Strain Name:
C57BL/6J-MtgxR3800Btlr/Mmmh
Stock Number:
040759-MU
Citation ID:
RRID:MMRRC_040759-MU
Other Names:
R3800 (G1), C57BL/6J-MtgxR3800Btlr
Major Collection:

Strain Information

Cpe
Name: carboxypeptidase E
Synonyms: carboxypeptidase H, CPH, Cph1, Cph-1, NF-alpha1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 12876
HGNC: HGNC:2303
Homologene: 48052
Abca12
Name: ATP-binding cassette, sub-family A (ABC1), member 12
Synonyms: 4832428G11Rik, 4833417A11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 74591
Homologene: 45441
Ncoa3
Name: nuclear receptor coactivator 3
Synonyms: pCIP, TRAM-1, AIB1, RAC3, TRAM1, Src3, 2010305B15Rik, KAT13B, bHLHe42
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 17979
HGNC: HGNC:7670
Homologene: 4764
Col18a1
Name: collagen, type XVIII, alpha 1
Synonyms: endostatin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 12822
HGNC: HGNC:2195
Homologene: 7673
Srgap2
Name: SLIT-ROBO Rho GTPase activating protein 2
Synonyms: FBP2, 9930124L22Rik, Fnbp2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 14270
Homologene: 52683
Adam23
Name: a disintegrin and metallopeptidase domain 23
Synonyms: MDC3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 23792
HGNC: HGNC:202
Homologene: 2826
Senp6
Name: SUMO/sentrin specific peptidase 6
Synonyms: E130319N12Rik, 2810017C20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 215351
Homologene: 9196
Gmps
Name: guanine monophosphate synthetase
Synonyms: Gm9479
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229363
HGNC: HGNC:4378
Homologene: 68367
Cep290
Name: centrosomal protein 290
Synonyms: Nphp6, b2b1454Clo, b2b1752Clo, Kiaa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 216274
VEGA: 10
Homologene: 77213
Map2k4
Name: mitogen-activated protein kinase kinase 4
Synonyms: MKK4, JNKK1, Serk1, Sek1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 26398
HGNC: HGNC:6844
Homologene: 48159
Btbd9
Name: BTB (POZ) domain containing 9
Synonyms: 1700023F20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224671
VEGA: 17
Homologene: 14995
Cux1
Name: cut-like homeobox 1
Synonyms: Cux, CDP, Cux-1, Cutl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 13047
HGNC: HGNC:2557
Fnbp1
Name: formin binding protein 1
Synonyms: FBP1, FBP17, 2210010H06Rik, 1110057E06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 14269
Homologene: 100983
Ppp2r1a
Name: protein phosphatase 2, regulatory subunit A, alpha
Synonyms: PR65, protein phosphatase PP2A, 6330556D22Rik, PP2A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 51792
HGNC: HGNC:9302
Homologene: 68559
Secisbp2l
Name: SECIS binding protein 2-like
Synonyms: 3110001I20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 70354
Homologene: 18923
Rnf34
Name: ring finger protein 34
Synonyms: phafin 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 80751
Homologene: 11839
Ift122
Name: intraflagellar transport 122
Synonyms: C86139, Wdr10, sopb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 81896
Homologene: 12819
Npnt
Name: nephronectin
Synonyms: POEM, 1110009H02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 114249
Homologene: 14138
Inpp5b
Name: inositol polyphosphate-5-phosphatase B
Synonyms: 75kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 16330
HGNC: HGNC:6077
Homologene: 69021
Dync2h1
Name: dynein cytoplasmic 2 heavy chain 1
Synonyms: DHC1b, DHC2, 4432416O06Rik, D330044F14Rik, D030010H02Rik, Dnchc2, b2b414Clo, m407Asp, m152Asp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 110350
HGNC: HGNC:2962
Homologene: 14468
Aire
Name: autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 11634
HGNC: HGNC:360
Homologene: 327
Sdccag8
Name: serologically defined colon cancer antigen 8
Synonyms: CCCAP, 2700048G21Rik, 5730470G24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 76816
Homologene: 4839
Arhgap28
Name: Rho GTPase activating protein 28
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 268970
Homologene: 18264
Dock8
Name: dedicator of cytokinesis 8
Synonyms: 1200017A24Rik, 5830472H07Rik, A130095G14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 76088
VEGA: 19
Homologene: 52414
Trpc6
Name: transient receptor potential cation channel, subfamily C, member 6
Synonyms: mtrp6, Trrp6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 22068
VEGA: 9
Homologene: 37944
Adgrf5
Name: adhesion G protein-coupled receptor F5
Synonyms: 8430401C09Rik, Gpr116
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224792
VEGA: 17
Homologene: 9065
Fbn1
Name: fibrillin 1
Synonyms: Fib-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 14118
HGNC: HGNC:3603
Homologene: 30958
Ttn
Name: titin
Synonyms: connectin, L56, mdm, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, shru
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22138
Homologene: 130650
Mccc1
Name: methylcrotonoyl-Coenzyme A carboxylase 1 (alpha)
Synonyms: 1810045E08Rik, MCCalpha, MCCA, 2310058B18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 72039
HGNC: HGNC:6936
Homologene: 10603
Fat4
Name: FAT atypical cadherin 4
Synonyms: 6030410K14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 329628
Homologene: 14377
Fbxw16
Name: F-box and WD-40 domain protein 16
Synonyms: 7420402K12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 320083
Homologene: 110776
Mbd6
Name: methyl-CpG binding domain protein 6
Synonyms: D10Wsu93e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 110962
Homologene: 14171
Caskin1
Name: CASK interacting protein 1
Synonyms: C630036E02Rik, 3300002N10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 268932
VEGA: 17
Homologene: 25873
Cacna1b
Name: calcium channel, voltage-dependent, N type, alpha 1B subunit
Synonyms: Cchn1a, alpha(1B), Cav2.2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 12287
HGNC: HGNC:1389
Homologene: 20184
Ino80c
Name: INO80 complex subunit C
Synonyms: D030070L09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 225280
Homologene: 45426
Sik2
Name: salt inducible kinase 2
Synonyms: G630080D20Rik, Snf1lk2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235344
Homologene: 22875
Kcnj6
Name: potassium inwardly-rectifying channel, subfamily J, member 6
Synonyms: Kir3.2, GIRK2, KCNJ7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 16522
VEGA: 16
HGNC: HGNC:6267
Homologene: 1688
Wdr66
Name: WD repeat domain 66
Synonyms: 4930415N18Rik, 4933428F06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 269701
Homologene: 16964
Shc2
Name: SHC (Src homology 2 domain containing) transforming protein 2
Synonyms: ShcB, Sli
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 216148
Homologene: 19127
AC211878.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Smarcd3
Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
Synonyms: 1500001J14Rik, BAF60C, 2210409C08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 66993
Homologene: 2314
Ccdc96
Name: coiled-coil domain containing 96
Synonyms: 4921513E08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 66717
Homologene: 32639
3425401B19Rik
Name: RIKEN cDNA 3425401B19 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 100504518
VEGA: 14
Homologene: 54908
Mrc2
Name: mannose receptor, C type 2
Synonyms: novel lectin, Endo180, uPARAP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 17534
Homologene: 4408
Vmn2r65
Name: vomeronasal 2, receptor 65
Synonyms: ENSMUSG00000070600
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 100009609
Alkbh2
Name: alkB homolog 2, alpha-ketoglutarate-dependent dioxygenase
Synonyms: Abh2, mABH2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231642
Homologene: 18393
Vav3
Name: vav 3 oncogene
Synonyms: A530094I06Rik, Idd18.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 57257
Homologene: 38143
Il18r1
Name: interleukin 18 receptor 1
Synonyms: Il1rrp, Il18ralpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 16182
HGNC: HGNC:5988
Homologene: 2861
Or10a4
Name: olfactory receptor family 10 subfamily A member 4
Synonyms: P2, MOR263-5, GA_x6K02T2PBJ9-9470146-9471093, Olfr17
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 18314
Homologene: 23241
Samm50
Name: SAMM50 sorting and assembly machinery component
Synonyms: 1110030L07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 68653
VEGA: 15
Homologene: 41034
Prpmp5
Name: proline-rich protein MP5
Synonyms: MP5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 381832
Ubash3a
Name: ubiquitin associated and SH3 domain containing, A
Synonyms: 5830413C03Rik, Sts-2, TULA
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 328795
Homologene: 56833
Or14j1
Name: olfactory receptor family 14 subfamily J member 1
Synonyms: MOR218-8, GA_x6K02T2PSCP-2291580-2292542, Olfr125
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 258287
Homologene: 114633
Habp4
Name: hyaluronic acid binding protein 4
Synonyms: 4933413D03Rik, 4933428J01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 56541
VEGA: 13
Homologene: 8615
Gm9845
Name: predicted pseudogene 9845
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 100040853
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 40,500,465 bp
  • C to T, chromosome 1 at 63,551,774 bp
  • C to T, chromosome 1 at 71,265,887 bp
  • T to A, chromosome 1 at 131,310,559 bp
  • A to T, chromosome 1 at 176,868,338 bp
  • C to T, chromosome 2 at 24,658,959 bp
  • T to C, chromosome 2 at 31,033,131 bp
  • C to T, chromosome 2 at 76,752,597 bp
  • T to A, chromosome 2 at 125,345,974 bp
  • C to T, chromosome 2 at 125,740,737 bp
  • T to C, chromosome 2 at 166,059,719 bp
  • G to A, chromosome 3 at 36,000,509 bp
  • T to A, chromosome 3 at 38,981,274 bp
  • T to C, chromosome 3 at 39,358,493 bp
  • T to C, chromosome 3 at 63,982,445 bp
  • A to G, chromosome 3 at 109,628,039 bp
  • C to A, chromosome 3 at 132,906,763 bp
  • C to T, chromosome 4 at 124,785,345 bp
  • T to A, chromosome 5 at 24,593,227 bp
  • A to G, chromosome 5 at 36,486,267 bp
  • C to T, chromosome 5 at 114,124,226 bp
  • A to G, chromosome 5 at 122,864,210 bp
  • T to C, chromosome 5 at 123,254,721 bp
  • A to G, chromosome 5 at 136,316,033 bp
  • T to A, chromosome 6 at 115,925,906 bp
  • G to A, chromosome 6 at 132,312,694 bp
  • A to G, chromosome 7 at 84,940,530 bp
  • C to T, chromosome 7 at 107,097,731 bp
  • A to G, chromosome 8 at 64,617,617 bp
  • A to C, chromosome 9 at 7,101,525 bp
  • G to A, chromosome 9 at 8,634,034 bp
  • T to C, chromosome 9 at 50,915,429 bp
  • A to G, chromosome 9 at 80,087,453 bp
  • T to G, chromosome 9 at 109,436,597 bp
  • C to A, chromosome 10 at 77,067,387 bp
  • A to G, chromosome 10 at 78,042,055 bp
  • C to T, chromosome 10 at 79,626,873 bp
  • T to C, chromosome 10 at 100,572,941 bp
  • A to G, chromosome 10 at 127,285,167 bp
  • A to T, chromosome 11 at 65,690,781 bp
  • G to A, chromosome 11 at 105,348,431 bp
  • T to C, chromosome 12 at 87,773,721 bp
  • C to T, chromosome 13 at 64,174,103 bp
  • G to T, chromosome 14 at 32,663,068 bp
  • T to C, chromosome 15 at 84,192,374 bp
  • G to A, chromosome 16 at 94,833,027 bp
  • A to T, chromosome 17 at 20,962,710 bp
  • T to G, chromosome 17 at 24,501,272 bp
  • T to C, chromosome 17 at 30,513,659 bp
  • T to C, chromosome 17 at 31,231,470 bp
  • T to G, chromosome 17 at 37,835,957 bp
  • T to C, chromosome 17 at 43,447,060 bp
  • T to C, chromosome 17 at 67,873,036 bp
  • T to C, chromosome 18 at 24,121,695 bp
  • T to A, chromosome 19 at 25,164,352 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3800 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040759-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.