Strain Name:
C57BL/6J-MtgxR3880Btlr/Mmmh
Stock Number:
040794-MU
Citation ID:
RRID:MMRRC_040794-MU
Other Names:
R3880 (G1), C57BL/6J-MtgxR3880Btlr
Major Collection:

Gene Information

Slc6a2
Name: solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2
Synonyms: Slc6a5, NE transporter, NET, norepinephrine transporter
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 20538
Homologene: 816
Dtx4
Name: deltex 4, E3 ubiquitin ligase
Synonyms: RNF155
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 207521
VEGA: 19
Homologene: 27781
Enox1
Name: ecto-NOX disulfide-thiol exchanger 1
Synonyms: D230005D02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 239188
VEGA: 14
Homologene: 56793
Trip13
Name: thyroid hormone receptor interactor 13
Synonyms: 2410002G23Rik, D13Ertd328e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 69716
Homologene: 3125
Srsf3
Name: serine and arginine-rich splicing factor 3
Synonyms: X16, Sfrs3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 20383
Homologene: 55708
Wdr7
Name: WD repeat domain 7
Synonyms: TGF-beta resistance associated gene, TRAG
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 104082
VEGA: 18
Homologene: 11408
Atp1b1
Name: ATPase, Na+/K+ transporting, beta 1 polypeptide
Synonyms: sodium/potassium ATPase beta subunit, Atpb-1, Atpb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 11931
HGNC: HGNC:804
Homologene: 37509
Bcas3
Name: breast carcinoma amplified sequence 3
Synonyms: K20D4, 1500019F07Rik, 2610028P08Rik, rudhira
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 192197
Homologene: 9778
Secisbp2l
Name: SECIS binding protein 2-like
Synonyms: 3110001I20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 70354
Homologene: 18923
Ubfd1
Name: ubiquitin family domain containing 1
Synonyms: D7Wsu105e, D7Wsu128e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 28018
Homologene: 10430
Psmd9
Name: proteasome (prosome, macropain) 26S subunit, non-ATPase, 9
Synonyms: P27, 1500011J20Rik, Bridge-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 67151
HGNC: HGNC:9567
Homologene: 2106
Fubp1
Name: far upstream element (FUSE) binding protein 1
Synonyms: FBP, Fubp, Fubp4, 9530027K12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 51886
HGNC: HGNC:4004
Homologene: 48253
Lipc
Name: lipase, hepatic
Synonyms: HL, Hpl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 15450
VEGA: 9
HGNC: HGNC:6619
Homologene: 199
Syngap1
Name: synaptic Ras GTPase activating protein 1 homolog (rat)
Synonyms: Syngap
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 240057
Homologene: 84739
Ccdc43
Name: coiled-coil domain containing 43
Synonyms: 2610001E01Rik, D11Ertd707e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 52715
Homologene: 12074
Uggt1
Name: UDP-glucose glycoprotein glucosyltransferase 1
Synonyms: A930007H10Rik, C820010P03Rik, 0910001L17Rik, Ugcgl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 320011
Homologene: 10586
Zfp345
Name: zinc finger protein 345
Synonyms: OTTMUSG00000015743
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 545471
Homologene: 134546
Khdc3
Name: KH domain containing 3, subcortical maternal complex member
Synonyms: ecat1, FILIA, 2410004A20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 66991
Homologene: 49842
Adgrv1
Name: adhesion G protein-coupled receptor V1
Synonyms: VLGR1, Mass1, Mgr1, Gpr98
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 110789
Homologene: 19815
Otog
Name: otogelin
Synonyms: Otgn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 18419
HGNC: HGNC:8516
Homologene: 8421
Myo7b
Name: myosin VIIB
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 17922
HGNC: HGNC:7607
Homologene: 81947
Trim30a
Name: tripartite motif-containing 30A
Synonyms: Rpt-1, Rpt1, Trim30
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 20128
Homologene: 114426
Abcc9
Name: ATP-binding cassette, sub-family C (CFTR/MRP), member 9
Synonyms: SUR2B, SUR2A, Sur2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 20928
HGNC: HGNC:60
Homologene: 56521
Otogl
Name: otogelin-like
Synonyms: Gm6924
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 628870
Homologene: 46008
Sspo
Name: SCO-spondin
Synonyms: C79529, Scospondin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 243369
Homologene: 45453
Abcg3
Name: ATP binding cassette subfamily G member 3
Synonyms: Mxr2, Abcp2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 27405
Homologene: 86845
Snx19
Name: sorting nexin 19
Synonyms: 3526401K03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 102607
VEGA: 9
Homologene: 8846
Grm8
Name: glutamate receptor, metabotropic 8
Synonyms: mGluR8, Gprc1h
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 14823
HGNC: HGNC:4600
Homologene: 654
Osgin1
Name: oxidative stress induced growth inhibitor 1
Synonyms: 1700012B18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 71839
Homologene: 16325
Armc2
Name: armadillo repeat containing 2
Synonyms: 2610018I05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 213402
Homologene: 41848
Itgav
Name: integrin alpha V
Synonyms: vitronectin receptor alpha polypeptide (VNRA), CD51, alphav-integrin, 1110004F14Rik, 2610028E01Rik, D430040G12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 16410
HGNC: HGNC:6150
Homologene: 20510
Thsd7b
Name: thrombospondin, type I, domain containing 7B
Synonyms: 1700074E13Rik, D130067I03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 210417
Homologene: 18180
Mael
Name: maelstrom spermatogenic transposon silencer
Synonyms: 4933405K18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 98558
Homologene: 13143
Tradd
Name: TNFRSF1A-associated via death domain
Synonyms: 9130005N23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 71609
Homologene: 2807
Telo2
Name: telomere maintenance 2
Synonyms: 1200003M09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 71718
Homologene: 41107
Evx1
Name: even-skipped homeobox 1
Synonyms: Evx-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 14028
HGNC: HGNC:3506
Homologene: 1507
Olfr622
Name: olfactory receptor 622
Synonyms: GA_x6K02T2PBJ9-6362863-6361910, MOR26-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 259087
Homologene: 100540
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 36,176,804 bp
  • G to A, chromosome 1 at 129,595,370 bp
  • C to T, chromosome 1 at 164,443,305 bp
  • T to C, chromosome 1 at 166,236,868 bp
  • T to C, chromosome 2 at 83,768,301 bp
  • C to T, chromosome 2 at 125,740,737 bp
  • T to C, chromosome 2 at 150,472,155 bp
  • T to A, chromosome 3 at 152,220,496 bp
  • T to C, chromosome 5 at 104,938,180 bp
  • C to T, chromosome 5 at 123,234,590 bp
  • A to T, chromosome 6 at 27,761,374 bp
  • G to A, chromosome 6 at 48,494,940 bp
  • A to T, chromosome 6 at 52,313,861 bp
  • A to G, chromosome 6 at 142,639,233 bp
  • C to T, chromosome 7 at 46,288,021 bp
  • T to G, chromosome 7 at 103,639,624 bp
  • C to A, chromosome 7 at 104,411,189 bp
  • T to A, chromosome 7 at 122,068,776 bp
  • C to A, chromosome 8 at 92,990,218 bp
  • A to T, chromosome 8 at 105,260,655 bp
  • A to G, chromosome 8 at 119,441,452 bp
  • A to T, chromosome 9 at 30,462,392 bp
  • T to A, chromosome 9 at 70,820,518 bp
  • T to C, chromosome 9 at 73,103,590 bp
  • T to C, chromosome 10 at 41,963,725 bp
  • T to C, chromosome 10 at 107,827,704 bp
  • A to G, chromosome 11 at 85,371,122 bp
  • T to C, chromosome 11 at 102,692,203 bp
  • T to C, chromosome 13 at 73,918,478 bp
  • T to A, chromosome 13 at 81,435,705 bp
  • A to T, chromosome 14 at 77,611,386 bp
  • A to T, chromosome 17 at 25,106,833 bp
  • T to A, chromosome 17 at 26,953,064 bp
  • T to C, chromosome 17 at 29,036,283 bp
  • T to G, chromosome 18 at 31,969,514 bp
  • T to A, chromosome 18 at 63,724,155 bp
  • A to C, chromosome 19 at 12,486,456 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3880 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040794-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.