Strain Name:
C57BL/6J-MtgxR3749Btlr/Mmmh
Stock Number:
040734-MU
Citation ID:
RRID:MMRRC_040734-MU
Other Names:
R3749 (G1), C57BL/6J-MtgxR3749Btlr
Major Collection:

Gene Information

Polr3e
Name: polymerase (RNA) III (DNA directed) polypeptide E
Synonyms: Sin, RPC5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 26939
Homologene: 14052
Zmynd8
Name: zinc finger, MYND-type containing 8
Synonyms: Prkcbp1, ZMYND8, 1110013E22Rik, 2010005I16Rik, RACK7, 3632413B07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228880
HGNC: HGNC:9397
Homologene: 32679
Slk
Name: STE20-like kinase
Synonyms: SLK, Stk2, Etk4, mSLK, 9A2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 20874
Homologene: 22515
Olfm1
Name: olfactomedin 1
Synonyms: Pancortin 1-4, Noelin 2, Noelin 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 56177
Homologene: 8612
Patj
Name: PATJ, crumbs cell polarity complex component
Synonyms: Cipp, Inadl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 12695
Homologene: 72199
Lrba
Name: LPS-responsive beige-like anchor
Synonyms: D3Ertd775e, Lba
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 80877
HGNC: HGNC:1742
Homologene: 36205
Ankib1
Name: ankyrin repeat and IBR domain containing 1
Synonyms: 2310061P20Rik, 4631416I11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 70797
Homologene: 19076
Slain2
Name: SLAIN motif family, member 2
Synonyms: 8030444K12Rik, 5033405K12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 75991
Homologene: 18952
Daam1
Name: dishevelled associated activator of morphogenesis 1
Synonyms: 2310028E21Rik, 1700066F09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 208846
VEGA: 12
Homologene: 36635
Slc25a25
Name: solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 25
Synonyms: 1110030N17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 227731
Homologene: 62165
Supt16
Name: SPT16, facilitates chromatin remodeling subunit
Synonyms: Spt16, Supt16h, Cdc68, Fact140
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 114741
VEGA: 14
Homologene: 5207
Secisbp2l
Name: SECIS binding protein 2-like
Synonyms: 3110001I20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 70354
Homologene: 18923
Zkscan1
Name: zinc finger with KRAB and SCAN domains 1
Synonyms: 9130423L19Rik, KOX18, 5930429A01Rik, 9230118B16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 74570
Homologene: 34523
Syne1
Name: spectrin repeat containing, nuclear envelope 1
Synonyms: A330049M09Rik, C130039F11Rik, SYNE-1, nesprin-1, enaptin165
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 64009
VEGA: 10
Homologene: 52329
Nuf2
Name: NUF2, NDC80 kinetochore complex component
Synonyms: 2410003C07Rik, Nuf2R, Cdca1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 66977
Homologene: 40205
Gpc1
Name: glypican 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 14733
HGNC: HGNC:4449
Homologene: 20477
Adam12
Name: a disintegrin and metallopeptidase domain 12 (meltrin alpha)
Synonyms: Mltna, ADAM12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 11489
HGNC: HGNC:190
Homologene: 74862
Lrp10
Name: low-density lipoprotein receptor-related protein 10
Synonyms: Lrp9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 65107
VEGA: 14
Homologene: 8535
Mme
Name: membrane metallo endopeptidase
Synonyms: CD10, 6030454K05Rik, neprilysin, NEP, neutral endopeptidase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 17380
HGNC: HGNC:7154
Homologene: 5275
Adam19
Name: a disintegrin and metallopeptidase domain 19 (meltrin beta)
Synonyms: Mltnb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 11492
HGNC: HGNC:197
Homologene: 74925
Dnah8
Name: dynein, axonemal, heavy chain 8
Synonyms: Hst6.7b, P1-Loop, Dnahc8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 13417
VEGA: 17
HGNC: HGNC:2952
Homologene: 1049
Bub1b
Name: BUB1B, mitotic checkpoint serine/threonine kinase
Synonyms: BUBR1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 12236
HGNC: HGNC:1149
Homologene: 933
Arhgap19
Name: Rho GTPase activating protein 19
Synonyms: 4933411B03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 71085
Homologene: 13159
Osbpl7
Name: oxysterol binding protein-like 7
Synonyms: 4933437E18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 71240
Homologene: 79672
Tpcn2
Name: two pore segment channel 2
Synonyms: D830047E22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233979
Homologene: 16375
Marchf6
Name: membrane associated ring-CH-type finger 6
Synonyms: F830029L24Rik, March6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223455
VEGA: 15
Homologene: 4301
Zfhx4
Name: zinc finger homeodomain 4
Synonyms: Zfh-4, Zfh4, C130041O22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 80892
Homologene: 23477
Ttn
Name: titin
Synonyms: D330041I19Rik, mdm, L56, connectin, 2310074I15Rik, 2310057K23Rik, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, shru
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22138
Homologene: 130650
Uggt2
Name: UDP-glucose glycoprotein glucosyltransferase 2
Synonyms: 1810064L21Rik, 3110001A05Rik, A230065J02Rik, 3110027P15Rik, Ugcgl2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 66435
Homologene: 56875
Kcnu1
Name: potassium channel, subfamily U, member 1
Synonyms: Slo3, Kcnma3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 16532
Homologene: 7392
Zdhhc25
Name: zinc finger, DHHC domain containing 25
Synonyms: 1700030J15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 70073
Homologene: 19298
Dnah17
Name: dynein, axonemal, heavy chain 17
Synonyms: 2810003K23Rik, Dnahcl1, Dnahc17, LOC382552
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 69926
HGNC: HGNC:2946
Homologene: 72102
Pkdrej
Name: polycystin (PKD) family receptor for egg jelly
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 18766
VEGA: 15
HGNC: HGNC:9015
Homologene: 4427
Scn2a
Name: sodium channel, voltage-gated, type II, alpha
Synonyms: Scn2a1, A230052E19Rik, Nav1.2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 110876
Homologene: 75001
Mroh2b
Name: maestro heat-like repeat family member 2B
Synonyms: Heatr7b2, 4930455B06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223825
VEGA: 15
Homologene: 128807
Faap24
Name: Fanconi anemia core complex associated protein 24
Synonyms: C230052I12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 101831
Homologene: 17535
Jakmip1
Name: janus kinase and microtubule interacting protein 1
Synonyms: C330021K24Rik, Marlin-1, Gababrbp, 5830437M04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 76071
Homologene: 90789
Ccdc134
Name: coiled-coil domain containing 134
Synonyms: 2310042L06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 76457
VEGA: 15
Homologene: 77543
Ccdc40
Name: coiled-coil domain containing 40
Synonyms: B930008I02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 207607
Homologene: 27890
Dab2
Name: disabled 2, mitogen-responsive phosphoprotein
Synonyms: D630005B22Rik, p96, D15Wsu122e, 5730435J12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 13132
HGNC: HGNC:2662
Homologene: 1026
Obsl1
Name: obscurin-like 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 98733
Colq
Name: collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 102639719
HGNC: HGNC:2226
Tpi1
Name: triosephosphate isomerase 1
Synonyms: Tpi-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 21991
Homologene: 128432
Tlr5
Name: toll-like receptor 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 53791
Homologene: 20698
Spon1
Name: spondin 1, (f-spondin) extracellular matrix protein
Synonyms: D330035F22Rik, FSP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233744
Homologene: 4453
Tas2r136
Name: taste receptor, type 2, member 136
Synonyms: mt2r52, Tas2r36
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 353165
Homologene: 136304
Olfr95
Name: olfactory receptor 95
Synonyms: MOR263-6, GA_x6K02T2PSCP-1651760-1650822
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 258506
HGNC: HGNC:8165
Homologene: 71990
Cfhr1
Name: complement factor H-related 1
Synonyms: Cfhl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 50702
HGNC: HGNC:4888
Homologene: 55632
Terb1
Name: telomere repeat binding bouquet formation protein 1
Synonyms: 4930532D21Rik, Ccdc79
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 320022
Homologene: 18330
Mfsd1
Name: major facilitator superfamily domain containing 1
Synonyms: 1200003O06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 66868
Homologene: 11228
Wnt2
Name: wingless-type MMTV integration site family, member 2
Synonyms: Int1l1, m-irp, 2610510E18Rik, Wnt-2, Wnt2a, Irp, Mirp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 22413
Homologene: 20719
Vmn1r158
Name: vomeronasal 1 receptor 158
Synonyms: Gm16455
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 100043067
Homologene: 104166
Oasl1
Name: 2'-5' oligoadenylate synthetase-like 1
Synonyms: 7530414C13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231655
HGNC: HGNC:8090
Homologene: 2769
Bckdk
Name: branched chain ketoacid dehydrogenase kinase
Synonyms: BCKD-kinase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 12041
Homologene: 37642
Olfr803
Name: olfactory receptor 803
Synonyms: GA_x6K02T2PULF-11370664-11369738, MOR111-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 258547
Homologene: 105153
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 75,498,246 bp
  • C to A, chromosome 1 at 92,857,582 bp
  • C to A, chromosome 1 at 139,557,634 bp
  • T to A, chromosome 1 at 169,525,376 bp
  • T to C, chromosome 1 at 182,974,439 bp
  • C to T, chromosome 2 at 28,208,088 bp
  • G to T, chromosome 2 at 32,420,380 bp
  • T to G, chromosome 2 at 65,713,771 bp
  • G to A, chromosome 2 at 76,754,006 bp
  • T to A, chromosome 2 at 118,615,455 bp
  • C to T, chromosome 2 at 125,740,737 bp
  • A to G, chromosome 2 at 165,805,198 bp
  • G to A, chromosome 3 at 5,243,165 bp
  • T to A, chromosome 3 at 63,343,540 bp
  • T to C, chromosome 3 at 67,582,953 bp
  • T to G, chromosome 3 at 86,375,953 bp
  • A to G, chromosome 4 at 98,469,600 bp
  • G to T, chromosome 5 at 3,734,097 bp
  • C to A, chromosome 5 at 37,128,667 bp
  • T to G, chromosome 5 at 72,957,279 bp
  • T to G, chromosome 5 at 114,936,908 bp
  • T to C, chromosome 5 at 138,101,441 bp
  • T to C, chromosome 6 at 18,023,168 bp
  • T to A, chromosome 6 at 124,812,791 bp
  • A to T, chromosome 6 at 132,777,237 bp
  • A to C, chromosome 7 at 22,790,214 bp
  • A to T, chromosome 7 at 35,393,012 bp
  • T to C, chromosome 7 at 113,766,384 bp
  • T to A, chromosome 7 at 114,016,791 bp
  • T to C, chromosome 7 at 120,933,671 bp
  • C to A, chromosome 7 at 127,905,418 bp
  • T to C, chromosome 7 at 134,172,865 bp
  • T to C, chromosome 7 at 145,255,523 bp
  • T to A, chromosome 8 at 25,886,770 bp
  • T to C, chromosome 8 at 104,496,834 bp
  • C to T, chromosome 10 at 5,052,267 bp
  • C to T, chromosome 10 at 129,691,961 bp
  • A to T, chromosome 11 at 46,137,610 bp
  • T to C, chromosome 11 at 97,056,053 bp
  • T to C, chromosome 11 at 118,082,916 bp
  • T to C, chromosome 11 at 119,264,426 bp
  • C to A, chromosome 12 at 71,971,166 bp
  • A to T, chromosome 14 at 31,549,453 bp
  • A to G, chromosome 14 at 52,180,139 bp
  • A to T, chromosome 14 at 54,469,266 bp
  • A to T, chromosome 14 at 119,057,672 bp
  • G to A, chromosome 15 at 4,952,246 bp
  • A to G, chromosome 15 at 6,427,321 bp
  • A to G, chromosome 15 at 31,462,014 bp
  • T to A, chromosome 15 at 82,135,057 bp
  • T to A, chromosome 15 at 85,821,077 bp
  • C to T, chromosome 15 at 88,601,023 bp
  • A to T, chromosome 17 at 30,784,174 bp
  • G to A, chromosome 17 at 37,211,800 bp
  • T to A, chromosome 19 at 41,774,079 bp
  • T to G, chromosome 19 at 47,619,809 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3749 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040734-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.