Strain Name:
C57BL/6J-MtgxR3901Btlr/Mmmh
Stock Number:
040810-MU
Citation ID:
RRID:MMRRC_040810-MU
Other Names:
R3901 (G1), C57BL/6J-MtgxR3901Btlr
Major Collection:

Gene Information

Adamts20
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 20
Synonyms: ADAMTS-20, bt
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 223838
Homologene: 11808
Pou2f1
Name: POU domain, class 2, transcription factor 1
Synonyms: Oct-1A, Otf1, Otf-1, Oct1, oct-1, 2810482H01Rik, Oct-1C, Oct-1z, Oct-1B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 18986
HGNC: HGNC:9212
Homologene: 37658
Epha4
Name: Eph receptor A4
Synonyms: Tyro1, rb, 2900005C20Rik, Sek, Sek1, Hek8, Cek8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 13838
HGNC: HGNC:3388
Homologene: 20933
Plk3
Name: polo like kinase 3
Synonyms: Cnk
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 12795
HGNC: HGNC:2154
Homologene: 20865
Kmt2e
Name: lysine (K)-specific methyltransferase 2E
Synonyms: 1810033J14Rik, 9530077A04Rik, D230038D11Rik, Mll5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 69188
Homologene: 18822
Csrnp1
Name: cysteine-serine-rich nuclear protein 1
Synonyms: CSRNP-1, 4931429D10Rik, taip-3, Axud1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 215418
VEGA: 9
Homologene: 13196
Brat1
Name: BRCA1-associated ATM activator 1
Synonyms: Baat1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 231841
Homologene: 16776
Lama5
Name: laminin, alpha 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 16776
HGNC: HGNC:6485
Homologene: 4060
Jph3
Name: junctophilin 3
Synonyms: JP-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 57340
Homologene: 10762
Dlst
Name: dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)
Synonyms: 4930529O08Rik, 4632413C10Rik, 1600017E01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 78920
VEGA: 12
HGNC: HGNC:2911
Homologene: 1456
Kcnj3
Name: potassium inwardly-rectifying channel, subfamily J, member 3
Synonyms: Kir3.1, Kcnf3, GIRK1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 16519
HGNC: HGNC:6264
Homologene: 1687
Clec7a
Name: C-type lectin domain family 7, member a
Synonyms: Clecsf12, beta-glucan receptor, beta-GR, dectin-1, BGR
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 56644
Homologene: 49606
Kirrel
Name: kirre like nephrin family adhesion molecule 1
Synonyms: Neph1, Kirrel1, 6720469N11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 170643
Homologene: 10089
Pgap1
Name: post-GPI attachment to proteins 1
Synonyms: PGAP1, oto, 9030223K07Rik, 5033403E17Rik, D230012E17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 241062
Homologene: 41605
Pdgfra
Name: platelet derived growth factor receptor, alpha polypeptide
Synonyms: Pdgfr-2, CD140a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 18595
HGNC: HGNC:8803
Homologene: 31361
Dock8
Name: dedicator of cytokinesis 8
Synonyms: A130095G14Rik, 1200017A24Rik, 5830472H07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 76088
VEGA: 19
Homologene: 52414
Cpne5
Name: copine V
Synonyms: A830083G22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 240058
HGNC: HGNC:2318
Homologene: 23266
Pla2g4e
Name: phospholipase A2, group IVE
Synonyms: 2310026J01Rik, Pla2epsilon
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 329502
Homologene: 65339
Atmin
Name: ATM interactor
Synonyms: Asciz, gpg6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 234776
Homologene: 35321
F5
Name: coagulation factor V
Synonyms: Cf5, Cf-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 14067
HGNC: HGNC:3542
Homologene: 104
Fbn2
Name: fibrillin 2
Synonyms: Sne, Fib-2, sy
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 14119
VEGA: 18
HGNC: HGNC:3604
Homologene: 1515
Lrp1b
Name: low density lipoprotein-related protein 1B
Synonyms: 9630004P12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 94217
HGNC: HGNC:6693
Homologene: 56810
Stxbp5
Name: syntaxin binding protein 5 (tomosyn)
Synonyms: LGL3, 0710001E20Rik, 4930565N16Rik, tomosyn 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 78808
Homologene: 16402
Cass4
Name: Cas scaffolding protein family member 4
Synonyms: F730031O20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 320664
Homologene: 75128
Zfp595
Name: zinc finger protein 595
Synonyms: A230042K10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 218314
Homologene: 120258
Kcnma1
Name: potassium large conductance calcium-activated channel, subfamily M, alpha member 1
Synonyms: 5730414M22Rik, BKCa, Slo, BK channel alpha subunit, MaxiK, Slo1, mSlo1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 16531
HGNC: HGNC:6284
Homologene: 1693
Pla2g10
Name: phospholipase A2, group X
Synonyms: mGXsPLA2, PLA2GX, GX sPLA2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 26565
HGNC: HGNC:9029
Homologene: 2636
Slc4a10
Name: solute carrier family 4, sodium bicarbonate cotransporter-like, member 10
Synonyms: NCBE
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 94229
Homologene: 23340
Mmp1a
Name: matrix metallopeptidase 1a (interstitial collagenase)
Synonyms: Mcol-A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 83995
VEGA: 9
HGNC: HGNC:7155
Homologene: 20544
Trim7
Name: tripartite motif-containing 7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 94089
Homologene: 14113
Tgfbr3
Name: transforming growth factor, beta receptor III
Synonyms: TBRIII, 1110036H20Rik, betaglycan
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 21814
Homologene: 2436
Fcnb
Name: ficolin B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 14134
Homologene: 1518
Apc2
Name: adenomatosis polyposis coli 2
Synonyms: APCL
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 23805
Homologene: 4299
Casp16
Name: caspase 16, apoptosis-related cysteine peptidase
Synonyms: Gm5146, Casp16-ps, Casp16
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 381070
Homologene: 72522
Dync2li1
Name: dynein cytoplasmic 2 light intermediate chain 1
Synonyms: CGI-60, D2lic, LIC3, 4933404O11Rik, mD2LIC
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 213575
VEGA: 17
Homologene: 9336
Pogk
Name: pogo transposable element with KRAB domain
Synonyms: BASS2, 9130401E23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 71592
Homologene: 32346
Shfl
Name: shiftless antiviral inhibitor of ribosomal frameshifting
Synonyms: A230050P20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 319278
Homologene: 10165
1700001C19Rik
Name: RIKEN cDNA 1700001C19 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 75462
Homologene: 129540
Rptn
Name: repetin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 20129
Homologene: 84780
Olfr867
Name: olfactory receptor 867
Synonyms: GA_x6K02T2PVTD-13795933-13794938, MOR143-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 257898
Homologene: 128152
Gm5444
Name: predicted gene 5444
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 54,493,348 bp
  • A to G, chromosome 1 at 77,380,902 bp
  • A to G, chromosome 1 at 164,176,229 bp
  • G to C, chromosome 1 at 165,894,969 bp
  • C to T, chromosome 1 at 166,403,624 bp
  • T to A, chromosome 2 at 28,079,196 bp
  • A to G, chromosome 2 at 40,822,695 bp
  • A to G, chromosome 2 at 55,437,348 bp
  • T to A, chromosome 2 at 62,228,552 bp
  • T to C, chromosome 2 at 120,168,604 bp
  • C to T, chromosome 2 at 172,432,558 bp
  • C to T, chromosome 2 at 180,182,351 bp
  • C to T, chromosome 3 at 87,089,151 bp
  • A to G, chromosome 3 at 93,398,357 bp
  • T to C, chromosome 4 at 117,133,436 bp
  • A to G, chromosome 5 at 23,501,642 bp
  • T to A, chromosome 5 at 75,192,508 bp
  • A to G, chromosome 5 at 107,214,887 bp
  • A to C, chromosome 5 at 140,717,996 bp
  • A to G, chromosome 6 at 129,468,914 bp
  • A to G, chromosome 8 at 116,956,297 bp
  • G to T, chromosome 8 at 121,753,419 bp
  • A to G, chromosome 9 at 7,475,345 bp
  • C to T, chromosome 9 at 20,054,873 bp
  • T to A, chromosome 9 at 20,871,245 bp
  • C to T, chromosome 9 at 119,972,641 bp
  • A to G, chromosome 10 at 9,769,419 bp
  • G to C, chromosome 10 at 80,315,088 bp
  • A to T, chromosome 11 at 48,837,608 bp
  • A to G, chromosome 12 at 85,132,691 bp
  • T to C, chromosome 13 at 4,834,279 bp
  • T to C, chromosome 13 at 67,317,315 bp
  • A to G, chromosome 14 at 23,505,255 bp
  • T to A, chromosome 15 at 94,328,845 bp
  • T to C, chromosome 16 at 13,730,342 bp
  • A to T, chromosome 17 at 23,552,948 bp
  • G to A, chromosome 17 at 29,159,108 bp
  • AC to A, chromosome 17 at 47,433,423 bp
  • A to G, chromosome 17 at 84,631,642 bp
  • T to A, chromosome 18 at 58,066,011 bp
  • A to G, chromosome 19 at 25,100,905 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3901 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040810-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.