Strain Name:
C57BL/6J-MtgxR3793Btlr/Mmmh
Stock Number:
040755-MU
Citation ID:
RRID:MMRRC_040755-MU
Other Names:
R3793 (G1), C57BL/6J-MtgxR3793Btlr
Major Collection:

Gene Information

Lrrc2
Name: leucine rich repeat containing 2
Synonyms: 2400002D05Rik, 4933431K03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 74249
Homologene: 23454
Trp53bp1
Name: transformation related protein 53 binding protein 1
Synonyms: 53BP1, p53BP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 27223
Homologene: 4137
Uba2
Name: ubiquitin-like modifier activating enzyme 2
Synonyms: SAE2, anthracycline-associated resistance, UBA2, Sumo-1 activating enzyme subunit 2, Uble1b, Arx
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 50995
Homologene: 4018
Ubap2l
Name: ubiquitin-associated protein 2-like
Synonyms: 3110083O19Rik, A430103N23Rik, NICE-4, 4932431F02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 74383
Homologene: 136291
Wac
Name: WW domain containing adaptor with coiled-coil
Synonyms: 1110067P07Rik, Wwp4, A230035H12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 225131
Homologene: 41148
Akap13
Name: A kinase (PRKA) anchor protein 13
Synonyms: 1700026G02Rik, 5830460E08Rik, 5730522G15Rik, AKAP-Lbc, PROTO-LBC, PROTO-LB, Ht31
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 75547
HGNC: HGNC:371
Homologene: 4903
Nfx1
Name: nuclear transcription factor, X-box binding 1
Synonyms: 1300017N15Rik, 3000003M19Rik, Tex42, TEG-42
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 74164
HGNC: HGNC:7803
Homologene: 1875
Wdr3
Name: WD repeat domain 3
Synonyms: D030020G18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 269470
Homologene: 4937
Arhgap32
Name: Rho GTPase activating protein 32
Synonyms: Grit, 3426406O18Rik, PX-RICS, GC-GAP, p200RhoGAP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 330914
Homologene: 8812
Pold1
Name: polymerase (DNA directed), delta 1, catalytic subunit
Synonyms: 125kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 18971
HGNC: HGNC:9175
Homologene: 2014
G3bp2
Name: GTPase activating protein (SH3 domain) binding protein 2
Synonyms: G3BP2, G3BP, E430034L04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 23881
Homologene: 137244
Nfrkb
Name: nuclear factor related to kappa B binding protein
Synonyms: A530090G11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 235134
HGNC: HGNC:7802
Homologene: 4492
Ubr3
Name: ubiquitin protein ligase E3 component n-recognin 3
Synonyms: Zfp650, 1110059H15Rik, 4833421P10Rik, A130030D10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 68795
Homologene: 52092
Sdf4
Name: stromal cell derived factor 4
Synonyms: Cab45
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 20318
Homologene: 32121
Adam17
Name: a disintegrin and metallopeptidase domain 17
Synonyms: CD156b, Tace
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 11491
HGNC: HGNC:195
Homologene: 2395
Per1
Name: period circadian clock 1
Synonyms: m-rigui, Hftm, mPer1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 18626
HGNC: HGNC:8845
Homologene: 1966
Kirrel
Name: kirre like nephrin family adhesion molecule 1
Synonyms: Neph1, Kirrel1, 6720469N11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 170643
Homologene: 10089
Ift172
Name: intraflagellar transport 172
Synonyms: avc1, wim, 4930553F24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 67661
Homologene: 15202
Esyt3
Name: extended synaptotagmin-like protein 3
Synonyms: D9Ertd280e, Fam62c
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 272636
Homologene: 18626
Sirt4
Name: sirtuin 4
Synonyms: 4930596O17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 75387
Homologene: 8164
Itga4
Name: integrin alpha 4
Synonyms: VLA-4 receptor, alpha 4 subunit
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 16401
HGNC: HGNC:6140
Homologene: 37364
Csn1s1
Name: casein alpha s1
Synonyms: Csna
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 12990
HGNC: HGNC:2445
Nlrp14
Name: NLR family, pyrin domain containing 14
Synonyms: Nalp14, 4921520L01Rik, GC-LRR, Nalp-iota
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 76858
Homologene: 18531
Cass4
Name: Cas scaffolding protein family member 4
Synonyms: F730031O20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 320664
Homologene: 75128
Krt71
Name: keratin 71
Synonyms: Cu, Krt2-6g, mK6irs1, Cal4, Ca, mK6irs
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 56735
Homologene: 88864
Unc79
Name: unc-79 homolog
Synonyms: Mlca3, 9030205A07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 217843
Homologene: 41397
Col14a1
Name: collagen, type XIV, alpha 1
Synonyms: 5730412L22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 12818
HGNC: HGNC:2191
Homologene: 18741
Zfp607a
Name: zinc finger protein 607A
Synonyms: 4732475C15Rik, Zfp607
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 545938
Homologene: 134321
Lingo4
Name: leucine rich repeat and Ig domain containing 4
Synonyms: A530050P17Rik, Lrrn6d, LERN4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 320747
Homologene: 18563
Osgepl1
Name: O-sialoglycoprotein endopeptidase-like 1
Synonyms: MGC13061, 2610001M19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 72085
Homologene: 5561
Sla2
Name: Src-like-adaptor 2
Synonyms: SLAP-2, SLAP2, A930009E21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 77799
Homologene: 49989
Asic1
Name: acid-sensing (proton-gated) ion channel 1
Synonyms: ASICalpha, ASIC1 beta, ASIC1a, B530003N02Rik, BNaC2, ASIC, Accn2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 11419
VEGA: 15
HGNC: HGNC:100
Homologene: 121755
Slco1b2
Name: solute carrier organic anion transporter family, member 1b2
Synonyms: Slc21a6, 7330442B20Rik, mlst-1, Oatp1b2, Slc21a10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 28253
Homologene: 75119
Itprid1
Name: ITPR interacting domain containing 1
Synonyms: Ccdc129, D530004J12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 232016
Homologene: 52344
Ptk2b
Name: PTK2 protein tyrosine kinase 2 beta
Synonyms: proline-rich tyrosine kinase 2, Raftk, calcium-dependent tyrosine kinase, E430023O05Rik, cellular adhesion kinase beta, PYK2, related adhesion focal tyrosine kinase, CAKbeta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 19229
HGNC: HGNC:9612
Homologene: 23001
Mapk8ip1
Name: mitogen-activated protein kinase 8 interacting protein 1
Synonyms: Skip, IB1, mjip-2a, Prkm8ip, MAPK8IP1, Jip1, JIP-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 19099
HGNC: HGNC:6882
Homologene: 31314
Ovgp1
Name: oviductal glycoprotein 1
Synonyms: OGP, Chit5, MOGP, muc9, mucin 9, oviductin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 12659
HGNC: HGNC:8524
Homologene: 74442
Ugt2b35
Name: UDP glucuronosyltransferase 2 family, polypeptide B35
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 243085
Homologene: 128251
Plch1
Name: phospholipase C, eta 1
Synonyms: Plcl3, PLCeta1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 269437
Homologene: 88833
Tmem200a
Name: transmembrane protein 200A
Synonyms: C030003D03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 77220
VEGA: 10
Homologene: 14175
B9d1
Name: B9 protein domain 1
Synonyms: Eppb9, B9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 27078
Homologene: 8440
Cyp2c69
Name: cytochrome P450, family 2, subfamily c, polypeptide 69
Synonyms: AI098658
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 100043108
VEGA: 19
Homologene: 74936
Cnfn
Name: cornifelin
Synonyms: 2210418J09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 72383
Homologene: 13039
Ocln
Name: occludin
Synonyms: Ocl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 18260
HGNC: HGNC:8104
Homologene: 1905
Casd1
Name: CAS1 domain containing 1
Synonyms: Cast1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 213819
Homologene: 11287
Olfr866
Name: olfactory receptor 866
Synonyms: GA_x6K02T2PVTD-13768406-13767468, MOR145-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 258551
Homologene: 133687
Dlg2
Name: discs large MAGUK scaffold protein 2
Synonyms: LOC382816, A330103J02Rik, B230218P12Rik, Gm21505, Dlgh2, B330007M19Rik, PSD93, Chapsyn-110
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 23859
HGNC: HGNC:2901
Homologene: 1046
Lhx1
Name: LIM homeobox protein 1
Synonyms: Lim1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 16869
HGNC: HGNC:6593
Homologene: 4068
Olfr1360
Name: olfactory receptor 1360
Synonyms: GA_x6K02T2QHY8-11561962-11562903, MOR256-35, MOR256-10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 258536
Homologene: 11056
Esp16
Name: exocrine gland secreted peptide 16
Synonyms: Gm4345
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 100043300
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 53,320,247 bp
  • T to C, chromosome 2 at 69,917,181 bp
  • A to G, chromosome 2 at 79,279,128 bp
  • A to G, chromosome 2 at 92,384,716 bp
  • T to C, chromosome 2 at 121,200,329 bp
  • G to A, chromosome 2 at 156,875,942 bp
  • C to T, chromosome 2 at 172,432,558 bp
  • A to G, chromosome 3 at 63,697,831 bp
  • C to T, chromosome 3 at 87,089,151 bp
  • T to C, chromosome 3 at 90,008,248 bp
  • A to G, chromosome 3 at 94,402,378 bp
  • A to T, chromosome 3 at 100,151,965 bp
  • A to G, chromosome 3 at 105,980,171 bp
  • T to A, chromosome 4 at 41,004,357 bp
  • T to A, chromosome 4 at 156,002,459 bp
  • C to T, chromosome 5 at 31,257,581 bp
  • A to G, chromosome 5 at 87,001,606 bp
  • T to A, chromosome 5 at 87,680,843 bp
  • A to G, chromosome 5 at 92,065,740 bp
  • T to C, chromosome 5 at 115,480,292 bp
  • T to C, chromosome 6 at 4,619,876 bp
  • A to T, chromosome 6 at 55,975,603 bp
  • A to G, chromosome 6 at 141,676,307 bp
  • T to C, chromosome 7 at 25,368,380 bp
  • A to T, chromosome 7 at 27,878,906 bp
  • A to C, chromosome 7 at 34,146,297 bp
  • A to G, chromosome 7 at 44,541,570 bp
  • A to G, chromosome 7 at 75,610,141 bp
  • A to T, chromosome 7 at 91,810,535 bp
  • A to T, chromosome 7 at 107,182,274 bp
  • T to A, chromosome 9 at 20,027,063 bp
  • A to T, chromosome 9 at 31,409,932 bp
  • T to A, chromosome 9 at 32,255,373 bp
  • A to T, chromosome 9 at 99,315,281 bp
  • T to A, chromosome 9 at 110,966,517 bp
  • A to T, chromosome 10 at 25,994,189 bp
  • A to G, chromosome 11 at 61,507,622 bp
  • A to G, chromosome 11 at 69,109,301 bp
  • A to G, chromosome 11 at 84,521,900 bp
  • T to C, chromosome 12 at 21,346,005 bp
  • T to C, chromosome 12 at 103,134,554 bp
  • T to C, chromosome 13 at 21,674,983 bp
  • T to C, chromosome 13 at 100,498,894 bp
  • A to T, chromosome 14 at 66,170,251 bp
  • G to T, chromosome 15 at 55,363,513 bp
  • A to T, chromosome 15 at 99,672,025 bp
  • C to T, chromosome 15 at 101,742,910 bp
  • T to C, chromosome 17 at 39,537,848 bp
  • T to C, chromosome 18 at 7,920,190 bp
  • T to C, chromosome 19 at 39,881,156 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3793 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040755-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.