Strain Name:
C57BL/6J-MtgxR3812Btlr/Mmmh
Stock Number:
040768-MU
Citation ID:
RRID:MMRRC_040768-MU
Other Names:
R3812 (G1), C57BL/6J-MtgxR3812Btlr
Major Collection:

Gene Information

Pkd1
Name: polycystin 1, transient receptor poteintial channel interacting
Synonyms: PC-1, PC1, polycystin-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 18763
VEGA: 17
HGNC: HGNC:9008
Homologene: 250
Arid2
Name: AT rich interactive domain 2 (ARID, RFX-like)
Synonyms: 1700124K17Rik, zipzap/p200, 4432409D24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 77044
Homologene: 14601
Zfp292
Name: zinc finger protein 292
Synonyms: 5730450D02Rik, Zn-16, Zn-15, Zfp-15, Krox-10, Zfp15, 9430062L07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 30046
Homologene: 8493
Usp34
Name: ubiquitin specific peptidase 34
Synonyms: Murr2, A530081C03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 17847
Homologene: 40978
Secisbp2l
Name: SECIS binding protein 2-like
Synonyms: 3110001I20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 70354
Homologene: 18923
Metap2
Name: methionine aminopeptidase 2
Synonyms: p67, eIF-2-associated p67, 4930584B20Rik, A930035J23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 56307
Homologene: 4981
Txndc5
Name: thioredoxin domain containing 5
Synonyms: ERp46, PC-TRP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 105245
Homologene: 11125
Clcn1
Name: chloride channel, voltage-sensitive 1
Synonyms: Clc-1, NMF355, SMCC1, nmf355, Clc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 12723
HGNC: HGNC:2019
Homologene: 63
Nlrp4a
Name: NLR family, pyrin domain containing 4A
Synonyms: E330028A19Rik, Nalp4a, Nalp-eta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 243880
Homologene: 79696
Fbxw28
Name: F-box and WD-40 domain protein 28
Synonyms: Gm9337
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 668758
Homologene: 110776
Krt73
Name: keratin 73
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223915
Homologene: 27875
Treh
Name: trehalase (brush-border membrane glycoprotein)
Synonyms: 2210412M19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 58866
Homologene: 5198
Bpifb2
Name: BPI fold containing family B, member 2
Synonyms: 2310034L21Rik, Bpil1, 2310069A01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 66557
Homologene: 11884
Sorbs2
Name: sorbin and SH3 domain containing 2
Synonyms: 2010203O03Rik, 9430041O17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234214
Homologene: 83295
AC165146.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Ccdc150
Name: coiled-coil domain containing 150
Synonyms: 4930511H11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 78016
Homologene: 15814
Galntl5
Name: UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 5
Synonyms: 1700021B12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 67909
Homologene: 12210
Vmn1r170
Name: vomeronasal 1 receptor 170
Synonyms: Gm5999
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 546944
Homologene: 128341
Otogl
Name: otogelin-like
Synonyms: Gm6924
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 628870
Homologene: 46008
Top2b
Name: topoisomerase (DNA) II beta
Synonyms: Top-2, D230016L12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 21974
Homologene: 134711
Myo1a
Name: myosin IA
Synonyms: Myhl, brush border myosin 1, BBM-I
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 432516
VEGA: 10
HGNC: HGNC:7595
Homologene: 21113
Syt10
Name: synaptotagmin X
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 54526
Homologene: 10303
Olfr1143
Name: olfactory receptor 1143
Synonyms: MOR177-14, GA_x6K02T2Q125-49303473-49304405
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258290
Homologene: 74079
Lcmt2
Name: leucine carboxyl methyltransferase 2
Synonyms: Tyw4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 329504
Homologene: 19642
Cyp4a31
Name: cytochrome P450, family 4, subfamily a, polypeptide 31
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 666168
HGNC: HGNC:2642
Homologene: 128044
Polm
Name: polymerase (DNA directed), mu
Synonyms: B230309I03Rik, Tdt-N
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 54125
HGNC: HGNC:9185
Homologene: 41170
Olfr1255
Name: olfactory receptor 1255
Synonyms: MOR232-4, GA_x6K02T2Q125-51257221-51258135
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258979
Homologene: 82298
Olfr1152
Name: olfactory receptor 1152
Synonyms: GA_x6K02T2Q125-49372426-49373358, MOR177-12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258103
Homologene: 79357
Tymp
Name: thymidine phosphorylase
Synonyms: Ecgf1, PDECGF, 2900072D10Rik, Pdgfec, gliostatin, PD-ECGF
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 72962
VEGA: 15
HGNC: HGNC:3148
Homologene: 1474
Cyp4f15
Name: cytochrome P450, family 4, subfamily f, polypeptide 15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 106648
HGNC: HGNC:2648
Homologene: 80199
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 54,368,310 bp
  • C to T, chromosome 2 at 87,803,052 bp
  • T to A, chromosome 2 at 87,868,401 bp
  • T to A, chromosome 2 at 89,817,051 bp
  • G to A, chromosome 2 at 121,138,706 bp
  • C to T, chromosome 2 at 125,740,737 bp
  • T to A, chromosome 2 at 153,891,951 bp
  • A to T, chromosome 4 at 34,810,326 bp
  • T to C, chromosome 4 at 115,566,509 bp
  • T to C, chromosome 5 at 25,186,180 bp
  • T to C, chromosome 6 at 42,313,794 bp
  • T to C, chromosome 7 at 23,606,292 bp
  • T to C, chromosome 7 at 26,449,693 bp
  • A to G, chromosome 8 at 45,763,030 bp
  • G to A, chromosome 9 at 44,683,973 bp
  • C to A, chromosome 9 at 109,338,530 bp
  • A to T, chromosome 10 at 93,870,164 bp
  • A to G, chromosome 10 at 107,899,471 bp
  • A to G, chromosome 10 at 127,707,415 bp
  • A to G, chromosome 11 at 5,829,512 bp
  • T to A, chromosome 11 at 23,464,517 bp
  • T to C, chromosome 13 at 38,523,405 bp
  • T to G, chromosome 14 at 16,409,189 bp
  • A to T, chromosome 14 at 19,402,398 bp
  • T to C, chromosome 15 at 89,373,679 bp
  • A to T, chromosome 15 at 89,790,797 bp
  • T to C, chromosome 15 at 96,289,086 bp
  • T to C, chromosome 15 at 101,800,702 bp
  • T to C, chromosome 17 at 24,565,641 bp
  • A to G, chromosome 17 at 32,686,177 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3812 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040768-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.