Strain Name:
C57BL/6J-MtgxR3736Btlr/Mmmh
Stock Number:
040723-MU
Citation ID:
RRID:MMRRC_040723-MU
Other Names:
R3736 (G1), C57BL/6J-MtgxR3736Btlr
Major Collection:

Strain Information

Tnrc6b
Name: trinucleotide repeat containing 6b
Synonyms: A730065C02Rik, D230019K20Rik, 2700090M07Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 213988
VEGA: 15
Homologene: 66194
Olr1
Name: oxidized low density lipoprotein (lectin-like) receptor 1
Synonyms: LOX-1, Scare1, SR-EI
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 108078
HGNC: HGNC:8133
Homologene: 1910
Scn3a
Name: sodium channel, voltage-gated, type III, alpha
Synonyms: LOC381367, Nav1.3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20269
Homologene: 56005
Nup210l
Name: nucleoporin 210-like
Synonyms: 4930548O11Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 77595
Homologene: 28122
Kcnc4
Name: potassium voltage gated channel, Shaw-related subfamily, member 4
Synonyms: Kcr2-4, Kv3.4
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 99738
HGNC: HGNC:6236
Homologene: 68427
Zfp273
Name: zinc finger protein 273
Synonyms: 6820416H06Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 212569
Homologene: 133729
Morc3
Name: microrchidia 3
Synonyms: Zcwcc3, D16Jhu32e, 1110051N18Rik, 1110051N18Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 338467
Homologene: 32257
Shroom3
Name: shroom family member 3
Synonyms: Shrm3, D5Ertd287e, Shrm
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 27428
Homologene: 9263
Suclg2
Name: succinate-Coenzyme A ligase, GDP-forming, beta subunit
Synonyms: D6Wsu120e
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 20917
Homologene: 2854
Ankrd11
Name: ankyrin repeat domain 11
Synonyms: 9530048I21Rik, Yod, 3010027A04Rik, 2410104C19Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 77087
Homologene: 69134
Sptlc2
Name: serine palmitoyltransferase, long chain base subunit 2
Synonyms: Spt2, LCB2
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 20773
Homologene: 21610
Evi5
Name: ecotropic viral integration site 5
Synonyms: NB4S
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 14020
HGNC: HGNC:3501
Homologene: 121902
Dync1h1
Name: dynein cytoplasmic 1 heavy chain 1
Synonyms: 9930018I23Rik, MAP1C, Swl, Dnec1, Loa, Dnchc1, dynein heavy chain, retrograde transport
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 13424
HGNC: HGNC:2961
Homologene: 1053
Vti1a
Name: vesicle transport through interaction with t-SNAREs 1A
Synonyms: 4921537J05Rik, 1110018K19Rik, Vti1-rp2, 1110014F16Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 53611
VEGA: 19
Homologene: 39963
Lef1
Name: lymphoid enhancer binding factor 1
Synonyms: Lef-1, lymphoid enhancer factor 1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 16842
HGNC: HGNC:6551
Homologene: 7813
Helq
Name: helicase, POLQ-like
Synonyms: D430018E21Rik, Hel308
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 191578
Homologene: 14667
Lyn
Name: LYN proto-oncogene, Src family tyrosine kinase
Synonyms: Yamaguchi sarcoma viral (v-yes-1) oncogene homolog, Hck-2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 17096
HGNC: HGNC:6735
Homologene: 55649
Ctps1
Name: cytidine 5'-triphosphate synthase 1
Synonyms: Ctps
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 51797
HGNC: HGNC:2519
Homologene: 20446
Poc5
Name: POC5 centriolar protein
Synonyms: 1200014M14Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 67463
VEGA: 13
Homologene: 12141
Ncapg
Name: non-SMC condensin I complex, subunit G
Synonyms: 5730507H05Rik, Hcapg, MFT.M05.13
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 54392
Homologene: 44071
Cep170b
Name: centrosomal protein 170B
Synonyms: AW555464
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217882
VEGA: 12
Homologene: 46165
Tbc1d32
Name: TBC1 domain family, member 32
Synonyms: C6orf170, b2b2284Clo, D630037F22Rik, Bromi
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 544696
VEGA: 10
Homologene: 51889
Atp12a
Name: ATPase, H+/K+ transporting, nongastric, alpha polypeptide
Synonyms: HKalpha2, ATPase H+K+-transporting, alpha 2, Atp1al1, cHKA
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 192113
VEGA: 14
Homologene: 68197
Shtn1
Name: shootin 1
Synonyms: shootin1, 4930506M07Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 71653
VEGA: 19
Homologene: 41249
Med12l
Name: mediator complex subunit 12-like
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 329650
Homologene: 43143
4930432E11Rik
Name: RIKEN cDNA 4930432E11 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 243900
Or5p76
Name: olfactory receptor family 5 subfamily P member 76
Synonyms: GA_x6K02T2PBJ9-10853935-10852991, MOR204-8, Olfr502
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258734
Homologene: 72021
Bbs7
Name: Bardet-Biedl syndrome 7
Synonyms: 8430406N16Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 71492
Homologene: 12395
C8a
Name: complement component 8, alpha polypeptide
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230558
HGNC: HGNC:1352
Homologene: 472
Rmnd5a
Name: required for meiotic nuclear division 5 homolog A
Synonyms: 1110007A06Rik, Gid2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 68477
Homologene: 5668
Acot12
Name: acyl-CoA thioesterase 12
Synonyms: 1300004O04Rik, 4930449F15Rik, Cach
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 74156
Homologene: 12540
Pde4dip
Name: phosphodiesterase 4D interacting protein (myomegalin)
Synonyms: D3Bwg1078e, D130016K21Rik, 9430063L05Rik, Usmg4, 4732458A06Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 83679
Homologene: 66961
Osmr
Name: oncostatin M receptor
Synonyms: OSMRB
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 18414
HGNC: HGNC:8507
Homologene: 2972
Ccdc158
Name: coiled-coil domain containing 158
Synonyms: 4932413O14Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 320696
Homologene: 18560
Irag2
Name: inositol 1,4,5-triphosphate receptor associated 2
Synonyms: D6Int5, Jaw1, Lrmp, D6Int7, D6Int8, D6Int4, D6Int3
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16970
HGNC: HGNC:6690
Homologene: 4483
Ang2
Name: angiogenin, ribonuclease A family, member 2
Synonyms: Angrp, Rnase5b
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 11731
VEGA: 14
HGNC: HGNC:483
Zfp683
Name: zinc finger protein 683
Synonyms: Hobit
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100503878
Irag1
Name: inositol 1,4,5-triphosphate receptor associated 1
Synonyms: Ris1, Mrvi1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 17540
HGNC: HGNC:7237
Homologene: 4425
Ccdc162
Name: coiled-coil domain containing 162
Synonyms: 5033413D22Rik, Gm29096, Gm6976
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 75973
Homologene: 136355
Kcnk10
Name: potassium channel, subfamily K, member 10
Synonyms: 3010005K24Rik, Trek2, 1700024D23Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 72258
VEGA: 12
HGNC: HGNC:6273
Homologene: 11321
Adgrf2
Name: adhesion G protein-coupled receptor F2
Synonyms: Gpr111, PGR20
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 435529
Homologene: 45213
Zfpm1
Name: zinc finger protein, multitype 1
Synonyms: Fog1, Friend of GATA-1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 22761
Homologene: 7606
Cyp2j8
Name: cytochrome P450, family 2, subfamily j, polypeptide 8
Synonyms: OTTMUSG00000007938, Cyp2j8-ps
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 665095
HGNC: HGNC:2634
Homologene: 133819
Zscan4d
Name: zinc finger and SCAN domain containing 4D
Synonyms: EG545913
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 545913
Homologene: 85986
F8
Name: coagulation factor VIII
Synonyms: Cf8, FVIII, Factor VIII, Cf-8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 14069
HGNC: HGNC:3546
Homologene: 49153
Tas2r134
Name: taste receptor, type 2, member 134
Synonyms: T2R134, Tas2r34
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 387511
Homologene: 66001
Cimip2c
Name: ciliary microtubule inner protein 2C
Synonyms: 1700001C02Rik, Fam166c
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 75434
Homologene: 49920
Mogs
Name: mannosyl-oligosaccharide glucosidase
Synonyms: Gcs1, 1810017N02Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 57377
Homologene: 4593
B230317F23Rik
Name: RIKEN cDNA B230317F23 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to A, chromosome 2 at 51,627,774 bp
  • T to A, chromosome 2 at 65,461,741 bp
  • A to G, chromosome 3 at 36,607,670 bp
  • T to A, chromosome 3 at 59,091,495 bp
  • A to G, chromosome 3 at 90,120,013 bp
  • A to T, chromosome 3 at 97,724,111 bp
  • C to T, chromosome 3 at 107,439,481 bp
  • C to T, chromosome 3 at 131,191,066 bp
  • G to T, chromosome 4 at 3,745,330 bp
  • T to A, chromosome 4 at 96,444,599 bp
  • T to C, chromosome 4 at 104,817,615 bp
  • T to C, chromosome 4 at 120,543,746 bp
  • C to A, chromosome 4 at 134,057,431 bp
  • A to T, chromosome 5 at 30,482,098 bp
  • A to T, chromosome 5 at 45,696,127 bp
  • A to C, chromosome 5 at 92,632,424 bp
  • T to C, chromosome 5 at 92,964,444 bp
  • T to G, chromosome 5 at 100,790,188 bp
  • A to T, chromosome 5 at 107,818,983 bp
  • T to C, chromosome 6 at 71,396,862 bp
  • C to A, chromosome 6 at 83,116,776 bp
  • T to A, chromosome 6 at 95,497,696 bp
  • T to A, chromosome 6 at 129,499,875 bp
  • G to A, chromosome 6 at 145,160,870 bp
  • T to C, chromosome 7 at 11,162,876 bp
  • G to A, chromosome 7 at 29,574,571 bp
  • A to G, chromosome 7 at 108,523,419 bp
  • A to G, chromosome 7 at 110,923,963 bp
  • T to A, chromosome 8 at 60,983,652 bp
  • G to A, chromosome 8 at 122,323,736 bp
  • A to T, chromosome 8 at 122,891,785 bp
  • T to C, chromosome 10 at 41,589,568 bp
  • A to G, chromosome 10 at 56,129,093 bp
  • G to A, chromosome 12 at 87,341,565 bp
  • A to G, chromosome 12 at 98,489,912 bp
  • G to A, chromosome 12 at 110,631,675 bp
  • A to T, chromosome 12 at 112,741,004 bp
  • T to A, chromosome 13 at 67,825,507 bp
  • T to A, chromosome 13 at 91,784,346 bp
  • A to G, chromosome 13 at 96,396,816 bp
  • G to A, chromosome 14 at 51,195,656 bp
  • G to A, chromosome 14 at 56,374,427 bp
  • A to T, chromosome 15 at 6,822,080 bp
  • G to C, chromosome 15 at 80,889,163 bp
  • T to A, chromosome 16 at 93,874,812 bp
  • T to C, chromosome 17 at 42,711,012 bp
  • T to A, chromosome 19 at 55,380,932 bp
  • A to T, chromosome 19 at 59,022,268 bp
  • G to A, chromosome X at 75,211,375 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3736 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040723-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.