Strain Name:
C57BL/6J-MtgxR3961Btlr/Mmmh
Stock Number:
040836-MU
Citation ID:
RRID:MMRRC_040836-MU
Other Names:
R3961 (G1), C57BL/6J-MtgxR3961Btlr
Major Collection:

Gene Information

Ltbp3
Name: latent transforming growth factor beta binding protein 3
Synonyms: Ltbp2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 16998
VEGA: 19
HGNC: HGNC:6716
Homologene: 7405
Actn4
Name: actinin alpha 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 60595
HGNC: HGNC:166
Homologene: 55857
Bicral
Name: BRD4 interacting chromatin remodeling complex associated protein like
Synonyms: BC032203, Gltscr1l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 210982
VEGA: 17
Homologene: 19366
Prkdc
Name: protein kinase, DNA activated, catalytic polypeptide
Synonyms: DNA-PKcs, slip, DNAPDcs, DNA-PK, XRCC7, DOXNPH, dxnph
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 19090
HGNC: HGNC:9413
Homologene: 5037
Cenpm
Name: centromere protein M
Synonyms: 2610019I03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 66570
VEGA: 15
Homologene: 11438
Polr3b
Name: polymerase (RNA) III (DNA directed) polypeptide B
Synonyms: RPC2, 2700078H01Rik, A330032P03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 70428
VEGA: 10
Homologene: 6981
Pdcl
Name: phosducin-like
Synonyms: 1200011E13Rik, PhLP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 67466
HGNC: HGNC:8770
Homologene: 38043
Minar1
Name: membrane integral NOTCH2 associated receptor 1
Synonyms: DD1, AF529169
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 209743
Homologene: 17782
Tmem131
Name: transmembrane protein 131
Synonyms: CC28, 2610524E03Rik, YR-23, D1Bwg0491e, Neg, Rw1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 56030
Homologene: 32428
Cdcp1
Name: CUB domain containing protein 1
Synonyms: 9030022E12Rik, E030027H19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 109332
Homologene: 11276
Mme
Name: membrane metallo endopeptidase
Synonyms: CD10, neprilysin, 6030454K05Rik, NEP, neutral endopeptidase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 17380
HGNC: HGNC:7154
Homologene: 5275
Ctps
Name: cytidine 5'-triphosphate synthase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 51797
HGNC: HGNC:2519
Homologene: 20446
Snx9
Name: sorting nexin 9
Synonyms: SH3PX1, SDP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 66616
VEGA: 17
Homologene: 49454
Btbd1
Name: BTB (POZ) domain containing 1
Synonyms: 1190005H08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 83962
HGNC: HGNC:1120
Homologene: 23529
Prss35
Name: protease, serine 35
Synonyms: 6030424L22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 244954
Homologene: 17734
Rtn3
Name: reticulon 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 20168
VEGA: 19
Homologene: 24934
Nphp3
Name: nephronophthisis 3 (adolescent)
Synonyms: D330020E01Rik, 3632410F03Rik, pcy, nephrocystin 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 74025
HGNC: HGNC:7907
Homologene: 32697
Tesk1
Name: testis specific protein kinase 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 21754
Homologene: 4577
Tmem63a
Name: transmembrane protein 63a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 208795
Homologene: 101673
Fras1
Name: Fraser extracellular matrix complex subunit 1
Synonyms: bl, E130113P14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231470
Homologene: 23516
Dazl
Name: deleted in azoospermia-like
Synonyms: Tpx-2, Tpx2, Dazla, Daz-like
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 13164
VEGA: 17
Homologene: 86954
Rtn2
Name: reticulon 2 (Z-band associated protein)
Synonyms: Nspl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 20167
Homologene: 32180
Trpv3
Name: transient receptor potential cation channel, subfamily V, member 3
Synonyms: 1110036I10Rik, VRL3, Nh
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 246788
Homologene: 17040
Tpte
Name: transmembrane phosphatase with tensin homology
Synonyms: Pten2, Vsp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234129
Homologene: 50411
Ncan
Name: neurocan
Synonyms: Tgfbit, Cspg3, Cspg3-rs
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 13004
HGNC: HGNC:2465
Homologene: 3229
Vmn2r107
Name: vomeronasal 2, receptor 107
Synonyms: V2r6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 22312
Homologene: 129750
Dsc2
Name: desmocollin 2
Synonyms: Dsc2b, Dsc2a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 13506
HGNC: HGNC:3036
Homologene: 8397
Cers3
Name: ceramide synthase 3
Synonyms: T3L, related to TRH3, LOC233330, CerS3, 4930550L11Rik, Lass3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 545975
Homologene: 18719
Slc19a3
Name: solute carrier family 19, member 3
Synonyms: ThTr2, A230084E24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 80721
Homologene: 23530
9930111J21Rik1
Name: RIKEN cDNA 9930111J21 gene 1
Synonyms: 9930111J21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 667214
Homologene: 83188
Olfr993
Name: olfactory receptor 993
Synonyms: GA_x6K02T2Q125-46891524-46890580, MOR203-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258427
Homologene: 79352
Pramel12
Name: PRAME like 12
Synonyms: 4732496O08Rik, Pramef8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242736
Homologene: 128393
Taf7
Name: TATA-box binding protein associated factor 7
Synonyms: TAFII55, Taf2f, 55kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 24074
Homologene: 133942
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 36,818,950 bp
  • A to T, chromosome 1 at 83,022,957 bp
  • G to A, chromosome 1 at 180,963,114 bp
  • T to C, chromosome 2 at 37,352,187 bp
  • T to C, chromosome 2 at 85,414,872 bp
  • T to A, chromosome 3 at 63,345,192 bp
  • A to G, chromosome 4 at 43,445,133 bp
  • A to G, chromosome 4 at 120,567,235 bp
  • T to A, chromosome 4 at 143,419,318 bp
  • T to C, chromosome 5 at 96,677,385 bp
  • T to C, chromosome 7 at 19,286,670 bp
  • G to A, chromosome 7 at 28,898,266 bp
  • G to T, chromosome 7 at 66,786,075 bp
  • C to A, chromosome 7 at 81,818,335 bp
  • A to G, chromosome 8 at 22,359,415 bp
  • G to A, chromosome 8 at 70,110,300 bp
  • A to G, chromosome 9 at 86,755,749 bp
  • G to A, chromosome 9 at 89,601,910 bp
  • G to T, chromosome 9 at 104,003,042 bp
  • T to C, chromosome 9 at 123,182,381 bp
  • T to C, chromosome 10 at 84,684,302 bp
  • T to C, chromosome 11 at 48,947,976 bp
  • A to T, chromosome 11 at 73,287,420 bp
  • A to T, chromosome 15 at 82,234,373 bp
  • T to G, chromosome 16 at 15,829,611 bp
  • T to A, chromosome 17 at 5,924,689 bp
  • G to A, chromosome 17 at 20,375,455 bp
  • T to C, chromosome 17 at 46,824,825 bp
  • A to G, chromosome 17 at 50,288,133 bp
  • C to T, chromosome 18 at 20,051,227 bp
  • A to G, chromosome 18 at 37,643,121 bp
  • G to A, chromosome 19 at 5,754,022 bp
  • T to C, chromosome 19 at 7,458,145 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3961 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040836-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.