Strain Name:
C57BL/6J-MtgxR3751Btlr/Mmmh
Stock Number:
040736-MU
Citation ID:
RRID:MMRRC_040736-MU
Other Names:
R3751 (G1), C57BL/6J-MtgxR3751Btlr
Major Collection:

Gene Information

Adam23
Name: a disintegrin and metallopeptidase domain 23
Synonyms: MDC3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 23792
HGNC: HGNC:202
Homologene: 2826
Ezh2
Name: enhancer of zeste 2 polycomb repressive complex 2 subunit
Synonyms: Enx-1, Enx1h, KMT6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 14056
HGNC: HGNC:3527
Homologene: 37926
Cep104
Name: centrosomal protein 104
Synonyms: BC046331
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230967
Homologene: 44919
Brd1
Name: bromodomain containing 1
Synonyms: 1110059H06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223770
HGNC: HGNC:1102
Homologene: 40956
Itpr1
Name: inositol 1,4,5-trisphosphate receptor 1
Synonyms: P400, IP3R1, Pcp-1, Itpr-1, Ip3r, opt, InsP3R type I, Pcp1, wblo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 16438
HGNC: HGNC:6180
Homologene: 1673
Irak4
Name: interleukin-1 receptor-associated kinase 4
Synonyms: NY-REN-64, IRAK-4, 9330209D03Rik, 8430405M07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 266632
Homologene: 41109
C77080
Name: expressed sequence C77080
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 97130
Homologene: 45837
Mib2
Name: mindbomb E3 ubiquitin protein ligase 2
Synonyms: 2210008I11Rik, Zzank1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 76580
Homologene: 16062
Clca2
Name: chloride channel accessory 2
Synonyms: Clca5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229933
HGNC: HGNC:2016
Homologene: 4765
Iqsec3
Name: IQ motif and Sec7 domain 3
Synonyms: BRAG3, synarfGEF
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 243621
Homologene: 46091
Erc1
Name: ELKS/RAB6-interacting/CAST family member 1
Synonyms: RAB6IP2B, RAB6IP2A, B430107L16Rik, 5033405M01Rik, 9630025C19Rik, Rab6ip2, Elks1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 111173
Homologene: 14229
Fbln1
Name: fibulin 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 14114
HGNC: HGNC:3600
Homologene: 21295
Mtmr9
Name: myotubularin related protein 9
Synonyms: LIP-STYX, MTMR8, 9430075G12Rik, mMTMH3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 210376
VEGA: 14
Homologene: 9148
Rnf214
Name: ring finger protein 214
Synonyms: D130054N24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235315
Homologene: 109357
Pdgfd
Name: platelet-derived growth factor, D polypeptide
Synonyms: 1110003I09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 71785
VEGA: 9
Homologene: 11875
Dlk1
Name: delta like non-canonical Notch ligand 1
Synonyms: pref-1, ZOG, SCP1, FA1, pG2, Peg9, DlkI
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 13386
HGNC: HGNC:2907
Homologene: 2846
E2f1
Name: E2F transcription factor 1
Synonyms: E2F-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 13555
HGNC: HGNC:3113
Homologene: 3828
Rbp3
Name: retinol binding protein 3, interstitial
Synonyms: Irbp, Rbp-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 19661
VEGA: 14
HGNC: HGNC:9921
Homologene: 9261
2900092C05Rik
Name: RIKEN cDNA 2900092C05 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 73090
Homologene: 49900
Ceacam18
Name: carcinoembryonic antigen-related cell adhesion molecule 18
Synonyms: 2010110O04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 72431
Homologene: 48111
Ccdc125
Name: coiled-coil domain containing 125
Synonyms: 5830436D01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 76041
VEGA: 13
Homologene: 27932
Unc80
Name: unc-80, NALCN activator
Synonyms: C230061B10Rik, C030018G13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 329178
Homologene: 122243
Man2c1
Name: mannosidase, alpha, class 2C, member 1
Synonyms: 1110025H24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 73744
HGNC: HGNC:6827
Homologene: 4887
BC016579
Name: cDNA sequence, BC016579
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 212998
VEGA: 16
Homologene: 11622
D430041D05Rik
Name: RIKEN cDNA D430041D05 gene
Synonyms: G2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241589
Homologene: 115928
Lrrd1
Name: leucine rich repeats and death domain containing 1
Synonyms: 4932412H11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 242838
Homologene: 18247
Slc8a3
Name: solute carrier family 8 (sodium/calcium exchanger), member 3
Synonyms: Ncx3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 110893
Homologene: 62645
Col6a4
Name: collagen, type VI, alpha 4
Synonyms: EG235580, 1110001D15Rik, Dvwa, Vwa6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 68553
Homologene: 130754
Slc51a
Name: solute carrier family 51, alpha subunit
Synonyms: OSTalpha, D630035O19Rik, Osta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 106407
Homologene: 44941
Myo5c
Name: myosin VC
Synonyms: 9130003O20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 208943
VEGA: 9
HGNC: HGNC:7604
Homologene: 135711
Zfp366
Name: zinc finger protein 366
Synonyms: DC-SCRIPT
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 238803
Homologene: 17637
Scaf11
Name: SR-related CTD-associated factor 11
Synonyms: 1110061H03Rik, SRRP129, CASP11, SIP1, 2610510E10Rik, Sfrs2ip, Srsf2ip
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 72193
VEGA: 15
Homologene: 37957
Paqr8
Name: progestin and adipoQ receptor family member VIII
Synonyms: 3110001D06Rik, 1700019B16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 74229
Homologene: 32702
Slc6a21
Name: solute carrier family 6 member 21
Synonyms: 1700039E15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 76713
Homologene: 66347
Olfr871
Name: olfactory receptor 871
Synonyms: GA_x6K02T2PVTD-13952555-13953490, MOR141-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258905
Homologene: 138319
Olfr123
Name: olfactory receptor 123
Synonyms: MOR256-9, GA_x6K02T2PSCP-2255106-2256035
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 258623
Homologene: 105169
Vmn1r189
Name: vomeronasal 1 receptor 189
Synonyms: V1rh2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 252906
Homologene: 110880
Clca1
Name: chloride channel accessory 1
Synonyms: gob-5, gob5, Clca3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 23844
HGNC: HGNC:2015
Homologene: 984
BC051665
Name: cDNA sequence BC051665
Synonyms: cathepsin L-like
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218275
VEGA: 13
Homologene: 74298
FP885536.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Spg7
Name: SPG7, paraplegin matrix AAA peptidase subunit
Synonyms: paraplegin, Cmar, spastic paraplegia 7 homolog (human)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234847
Homologene: 31133
Tymp
Name: thymidine phosphorylase
Synonyms: PDECGF, PD-ECGF, gliostatin, Pdgfec, 2900072D10Rik, Ecgf1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 72962
VEGA: 15
HGNC: HGNC:3148
Homologene: 1474
Ppm1k
Name: protein phosphatase 1K (PP2C domain containing)
Synonyms: 2900063A19Rik, A930026L03Rik, PP2Cm
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 243382
Homologene: 36819
Olfr768
Name: olfactory receptor 768
Synonyms: GA_x6K02T2PULF-10779441-10778503, MOR114-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 258863
Homologene: 17159
Efcab9
Name: EF-hand calcium binding domain 9
Synonyms: 4930403C08Rik, 1700007I06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 69306
Homologene: 12309
Krtap17-1
Name: keratin associated protein 17-1
Synonyms: A030006P16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 77914
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 20,935,632 bp
  • A to G, chromosome 1 at 63,581,236 bp
  • G to T, chromosome 1 at 66,636,915 bp
  • T to C, chromosome 2 at 104,255,058 bp
  • C to G, chromosome 2 at 154,564,022 bp
  • A to G, chromosome 3 at 145,018,663 bp
  • A to T, chromosome 3 at 145,071,455 bp
  • A to G, chromosome 4 at 129,224,322 bp
  • A to G, chromosome 4 at 153,981,756 bp
  • A to G, chromosome 4 at 155,655,284 bp
  • G to T, chromosome 4 at 156,334,397 bp
  • T to A, chromosome 5 at 3,850,282 bp
  • T to C, chromosome 6 at 47,556,064 bp
  • T to G, chromosome 6 at 57,524,860 bp
  • T to A, chromosome 6 at 108,349,680 bp
  • T to A, chromosome 6 at 119,824,960 bp
  • C to T, chromosome 6 at 121,376,255 bp
  • G to T, chromosome 7 at 12,556,046 bp
  • T to A, chromosome 7 at 43,641,948 bp
  • G to A, chromosome 7 at 45,280,504 bp
  • G to C, chromosome 8 at 123,087,373 bp
  • A to T, chromosome 9 at 6,337,447 bp
  • C to T, chromosome 9 at 20,213,260 bp
  • A to C, chromosome 9 at 45,867,603 bp
  • A to G, chromosome 9 at 57,140,774 bp
  • A to G, chromosome 9 at 75,276,002 bp
  • G to T, chromosome 9 at 106,072,114 bp
  • T to A, chromosome 10 at 129,093,306 bp
  • T to C, chromosome 11 at 32,527,420 bp
  • A to T, chromosome 11 at 99,993,655 bp
  • G to T, chromosome 12 at 81,204,138 bp
  • A to G, chromosome 12 at 109,460,313 bp
  • T to C, chromosome 13 at 22,102,212 bp
  • A to T, chromosome 13 at 60,783,331 bp
  • A to G, chromosome 13 at 99,228,844 bp
  • A to G, chromosome 13 at 100,677,951 bp
  • A to T, chromosome 14 at 33,956,012 bp
  • A to G, chromosome 14 at 63,543,548 bp
  • T to A, chromosome 15 at 85,227,078 bp
  • C to T, chromosome 15 at 88,689,618 bp
  • C to A, chromosome 15 at 89,373,923 bp
  • T to C, chromosome 15 at 94,561,595 bp
  • A to G, chromosome 15 at 96,418,536 bp
  • A to G, chromosome 16 at 32,476,474 bp
  • A to T, chromosome 16 at 45,632,998 bp
  • T to C, chromosome 17 at 37,796,232 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3751 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040736-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.