Strain Name:
C57BL/6J-MtgxR3972Btlr/Mmmh
Stock Number:
040840-MU
Citation ID:
RRID:MMRRC_040840-MU
Other Names:
R3972 (G1), C57BL/6J-MtgxR3972Btlr
Major Collection:

Gene Information

Ncor1
Name: nuclear receptor co-repressor 1
Synonyms: A230020K14Rik, 5730405M06Rik, Rxrip13, N-CoR
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 20185
HGNC: HGNC:7672
Homologene: 38166
Ltbp3
Name: latent transforming growth factor beta binding protein 3
Synonyms: Ltbp2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 16998
VEGA: 19
HGNC: HGNC:6716
Homologene: 7405
Lyst
Name: lysosomal trafficking regulator
Synonyms: D13Sfk13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 17101
VEGA: 13
HGNC: HGNC:1968
Homologene: 61
Slc17a7
Name: solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7
Synonyms: 2900052E22Rik, Vglut1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 72961
Homologene: 113454
Tet1
Name: tet methylcytosine dioxygenase 1
Synonyms: 2510010B09Rik, BB001228, Cxxc6, D10Ertd17e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 52463
Homologene: 12735
Pdia3
Name: protein disulfide isomerase associated 3
Synonyms: Grp58, PDI-Q2, ERp57, ERp60, PDI, ERp61, Plca, Erp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 14827
HGNC: HGNC:4606
Homologene: 68454
Fgf1
Name: fibroblast growth factor 1
Synonyms: Fgfa, fibroblast growth factor 1 (acidic), Fgf-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 14164
HGNC: HGNC:3665
Homologene: 625
Pi4ka
Name: phosphatidylinositol 4-kinase alpha
Synonyms: Pik4ca
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 224020
HGNC: HGNC:8983
Homologene: 11171
Dusp12
Name: dual specificity phosphatase 12
Synonyms: ESTM36, mVH1, VH1, LMW-DSP4, T-DSP4, 1190004O14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 80915
HGNC: HGNC:3067
Homologene: 5238
Setdb1
Name: SET domain, bifurcated 1
Synonyms: ESET, KMT1E
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 84505
Homologene: 32157
Mki67
Name: antigen identified by monoclonal antibody Ki 67
Synonyms: D630048A14Rik, Ki67, Ki-67
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 17345
HGNC: HGNC:7107
Homologene: 1814
Cct7
Name: chaperonin containing Tcp1, subunit 7 (eta)
Synonyms: Cctz, Ccth
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 12468
HGNC: HGNC:1622
Homologene: 4694
Usp34
Name: ubiquitin specific peptidase 34
Synonyms: Murr2, A530081C03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 17847
Homologene: 40978
Lpar6
Name: lysophosphatidic acid receptor 6
Synonyms: P2y5, P2ry5, 2610302I02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 67168
Homologene: 55925
Ubfd1
Name: ubiquitin family domain containing 1
Synonyms: D7Wsu105e, D7Wsu128e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 28018
Homologene: 10430
Gabbr1
Name: gamma-aminobutyric acid (GABA) B receptor, 1
Synonyms: GABAbR1, GABAB1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 54393
HGNC: HGNC:4070
Homologene: 1132
Gucy2c
Name: guanylate cyclase 2c
Synonyms: GC-C
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 14917
HGNC: HGNC:4688
Homologene: 3641
Mme
Name: membrane metallo endopeptidase
Synonyms: neprilysin, NEP, neutral endopeptidase, CD10, 6030454K05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 17380
HGNC: HGNC:7154
Homologene: 5275
Psrc1
Name: proline/serine-rich coiled-coil 1
Synonyms: 5430413I02Rik, DDA3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 56742
Homologene: 49603
Wdr75
Name: WD repeat domain 75
Synonyms: 2410118I19Rik, 1300003A18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 73674
Homologene: 32771
Nudt9
Name: nudix (nucleoside diphosphate linked moiety X)-type motif 9
Synonyms: 1190002C07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 74167
HGNC: HGNC:8056
Homologene: 11435
Zfp266
Name: zinc finger protein 266
Synonyms: 5330440G10Rik, 5730601F06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 77519
Homologene: 105676
Zfp979
Name: zinc finger protein 979
Synonyms: 2610305D13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 112422
Homologene: 133076
Tpcn1
Name: two pore channel 1
Synonyms: 5730403B01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 252972
Homologene: 9905
Otp
Name: orthopedia homeobox
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 18420
HGNC: HGNC:8518
Homologene: 7874
Pde4a
Name: phosphodiesterase 4A, cAMP specific
Synonyms: Dpde2, D9Ertd60e, dunce
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 18577
HGNC: HGNC:8780
Homologene: 4520
Reln
Name: reelin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 19699
HGNC: HGNC:9957
Homologene: 3699
Ttn
Name: titin
Synonyms: shru, connectin, mdm, 2310057K23Rik, D330041I19Rik, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, L56, 2310074I15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 22138
Homologene: 130650
Otop1
Name: otopetrin 1
Synonyms: tlt, A530025J20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 21906
Homologene: 35244
Nell1
Name: NEL-like 1
Synonyms: B230343H07Rik, l7R6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 338352
HGNC: HGNC:7750
Homologene: 4486
Uckl1
Name: uridine-cytidine kinase 1-like 1
Synonyms: 1110007H10Rik, Urkl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 68556
Homologene: 101414
Fat3
Name: FAT atypical cadherin 3
Synonyms: LOC382129, 9430076A06Rik, LOC234973, D430038H04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 270120
VEGA: 9
Homologene: 82252
Avl9
Name: AVL9 cell migration associated
Synonyms: 5830411G16Rik, D730049P16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 78937
Homologene: 62425
Dnah3
Name: dynein, axonemal, heavy chain 3
Synonyms: Dnahc3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 381917
HGNC: HGNC:2949
Homologene: 19674
C7
Name: complement component 7
Synonyms: LOC383055
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 109828
VEGA: 15
HGNC: HGNC:1346
Homologene: 489
Man2b1
Name: mannosidase 2, alpha B1
Synonyms: lysosomal alpha-mannosidase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 17159
HGNC: HGNC:6826
Homologene: 37322
Irf2bp1
Name: interferon regulatory factor 2 binding protein 1
Synonyms: 6330414O09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 272359
Homologene: 32276
Trmt1l
Name: tRNA methyltransferase 1 like
Synonyms: Trm1-like, 1190005F20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 98685
Homologene: 12801
Myo5b
Name: myosin VB
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 17919
HGNC: HGNC:7603
Homologene: 49481
Serpinb10
Name: serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 241197
HGNC: HGNC:8942
Homologene: 68430
Mak
Name: male germ cell-associated kinase
Synonyms: A930010O05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 17152
VEGA: 13
HGNC: HGNC:6816
Homologene: 31344
Alk
Name: anaplastic lymphoma kinase
Synonyms: CD246, Tcrz
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 11682
VEGA: 17
HGNC: HGNC:427
Homologene: 68387
Olfr1423
Name: olfactory receptor 1423
Synonyms: GA_x6K02T2RE5P-2393361-2392429, MOR239-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 258675
Homologene: 128078
Ttll12
Name: tubulin tyrosine ligase-like family, member 12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 223723
Homologene: 9036
Coro2b
Name: coronin, actin binding protein, 2B
Synonyms: E130012P22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 235431
HGNC: HGNC:2256
Homologene: 21228
Cldn20
Name: claudin 20
Synonyms: EG621628
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 621628
VEGA: 17
HGNC: HGNC:2042
Homologene: 47972
Mrpl16
Name: mitochondrial ribosomal protein L16
Synonyms: 2310039D06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 94063
VEGA: 19
Homologene: 9872
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 45,822,554 bp
  • T to A, chromosome 1 at 107,536,122 bp
  • A to G, chromosome 1 at 151,433,883 bp
  • T to C, chromosome 1 at 170,879,775 bp
  • A to T, chromosome 2 at 76,811,243 bp
  • T to C, chromosome 2 at 121,424,513 bp
  • T to C, chromosome 2 at 181,574,463 bp
  • A to G, chromosome 3 at 63,342,011 bp
  • A to T, chromosome 3 at 95,341,338 bp
  • T to A, chromosome 3 at 108,384,958 bp
  • G to A, chromosome 4 at 147,618,419 bp
  • A to T, chromosome 5 at 21,979,001 bp
  • A to G, chromosome 5 at 38,300,189 bp
  • G to T, chromosome 5 at 104,047,125 bp
  • C to A, chromosome 5 at 120,553,752 bp
  • T to C, chromosome 6 at 56,743,408 bp
  • G to T, chromosome 6 at 85,452,142 bp
  • C to T, chromosome 6 at 136,708,366 bp
  • T to A, chromosome 7 at 19,005,444 bp
  • A to G, chromosome 7 at 45,169,910 bp
  • T to C, chromosome 7 at 50,448,979 bp
  • T to A, chromosome 7 at 120,086,720 bp
  • T to G, chromosome 7 at 122,067,433 bp
  • A to C, chromosome 7 at 135,696,130 bp
  • A to G, chromosome 8 at 85,085,391 bp
  • G to A, chromosome 9 at 15,998,271 bp
  • A to G, chromosome 9 at 20,500,150 bp
  • A to G, chromosome 9 at 21,206,217 bp
  • C to T, chromosome 9 at 62,429,240 bp
  • T to A, chromosome 10 at 62,813,726 bp
  • T to C, chromosome 11 at 23,457,803 bp
  • T to A, chromosome 11 at 62,395,236 bp
  • T to C, chromosome 13 at 13,706,625 bp
  • C to A, chromosome 13 at 41,051,358 bp
  • T to G, chromosome 13 at 94,883,184 bp
  • A to G, chromosome 14 at 73,239,073 bp
  • C to T, chromosome 15 at 5,007,651 bp
  • A to T, chromosome 15 at 83,582,096 bp
  • A to G, chromosome 16 at 17,293,875 bp
  • A to G, chromosome 17 at 3,532,639 bp
  • T to C, chromosome 17 at 37,048,414 bp
  • T to G, chromosome 17 at 71,985,447 bp
  • T to C, chromosome 18 at 38,847,094 bp
  • C to T, chromosome 18 at 74,740,527 bp
  • G to A, chromosome 19 at 5,754,022 bp
  • A to G, chromosome 19 at 11,772,875 bp
  • G to T, chromosome 19 at 12,036,019 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3972 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040840-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.