Strain Name:
C57BL/6J-MtgxR3895Btlr/Mmmh
Stock Number:
040806-MU
Citation ID:
RRID:MMRRC_040806-MU
Other Names:
R3895 (G1), C57BL/6J-MtgxR3895Btlr
Major Collection:

Gene Information

Sbf2
Name: SET binding factor 2
Synonyms: SBF2, 4833411B01Rik, mMTMH1, B430219L04Rik, Mtmr13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 319934
HGNC: HGNC:2135
Homologene: 41810
Pcdh9
Name: protocadherin 9
Synonyms: C630029H24Rik, 1500001L12Rik, LOC382930, A730003J17Rik, C530050I23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 211712
HGNC: HGNC:8661
Homologene: 10698
Ccnd1
Name: cyclin D1
Synonyms: Cyl-1, bcl-1, PRAD1, cD1, CycD1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 12443
HGNC: HGNC:1582
Homologene: 1334
Ptpn14
Name: protein tyrosine phosphatase, non-receptor type 14
Synonyms: PTP36, C130080N23Rik, OTTMUSG00000022087
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 19250
HGNC: HGNC:9647
Homologene: 3941
Ints6
Name: integrator complex subunit 6
Synonyms: Notch2l, 2900075H24Rik, DICE1, Ddx26
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 18130
VEGA: 14
Homologene: 8121
Morf4l1
Name: mortality factor 4 like 1
Synonyms: TEG-189, MRG15, MORFRG15, Tex189
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 21761
Homologene: 86043
Med13l
Name: mediator complex subunit 13-like
Synonyms: 2210413I17Rik, 6330591G05Rik, Trap240L, 9030618F05Rik, Thrap2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 76199
Homologene: 25256
Sart3
Name: squamous cell carcinoma antigen recognized by T cells 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 53890
Homologene: 40977
Nusap1
Name: nucleolar and spindle associated protein 1
Synonyms: 2610201A12Rik, NuSAP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 108907
Homologene: 10207
Fntb
Name: farnesyltransferase, CAAX box, beta
Synonyms: 2010013E13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 110606
HGNC: HGNC:3785
Homologene: 1535
Rho
Name: rhodopsin
Synonyms: Red Opsin, L opsin, LWS opsin, Long Wavelength Sensitive opsin, Rod Opsin, opsin 2, RP4, Opn2, Ops, Noerg1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 212541
Homologene: 68068
Myt1
Name: myelin transcription factor 1
Synonyms: NZF-2b, NZF-2a, Nzf2, Nztf2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 17932
HGNC: HGNC:7622
Homologene: 3332
C6
Name: complement component 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 12274
HGNC: HGNC:1339
Homologene: 47
Rps3
Name: ribosomal protein S3
Synonyms: D7Ertd795e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 27050
Homologene: 779
Mkln1
Name: muskelin 1, intracellular mediator containing kelch motifs
Synonyms: A130067F06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 27418
HGNC: HGNC:7109
Homologene: 8305
Nol11
Name: nucleolar protein 11
Synonyms: 1500002M01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 68979
Homologene: 32264
Hectd3
Name: HECT domain E3 ubiquitin protein ligase 3
Synonyms: 1700064K09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 76608
Homologene: 18426
Dock8
Name: dedicator of cytokinesis 8
Synonyms: 1200017A24Rik, 5830472H07Rik, A130095G14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 76088
VEGA: 19
Homologene: 52414
Tsc2
Name: TSC complex subunit 2
Synonyms: tuberin, Nafld, tuberous sclerosis 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 22084
VEGA: 17
Homologene: 462
Mslnl
Name: mesothelin-like
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 328783
VEGA: 17
Homologene: 18633
AC159748.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Mgam
Name: maltase-glucoamylase
Synonyms: 6030407P20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232714
HGNC: HGNC:7043
Homologene: 130099
Fsip2
Name: fibrous sheath-interacting protein 2
Synonyms: OTTMUSG00000013335
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241516
Homologene: 110349
Unc13c
Name: unc-13 homolog C
Synonyms: Munc13-3, Unc13h3, D9Ertd414e, 1500037O19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 208898
Homologene: 45443
Lrp4
Name: low density lipoprotein receptor-related protein 4
Synonyms: 6430526J12Rik, Megf7, mdig
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228357
HGNC: HGNC:6696
Homologene: 17964
Prg4
Name: proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein)
Synonyms: MSF, DOL54, lubricin, SZP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 96875
HGNC: HGNC:9364
Homologene: 137352
Ighg2c
Name: immunoglobulin heavy constant gamma 2C
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 404711
Slc22a5
Name: solute carrier family 22 (organic cation transporter), member 5
Synonyms: Octn2, Lstpl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 20520
Homologene: 68295
Plekhh1
Name: pleckstrin homology domain containing, family H (with MyTH4 domain) member 1
Synonyms: D630024D12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 211945
VEGA: 12
Homologene: 121939
Rufy4
Name: RUN and FYVE domain containing 4
Synonyms: F930048N03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 435626
Homologene: 52359
Manea
Name: mannosidase, endo-alpha
Synonyms: 4932703L02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242362
Homologene: 11636
CK137956
Name: cDNA sequence CK137956
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 635169
Homologene: 57187
Twnk
Name: twinkle mtDNA helicase
Synonyms: twinkle, Twinl, D19Ertd626e, Peo1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 226153
VEGA: 19
HGNC: HGNC:1160
Homologene: 11052
AC149051.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Lrrc49
Name: leucine rich repeat containing 49
Synonyms: D430025H09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 102747
Homologene: 9782
Fbxo8
Name: F-box protein 8
Synonyms: Fbx8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 50753
Homologene: 8137
Mast1
Name: microtubule associated serine/threonine kinase 1
Synonyms: 9430008B02Rik, SAST170, SAST
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 56527
Homologene: 10543
Ovgp1
Name: oviductal glycoprotein 1
Synonyms: MOGP, muc9, mucin 9, oviductin, Chit5, OGP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 12659
HGNC: HGNC:8524
Homologene: 74442
Gvin-ps6
Name: GTPase, very large interferon inducible, pseudogene 6
Synonyms: Gm4759
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 209380
Vps16
Name: VSP16 CORVET/HOPS core subunit
Synonyms: 1810074M16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 80743
Homologene: 7116
Acoxl
Name: acyl-Coenzyme A oxidase-like
Synonyms: 1200014P05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 74121
Homologene: 75083
Sall2
Name: spalt like transcription factor 2
Synonyms: Msal-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 50524
Homologene: 9269
Trafd1
Name: TRAF type zinc finger domain containing 1
Synonyms: 1110008K06Rik, Fln29
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231712
Homologene: 31399
Med24
Name: mediator complex subunit 24
Synonyms: Trap100, D11Ertd307e, R75526, 100kDa, DRIP100, Gse2, Pparb2, Thrap4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 23989
Homologene: 40795
Hoxd11
Name: homeobox D11
Synonyms: Hox-5.4, Hox-4.6, E230017H14Rik, Hox-5.5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 15431
HGNC: HGNC:5134
Homologene: 7368
Gm12258
Name: predicted gene 12258
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 108167848
Csta1
Name: cystatin A1
Synonyms: Csta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 209294
HGNC: HGNC:2481
Homologene: 3819
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 74,147,663 bp
  • G to C, chromosome 1 at 150,454,759 bp
  • C to T, chromosome 1 at 189,850,546 bp
  • C to T, chromosome 2 at 74,682,792 bp
  • T to C, chromosome 2 at 82,997,949 bp
  • G to A, chromosome 2 at 91,473,949 bp
  • C to A, chromosome 2 at 119,627,691 bp
  • T to C, chromosome 2 at 127,972,525 bp
  • T to C, chromosome 2 at 130,438,676 bp
  • T to A, chromosome 2 at 181,820,070 bp
  • A to G, chromosome 3 at 105,986,596 bp
  • A to G, chromosome 4 at 26,340,402 bp
  • A to G, chromosome 4 at 116,996,089 bp
  • A to T, chromosome 4 at 127,946,648 bp
  • G to A, chromosome 5 at 113,752,427 bp
  • A to G, chromosome 5 at 118,761,323 bp
  • T to C, chromosome 5 at 121,378,741 bp
  • T to A, chromosome 6 at 31,507,667 bp
  • T to A, chromosome 6 at 40,759,120 bp
  • A to G, chromosome 6 at 115,933,902 bp
  • C to T, chromosome 7 at 99,479,896 bp
  • T to A, chromosome 7 at 106,423,414 bp
  • T to C, chromosome 7 at 110,447,091 bp
  • T to C, chromosome 7 at 144,937,894 bp
  • A to T, chromosome 8 at 56,591,521 bp
  • A to T, chromosome 8 at 63,928,733 bp
  • G to A, chromosome 8 at 84,935,723 bp
  • A to G, chromosome 9 at 60,587,898 bp
  • A to T, chromosome 9 at 73,933,523 bp
  • A to T, chromosome 9 at 90,094,448 bp
  • A to G, chromosome 10 at 5,405,456 bp
  • T to C, chromosome 11 at 53,865,825 bp
  • T to G, chromosome 11 at 58,858,549 bp
  • A to G, chromosome 11 at 98,706,388 bp
  • C to A, chromosome 11 at 107,168,347 bp
  • C to A, chromosome 12 at 76,887,888 bp
  • T to C, chromosome 12 at 79,055,232 bp
  • T to C, chromosome 12 at 113,287,658 bp
  • T to C, chromosome 14 at 52,314,047 bp
  • T to C, chromosome 14 at 62,696,611 bp
  • C to T, chromosome 14 at 93,887,538 bp
  • T to C, chromosome 15 at 4,808,470 bp
  • T to C, chromosome 16 at 36,131,032 bp
  • T to C, chromosome 17 at 24,599,812 bp
  • G to A, chromosome 17 at 25,742,934 bp
  • A to G, chromosome 19 at 25,051,501 bp
  • A to G, chromosome 19 at 45,007,451 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3895 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040806-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.