Vwf
Name: Von Willebrand factor
Synonyms: B130011O06Rik, 6820430P06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 22371
Homologene: 466
Rapgef5
Name: Rap guanine nucleotide exchange factor (GEF) 5
Synonyms: mr-gef, D030051B22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217944
VEGA: 12
Homologene: 56563
Iqcg
Name: IQ motif containing G
Synonyms: G1-374-12, stubby12d, repro1, 2400003L07Rik, esgd12d
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 69707
Homologene: 32776
Wdr53
Name: WD repeat domain 53
Synonyms: 1500002B03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 68980
Homologene: 15591
Rbbp8
Name: retinoblastoma binding protein 8, endonuclease
Synonyms: 9930104E21Rik, CtIP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 225182
VEGA: 18
HGNC: HGNC:9891
Homologene: 28546
Col9a1
Name: collagen, type IX, alpha 1
Synonyms: Col9a-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12839
HGNC: HGNC:2217
Homologene: 1393
Trpm8
Name: transient receptor potential cation channel, subfamily M, member 8
Synonyms: CMR1, TRPP8, Trp-p8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 171382
Homologene: 23433
Zfp217
Name: zinc finger protein 217
Synonyms: 4933431C08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228913
Homologene: 4757
Olfr805
Name: olfactory receptor 805
Synonyms: GA_x6K02T2PULF-11402237-11401278, MOR110-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 258548
Smarcal1
Name: SWI/SNF related matrix associated, actin dependent regulator of chromatin, subfamily a-like 1
Synonyms: Mharp, 6030401P21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 54380
Homologene: 8558
Pcdhb9
Name: protocadherin beta 9
Synonyms: Pcdhb4C, PcdhbI
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 93880
Homologene: 87124
Galnt13
Name: polypeptide N-acetylgalactosaminyltransferase 13
Synonyms: pp-GalNAc-T13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 271786
Homologene: 62167
Daam2
Name: dishevelled associated activator of morphogenesis 2
Synonyms: 2310016D11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 76441
VEGA: 17
Homologene: 69186
Fam209
Name: family with sequence similarity 209
Synonyms: 1700029J11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 76426
Homologene: 19218
F11
Name: coagulation factor XI
Synonyms: plasma thromboplastin antecedent, FXI, Cf11, 1600027G01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 109821
HGNC: HGNC:3529
Homologene: 86654
Rars2
Name: arginyl-tRNA synthetase 2, mitochondrial
Synonyms: PRO1992, 1500002I10Rik, Rarsl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 109093
Homologene: 5707
Six5
Name: sine oculis-related homeobox 5
Synonyms: MDMAHP, Dmahp, TrexBF
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 20475
Homologene: 72248
Ube4a
Name: ubiquitination factor E4A
Synonyms: UFD2b, 9930123J21Rik, 4732444G18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 140630
Homologene: 3517
Mrc2
Name: mannose receptor, C type 2
Synonyms: novel lectin, Endo180, uPARAP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 17534
Homologene: 4408
Fam50b
Name: family with sequence similarity 50, member B
Synonyms: XAP-5-like, X5L, D0H6S2654E
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 108161
VEGA: 13
Homologene: 101669
Tmem19
Name: transmembrane protein 19
Synonyms: 2810428F02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 67226
VEGA: 10
Homologene: 10107
Rimkla
Name: ribosomal modification protein rimK-like family member A
Synonyms: Rimk, NAAGS-II
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 194237
Homologene: 18336
Tmod1
Name: tropomodulin 1
Synonyms: E-Tmod, erythrocyte tropomodulin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 21916
Homologene: 20701
Coq3
Name: coenzyme Q3 methyltransferase
Synonyms: C77934
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230027
Homologene: 9683
Ac174597.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Slc11a1
Name: solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1
Synonyms: host resistance locus Bcg/Ity/Lsh, Bcg, Lsh, Ity, Nramp, ity, Nramp1, Ity1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 18173
Homologene: 73884
Sptssa
Name: serine palmitoyltransferase, small subunit A
Synonyms: 1110002B05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 104725
VEGA: 12
Homologene: 15889
Gm8730
Name: predicted pseudogene 8730
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 667618
1700054N08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
4930402K13Rik
Name: RIKEN cDNA 4930402K13 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 75775
Homologene: 136629
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 24,195,460 bp
  • T to C, chromosome 1 at 72,626,596 bp
  • C to A, chromosome 1 at 74,376,784 bp
  • A to T, chromosome 1 at 88,328,196 bp
  • T to C, chromosome 1 at 128,304,226 bp
  • G to A, chromosome 2 at 12,132,562 bp
  • G to A, chromosome 2 at 30,018,419 bp
  • A to G, chromosome 2 at 55,098,657 bp
  • G to T, chromosome 2 at 82,988,967 bp
  • A to G, chromosome 2 at 118,114,710 bp
  • A to G, chromosome 2 at 170,119,210 bp
  • T to C, chromosome 2 at 172,473,995 bp
  • T to C, chromosome 3 at 87,914,497 bp
  • T to C, chromosome 4 at 21,892,941 bp
  • A to G, chromosome 4 at 34,645,787 bp
  • T to C, chromosome 4 at 46,097,026 bp
  • C to A, chromosome 4 at 70,235,437 bp
  • A to T, chromosome 4 at 94,501,143 bp
  • A to T, chromosome 4 at 119,477,789 bp
  • G to A, chromosome 4 at 145,702,083 bp
  • A to T, chromosome 5 at 143,027,946 bp
  • C to A, chromosome 6 at 68,632,274 bp
  • G to T, chromosome 6 at 125,677,948 bp
  • T to A, chromosome 7 at 19,096,930 bp
  • T to C, chromosome 8 at 3,603,785 bp
  • A to G, chromosome 8 at 33,671,537 bp
  • A to G, chromosome 8 at 45,248,638 bp
  • A to G, chromosome 8 at 70,487,301 bp
  • T to C, chromosome 8 at 102,865,032 bp
  • A to G, chromosome 8 at 119,603,070 bp
  • A to G, chromosome 8 at 121,578,509 bp
  • T to C, chromosome 8 at 123,533,244 bp
  • T to C, chromosome 8 at 123,859,361 bp
  • T to C, chromosome 9 at 44,933,323 bp
  • G to A, chromosome 10 at 75,943,291 bp
  • A to G, chromosome 10 at 115,359,770 bp
  • A to T, chromosome 10 at 129,723,115 bp
  • A to G, chromosome 11 at 75,543,154 bp
  • A to G, chromosome 11 at 84,854,094 bp
  • G to A, chromosome 11 at 105,348,431 bp
  • C to T, chromosome 12 at 31,321,075 bp
  • T to C, chromosome 12 at 54,656,395 bp
  • T to A, chromosome 12 at 117,755,950 bp
  • G to A, chromosome 13 at 34,746,886 bp
  • A to G, chromosome 14 at 20,530,942 bp
  • C to A, chromosome 14 at 26,427,242 bp
  • T to C, chromosome 16 at 32,256,720 bp
  • C to T, chromosome 16 at 33,029,041 bp
  • T to A, chromosome 17 at 49,469,738 bp
  • A to G, chromosome 17 at 56,618,310 bp
  • G to T, chromosome 18 at 11,732,176 bp
  • T to C, chromosome 18 at 37,401,601 bp
  • AGAGGAG to AGAG, chromosome X at 9,105,103 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3726 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040717-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.