Strain Name:
C57BL/6J-MtgxR3976Btlr/Mmmh
Stock Number:
040842-MU
Citation ID:
RRID:MMRRC_040842-MU
Other Names:
R3976 (G1), C57BL/6J-MtgxR3976Btlr
Major Collection:

Gene Information

Setd3
Name: SET domain containing 3
Synonyms: D12Ertd771e, 2610305M23Rik, 2610102I01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 52690
Homologene: 41748
Ppp1r12a
Name: protein phosphatase 1, regulatory subunit 12A
Synonyms: 5730577I22Rik, Mypt1, 1200015F06Rik, D10Ertd625e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 17931
VEGA: 10
HGNC: HGNC:7618
Homologene: 1855
Tsc22d1
Name: TSC22 domain family, member 1
Synonyms: TSC-22, Egr5, Tgfb1i4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 21807
Homologene: 7573
Cyb5r3
Name: cytochrome b5 reductase 3
Synonyms: 2500002N19Rik, Dia1, 0610016L08Rik, Dia-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 109754
HGNC: HGNC:2873
Homologene: 47921
Asb4
Name: ankyrin repeat and SOCS box-containing 4
Synonyms: 8430401O13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 65255
Homologene: 9392
Runx2
Name: runt related transcription factor 2
Synonyms: Pebpa2a, SL3-3 enhancer factor 1, polyomavirus enhancer binding factor 2 (PEBP2), Osf2, Cbfa1, PEBP2aA, AML3, PEBP2 alpha A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 12393
Homologene: 68389
Herpud2
Name: HERPUD family member 2
Synonyms: 5031400M07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 80517
VEGA: 9
Homologene: 10756
Eml5
Name: echinoderm microtubule associated protein like 5
Synonyms: C130068M19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 319670
VEGA: 12
Homologene: 26807
Opn4
Name: opsin 4 (melanopsin)
Synonyms: 1110007J02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 30044
VEGA: 14
Homologene: 69152
Lrp3
Name: low density lipoprotein receptor-related protein 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 435965
HGNC: HGNC:6695
Homologene: 1745
Rel
Name: reticuloendotheliosis oncogene
Synonyms: c-Rel
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 19696
HGNC: HGNC:9954
Homologene: 2182
Fermt3
Name: fermitin family member 3
Synonyms: C79673, Kindlin-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 108101
VEGA: 19
Homologene: 12877
Tesk1
Name: testis specific protein kinase 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 21754
Homologene: 4577
Gm872
Name: predicted gene 872
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
Clspn
Name: claspin
Synonyms: E130314M08Rik, C85083
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 269582
Homologene: 11138
Sptbn5
Name: spectrin beta, non-erythrocytic 5
Synonyms: Spnb5, EG640524
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 640524
Homologene: 41150
Ryr3
Name: ryanodine receptor 3
Synonyms: calcium release channel isoform 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 20192
Homologene: 68151
Fbxw16
Name: F-box and WD-40 domain protein 16
Synonyms: 7420402K12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 320083
Homologene: 110776
Abca9
Name: ATP-binding cassette, sub-family A (ABC1), member 9
Synonyms: D630040K07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 217262
HGNC: HGNC:39
Homologene: 33332
Phf8-ps
Name: PHD finger protein 8, pseudogene
Synonyms: 4921501E09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 74042
VEGA: 17
Homologene: 66275
AC104834.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
Rp1l1
Name: retinitis pigmentosa 1 homolog like 1
Synonyms: Dcdc4, Rp1hl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 271209
VEGA: 14
Homologene: 105870
Dglucy
Name: D-glutamate cyclase
Synonyms: 9030617O03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 217830
Homologene: 11798
Mapkbp1
Name: mitogen-activated protein kinase binding protein 1
Synonyms: Jnkbp1, 2810483F24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 26390
Homologene: 69109
Serpina1d
Name: serine (or cysteine) peptidase inhibitor, clade A, member 1D
Synonyms: Spi1-4, PI4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 20703
HGNC: HGNC:8941
Homologene: 20103
Ugt2b1
Name: UDP glucuronosyltransferase 2 family, polypeptide B1
Synonyms: 1300012D20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 71773
Homologene: 68144
Cacna2d4
Name: calcium channel, voltage-dependent, alpha 2/delta subunit 4
Synonyms: 5730412N02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 319734
Homologene: 26544
Pla2g4b
Name: phospholipase A2, group IVB (cytosolic)
Synonyms: A030011C02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 211429
HGNC: HGNC:9036
Homologene: 3730
Atxn7l1
Name: ataxin 7-like 1
Synonyms: Atxn7l4, 2810423G08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 380753
Homologene: 53366
Olfr267
Name: olfactory receptor 267
Synonyms: GA_x6K02T2N78B-1272842-1273783, MOR262-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 258922
HGNC: HGNC:8264
Homologene: 17436
AC162391.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
Suox
Name: sulfite oxidase
Synonyms: SO
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 211389
VEGA: 10
Homologene: 394
Fam90a1a
Name: family with sequence similarity 90, member A1A
Synonyms: C86695
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 97476
Homologene: 135718
Tubal3
Name: tubulin, alpha-like 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 238463
VEGA: 13
Homologene: 23488
Rhbg
Name: Rhesus blood group-associated B glycoprotein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 58176
Homologene: 9469
Olfr1306
Name: olfactory receptor 1306
Synonyms: MOR245-15, GA_x6K02T2Q125-72954873-72953935
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 258023
Homologene: 128383
Gdf2
Name: growth differentiation factor 2
Synonyms: Bmp9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 12165
VEGA: 14
HGNC: HGNC:4217
Homologene: 32299
Spg7
Name: SPG7, paraplegin matrix AAA peptidase subunit
Synonyms: spastic paraplegia 7 homolog (human), paraplegin, Cmar
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 234847
Homologene: 31133
Fbxo16
Name: F-box protein 16
Synonyms: Fbx16
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 50759
VEGA: 14
Homologene: 9273
Mepe
Name: matrix extracellular phosphoglycoprotein with ASARM motif (bone)
Synonyms: OF45
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 94111
Homologene: 10623
Gcsam
Name: germinal center associated, signaling and motility
Synonyms: M17, Gcet2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 14525
Homologene: 49157
Prdm6
Name: PR domain containing 6
Synonyms: PRISM, LOC225518
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 225518
HGNC: HGNC:9350
Homologene: 79756
Nt5dc2
Name: 5'-nucleotidase domain containing 2
Synonyms: 2510015F01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 70021
VEGA: 14
Homologene: 11290
Rab18
Name: RAB18, member RAS oncogene family
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 19330
VEGA: 18
Homologene: 40765
Bola3
Name: bolA-like 3 (E. coli)
Synonyms: 1810056O20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 78653
Homologene: 5288
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 2 at 111,912,606 bp
  • T to C, chromosome 2 at 112,675,837 bp
  • T to C, chromosome 2 at 120,021,858 bp
  • C to T, chromosome 2 at 120,036,756 bp
  • C to T, chromosome 2 at 120,048,261 bp
  • C to A, chromosome 3 at 88,244,536 bp
  • C to T, chromosome 4 at 43,445,786 bp
  • A to G, chromosome 4 at 58,785,164 bp
  • C to T, chromosome 4 at 126,587,697 bp
  • C to A, chromosome 5 at 86,917,675 bp
  • C to T, chromosome 5 at 104,337,078 bp
  • A to T, chromosome 6 at 5,390,771 bp
  • A to T, chromosome 6 at 7,983,149 bp
  • T to C, chromosome 6 at 83,351,267 bp
  • A to G, chromosome 6 at 119,278,173 bp
  • T to C, chromosome 7 at 35,204,105 bp
  • G to A, chromosome 8 at 21,961,416 bp
  • A to G, chromosome 8 at 123,079,448 bp
  • A to G, chromosome 9 at 25,110,438 bp
  • A to G, chromosome 9 at 109,439,629 bp
  • A to G, chromosome 10 at 92,839,471 bp
  • T to C, chromosome 10 at 108,253,480 bp
  • A to G, chromosome 10 at 128,671,037 bp
  • A to G, chromosome 11 at 23,742,939 bp
  • T to C, chromosome 11 at 110,148,789 bp
  • T to C, chromosome 12 at 33,325,955 bp
  • A to T, chromosome 12 at 98,802,465 bp
  • A to T, chromosome 12 at 100,841,389 bp
  • A to T, chromosome 12 at 103,767,848 bp
  • T to C, chromosome 12 at 108,165,158 bp
  • C to T, chromosome 13 at 3,932,946 bp
  • T to C, chromosome 14 at 31,138,875 bp
  • T to A, chromosome 14 at 33,944,834 bp
  • C to T, chromosome 14 at 34,597,109 bp
  • T to A, chromosome 14 at 64,030,309 bp
  • T to A, chromosome 14 at 65,287,157 bp
  • T to C, chromosome 14 at 76,418,609 bp
  • A to G, chromosome 15 at 83,160,129 bp
  • A to G, chromosome 15 at 101,052,586 bp
  • T to G, chromosome 16 at 45,619,829 bp
  • A to T, chromosome 17 at 33,066,431 bp
  • T to C, chromosome 17 at 44,610,079 bp
  • T to A, chromosome 18 at 6,778,529 bp
  • T to C, chromosome 18 at 53,540,206 bp
  • G to A, chromosome 19 at 7,002,424 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3976 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040842-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.