Strain Name:
C57BL/6J-MtgxR3786Btlr/Mmmh
Stock Number:
040753-MU
Citation ID:
RRID:MMRRC_040753-MU
Other Names:
R3786 (G1), C57BL/6J-MtgxR3786Btlr
Major Collection:

Gene Information

Smarca4
Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
Synonyms: b2b692Clo, SW1/SNF, b2b508.1Clo, Brg1, SNF2beta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 20586
Homologene: 135927
Neurod1
Name: neurogenic differentiation 1
Synonyms: BETA2, bHLHa3, Neurod, Nd1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 18012
HGNC: HGNC:7762
Homologene: 1871
Thbs4
Name: thrombospondin 4
Synonyms: TSP4, TSP-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 21828
Homologene: 20691
Nrg1
Name: neuregulin 1
Synonyms: HGL, heregulin, HRG, Hgl, ARIA, GGF, SMDF, NDF, GGFII, HRGalpha, D230005F13Rik, 6030402G23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 211323
HGNC: HGNC:7997
Homologene: 138451
Fancd2
Name: Fanconi anemia, complementation group D2
Synonyms: 2410150O07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 211651
HGNC: HGNC:3585
Homologene: 13212
Kif13b
Name: kinesin family member 13B
Synonyms: 5330429L19Rik, N-3 kinesin, GAKIN, C130021D12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 16554
VEGA: 14
Homologene: 9073
Mettl3
Name: methyltransferase like 3
Synonyms: M6A, Spo8, 2310024F18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 56335
Homologene: 10501
Heatr1
Name: HEAT repeat containing 1
Synonyms: B130016L12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 217995
VEGA: 13
Homologene: 34562
Dmxl1
Name: Dmx-like 1
Synonyms: C630007L23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 240283
HGNC: HGNC:2937
Homologene: 21136
Rttn
Name: rotatin
Synonyms: C530033I08Rik, 4921538A15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 246102
VEGA: 18
Homologene: 65275
Cenpf
Name: centromere protein F
Synonyms: 6530404A22Rik, mitosin, Lek1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 108000
HGNC: HGNC:1857
Homologene: 22969
Xdh
Name: xanthine dehydrogenase
Synonyms: xanthine oxidase, Xox-1, XO, Xox1, Xor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 22436
VEGA: 17
Homologene: 324
Wap
Name: whey acidic protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 22373
HGNC: null
Homologene: 137242
Robo3
Name: roundabout guidance receptor 3
Synonyms: Rig-1, Rig1, Robo3a, Rbig1, Robo3b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 19649
Homologene: 32119
Hnrnpl
Name: heterogeneous nuclear ribonucleoprotein L
Synonyms: D830027H13Rik, Hnrpl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 15388
HGNC: HGNC:5045
Homologene: 1174
Rala
Name: v-ral simian leukemia viral oncogene A (ras related)
Synonyms: 3010001O15Rik, Rasl1, Ral
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 56044
HGNC: HGNC:9839
Homologene: 3942
Dzip3
Name: DAZ interacting protein 3, zinc finger
Synonyms: 6430549P11Rik, 2A-HUB, 2310047C04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 224170
Homologene: 8771
Acp6
Name: acid phosphatase 6, lysophosphatidic
Synonyms: mPACPL1, ACPL1, 5730559A09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 66659
Homologene: 41128
Itgb1
Name: integrin beta 1 (fibronectin receptor beta)
Synonyms: Gm9863, CD29, 4633401G24Rik, Fnrb, beta1 integrin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 16412
HGNC: HGNC:6153
Homologene: 22999
Dnpep
Name: aspartyl aminopeptidase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 13437
HGNC: HGNC:2981
Homologene: 6110
Ppp1r21
Name: protein phosphatase 1, regulatory subunit 21
Synonyms: Ccdc128, 1110018J12Rik, Klraq1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 73825
Homologene: 44811
Tsc1
Name: TSC complex subunit 1
Synonyms: tuberous sclerosis 1, hamartin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 64930
Homologene: 314
Mgat4c
Name: MGAT4 family, member C
Synonyms: 9130411I17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 67569
Homologene: 8297
Wnt16
Name: wingless-type MMTV integration site family, member 16
Synonyms: E130309I19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 93735
Homologene: 62175
Myo15
Name: myosin XV
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 17910
HGNC: HGNC:7594
Homologene: 56504
Scn1a
Name: sodium channel, voltage-gated, type I, alpha
Synonyms: Nav1.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 20265
Homologene: 21375
Myh13
Name: myosin, heavy polypeptide 13, skeletal muscle
Synonyms: MyHC-eo, extraocular myosin, EO Myosin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 544791
HGNC: HGNC:7571
Homologene: 55780
Magi2
Name: membrane associated guanylate kinase, WW and PDZ domain containing 2
Synonyms: S-SCAM, Acvrinp1, Magi-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 50791
Homologene: 8189
Neb
Name: nebulin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 17996
HGNC: HGNC:7720
Homologene: 136285
Rtcb
Name: RNA 2',3'-cyclic phosphate and 5'-OH ligase
Synonyms: HSPC117, D10Wsu52e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 28088
Homologene: 36344
Muc5b
Name: mucin 5, subtype B, tracheobronchial
Synonyms: MUC5, MUC9, 2300002I04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 74180
HGNC: HGNC:7516
Homologene: 136756
Sacs
Name: sacsin
Synonyms: E130115J16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 50720
Homologene: null
Aoc1
Name: amine oxidase, copper-containing 1
Synonyms: 1600012D06Rik, Abp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 76507
HGNC: HGNC:80
Homologene: 68159
Rhoc
Name: ras homolog family member C
Synonyms: Arh9, Arhc
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 11853
HGNC: HGNC:669
Homologene: 90945
Sgsm3
Name: small G protein signaling modulator 3
Synonyms: Rutbc3, 1810012I01Rik, CIP85
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 105835
Homologene: 9249
Dennd3
Name: DENN/MADD domain containing 3
Synonyms: E030003N15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 105841
Homologene: 28254
Cfap57
Name: cilia and flagella associated protein 57
Synonyms: LOC384050, C130004B06Rik, 1110020C03Rik, Wdr65
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 68625
Homologene: 51350
Ttbk2
Name: tau tubulin kinase 2
Synonyms: 2610507N02Rik, B930008N24Rik, TTK
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 140810
Homologene: 62795
Ctnna3
Name: catenin (cadherin associated protein), alpha 3
Synonyms: 4930429L08Rik, alphaT-catenin, Catna3, Vr22
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 216033
HGNC: HGNC:2511
Homologene: 56583
Odr4
Name: odr4 GPCR localization factor homolog
Synonyms: 1810053E15Rik, BC003331
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 226499
Homologene: 41202
Fam161b
Name: family with sequence similarity 161, member B
Synonyms: 9830169C18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 217705
Homologene: 17581
Spatc1l
Name: spermatogenesis and centriole associated 1 like
Synonyms: 1700022B01Rik, 1700027D21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 76573
HGNC: HGNC:1298
Homologene: 75292
Hao2
Name: hydroxyacid oxidase 2
Synonyms: Hao3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 56185
HGNC: HGNC:4810
Homologene: 97412
Ttll1
Name: tubulin tyrosine ligase-like 1
Synonyms: 6330444E16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 319953
HGNC: HGNC:1312
Homologene: 8174
Misp
Name: mitotic spindle positioning
Synonyms: 9130017N09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 78906
VEGA: 10
Homologene: 49933
Gpt2
Name: glutamic pyruvate transaminase (alanine aminotransferase) 2
Synonyms: ALT2, 4631422C05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 108682
Homologene: 68832
Btbd7
Name: BTB (POZ) domain containing 7
Synonyms: E130118E17Rik, 5730507E09Rik, FUP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 238386
VEGA: 12
Homologene: 34300
C1qtnf12
Name: C1q and tumor necrosis factor related 12
Synonyms: Fam132a, 1110035L05Rik, alipolin, C1qdc2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 67389
Homologene: 12123
Nsa2
Name: NSA2 ribosome biogenesis homolog
Synonyms: 5730427N09Rik, LNR42, Nsa2p, Yr29
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 59050
VEGA: 13
Homologene: 5844
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 75,316,640 bp
  • A to G, chromosome 1 at 150,384,531 bp
  • T to A, chromosome 1 at 189,658,337 bp
  • A to G, chromosome 2 at 28,687,142 bp
  • C to A, chromosome 2 at 52,201,915 bp
  • A to T, chromosome 2 at 66,328,553 bp
  • T to A, chromosome 2 at 79,454,595 bp
  • A to T, chromosome 2 at 120,773,815 bp
  • T to A, chromosome 3 at 97,159,289 bp
  • T to A, chromosome 3 at 98,876,752 bp
  • T to C, chromosome 3 at 104,792,687 bp
  • A to G, chromosome 4 at 118,595,743 bp
  • G to A, chromosome 4 at 155,965,899 bp
  • C to T, chromosome 5 at 20,465,909 bp
  • A to G, chromosome 6 at 22,298,022 bp
  • T to C, chromosome 6 at 48,905,655 bp
  • T to G, chromosome 6 at 113,565,204 bp
  • A to G, chromosome 7 at 28,811,011 bp
  • C to T, chromosome 7 at 141,865,116 bp
  • A to T, chromosome 8 at 31,821,383 bp
  • G to T, chromosome 8 at 85,525,573 bp
  • T to A, chromosome 8 at 128,713,358 bp
  • A to G, chromosome 9 at 21,672,059 bp
  • A to G, chromosome 9 at 37,422,225 bp
  • T to C, chromosome 10 at 63,537,507 bp
  • C to T, chromosome 10 at 76,563,902 bp
  • G to A, chromosome 10 at 79,825,961 bp
  • G to T, chromosome 10 at 85,942,594 bp
  • A to G, chromosome 10 at 102,385,070 bp
  • G to A, chromosome 11 at 6,638,550 bp
  • A to T, chromosome 11 at 60,477,572 bp
  • A to G, chromosome 11 at 67,327,188 bp
  • A to T, chromosome 12 at 84,361,690 bp
  • C to T, chromosome 12 at 102,838,152 bp
  • G to T, chromosome 13 at 12,434,460 bp
  • T to A, chromosome 13 at 17,882,446 bp
  • T to C, chromosome 13 at 92,773,164 bp
  • G to T, chromosome 13 at 97,135,534 bp
  • A to T, chromosome 14 at 52,299,906 bp
  • C to A, chromosome 14 at 61,183,961 bp
  • C to T, chromosome 14 at 64,800,400 bp
  • T to C, chromosome 15 at 73,547,577 bp
  • T to C, chromosome 15 at 81,003,798 bp
  • T to C, chromosome 15 at 83,484,218 bp
  • C to A, chromosome 16 at 48,975,543 bp
  • C to T, chromosome 17 at 73,893,595 bp
  • T to A, chromosome 17 at 88,577,127 bp
  • G to A, chromosome 18 at 49,865,122 bp
  • A to G, chromosome 18 at 89,037,894 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3786 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040753-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.