Strain Name:
C57BL/6J-MtgxR3837Btlr/Mmmh
Stock Number:
040778-MU
Citation ID:
RRID:MMRRC_040778-MU
Other Names:
R3837 (G1), C57BL/6J-MtgxR3837Btlr
Major Collection:

Gene Information

Gldc
Name: glycine decarboxylase
Synonyms: D030049L12Rik, b2b2679Clo, D19Wsu57e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 104174
VEGA: 19
HGNC: HGNC:4313
Homologene: 141
Nagk
Name: N-acetylglucosamine kinase
Synonyms: GlcNAc kinase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 56174
Homologene: 9720
Nap1l1
Name: nucleosome assembly protein 1-like 1
Synonyms: D10Ertd68e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 53605
VEGA: 10
HGNC: HGNC:7637
Homologene: 129218
Myl12b
Name: myosin, light chain 12B, regulatory
Synonyms: 1500001M02Rik, Mylc2b, RLC-B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 67938
Homologene: 23407
Fryl
Name: FRY like transcription coactivator
Synonyms: 2510002A14Rik, 2310004H21Rik, 9030227G01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 72313
Homologene: 103956
Skap2
Name: src family associated phosphoprotein 2
Synonyms: 2610021A10Rik, RA70, Saps, SKAP-HOM, mSKAP55R
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 54353
Homologene: 2919
Wnk1
Name: WNK lysine deficient protein kinase 1
Synonyms: EG406236, Hsn2, 6430573H23Rik, Prkwnk1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 232341
Homologene: 14253
Hmgcr
Name: 3-hydroxy-3-methylglutaryl-Coenzyme A reductase
Synonyms: 3-hydroxy-3-methylglutaryl-CoA reductase, HMG-CoAR, Red
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 15357
HGNC: HGNC:5006
Homologene: 30994
Usp14
Name: ubiquitin specific peptidase 14
Synonyms: nmf375, ax, ataxia, 2610037B11Rik, 2610005K12Rik, dUB-type TGT, NMF375
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 59025
Homologene: 3780
Tdp1
Name: tyrosyl-DNA phosphodiesterase 1
Synonyms: SCAN1, E430034L06Rik, 4921509N21Rik, 2810481F14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 104884
Homologene: 5424
Polr1b
Name: polymerase (RNA) I polypeptide B
Synonyms: 128kDa, D630020H17Rik, RPA116, RPA2, Rpo1-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 20017
Homologene: 7133
Shld2
Name: shieldin complex subunit 2
Synonyms: Fam35a, 3110001K24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 75698
VEGA: 14
Homologene: 56840
Cdh9
Name: cadherin 9
Synonyms: T1-cadherin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 12565
HGNC: HGNC:1768
Homologene: 9450
Msh3
Name: mutS homolog 3
Synonyms: D13Em1, Rep-3, Rep3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 17686
HGNC: HGNC:7326
Homologene: 1829
Yme1l1
Name: YME1-like 1 (S. cerevisiae)
Synonyms: ATP-dependent metalloprotease FtsH1, Ftsh
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 27377
Homologene: 31996
Lamtor1
Name: late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
Synonyms: 2400001E08Rik, p18
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 66508
Homologene: 9909
Fam13c
Name: family with sequence similarity 13, member C
Synonyms: C030038O19Rik, 1200015N20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 71721
Homologene: 11490
Dnajb2
Name: DnaJ heat shock protein family (Hsp40) member B2
Synonyms: 2700059H22Rik, mDj8, Dnajb10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 56812
HGNC: HGNC:5228
Homologene: 4902
Rrbp1
Name: ribosome binding protein 1
Synonyms: ES/130, mRRp2, mRRp16.8, mRRp5.4, mRRp15a, 5730465C04Rik, mRRp15b, mRRp47, mRRp10, mRRp41, 1700087N07Rik, mRRp1.8, p180, mRRp0
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 81910
Homologene: 68138
Tlr3
Name: toll-like receptor 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 142980
Homologene: 20696
Amigo2
Name: adhesion molecule with Ig like domain 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 105827
VEGA: 15
Homologene: 18649
Hmcn2
Name: hemicentin 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 665700
Homologene: 90772
Col28a1
Name: collagen, type XXVIII, alpha 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 213945
Homologene: 66345
Hivep2
Name: human immunodeficiency virus type I enhancer binding protein 2
Synonyms: MIBP1, Gm20114, Shn-2, Schnurri-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 15273
HGNC: HGNC:4921
Homologene: 4900
Myo3a
Name: myosin IIIA
Synonyms: 9030416P08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 667663
HGNC: HGNC:7601
Homologene: 49486
Vmn1r33
Name: vomeronasal 1 receptor 33
Synonyms: V1rc14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 171187
HGNC: null
Homologene: 110800
Magi2
Name: membrane associated guanylate kinase, WW and PDZ domain containing 2
Synonyms: S-SCAM, Acvrinp1, Magi-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 50791
Homologene: 8189
Ogfrl1
Name: opioid growth factor receptor-like 1
Synonyms: 2210417C17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 70155
Homologene: 11595
Apol7d
Name: apolipoprotein L 7d
Synonyms: ENSMUSG00000073652, Gm15456
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 100042814
HGNC: null
Homologene: null
Col6a3
Name: collagen, type VI, alpha 3
Synonyms: Col6a-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 12835
HGNC: HGNC:2213
Homologene: 37917
Skint5
Name: selection and upkeep of intraepithelial T cells 5
Synonyms: OTTMUSG00000008560
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 242627
HGNC: null
Homologene: 135888
Nlrc5
Name: NLR family, CARD domain containing 5
Synonyms: AI451557
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 434341
Homologene: 88935
Lrrd1
Name: leucine rich repeats and death domain containing 1
Synonyms: 4932412H11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 242838
Homologene: 18247
Itih1
Name: inter-alpha trypsin inhibitor, heavy chain 1
Synonyms: inter-alpha (globulin) inhibitor, H1 polypeptide, Itih-1, Intin1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 16424
HGNC: HGNC:6166
Homologene: 1667
Tmem210
Name: transmembrane protein 210
Synonyms: 4930571C24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 78217
Homologene: 90047
AW551984
Name: expressed sequence AW551984
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 244810
HGNC: null
Homologene: null
Mmrn1
Name: multimerin 1
Synonyms: 4921530G03Rik, Emilin4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 70945
HGNC: HGNC:7178
Homologene: 49134
Adam24
Name: a disintegrin and metallopeptidase domain 24 (testase 1)
Synonyms: Dtgn5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 13526
HGNC: HGNC:203
Homologene: 137232
Cdc20b
Name: cell division cycle 20B
Synonyms: EG622422, EG238896
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 238896
Homologene: 65056
Tubb2a
Name: tubulin, beta 2A class IIA
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 22151
VEGA: 13
Homologene: 134314
Mrc2
Name: mannose receptor, C type 2
Synonyms: Endo180, novel lectin, uPARAP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 17534
Homologene: 4408
Grik2
Name: glutamate receptor, ionotropic, kainate 2 (beta 2)
Synonyms: C130030K03Rik, Glurbeta2, Glur6, Glur-6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 14806
HGNC: HGNC:4580
Homologene: 40717
Gcnt4
Name: glucosaminyl (N-acetyl) transferase 4, core 2 (beta-1,6-N-acetylglucosaminyltransferase)
Synonyms: LOC218476, Gm73, C2GNT3, LOC238786
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 218476
VEGA: 13
Homologene: 41144
Atg10
Name: autophagy related 10
Synonyms: 5330424L23Rik, 5430428K15Rik, Apg10l, APG10, Apg10p
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 66795
VEGA: 13
Homologene: 12036
Gpam
Name: glycerol-3-phosphate acyltransferase, mitochondrial
Synonyms: GPAT1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 14732
Homologene: 7343
Zfp111
Name: zinc finger protein 111
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 56707
Homologene: 128597
4930474N05Rik
Name: RIKEN cDNA 4930474N05 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 218921
HGNC: null
Homologene: 138428
Fcamr
Name: Fc receptor, IgA, IgM, high affinity
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 64435
Homologene: 12929
Slc17a4
Name: solute carrier family 17 (sodium phosphate), member 4
Synonyms: 9130214H05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 319848
Homologene: 21127
9330154J02Rik
Name: RIKEN cDNA 9330154J02 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 442799
HGNC: null
Homologene: null
1700028I16Rik
Name: RIKEN cDNA 1700028I16 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 70003
HGNC: null
Homologene: null
Gm11562
Name: predicted gene 11562
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 100502803
Homologene: 136079
Mid1ip1
Name: Mid1 interacting protein 1 (gastrulation specific G12-like (zebrafish))
Synonyms: Mig12, 3110038L01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
Alteration at locus: Chemically Induced
NCBI: 68041
Homologene: 10936
Glra2
Name: glycine receptor, alpha 2 subunit
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
Alteration at locus: Chemically Induced
NCBI: 237213
HGNC: HGNC:4327
Homologene: 31070
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 23,369,960 bp
  • A to T, chromosome 1 at 71,653,155 bp
  • G to A, chromosome 1 at 75,241,480 bp
  • T to C, chromosome 1 at 90,780,081 bp
  • C to T, chromosome 1 at 130,813,985 bp
  • T to G, chromosome 2 at 22,565,109 bp
  • A to T, chromosome 2 at 23,191,080 bp
  • A to G, chromosome 2 at 25,288,432 bp
  • T to C, chromosome 2 at 31,413,407 bp
  • T to A, chromosome 2 at 129,119,107 bp
  • T to C, chromosome 2 at 143,989,558 bp
  • A to T, chromosome 4 at 113,940,741 bp
  • A to T, chromosome 5 at 3,850,204 bp
  • G to A, chromosome 5 at 20,215,468 bp
  • T to C, chromosome 5 at 73,071,265 bp
  • C to T, chromosome 6 at 8,014,601 bp
  • C to T, chromosome 6 at 51,909,299 bp
  • G to A, chromosome 6 at 60,944,847 bp
  • A to T, chromosome 6 at 66,611,717 bp
  • A to T, chromosome 6 at 83,801,157 bp
  • T to C, chromosome 6 at 119,950,043 bp
  • T to C, chromosome 7 at 24,199,466 bp
  • T to C, chromosome 7 at 101,910,108 bp
  • T to C, chromosome 8 at 40,680,545 bp
  • G to A, chromosome 8 at 45,396,939 bp
  • A to G, chromosome 8 at 94,511,301 bp
  • T to C, chromosome 9 at 39,597,908 bp
  • T to C, chromosome 9 at 85,843,114 bp
  • C to A, chromosome 10 at 14,128,969 bp
  • T to A, chromosome 10 at 49,240,808 bp
  • C to T, chromosome 10 at 70,542,648 bp
  • A to G, chromosome 10 at 82,812,385 bp
  • T to A, chromosome 10 at 111,495,322 bp
  • A to G, chromosome 11 at 99,620,200 bp
  • G to A, chromosome 11 at 105,348,431 bp
  • A to G, chromosome 12 at 99,894,708 bp
  • C to T, chromosome 13 at 23,901,769 bp
  • G to T, chromosome 13 at 34,075,311 bp
  • A to T, chromosome 13 at 90,937,380 bp
  • C to A, chromosome 13 at 92,354,858 bp
  • A to G, chromosome 13 at 96,659,089 bp
  • A to T, chromosome 13 at 96,947,014 bp
  • T to C, chromosome 13 at 113,084,008 bp
  • T to A, chromosome 14 at 30,935,828 bp
  • A to G, chromosome 14 at 34,249,185 bp
  • G to A, chromosome 14 at 36,095,478 bp
  • G to T, chromosome 15 at 16,823,438 bp
  • T to C, chromosome 15 at 97,245,315 bp
  • C to A, chromosome 17 at 70,974,485 bp
  • A to G, chromosome 18 at 10,024,532 bp
  • T to A, chromosome 19 at 30,118,675 bp
  • T to C, chromosome 19 at 55,080,458 bp
  • T to C, chromosome X at 10,718,381 bp
  • C to T, chromosome X at 165,289,616 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3837 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040778-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.