Strain Name:
C57BL/6J-MtgxR3755Btlr/Mmmh
Stock Number:
040738-MU
Citation ID:
RRID:MMRRC_040738-MU
Other Names:
R3755 (G1), C57BL/6J-MtgxR3755Btlr
Major Collection:

Strain Information

Ubap2
Name: ubiquitin-associated protein 2
Synonyms: 1190005K07Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 68926
Homologene: 73649
Lpp
Name: LIM domain containing preferred translocation partner in lipoma
Synonyms: B130055L10Rik, 9430020K16Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 210126
VEGA: 16
HGNC: HGNC:6679
Homologene: 4075
Nfib
Name: nuclear factor I/B
Synonyms: E030026I10Rik, 6720429L07Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 18028
HGNC: HGNC:7785
Homologene: 4087
Chchd6
Name: coiled-coil-helix-coiled-coil-helix domain containing 6
Synonyms: 0710001P09Rik, Micos25, 1700021B03Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 66098
Homologene: 11920
Lrch4
Name: leucine-rich repeats and calponin homology (CH) domain containing 4
Synonyms: 2900069C24Rik, 2810008P14Rik, LRRN4, LRN
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231798
HGNC: HGNC:6691
Homologene: 20532
Knl1
Name: kinetochore scaffold 1
Synonyms: Casc5, 2310043D08Rik, 5730505K17Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 76464
Homologene: 44890
Etl4
Name: enhancer trap locus 4
Synonyms: 6620402G01Rik, Sickle tail, Skt, Etl-4, 9430077C05Rik, E330027G05Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 208618
Homologene: 10477
Atf7ip
Name: activating transcription factor 7 interacting protein
Synonyms: AM, ATFa-associated Modulator, 2610204M12Rik, Mcaf1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 54343
Homologene: 10051
Ptpn1
Name: protein tyrosine phosphatase, non-receptor type 1
Synonyms: PTP1B, PTP-1B
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 19246
HGNC: HGNC:9642
Homologene: 2119
Tipin
Name: timeless interacting protein
Synonyms: 1110018P21Rik, 1110005A05Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 66131
VEGA: 9
Homologene: 32373
Poldip3
Name: polymerase (DNA-directed), delta interacting protein 3
Synonyms: PDIP46, 1110008P04Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 73826
Homologene: 13007
Mettl13
Name: methyltransferase 13, eEF1A lysine and N-terminal methyltransferase
Synonyms: Eef1aknmt, 5630401D24Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 71449
Homologene: 32285
Kdm3b
Name: KDM3B lysine (K)-specific demethylase 3B
Synonyms: Jmjd1b, JHDM2B, 5830462I21Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 277250
VEGA: 18
HGNC: HGNC:1337
Homologene: 41145
Fabp3
Name: fatty acid binding protein 3, muscle and heart
Synonyms: Fabp3, Fabph1, Mdgi, Fabph-1, Fabph4, Fabph-4, H-FABP
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 14077
HGNC: HGNC:3557
Homologene: 68379
Eif4g1
Name: eukaryotic translation initiation factor 4, gamma 1
Synonyms: E030015G23Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 208643
HGNC: HGNC:3296
Homologene: 110725
Mcm9
Name: minichromosome maintenance 9 homologous recombination repair factor
Synonyms: Mcmdc1, 9030408O17Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 71567
VEGA: 10
Homologene: 13546
Zfp524
Name: zinc finger protein 524
Synonyms: 2300009P13Rik, 0610012F07Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 66056
Homologene: 11912
Gcdh
Name: glutaryl-Coenzyme A dehydrogenase
Synonyms: D17825
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 270076
HGNC: HGNC:4189
Homologene: 130
Rundc3a
Name: RUN domain containing 3A
Synonyms: Rpip8, Rap2ip
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 51799
Homologene: 4871
Urod
Name: uroporphyrinogen decarboxylase
Synonyms: Uro-d
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 22275
Homologene: 320
Cntnap5c
Name: contactin associated protein-like 5C
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 620292
VEGA: 17
Homologene: 128806
Pkhd1l1
Name: polycystic kidney and hepatic disease 1-like 1
Synonyms: D86 mRNA, fibrocystin L, PKHDL1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 192190
Homologene: 16332
Fsip2
Name: fibrous sheath-interacting protein 2
Synonyms: OTTMUSG00000013335
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241516
Homologene: 110349
Slc4a5
Name: solute carrier family 4, sodium bicarbonate cotransporter, member 5
Synonyms: C330016K18Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232156
Homologene: 31125
Kprp
Name: keratinocyte expressed, proline-rich
Synonyms: 1110001M24Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 433619
Homologene: 54921
Prpf40b
Name: pre-mRNA processing factor 40B
Synonyms: 2610317D23Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 54614
Homologene: 81828
Ces5a
Name: carboxylesterase 5A
Synonyms: LOC244598, Ces7, 1700122C07Rik, cauxin, 1700081L16Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 67935
Homologene: 74305
Capn13
Name: calpain 13
Synonyms: LOC381122
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 381122
VEGA: 17
Homologene: 27026
Ccdc30
Name: coiled-coil domain containing 30
Synonyms: 1700001O02Rik, 4930445I03Rik, 1700041C02Rik, 1700111D19Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 73332
Homologene: 137391
Stat6
Name: signal transducer and activator of transcription 6
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 20852
Homologene: 2373
Zbbx
Name: zinc finger, B-box domain containing
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 213234
Homologene: 11661
Tssk2
Name: testis-specific serine kinase 2
Synonyms: DGS-G, Stk22b, Tsk2, SPOGA2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 22115
VEGA: 16
Homologene: 31512
Wiz
Name: widely-interspaced zinc finger motifs
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 22404
Homologene: 7997
Adamdec1
Name: ADAM-like, decysin 1
Synonyms: 2210414L24Rik, Dcsn
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 58860
VEGA: 14
Homologene: 8711
Or52b1
Name: olfactory receptor family 52 subfamily B member 1
Synonyms: GA_x6K02T2PBJ9-7959171-7958224, MOR31-2, Olfr690
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 56860
Homologene: 10653
Bace2
Name: beta-site APP-cleaving enzyme 2
Synonyms: ASP21, CEAP1, CDA13, ALP56, BAE2, ARP1, 1110059C24Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 56175
VEGA: 16
HGNC: HGNC:934
Homologene: 22696
9330159F19Rik
Name: RIKEN cDNA 9330159F19 gene
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 212448
VEGA: 10
Homologene: 8804
Spag6l
Name: sperm associated antigen 6-like
Synonyms: Spag6, PF16
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 50525
Homologene: 8252
Rgl2
Name: ral guanine nucleotide dissociation stimulator-like 2
Synonyms: KE1.5, Rab2l, Rgt2, Rlf
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 19732
HGNC: HGNC:9769
Homologene: 3494
Kcna7
Name: potassium voltage-gated channel, shaker-related subfamily, member 7
Synonyms: Kv1.7
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16495
HGNC: HGNC:6226
Homologene: 7791
Pcdhb3
Name: protocadherin beta 3
Synonyms: PcdhbC
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93874
HGNC: HGNC:8688
Homologene: 115665
Abcb1a
Name: ATP-binding cassette, sub-family B member 1A
Synonyms: Pgy-3, P-gp, multiple drug resistant 1a, MDR3, Pgp, P-glycoprotein, mdr-3, Pgy3, Mdr1a, Evi32
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 18671
HGNC: HGNC:40
Homologene: 55496
Slamf1
Name: signaling lymphocytic activation molecule family member 1
Synonyms: CDw150, IPO-3, ESTM51, CD150, Slam
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 27218
Homologene: 48162
Trappc13
Name: trafficking protein particle complex 13
Synonyms: 2410002O22Rik, 2610524F24Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 66975
Homologene: 11792
Zbtb7a
Name: zinc finger and BTB domain containing 7a
Synonyms: Zbtb7, 9130006G12Rik, FBI-1, Pokemon, 9030619K07Rik, Leukemia/lymphoma Related Factor, Lrf
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 16969
Homologene: 7820
Ugt3a1
Name: UDP glycosyltransferases 3 family, polypeptide A1
Synonyms: Ugt3a2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223337
Homologene: 122787
Creb3l2
Name: cAMP responsive element binding protein 3-like 2
Synonyms: BBF2H7, C530025K05Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 208647
Homologene: 18690
Vmn1r234
Name: vomeronasal 1 receptor 234
Synonyms: V1rf1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 171232
Rad18
Name: RAD18 E3 ubiquitin protein ligase
Synonyms: 2810024C04Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 58186
Homologene: 48572
BC007180
Name: cDNA sequence BC007180
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Reep5
Name: receptor accessory protein 5
Synonyms: DP1/TB2, Dp1, TB2/DP1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 13476
VEGA: 18
Homologene: 68479
Snap23
Name: synaptosomal-associated protein 23
Synonyms: SNAP-23, Sndt, Syndet
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20619
Homologene: 37857
Copz2
Name: coatomer protein complex, subunit zeta 2
Synonyms: 1110012D12Rik, zeta2-COP, nonclathrin coat protein zeta2-COP
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 56358
Homologene: 69215
Or8s2
Name: olfactory receptor family 8 subfamily S member 2
Synonyms: GA_x6K02T2NBG7-5351896-5352825, Olfr283, MOR160-1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 259038
Homologene: 64944
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 162,544,220 bp
  • C to T, chromosome 1 at 171,777,160 bp
  • G to A, chromosome 2 at 20,743,537 bp
  • G to A, chromosome 2 at 82,978,217 bp
  • T to A, chromosome 2 at 119,102,579 bp
  • T to A, chromosome 2 at 120,586,245 bp
  • T to C, chromosome 2 at 167,974,223 bp
  • C to T, chromosome 3 at 75,105,671 bp
  • A to G, chromosome 3 at 92,825,039 bp
  • A to G, chromosome 3 at 154,764,321 bp
  • A to G, chromosome 4 at 41,195,482 bp
  • A to T, chromosome 4 at 82,323,699 bp
  • C to T, chromosome 4 at 116,993,404 bp
  • A to T, chromosome 4 at 119,367,808 bp
  • C to T, chromosome 4 at 130,312,387 bp
  • G to A, chromosome 5 at 8,747,403 bp
  • T to A, chromosome 5 at 137,637,730 bp
  • A to T, chromosome 6 at 37,364,026 bp
  • A to G, chromosome 6 at 83,288,303 bp
  • T to C, chromosome 6 at 89,574,355 bp
  • T to C, chromosome 6 at 112,693,471 bp
  • T to A, chromosome 6 at 136,560,817 bp
  • C to A, chromosome 7 at 5,017,885 bp
  • T to C, chromosome 7 at 45,408,945 bp
  • A to G, chromosome 7 at 105,330,151 bp
  • A to G, chromosome 8 at 84,893,480 bp
  • T to C, chromosome 8 at 93,528,502 bp
  • C to T, chromosome 8 at 109,632,539 bp
  • A to G, chromosome 9 at 64,289,795 bp
  • C to A, chromosome 10 at 29,222,114 bp
  • T to C, chromosome 10 at 53,625,952 bp
  • C to T, chromosome 10 at 81,144,266 bp
  • C to A, chromosome 10 at 127,659,507 bp
  • T to G, chromosome 11 at 96,852,103 bp
  • A to G, chromosome 11 at 102,399,259 bp
  • C to T, chromosome 13 at 104,168,560 bp
  • A to T, chromosome 14 at 68,577,138 bp
  • A to G, chromosome 15 at 9,367,412 bp
  • A to T, chromosome 15 at 44,589,406 bp
  • A to G, chromosome 15 at 83,131,475 bp
  • A to C, chromosome 15 at 98,378,582 bp
  • T to C, chromosome 15 at 99,306,945 bp
  • A to C, chromosome 16 at 16,763,020 bp
  • G to A, chromosome 16 at 17,898,963 bp
  • C to A, chromosome 16 at 20,689,183 bp
  • A to G, chromosome 16 at 24,845,161 bp
  • C to G, chromosome 16 at 97,436,657 bp
  • A to G, chromosome 17 at 21,229,009 bp
  • A to G, chromosome 17 at 32,359,132 bp
  • C to A, chromosome 17 at 33,932,597 bp
  • T to C, chromosome 17 at 58,104,599 bp
  • G to A, chromosome 17 at 73,331,119 bp
  • T to C, chromosome 18 at 34,372,474 bp
  • T to C, chromosome 18 at 34,808,296 bp
  • T to C, chromosome 18 at 37,302,825 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3755 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040738-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.