Strain Name:
C57BL/6J-MtgxR3951Btlr/Mmmh
Stock Number:
040828-MU
Citation ID:
RRID:MMRRC_040828-MU
Other Names:
R3951 (G1), C57BL/6J-MtgxR3951Btlr
Major Collection:

Gene Information

Epha4
Name: Eph receptor A4
Synonyms: Sek, Sek1, Tyro1, Hek8, Cek8, 2900005C20Rik, rb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 13838
HGNC: HGNC:3388
Homologene: 20933
Scarb1
Name: scavenger receptor class B, member 1
Synonyms: D5Ertd460e, Srb1, Cd36l1, Cla-1, SRBI, SR-BI, Hlb398, Hdlq1, Chohd1, Chohd1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 20778
HGNC: HGNC:1664
Homologene: 21132
Ltbp3
Name: latent transforming growth factor beta binding protein 3
Synonyms: Ltbp2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 16998
VEGA: 19
HGNC: HGNC:6716
Homologene: 7405
Trpc2
Name: transient receptor potential cation channel, subfamily C, member 2
Synonyms: TRPC2b, TRPC2a, mTrp2, trp2, Trrp2, 3010009O07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 22064
Homologene: 135989
Nsd1
Name: nuclear receptor-binding SET-domain protein 1
Synonyms: KMT3B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 18193
VEGA: 13
Homologene: 32543
Thop1
Name: thimet oligopeptidase 1
Synonyms: EP24.15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 50492
Homologene: 55726
Skap2
Name: src family associated phosphoprotein 2
Synonyms: RA70, Saps, mSKAP55R, 2610021A10Rik, SKAP-HOM
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 54353
Homologene: 2919
Ndnf
Name: neuron-derived neurotrophic factor
Synonyms: epidermacan, A930038C07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 68169
Homologene: 11593
Kif16b
Name: kinesin family member 16B
Synonyms: N-3 kinesin, 8430434E15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 16558
Homologene: 135708
Ticrr
Name: TOPBP1-interacting checkpoint and replication regulator
Synonyms: 5730590G19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 77011
Homologene: 67120
Ect2
Name: ect2 oncogene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 13605
HGNC: HGNC:3155
Homologene: 7298
Ncor2
Name: nuclear receptor co-repressor 2
Synonyms: SMRTe, SMRT
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 20602
HGNC: HGNC:7673
Homologene: 31370
Ttc37
Name: tetratricopeptide repeat domain 37
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218343
VEGA: 13
Homologene: 40966
Uhrf2
Name: ubiquitin-like, containing PHD and RING finger domains 2
Synonyms: 2310065A22Rik, Nirf, D130071B19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 109113
Homologene: 17001
Ncapd2
Name: non-SMC condensin I complex, subunit D2
Synonyms: CNAP1, CAP-D2, 2810406C15Rik, 2810465G24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 68298
Homologene: 6497
Map3k20
Name: mitogen-activated protein kinase kinase kinase 20
Synonyms: MLTKbeta, MLTKalpha, B230120H23Rik, Zak
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 65964
Homologene: 32331
Tubb3
Name: tubulin, beta 3 class III
Synonyms: 3200002H15Rik, betaIII-tubulin, Tuj1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 22152
Homologene: 68503
Sos1
Name: SOS Ras/Rac guanine nucleotide exchange factor 1
Synonyms: 4430401P03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 20662
VEGA: 17
Homologene: 4117
Fkbp8
Name: FK506 binding protein 8
Synonyms: Fkbp38, 38kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 14232
HGNC: HGNC:3724
Homologene: 7720
Ubr4
Name: ubiquitin protein ligase E3 component n-recognin 4
Synonyms: A930005E13Rik, LOC381562, D930005K06Rik, 1810009A16Rik, Zubr1, p600
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 69116
Homologene: 10804
Gda
Name: guanine deaminase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 14544
HGNC: HGNC:4212
Homologene: 3171
Csgalnact1
Name: chondroitin sulfate N-acetylgalactosaminyltransferase 1
Synonyms: CSGalNAcT-1, 4732435N03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234356
Homologene: 23099
Hsd17b11
Name: hydroxysteroid (17-beta) dehydrogenase 11
Synonyms: Pan1b, retSDR2, Dhrs8, 17beta-HSD11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 114664
Homologene: 69209
Dera
Name: deoxyribose-phosphate aldolase (putative)
Synonyms: 2010002D22Rik, 2500002K03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232449
Homologene: 14562
Atp2b2
Name: ATPase, Ca++ transporting, plasma membrane 2
Synonyms: PMCA2, D6Abb2e, wms, jog, Tmy, Gena300
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 11941
HGNC: HGNC:815
Homologene: 56150
Rasgef1b
Name: RasGEF domain family, member 1B
Synonyms: Gpig4, 4732452O09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 320292
Homologene: 14860
Akr1c18
Name: aldo-keto reductase family 1, member C18
Synonyms: 20alpha-HSD, 20alpha-hydroxysteroid dehydrogenase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 105349
HGNC: HGNC:386
Homologene: 128661
Cdh23
Name: cadherin 23 (otocadherin)
Synonyms: 4930542A03Rik, USH1D, mdfw, ahl, bob, nmf112, nmf181, nmf252, sals
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 22295
Homologene: 11142
Fat2
Name: FAT atypical cadherin 2
Synonyms: LOC245827, mKIAA0811, Fath2, EMI2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 245827
HGNC: HGNC:3596
Homologene: 1110
Olfr1413
Name: olfactory receptor 1413
Synonyms: GA_x6K02T2R7CC-81180849-81179878, MOR208-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 259039
Homologene: 128165
Rtn4ip1
Name: reticulon 4 interacting protein 1
Synonyms: NIMP, D10Ertd690e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 170728
Homologene: 13105
Unc80
Name: unc-80, NALCN activator
Synonyms: C230061B10Rik, C030018G13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 329178
Homologene: 122243
Clspn
Name: claspin
Synonyms: E130314M08Rik, C85083
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 269582
Homologene: 11138
Sntg1
Name: syntrophin, gamma 1
Synonyms: G1SYN, SYN4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 71096
Homologene: 56834
Gabrb2
Name: gamma-aminobutyric acid (GABA) A receptor, subunit beta 2
Synonyms: Gabrb-2, C030021G16Rik, C030002O17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 14401
HGNC: HGNC:4082
Homologene: 7327
Myom2
Name: myomesin 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 17930
HGNC: HGNC:7614
Homologene: 2953
1700017N19Rik
Name: RIKEN cDNA 1700017N19 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 66605
Homologene: 45135
Tcaf1
Name: TRPM8 channel-associated factor 1
Synonyms: A230020K05Rik, 2810407D09Rik, 3321401G04Rik, Fam115a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 77574
Homologene: 8815
Abca2
Name: ATP-binding cassette, sub-family A (ABC1), member 2
Synonyms: Abc2, D2H0S1474E
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 11305
HGNC: HGNC:32
Homologene: 55590
Spata7
Name: spermatogenesis associated 7
Synonyms: HSD3, B230306G18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 104871
Homologene: 10189
Olfr1043
Name: olfactory receptor 1043
Synonyms: GA_x6K02T2Q125-47631900-47630956, MOR185-7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258570
Homologene: 88364
Nmur2
Name: neuromedin U receptor 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216749
Homologene: 49618
4932414N04Rik
Name: RIKEN cDNA 4932414N04 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 75721
Homologene: 138468
Klhl29
Name: kelch-like 29
Synonyms: A230106N14Rik, Kbtbd9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 208439
VEGA: 12
Homologene: 66272
Pom121l2
Name: POM121 membrane glycoprotein-like 2 (rat)
Synonyms: LOC195236
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 195236
Homologene: 123536
Lrrc8d
Name: leucine rich repeat containing 8D
Synonyms: 4930525N13Rik, Lrrc5, 2810473G09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231549
Homologene: 10004
Olfr229
Name: olfactory receptor 229
Synonyms: GA_x6K02T02EEW-227-373, GA_x6K02T2PVTD-33608180-33608971, MOR171-14, Olfr973
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258606
VEGA: 9
HGNC: HGNC:8485
Homologene: 115513
Ggcx
Name: gamma-glutamyl carboxylase
Synonyms: vitamin K-dependent carboxylase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 56316
HGNC: HGNC:4247
Homologene: 639
Map3k9
Name: mitogen-activated protein kinase kinase kinase 9
Synonyms: Mlk1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 338372
VEGA: 12
HGNC: HGNC:6861
Homologene: 76377
Gm10283
Name: predicted gene 10283
Synonyms: EG330776
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Ndst1
Name: N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
Synonyms: glucosaminyl N-deacetylase/N-sulfotransferase 1, Hsst, 1200015G06Rik, Ndst-1, b2b2230Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 15531
VEGA: 18
HGNC: HGNC:7680
Homologene: 20386
Lpcat2
Name: lysophosphatidylcholine acyltransferase 2
Synonyms: Aytl1, lysoPAFAT/LPCAT2, LPCAT2, Aytl1a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 270084
Homologene: 41201
Sh2d4b
Name: SH2 domain containing 4B
Synonyms: A430109M18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 328381
Homologene: 19164
Prpmp5
Name: proline-rich protein MP5
Synonyms: MP5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 381832
Olfr1128
Name: olfactory receptor 1128
Synonyms: GA_x6K02T2Q125-49048592-49047657, MOR176-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258346
Vmn2r43
Name: vomeronasal 2, receptor 43
Synonyms: EC2-V2R
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 381838
Homologene: 113703
Gm527
Name: predicted gene 527
Synonyms: LOC217648
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217648
VEGA: 12
Homologene: 19024
Osgep
Name: O-sialoglycoprotein endopeptidase
Synonyms: 1500019L24Rik, PRSMG1, GCPL-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 66246
Homologene: 6395
Hoxb2
Name: homeobox B2
Synonyms: Hox-2.8, Hoxbes2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 103889
HGNC: HGNC:5113
Homologene: 37584
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 8,782,901 bp
  • G to A, chromosome 1 at 66,671,722 bp
  • A to T, chromosome 1 at 77,399,716 bp
  • T to A, chromosome 1 at 92,573,789 bp
  • A to G, chromosome 2 at 25,442,637 bp
  • T to C, chromosome 2 at 68,664,403 bp
  • T to G, chromosome 2 at 72,438,300 bp
  • G to T, chromosome 2 at 86,162,618 bp
  • T to C, chromosome 2 at 87,545,065 bp
  • C to T, chromosome 2 at 142,707,359 bp
  • A to T, chromosome 3 at 27,130,120 bp
  • A to G, chromosome 4 at 126,576,379 bp
  • G to A, chromosome 4 at 139,393,094 bp
  • A to T, chromosome 5 at 99,223,050 bp
  • G to A, chromosome 5 at 103,992,937 bp
  • G to T, chromosome 5 at 105,814,276 bp
  • G to T, chromosome 5 at 125,032,256 bp
  • A to C, chromosome 5 at 125,287,411 bp
  • T to C, chromosome 6 at 42,679,059 bp
  • T to C, chromosome 6 at 51,859,984 bp
  • T to C, chromosome 6 at 65,703,141 bp
  • G to A, chromosome 6 at 72,426,558 bp
  • T to A, chromosome 6 at 113,760,831 bp
  • T to C, chromosome 6 at 125,186,784 bp
  • G to A, chromosome 6 at 132,312,694 bp
  • A to G, chromosome 6 at 137,837,120 bp
  • T to A, chromosome 7 at 8,255,320 bp
  • T to C, chromosome 7 at 79,682,069 bp
  • T to A, chromosome 7 at 102,093,574 bp
  • A to T, chromosome 8 at 15,084,556 bp
  • C to T, chromosome 8 at 60,501,364 bp
  • T to C, chromosome 8 at 68,461,262 bp
  • T to A, chromosome 8 at 70,532,661 bp
  • G to T, chromosome 8 at 92,864,903 bp
  • C to A, chromosome 8 at 123,421,264 bp
  • A to T, chromosome 9 at 39,910,725 bp
  • T to A, chromosome 10 at 43,909,897 bp
  • T to C, chromosome 10 at 60,657,326 bp
  • C to T, chromosome 10 at 81,080,629 bp
  • T to C, chromosome 10 at 100,615,296 bp
  • A to G, chromosome 11 at 42,626,881 bp
  • T to C, chromosome 11 at 55,296,382 bp
  • G to C, chromosome 11 at 56,040,225 bp
  • A to G, chromosome 11 at 96,353,175 bp
  • T to A, chromosome 12 at 5,140,660 bp
  • T to G, chromosome 12 at 64,923,502 bp
  • T to C, chromosome 12 at 81,722,521 bp
  • T to A, chromosome 12 at 98,669,473 bp
  • C to T, chromosome 13 at 4,135,285 bp
  • T to G, chromosome 13 at 21,982,128 bp
  • G to C, chromosome 13 at 55,268,454 bp
  • T to G, chromosome 13 at 76,130,219 bp
  • A to G, chromosome 14 at 40,872,546 bp
  • A to G, chromosome 14 at 50,916,875 bp
  • G to A, chromosome 17 at 80,424,181 bp
  • T to C, chromosome 18 at 60,697,139 bp
  • T to C, chromosome 19 at 5,756,001 bp
  • T to C, chromosome 19 at 21,472,445 bp
  • G to A, chromosome 19 at 30,079,861 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3951 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040828-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.