Strain Name:
C57BL/6J-MtgxR4042Btlr/Mmmh
Stock Number:
040851-MU
Citation ID:
RRID:MMRRC_040851-MU
Other Names:
R4042 (G1), C57BL/6J-MtgxR4042Btlr
Major Collection:

Gene Information

Bcl2l2
Name: BCL2-like 2
Synonyms: bclw, Bcl-w, Gtrosa41, Gtrgal2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 12050
HGNC: HGNC:995
Homologene: 2989
Vcan
Name: versican
Synonyms: DPEAAE, heart defect, 5430420N07Rik, hdf, PG-M, Cspg2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 13003
HGNC: HGNC:2464
Homologene: 3228
Usp34
Name: ubiquitin specific peptidase 34
Synonyms: Murr2, A530081C03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 17847
Homologene: 40978
Prune2
Name: prune homolog 2
Synonyms: 6330414G02Rik, A230083H22Rik, A330102H22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 353211
VEGA: 19
Homologene: 18939
Cog1
Name: component of oligomeric golgi complex 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 16834
HGNC: HGNC:6545
Homologene: 8411
Mettl16
Name: methyltransferase like 16
Synonyms: Mett10d, 2610100D03Rik, A830095F14Rik, 2810013M15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 67493
Homologene: 34653
Chd6
Name: chromodomain helicase DNA binding protein 6
Synonyms: 5430439G14Rik, 6330406J24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 71389
Homologene: 32772
Ppme1
Name: protein phosphatase methylesterase 1
Synonyms: PME-1, 2700017M01Rik, 1110069N17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 72590
Homologene: 6099
Ythdc1
Name: YTH domain containing 1
Synonyms: A730098D12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 231386
Homologene: 15796
Ncoa1
Name: nuclear receptor coactivator 1
Synonyms: SRC-a/NCoA-1, SRC1, steroid receptor coactivator-1, bHLHe74, SRC-1, KAT13A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 17977
VEGA: 12
HGNC: HGNC:7668
Homologene: 7859
Rnf157
Name: ring finger protein 157
Synonyms: 2610036E23Rik, A130073L17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 217340
Homologene: 28235
Akap6
Name: A kinase (PRKA) anchor protein 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 238161
VEGA: 12
HGNC: HGNC:376
Homologene: 3157
Col28a1
Name: collagen, type XXVIII, alpha 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 213945
Homologene: 66345
Insrr
Name: insulin receptor-related receptor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 23920
HGNC: HGNC:6093
Homologene: 56539
Fsip2
Name: fibrous sheath-interacting protein 2
Synonyms: OTTMUSG00000013335
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 241516
Homologene: 110349
Cst11
Name: cystatin 11
Synonyms: mCST E1, cystatin E1, 9230101F08Rik, CRES2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 78240
Homologene: 15634
Uchl4
Name: ubiquitin carboxyl-terminal esterase L4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 93841
VEGA: 9
Csmd3
Name: CUB and Sushi multiple domains 3
Synonyms: 4930500N14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 239420
Homologene: 65982
Muc5b
Name: mucin 5, subtype B, tracheobronchial
Synonyms: MUC5, MUC9, 2300002I04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 74180
HGNC: HGNC:7516
Homologene: 136756
Selenbp2
Name: selenium binding protein 2
Synonyms: AP56, Lpsb2, acetaminophen-binding protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 20342
Homologene: 2930
Ush1c
Name: USH1 protein network component harmonin
Synonyms: harmonin, 2010016F01Rik, Usher syndrome 1C
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 72088
Homologene: 77476
Otol1
Name: otolin 1
Synonyms: Gm414, LOC229389
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 229389
Homologene: 19018
Cyp2d10
Name: cytochrome P450, family 2, subfamily d, polypeptide 10
Synonyms: Cyp2d, P450-2D
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 13101
VEGA: 15
Homologene: 86099
Plxnb1
Name: plexin B1
Synonyms: 2900002G15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 235611
HGNC: HGNC:9103
Homologene: 130508
Adamts10
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 10
Synonyms: ZnMP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 224697
Homologene: 81940
Alox5
Name: arachidonate 5-lipoxygenase
Synonyms: 5-LOX, 5LO, 5LX
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 11689
HGNC: HGNC:435
Homologene: 561
Prss40
Name: protease, serine 40
Synonyms: Tesp2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 21756
Homologene: 69043
Itih4
Name: inter alpha-trypsin inhibitor, heavy chain 4
Synonyms: Itih-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 16427
HGNC: HGNC:6169
Homologene: 1670
Rgl2
Name: ral guanine nucleotide dissociation stimulator-like 2
Synonyms: Rgt2, Rlf, KE1.5, Rab2l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 19732
HGNC: HGNC:9769
Homologene: 3494
H2-Ab1
Name: histocompatibility 2, class II antigen A, beta 1
Synonyms: IAb, I-Abeta, Abeta, Ia2, Ia-2, Rmcs1, I-Ab, H2-Ab, A beta, H-2Ab
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 14961
HGNC: HGNC:4944
Homologene: 1603
Miga2
Name: mitoguardin 2
Synonyms: Fam73b, R74766, 5730472N09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 108958
Homologene: 13125
Gm7732
Name: predicted gene 7732
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 665654
Pdlim2
Name: PDZ and LIM domain 2
Synonyms: 4732462F18Rik, mystique, SLIM
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 213019
Homologene: 11006
4430402I18Rik
Name: RIKEN cDNA 4430402I18 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 381218
Homologene: 128454
Olfr1432
Name: olfactory receptor 1432
Synonyms: MOR202-32P, GA_x6K02T2RE5P-2593538-2592756
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 257961
Rrm2
Name: ribonucleotide reductase M2
Synonyms: R2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 20135
Homologene: 20277
4930415L06Rik
Name: RIKEN cDNA 4930415L06 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
Alteration at locus: Chemically Induced
NCBI: 245511
Homologene: 133109
Gm11940
Name: predicted gene 11940
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
Hdac6
Name: histone deacetylase 6
Synonyms: mHDA2, Sfc6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
Alteration at locus: Chemically Induced
NCBI: 15185
Homologene: 31353
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to T, chromosome 1 at 34,560,879 bp
  • T to C, chromosome 2 at 30,367,726 bp
  • G to T, chromosome 2 at 82,983,552 bp
  • A to G, chromosome 2 at 148,771,280 bp
  • A to T, chromosome 2 at 160,988,333 bp
  • A to G, chromosome 3 at 70,027,779 bp
  • T to A, chromosome 3 at 87,813,827 bp
  • C to T, chromosome 3 at 94,703,742 bp
  • T to C, chromosome 5 at 86,816,524 bp
  • G to A, chromosome 6 at 8,014,678 bp
  • A to G, chromosome 6 at 116,461,018 bp
  • T to C, chromosome 7 at 46,221,528 bp
  • A to G, chromosome 7 at 100,341,065 bp
  • T to C, chromosome 7 at 141,864,887 bp
  • A to C, chromosome 9 at 64,235,557 bp
  • A to G, chromosome 9 at 109,105,173 bp
  • C to T, chromosome 11 at 23,489,033 bp
  • T to A, chromosome 11 at 74,792,292 bp
  • C to T, chromosome 11 at 99,386,993 bp
  • A to T, chromosome 11 at 113,661,010 bp
  • G to A, chromosome 11 at 116,345,929 bp
  • A to G, chromosome 12 at 4,267,871 bp
  • T to C, chromosome 12 at 24,711,451 bp
  • A to T, chromosome 12 at 53,139,379 bp
  • T to A, chromosome 13 at 89,692,543 bp
  • A to T, chromosome 14 at 30,895,038 bp
  • G to A, chromosome 14 at 54,884,634 bp
  • C to T, chromosome 14 at 70,164,779 bp
  • C to T, chromosome 15 at 47,614,084 bp
  • C to T, chromosome 15 at 82,406,068 bp
  • T to C, chromosome 17 at 21,129,364 bp
  • A to G, chromosome 17 at 33,549,540 bp
  • C to T, chromosome 17 at 33,937,262 bp
  • T to C, chromosome 17 at 34,264,860 bp
  • A to T, chromosome 19 at 12,229,312 bp
  • T to C, chromosome 19 at 17,003,826 bp
  • A to T, chromosome 19 at 28,945,783 bp
  • T to C, chromosome X at 7,931,492 bp
  • A to G, chromosome X at 89,932,303 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4042 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040851-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.