Strain Name:
C57BL/6J-MtgxR3971Btlr/Mmmh
Stock Number:
040839-MU
Citation ID:
RRID:MMRRC_040839-MU
Other Names:
R3971 (G1), C57BL/6J-MtgxR3971Btlr
Major Collection:

Gene Information

Sema3b
Name: sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
Synonyms: Semaa, sema5, SemA, LUCA-1, SemA, semaV
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 20347
Homologene: 20972
Dock1
Name: dedicator of cytokinesis 1
Synonyms: D630004B07Rik, b2b3190Clo, Dock180, 9130006G06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 330662
HGNC: HGNC:2987
Homologene: 55575
Vps35l
Name: VPS35 endosomal protein sorting factor like
Synonyms: Vsp35l, 9030624J02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 71517
Homologene: 10659
Aunip
Name: aurora kinase A and ninein interacting protein
Synonyms: 2610002D18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 69885
Homologene: 81895
Rbm25
Name: RNA binding motif protein 25
Synonyms: 2610015J01Rik, A130095G20Rik, 2600011C06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 67039
Wac
Name: WW domain containing adaptor with coiled-coil
Synonyms: 1110067P07Rik, Wwp4, A230035H12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 225131
Homologene: 41148
Kif5b
Name: kinesin family member 5B
Synonyms: Khc, kinesin heavy chain
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 16573
HGNC: HGNC:6324
Homologene: 55829
Slc12a2
Name: solute carrier family 12, member 2
Synonyms: sodium/potassium/chloride cotransporters, sy-ns, Nkcc1, mBSC2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 20496
VEGA: 18
Homologene: 20283
Mki67
Name: antigen identified by monoclonal antibody Ki 67
Synonyms: D630048A14Rik, Ki67, Ki-67
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 17345
HGNC: HGNC:7107
Homologene: 1814
Dync1h1
Name: dynein cytoplasmic 1 heavy chain 1
Synonyms: Dnec1, dynein heavy chain, retrograde transport, MAP1C, 9930018I23Rik, Swl, Loa, Dnchc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 13424
HGNC: HGNC:2961
Homologene: 1053
Cct7
Name: chaperonin containing Tcp1, subunit 7 (eta)
Synonyms: Cctz, Ccth
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 12468
HGNC: HGNC:1622
Homologene: 4694
Ccdc80
Name: coiled-coil domain containing 80
Synonyms: DRO1, 2610001E17Rik, Ssg1, Urb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 67896
Homologene: 12206
Cd72
Name: CD72 antigen
Synonyms: Ly-19, Ly-m19, Lyb-2, Ly-32
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 12517
HGNC: HGNC:1696
Homologene: 1350
Muc2
Name: mucin 2
Synonyms: 2010015E03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 17831
HGNC: HGNC:7512
Homologene: 136755
Zfhx2
Name: zinc finger homeobox 2
Synonyms: zfh-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 239102
Homologene: 52657
Tmem130
Name: transmembrane protein 130
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 243339
Homologene: 17680
Mcoln1
Name: mucolipin 1
Synonyms: TRPML1, 2210015I05Rik, mucolipidin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 94178
Homologene: 10744
Ddr2
Name: discoidin domain receptor family, member 2
Synonyms: Ntrkr3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 18214
HGNC: HGNC:2731
Homologene: 68505
Zfp993
Name: zinc finger protein 993
Synonyms: Gm13248
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 100503000
Tsc2
Name: TSC complex subunit 2
Synonyms: tuberin, Nafld, tuberous sclerosis 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 22084
VEGA: 17
Homologene: 462
Ttn
Name: titin
Synonyms: shru, connectin, mdm, 2310057K23Rik, D330041I19Rik, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, L56, 2310074I15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 22138
Homologene: 130650
Otop1
Name: otopetrin 1
Synonyms: tlt, A530025J20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 21906
Homologene: 35244
Nell1
Name: NEL-like 1
Synonyms: B230343H07Rik, l7R6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 338352
HGNC: HGNC:7750
Homologene: 4486
Glp2r
Name: glucagon-like peptide 2 receptor
Synonyms: GLP-2, 9530092J08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 93896
HGNC: HGNC:4325
Homologene: 3132
Psma8
Name: proteasome (prosome, macropain) subunit, alpha type, 8
Synonyms: 2410072D24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 73677
VEGA: 18
Homologene: 2086
Aadat
Name: aminoadipate aminotransferase
Synonyms: mKat-2, Kyat2, Kat2, KATII
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 23923
Homologene: 56540
Nckap1l
Name: NCK associated protein 1 like
Synonyms: Hem1, 4930568P13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 105855
VEGA: 15
HGNC: HGNC:4862
Homologene: 3901
Ifit2
Name: interferon-induced protein with tetratricopeptide repeats 2
Synonyms: Ifi54
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 15958
HGNC: HGNC:5409
Homologene: 1187
Man2b1
Name: mannosidase 2, alpha B1
Synonyms: lysosomal alpha-mannosidase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 17159
HGNC: HGNC:6826
Homologene: 37322
Obscn
Name: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Synonyms: LOC380698, OTTMUSG00000005786
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 380698
Homologene: 70869
Atp10b
Name: ATPase, class V, type 10B
Synonyms: 9030605H24Rik, 5930426O13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 319767
Homologene: 70969
Gm7247
Name: predicted gene 7247
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 638695
Myo5b
Name: myosin VB
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 17919
HGNC: HGNC:7603
Homologene: 49481
Synj1
Name: synaptojanin 1
Synonyms: A930006D20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 104015
Homologene: 48252
Mrc2
Name: mannose receptor, C type 2
Synonyms: Endo180, novel lectin, uPARAP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 17534
Homologene: 4408
Fam75d3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
CT009546.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
Apbb1ip
Name: amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
Synonyms: 9930118P07Rik, Prp48, proline-rich protein 48
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 54519
Homologene: 32434
Chrnb1
Name: cholinergic receptor, nicotinic, beta polypeptide 1 (muscle)
Synonyms: Acrb, Achr-2, AChR beta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 11443
HGNC: HGNC:1961
Homologene: 594
Prpsap2
Name: phosphoribosyl pyrophosphate synthetase-associated protein 2
Synonyms: A230054F23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 212627
HGNC: HGNC:9467
Homologene: 2073
Olfr816
Name: olfactory receptor 816
Synonyms: GA_x6K02T2PULF-11590830-11589892, MOR113-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 258667
Homologene: 133584
Coro2b
Name: coronin, actin binding protein, 2B
Synonyms: E130012P22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 235431
HGNC: HGNC:2256
Homologene: 21228
Hecw1
Name: HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
Synonyms: E130207I19Rik, NEDL1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 94253
VEGA: 13
Homologene: 9004
Vegfc
Name: vascular endothelial growth factor C
Synonyms: VEGF-C
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 22341
Homologene: 3962
Epha10
Name: Eph receptor A10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 230735
Homologene: 67804
Fam174b
Name: family with sequence similarity 174, member B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 100038347
Homologene: 121932
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 169,988,417 bp
  • T to A, chromosome 2 at 22,823,494 bp
  • A to T, chromosome 2 at 76,811,243 bp
  • C to T, chromosome 4 at 43,449,491 bp
  • T to C, chromosome 4 at 124,915,605 bp
  • A to G, chromosome 4 at 134,523,469 bp
  • A to G, chromosome 4 at 146,657,632 bp
  • A to G, chromosome 5 at 38,300,189 bp
  • T to A, chromosome 5 at 144,755,321 bp
  • G to T, chromosome 6 at 85,452,142 bp
  • T to C, chromosome 7 at 50,448,979 bp
  • T to C, chromosome 7 at 73,766,600 bp
  • T to C, chromosome 7 at 118,833,799 bp
  • G to A, chromosome 7 at 134,746,908 bp
  • A to C, chromosome 7 at 135,696,130 bp
  • T to C, chromosome 7 at 141,752,116 bp
  • T to A, chromosome 8 at 3,507,408 bp
  • T to C, chromosome 8 at 54,156,948 bp
  • C to T, chromosome 8 at 60,518,581 bp
  • A to G, chromosome 8 at 85,085,391 bp
  • C to T, chromosome 9 at 62,429,240 bp
  • A to G, chromosome 9 at 107,600,368 bp
  • T to C, chromosome 10 at 129,911,873 bp
  • A to G, chromosome 11 at 43,216,512 bp
  • T to C, chromosome 11 at 59,131,646 bp
  • A to G, chromosome 11 at 61,752,856 bp
  • T to A, chromosome 11 at 67,746,815 bp
  • A to G, chromosome 11 at 69,792,916 bp
  • G to A, chromosome 11 at 105,328,031 bp
  • A to G, chromosome 12 at 83,675,208 bp
  • A to G, chromosome 12 at 110,665,965 bp
  • A to T, chromosome 13 at 13,964,848 bp
  • T to C, chromosome 13 at 14,236,929 bp
  • T to A, chromosome 13 at 59,702,157 bp
  • A to G, chromosome 14 at 51,365,384 bp
  • A to G, chromosome 14 at 55,074,475 bp
  • A to G, chromosome 15 at 103,462,560 bp
  • A to G, chromosome 16 at 45,095,820 bp
  • A to G, chromosome 16 at 90,991,603 bp
  • T to C, chromosome 17 at 24,623,588 bp
  • T to A, chromosome 18 at 6,213,467 bp
  • T to C, chromosome 18 at 7,916,175 bp
  • A to G, chromosome 18 at 14,757,387 bp
  • T to A, chromosome 18 at 57,930,196 bp
  • C to T, chromosome 18 at 74,740,527 bp
  • A to G, chromosome 19 at 34,574,041 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3971 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040839-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.