Strain Name:
C57BL/6J-MtgxR3873Btlr/Mmmh
Stock Number:
040791-MU
Citation ID:
RRID:MMRRC_040791-MU
Other Names:
R3873 (G1), C57BL/6J-MtgxR3873Btlr
Major Collection:

Strain Information

Gli1
Name: GLI-Kruppel family member GLI1
Synonyms: Zfp-5, Zfp5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 14632
VEGA: 10
HGNC: HGNC:4317
Homologene: 3859
Dst
Name: dystonin
Synonyms: bullous pemphigoid antigen 1, BPAG1-n, BPAG1, Bpag1, Bpag, ah, bullous pemphigoid antigen 1, athetoid, Macf2, 2310001O04Rik, nmf203, A830042E19Rik, nmf339
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 13518
HGNC: HGNC:1090
Homologene: 136716
Vipr2
Name: vasoactive intestinal peptide receptor 2
Synonyms: VIP receptor subtype 2, VPAC2, Vip2, VPAC2R
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 22355
Homologene: 2540
Morc3
Name: microrchidia 3
Synonyms: 1110051N18Rik, D16Jhu32e, 1110051N18Rik, Zcwcc3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 338467
Homologene: 32257
Dlgap4
Name: DLG associated protein 4
Synonyms: WBP16, SAP90/PSD-95-associated protein 4, PSD-95/SAP90 binding protein 4, DAP4, Sapap4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228836
Homologene: 8935
Baz2a
Name: bromodomain adjacent to zinc finger domain, 2A
Synonyms: Tip5, Walp3, C030005G16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 116848
VEGA: 10
HGNC: HGNC:962
Homologene: 8393
Smg1
Name: SMG1 nonsense mediated mRNA decay associated PI3K related kinase
Synonyms: C130002K18Rik, 5430435M13Rik, 2610207I05Rik, SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233789
Homologene: 56697
Yars
Name: tyrosyl-tRNA synthetase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 107271
Homologene: 2730
Usp34
Name: ubiquitin specific peptidase 34
Synonyms: A530081C03Rik, Murr2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 17847
Homologene: 40978
Il7
Name: interleukin 7
Synonyms: Il-7, hlb368, A630026I06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 16196
HGNC: HGNC:6023
Homologene: 680
Acaca
Name: acetyl-Coenzyme A carboxylase alpha
Synonyms: acetyl-CoA carboxylase, Acc1, LOC327983, Acac, A530025K05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 107476
HGNC: HGNC:84
Homologene: 31015
Ubr4
Name: ubiquitin protein ligase E3 component n-recognin 4
Synonyms: A930005E13Rik, LOC381562, D930005K06Rik, 1810009A16Rik, Zubr1, p600
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 69116
Homologene: 10804
Hspg2
Name: perlecan (heparan sulfate proteoglycan 2)
Synonyms: per, Pcn, Plc, perlecan
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 15530
HGNC: HGNC:5273
Homologene: 68473
Itpa
Name: inosine triphosphatase (nucleoside triphosphate pyrophosphatase)
Synonyms: Itp, 2010016I08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 16434
HGNC: HGNC:6176
Homologene: 6289
Pgam5
Name: phosphoglycerate mutase family member 5
Synonyms: 2610528A17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 72542
Homologene: 14597
Nup54
Name: nucleoporin 54
Synonyms: 3110079L04Rik, 54kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 269113
Homologene: 41169
Tmem51
Name: transmembrane protein 51
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 214359
Homologene: 9966
Pomt2
Name: protein-O-mannosyltransferase 2
Synonyms: A830009D15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217734
VEGA: 12
Homologene: 5297
Cep295
Name: centrosomal protein 295
Synonyms: LOC382128, 5830418K08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 319675
Homologene: 27936
Agtpbp1
Name: ATP/GTP binding protein 1
Synonyms: Nna1, 2900054O13Rik, 4930445M19Rik, 5730402G09Rik, 1700020N17Rik, 2310001G17Rik, Ccp1, atms
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 67269
Homologene: 9067
Phf5a
Name: PHD finger protein 5A
Synonyms: 1110007B08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 68479
Homologene: 7151
Itgae
Name: integrin alpha E, epithelial-associated
Synonyms: CD103, alpha-E1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 16407
HGNC: HGNC:6147
Homologene: 113560
Cfap299
Name: cilia and flagella associated protein 299
Synonyms: 1700007G11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 75784
Homologene: 51893
Dnah2
Name: dynein, axonemal, heavy chain 2
Synonyms: D330014H01Rik, 2900022L05Rik, Dnhd3, Dnahc2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 327954
HGNC: HGNC:2948
Homologene: 72110
Scyl3
Name: SCY1-like 3 (S. cerevisiae)
Synonyms: Pace1, 1200016D23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 240880
Homologene: 10706
Taar1
Name: trace amine-associated receptor 1
Synonyms: Tar1, Trar1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 111174
VEGA: 10
Homologene: 24938
Or4f6
Name: olfactory receptor family 4 subfamily F member 6
Synonyms: GA_x6K02T2Q125-73056609-73055671, MOR245-3, Olfr1310
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258441
Homologene: 74053
Ankrd61
Name: ankyrin repeat domain 61
Synonyms: 4921520G13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 66729
Homologene: 87028
Arvcf
Name: armadillo repeat gene deleted in velocardiofacial syndrome
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 11877
HGNC: HGNC:728
Homologene: 31046
Fscb
Name: fibrous sheath CABYR binding protein
Synonyms: EG623046
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 623046
VEGA: 12
Homologene: 136275
Or5m10b
Name: olfactory receptor family 5 subfamily M member 10B
Synonyms: GA_x6K02T2Q125-47347069-47348016, MOR196-1, Olfr1022
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258582
Homologene: 128086
Zfp53
Name: zinc finger protein 53
Synonyms: zfas8, KRAZ1, Zfp-53, Zfp118, D030067O06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 24132
VEGA: 17
Homologene: 135946
Adam5
Name: a disintegrin and metallopeptidase domain 5
Synonyms: tMDCII
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 11499
HGNC: HGNC:212
Homologene: 49138
Sacs
Name: sacsin
Synonyms: E130115J16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 50720
Abca5
Name: ATP-binding cassette, sub-family A (ABC1), member 5
Synonyms: ABC13, B930033A02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217265
HGNC: HGNC:35
Homologene: 10263
Vmn2r9
Name: vomeronasal 2, receptor 9
Synonyms: EG435864
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 435864
Homologene: 129606
Krt26
Name: keratin 26
Synonyms: 4732407F15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 320864
Homologene: 37118
Akt1
Name: thymoma viral proto-oncogene 1
Synonyms: PKB/Akt, PKBalpha, Akt, PKB
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 11651
HGNC: HGNC:391
Homologene: 3785
Vmn2r22
Name: vomeronasal 2, receptor 22
Synonyms: EG546913
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 546913
Homologene: 84037
Vmn2r16
Name: vomeronasal 2, receptor 16
Synonyms: EG384220
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 384220
Homologene: 104825
Or5l13
Name: olfactory receptor family 5 subfamily L member 13
Synonyms: GA_x6K02T2Q125-49433499-49432537, MOR174-3, Olfr1156
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258814
Homologene: 72031
Nek2
Name: NIMA (never in mitosis gene a)-related expressed kinase 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 18005
HGNC: HGNC:7745
Homologene: 74441
Cyp2c29
Name: cytochrome P450, family 2, subfamily c, polypeptide 29
Synonyms: AHOH, AHOHase, P450-2C, Ahh-1, Ah-2, Cyp2c
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 13095
Homologene: 117948
Arl8a
Name: ADP-ribosylation factor-like 8A
Synonyms: 1110033P22Rik, Arl10b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 68724
Homologene: 23600
Ncald
Name: neurocalcin delta
Synonyms: D030020D09Rik, D15Ertd412e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 52589
HGNC: HGNC:7655
Homologene: 49978
Prl7d1
Name: prolactin family 7, subfamily d, member 1
Synonyms: PRP, PLF-RP, Plfr
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 18814
HGNC: HGNC:9445
Homologene: 7894
Sgsh
Name: N-sulfoglucosamine sulfohydrolase (sulfamidase)
Synonyms: sulphamidase, 4632406A19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 27029
Homologene: 167
Cdc14a
Name: CDC14 cell division cycle 14A
Synonyms: CDC14A2, CDC14a1, Cdc14, A830059A17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229776
HGNC: HGNC:1718
Homologene: 75343
Ly6g6e
Name: lymphocyte antigen 6 complex, locus G6E
Synonyms: 2310011I02Rik, G6e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 70274
Homologene: 41553
Igfals
Name: insulin-like growth factor binding protein, acid labile subunit
Synonyms: ALS, Albs
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 16005
VEGA: 17
HGNC: HGNC:5468
Homologene: 37987
Or12d12
Name: olfactory receptor family 12 subfamily D member 12
Synonyms: MOR250-2, GA_x6K02T2PSCP-1761617-1760691, Olfr101
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 258831
Homologene: 133728
Mrpl32
Name: mitochondrial ribosomal protein L32
Synonyms: 0610033O15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 75398
VEGA: 13
Homologene: 32711
Serpinb9g
Name: serine (or cysteine) peptidase inhibitor, clade B, member 9g
Synonyms: 1600002F03Rik, NK21B, ovalbumin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 93806
HGNC: HGNC:8955
Homologene: 69093
CT030687.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 34,289,620 bp
  • T to C, chromosome 1 at 135,152,872 bp
  • A to G, chromosome 1 at 163,950,637 bp
  • T to C, chromosome 1 at 191,827,208 bp
  • T to A, chromosome 2 at 85,868,962 bp
  • T to A, chromosome 2 at 87,949,530 bp
  • T to C, chromosome 2 at 112,008,323 bp
  • T to G, chromosome 2 at 130,681,010 bp
  • T to C, chromosome 2 at 156,749,347 bp
  • A to T, chromosome 3 at 7,604,164 bp
  • C to A, chromosome 3 at 116,366,618 bp
  • A to C, chromosome 4 at 129,210,593 bp
  • T to C, chromosome 4 at 137,539,349 bp
  • T to C, chromosome 4 at 139,423,990 bp
  • T to C, chromosome 4 at 142,031,748 bp
  • A to G, chromosome 5 at 92,431,027 bp
  • A to T, chromosome 5 at 98,737,623 bp
  • C to A, chromosome 5 at 108,847,835 bp
  • T to C, chromosome 5 at 109,340,311 bp
  • T to C, chromosome 5 at 110,265,599 bp
  • T to A, chromosome 5 at 143,891,828 bp
  • T to C, chromosome 6 at 123,637,380 bp
  • T to C, chromosome 7 at 118,154,662 bp
  • T to C, chromosome 8 at 24,815,109 bp
  • A to T, chromosome 9 at 15,333,365 bp
  • T to C, chromosome 10 at 23,920,584 bp
  • T to A, chromosome 10 at 127,331,356 bp
  • T to A, chromosome 10 at 128,124,110 bp
  • C to T, chromosome 11 at 23,489,033 bp
  • A to G, chromosome 11 at 69,429,348 bp
  • T to A, chromosome 11 at 73,113,616 bp
  • A to G, chromosome 11 at 84,312,721 bp
  • T to C, chromosome 11 at 99,334,744 bp
  • T to A, chromosome 11 at 110,310,233 bp
  • A to G, chromosome 11 at 119,350,947 bp
  • G to T, chromosome 12 at 64,473,132 bp
  • C to T, chromosome 12 at 87,111,962 bp
  • T to C, chromosome 12 at 88,249,706 bp
  • T to C, chromosome 12 at 112,656,533 bp
  • T to C, chromosome 12 at 116,136,104 bp
  • G to T, chromosome 13 at 14,613,045 bp
  • A to G, chromosome 13 at 27,716,668 bp
  • A to T, chromosome 13 at 33,486,535 bp
  • T to C, chromosome 13 at 59,460,596 bp
  • A to G, chromosome 14 at 61,192,286 bp
  • G to A, chromosome 15 at 37,397,253 bp
  • T to C, chromosome 15 at 81,870,427 bp
  • G to A, chromosome 16 at 18,403,033 bp
  • G to A, chromosome 16 at 93,862,436 bp
  • C to T, chromosome 17 at 21,508,631 bp
  • G to A, chromosome 17 at 24,881,605 bp
  • T to C, chromosome 17 at 35,077,183 bp
  • T to A, chromosome 17 at 37,299,979 bp
  • A to G, chromosome 19 at 39,329,144 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3873 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040791-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.