Strain Name:
C57BL/6J-MtgxR3959Btlr/Mmmh
Stock Number:
040835-MU
Citation ID:
RRID:MMRRC_040835-MU
Other Names:
R3959 (G1), C57BL/6J-MtgxR3959Btlr
Major Collection:

Gene Information

Npm1
Name: nucleophosmin 1
Synonyms: nucleolar protein NO38, B23, NO38
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 18148
HGNC: HGNC:7910
Homologene: 81697
Espl1
Name: extra spindle pole bodies 1, separase
Synonyms: separase, SSE, ESP1, PRCE, PRCE, Cerp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 105988
VEGA: 15
Homologene: 32151
Ntrk3
Name: neurotrophic tyrosine kinase, receptor, type 3
Synonyms: TrkC
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 18213
HGNC: HGNC:8033
Homologene: 49183
Mapk8
Name: mitogen-activated protein kinase 8
Synonyms: JNK1, c-Jun N-terminal kinase, Prkm8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 26419
HGNC: HGNC:6881
Homologene: 56760
Mycbp2
Name: MYC binding protein 2, E3 ubiquitin protein ligase
Synonyms: Pam, C130061D10Rik, Phr1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 105689
Homologene: 9005
Triobp
Name: TRIO and F-actin binding protein
Synonyms: Mus EST 478828, Tara, EST478828
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 110253
Homologene: 5104
Sec23ip
Name: Sec23 interacting protein
Synonyms: D7Ertd373e, p125
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 207352
Homologene: 38288
Prrc2c
Name: proline-rich coiled-coil 2C
Synonyms: 9630039I18Rik, 1810043M20Rik, Bat2d, Bat2l2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226562
Homologene: 41015
Etl4
Name: enhancer trap locus 4
Synonyms: Etl-4, E330027G05Rik, 6620402G01Rik, 9430077C05Rik, Skt, Sickle tail
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 208618
Homologene: 10477
Eed
Name: embryonic ectoderm development
Synonyms: l(7)5Rn, l7Rn5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 13626
HGNC: HGNC:3188
Homologene: 2814
1110004F10Rik
Name: RIKEN cDNA 1110004F10 gene
Synonyms: sid2057
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 56372
Homologene: 8606
Rrn3
Name: RRN3 RNA polymerase I transcription factor homolog (yeast)
Synonyms: E130302O19Rik, TIF-1A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 106298
VEGA: 16
Homologene: 39531
Dtl
Name: denticleless E3 ubiquitin protein ligase
Synonyms: 5730564G15Rik, 2810047L02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 76843
Homologene: 32313
Nfatc3
Name: nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3
Synonyms: NFAT4, NFATx, D8Ertd281e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 18021
HGNC: HGNC:7777
Homologene: 27827
Ppp1r21
Name: protein phosphatase 1, regulatory subunit 21
Synonyms: 1110018J12Rik, Ccdc128, Klraq1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 73825
Homologene: 44811
2700049A03Rik
Name: RIKEN cDNA 2700049A03 gene
Synonyms: talpid3, Ta3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 76967
Homologene: 8839
Nup153
Name: nucleoporin 153
Synonyms: B130015D15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218210
HGNC: HGNC:8062
Homologene: 68442
Ucp3
Name: uncoupling protein 3 (mitochondrial, proton carrier)
Synonyms: UCP-3, Slc25a9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 22229
Homologene: 2517
Dock8
Name: dedicator of cytokinesis 8
Synonyms: 1200017A24Rik, 5830472H07Rik, A130095G14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 76088
VEGA: 19
Homologene: 52414
Dnhd1
Name: dynein heavy chain domain 1
Synonyms: 8030491N06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 77505
Homologene: 131117
Itpr2
Name: inositol 1,4,5-triphosphate receptor 2
Synonyms: Ip3r2, Itpr5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 16439
HGNC: HGNC:6181
Homologene: 37593
Evc2
Name: EvC ciliary complex subunit 2
Synonyms: limbin, Lbn, Ellis van Creveld syndrome 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 68525
Homologene: 17117
Ugcg
Name: UDP-glucose ceramide glucosyltransferase
Synonyms: GlcT-1, Epcs21, Ugcgl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 22234
Homologene: 37763
Vmn2r2
Name: vomeronasal 2, receptor 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 100125586
Homologene: 129753
Csmd3
Name: CUB and Sushi multiple domains 3
Synonyms: 4930500N14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 239420
Homologene: 65982
Vmn2r72
Name: vomeronasal 2, receptor 72
Synonyms: EG244114, Vmn2r72-ps
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 244114
Homologene: 115466
Nin
Name: ninein
Synonyms: 3110068G20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 18080
Homologene: 40632
Zfp518a
Name: zinc finger protein 518A
Synonyms: 6330417C12Rik, 2810401C22Rik, Zfp518
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 72672
VEGA: 19
Homologene: 19378
Serpina3f
Name: serine (or cysteine) peptidase inhibitor, clade A, member 3F
Synonyms: 2A1, antitrypsin, alpha-1 antiproteinasin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 238393
HGNC: HGNC:16
Homologene: 115927
Slc22a27
Name: solute carrier family 22, member 27
Synonyms: mOAT6 related protein, AB056442
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 171405
Homologene: 77136
Itprid1
Name: ITPR interacting domain containing 1
Synonyms: D530004J12Rik, Ccdc129
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232016
Homologene: 52344
Adam26a
Name: a disintegrin and metallopeptidase domain 26A (testase 3)
Synonyms: Dtgn4, Adam26
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 13525
Homologene: 128363
Olfr1093
Name: olfactory receptor 1093
Synonyms: GA_x6K02T2Q125-48278396-48279364, MOR179-6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258363
Homologene: 133610
Pira2
Name: paired-Ig-like receptor A2
Synonyms: 6M23
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 18725
HGNC: HGNC:6607
Homologene: 134028
Hmgcs2
Name: 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2
Synonyms: mHS
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 15360
HGNC: HGNC:5008
Homologene: 38066
Celf4
Name: CUGBP, Elav-like family member 4
Synonyms: BRUNOL-4, Brul4, C130060B05Rik, A230070D14Rik, Brunol4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 108013
VEGA: 18
Homologene: 23202
Il18bp
Name: interleukin 18 binding protein
Synonyms: IL-18BP, MC54L, Igifbp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 16068
HGNC: HGNC:5987
Homologene: 7781
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 162,708,892 bp
  • A to T, chromosome 1 at 191,540,692 bp
  • A to G, chromosome 2 at 20,340,043 bp
  • G to A, chromosome 2 at 86,785,996 bp
  • C to T, chromosome 3 at 64,140,526 bp
  • T to C, chromosome 3 at 98,297,477 bp
  • C to T, chromosome 4 at 59,207,798 bp
  • T to A, chromosome 5 at 37,415,776 bp
  • A to T, chromosome 6 at 55,897,740 bp
  • C to T, chromosome 6 at 146,425,510 bp
  • C to T, chromosome 7 at 3,844,629 bp
  • T to C, chromosome 7 at 78,198,842 bp
  • A to T, chromosome 7 at 85,751,131 bp
  • C to T, chromosome 7 at 89,954,941 bp
  • A to G, chromosome 7 at 100,482,739 bp
  • A to G, chromosome 7 at 102,016,737 bp
  • A to G, chromosome 7 at 105,713,122 bp
  • A to T, chromosome 7 at 116,102,016 bp
  • C to G, chromosome 7 at 128,776,850 bp
  • T to C, chromosome 8 at 43,569,871 bp
  • C to T, chromosome 8 at 106,099,077 bp
  • T to A, chromosome 11 at 33,154,012 bp
  • A to T, chromosome 12 at 70,050,752 bp
  • G to T, chromosome 12 at 71,164,546 bp
  • A to T, chromosome 12 at 71,164,547 bp
  • T to A, chromosome 12 at 104,217,140 bp
  • T to C, chromosome 13 at 46,705,155 bp
  • A to C, chromosome 14 at 33,382,253 bp
  • T to C, chromosome 14 at 103,295,252 bp
  • A to T, chromosome 15 at 47,644,189 bp
  • T to A, chromosome 15 at 79,002,389 bp
  • A to G, chromosome 15 at 102,312,989 bp
  • T to C, chromosome 16 at 13,782,100 bp
  • A to G, chromosome 17 at 88,549,816 bp
  • A to G, chromosome 18 at 25,537,754 bp
  • G to A, chromosome 19 at 7,910,049 bp
  • G to A, chromosome 19 at 25,184,941 bp
  • A to C, chromosome 19 at 40,912,698 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3959 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040835-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.