Strain Name:
C57BL/6J-MtgxR3857Btlr/Mmmh
Stock Number:
040785-MU
Citation ID:
RRID:MMRRC_040785-MU
Other Names:
R3857 (G1), C57BL/6J-MtgxR3857Btlr
Major Collection:

Gene Information

Rtn4rl2
Name: reticulon 4 receptor-like 2
Synonyms: Ngr2, Ngrh1, Ngrl3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 269295
Homologene: 18683
Pitpnc1
Name: phosphatidylinositol transfer protein, cytoplasmic 1
Synonyms: C330017I21Rik, 5830436L09Rik, 1110020B03Rik, RDGB-BETA, RDGBB1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 71795
Homologene: 138301
Senp6
Name: SUMO/sentrin specific peptidase 6
Synonyms: E130319N12Rik, 2810017C20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 215351
Homologene: 9196
Zfp101
Name: zinc finger protein 101
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 22643
Homologene: 137226
Gse1
Name: genetic suppressor element 1, coiled-coil protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 382034
Homologene: 40964
Celf1
Name: CUGBP, Elav-like family member 1
Synonyms: CUG-BP, Brunol2, D2Wsu101e, 1600010O03Rik, CUG-BP1, Cugbp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 13046
HGNC: HGNC:2549
Homologene: 134102
Zmym2
Name: zinc finger, MYM-type 2
Synonyms: SCLL, RAMP, MYM, FIM, Zfp198
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 76007
VEGA: 14
Homologene: 12631
Zfp512
Name: zinc finger protein 512
Synonyms: 2500002M11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 269639
Homologene: 13026
Kdm3b
Name: KDM3B lysine (K)-specific demethylase 3B
Synonyms: 5830462I21Rik, JHDM2B, Jmjd1b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 277250
VEGA: 18
HGNC: HGNC:1337
Homologene: 41145
Fzd3
Name: frizzled class receptor 3
Synonyms: Fz3, D930050A07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 14365
HGNC: HGNC:4041
Homologene: 23004
Pigr
Name: polymeric immunoglobulin receptor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 18703
HGNC: HGNC:8968
Homologene: 1984
Hjurp
Name: Holliday junction recognition protein
Synonyms: C330011F01Rik, A730008H23Rik, 6430706D22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 381280
Homologene: 10184
Ccng1
Name: cyclin G1
Synonyms: cyclin G
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 12450
HGNC: HGNC:1592
Homologene: 2995
Dnah8
Name: dynein, axonemal, heavy chain 8
Synonyms: Hst6.7b, P1-Loop, Dnahc8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 13417
VEGA: 17
HGNC: HGNC:2952
Homologene: 1049
Erc2
Name: ELKS/RAB6-interacting/CAST family member 2
Synonyms: D14Ertd171e, ELKS2alpha, CAST
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 238988
Homologene: 69188
Ercc8
Name: excision repaiross-complementing rodent repair deficiency, complementation group 8
Synonyms: Csa, 2410022P04Rik, 4631412O06Rik, 2810431L23Rik, B130065P18Rik, Ckn1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 71991
HGNC: HGNC:3439
Homologene: 62
Mtmr4
Name: myotubularin related protein 4
Synonyms: ESTM44, FYVE-DSP2, FYVE zinc finger phosphatase, ZFYVE11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 170749
HGNC: HGNC:7452
Homologene: 3440
Tctn1
Name: tectonic family member 1
Synonyms: Tect1, G730031O11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 654470
Homologene: 49770
Ttn
Name: titin
Synonyms: connectin, L56, mdm, 1100001C23Rik, 2310036G12Rik, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, D830007G01Rik, shru
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22138
Homologene: 130650
Col5a3
Name: collagen, type V, alpha 3
Synonyms: Pro-alpha3(V)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 53867
Homologene: 9253
Slc4a1
Name: solute carrier family 4 (anion exchanger), member 1
Synonyms: erythrocyte membrane protein band 3, band 3, Empb3, Ae1, CD233, l11Jus51
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 20533
Homologene: 133556
Unc13c
Name: unc-13 homolog C
Synonyms: Munc13-3, Unc13h3, D9Ertd414e, 1500037O19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 208898
Homologene: 45443
Nfatc1
Name: nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1
Synonyms: NFAT2, NFATc, NF-ATc, 2210017P03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 18018
VEGA: 18
HGNC: HGNC:7775
Homologene: 32336
Obscn
Name: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Synonyms: LOC380698, OTTMUSG00000005786
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 380698
Homologene: 70869
F13a1
Name: coagulation factor XIII, A1 subunit
Synonyms: Factor XIIIA, 1200014I03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 74145
VEGA: 13
HGNC: HGNC:3531
Homologene: 20077
Thsd7a
Name: thrombospondin, type I, domain containing 7A
Synonyms: LOC330267
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 330267
Homologene: 46582
Cps1
Name: carbamoyl-phosphate synthetase 1
Synonyms: CPS, CPSase I, 4732433M03Rik, D1Ucla3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 227231
HGNC: HGNC:2323
Homologene: 68208
Gm15217
Name: predicted gene 15217
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 100041724
Spty2d1
Name: SPT2 chromatin protein domain containing 1
Synonyms: 5830435K17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 101685
Homologene: 45499
Spice1
Name: spindle and centriole associated protein 1
Synonyms: D16Ertd480e, Ccdc52
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 212514
Homologene: 16931
Pth2r
Name: parathyroid hormone 2 receptor
Synonyms: Pthr2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 213527
HGNC: HGNC:9609
Homologene: 3701
Vmn1r19
Name: vomeronasal 1 receptor 19
Synonyms: V1rc27
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 171200
Homologene: 134034
Zfyve16
Name: zinc finger, FYVE domain containing 16
Synonyms: B130024H06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218441
Homologene: 8826
Pde11a
Name: phosphodiesterase 11A
Synonyms: A630086N24Rik, 6330414F14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241489
HGNC: HGNC:8773
Homologene: 56763
Bdkrb2
Name: bradykinin receptor, beta 2
Synonyms: B2, B(2), kinin B2, BK2R, B2R
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 12062
VEGA: 12
HGNC: HGNC:1030
Homologene: 519
Togaram1
Name: TOG array regulator of axonemal microtubules 1
Synonyms: A430041B07Rik, Fam179b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 328108
VEGA: 12
Homologene: 15025
Psph
Name: phosphoserine phosphatase
Synonyms: PSPase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 100678
HGNC: HGNC:9577
Homologene: 31245
Irx1
Name: Iroquois homeobox 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 16371
Homologene: 19065
Pcna
Name: proliferating cell nuclear antigen
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 18538
HGNC: HGNC:8729
Homologene: 1945
Ezhip
Name: EZH inhibitory protein
Synonyms: AU022751
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 102991
Hs3st1
Name: heparan sulfate (glucosamine) 3-O-sulfotransferase 1
Synonyms: 3-OST, D5Wsu110e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 15476
HGNC: HGNC:5194
Homologene: 3751
Eif1ad17
Name: eukaryotic translation initiation factor 1A domain containing 17
Synonyms: Gm2075
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 100039162
VEGA: 12
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 65,322,047 bp
  • A to G, chromosome 1 at 67,168,278 bp
  • GT to GTT, chromosome 1 at 88,266,524 bp
  • T to C, chromosome 1 at 130,847,261 bp
  • G to A, chromosome 2 at 76,046,765 bp
  • T to A, chromosome 2 at 76,908,975 bp
  • A to G, chromosome 2 at 84,880,386 bp
  • A to G, chromosome 2 at 91,012,741 bp
  • A to T, chromosome 2 at 132,249,621 bp
  • G to T, chromosome 5 at 31,472,840 bp
  • G to A, chromosome 5 at 39,614,913 bp
  • A to G, chromosome 5 at 122,241,844 bp
  • A to G, chromosome 5 at 129,771,476 bp
  • C to T, chromosome 6 at 12,555,226 bp
  • A to T, chromosome 6 at 57,405,113 bp
  • G to A, chromosome 7 at 46,998,296 bp
  • T to A, chromosome 8 at 120,571,133 bp
  • A to G, chromosome 9 at 20,793,630 bp
  • G to T, chromosome 9 at 73,699,108 bp
  • A to G, chromosome 9 at 80,092,321 bp
  • A to G, chromosome 11 at 40,753,833 bp
  • A to G, chromosome 11 at 59,080,969 bp
  • G to A, chromosome 11 at 87,597,262 bp
  • A to T, chromosome 11 at 102,357,121 bp
  • T to C, chromosome 11 at 107,320,805 bp
  • A to G, chromosome 12 at 64,980,859 bp
  • T to A, chromosome 12 at 88,012,246 bp
  • T to C, chromosome 12 at 105,592,439 bp
  • A to G, chromosome 13 at 37,025,694 bp
  • A to T, chromosome 13 at 71,963,458 bp
  • A to T, chromosome 13 at 92,494,971 bp
  • A to G, chromosome 13 at 108,194,114 bp
  • A to G, chromosome 14 at 28,475,642 bp
  • T to A, chromosome 14 at 46,379,523 bp
  • A to G, chromosome 14 at 56,944,250 bp
  • A to T, chromosome 14 at 65,239,839 bp
  • T to C, chromosome 16 at 44,355,443 bp
  • A to G, chromosome 17 at 30,663,422 bp
  • G to T, chromosome 17 at 33,382,431 bp
  • T to A, chromosome 18 at 34,833,387 bp
  • T to C, chromosome 18 at 80,665,275 bp
  • A to G, chromosome X at 6,082,656 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3857 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040785-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.