Strain Name:
C57BL/6J-MtgxR4170Btlr/Mmmh
Stock Number:
040863-MU
Citation ID:
RRID:MMRRC_040863-MU
Other Names:
R4170 (G1), C57BL/6J-MtgxR4170Btlr
Major Collection:

Gene Information

Tnrc6b
Name: trinucleotide repeat containing 6b
Synonyms: A730065C02Rik, D230019K20Rik, 2700090M07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 213988
VEGA: 15
Homologene: 66194
Ptf1a
Name: pancreas specific transcription factor, 1a
Synonyms: PTF1-p48, bHLHa29
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 19213
Homologene: 10304
Gdf6
Name: growth differentiation factor 6
Synonyms: BMP13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242316
HGNC: HGNC:4221
Homologene: 40883
Sptan1
Name: spectrin alpha, non-erythrocytic 1
Synonyms: alpha-fodrin, Spna-2, 2610027H02Rik, Spna2, alphaII-spectrin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 20740
Homologene: 2353
Zfp7
Name: zinc finger protein 7
Synonyms: Krox-2, Zfp-7, Zfp65, mszf73-2, KRAB7, Zfp80, KRAB20, Zfp86-rs1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223669
VEGA: 15
Homologene: 20729
Efr3a
Name: EFR3 homolog A
Synonyms: A130089M23Rik, D030063F01Rik, C920006C10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 76740
Homologene: 44222
Phf3
Name: PHD finger protein 3
Synonyms: 2310061N19Rik, AU020177
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 213109
HGNC: HGNC:8921
Homologene: 9040
Diaph3
Name: diaphanous related formin 3
Synonyms: p134MDia2, mDia2, 4930417P13Rik, Drf3, Diap3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 56419
VEGA: 14
Homologene: 84829
Ercc6
Name: excision repair cross-complementing rodent repair deficiency, complementation group 6
Synonyms: CS group B correcting gene, CSB, C130058G22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 319955
VEGA: 14
HGNC: HGNC:3438
Homologene: 133552
Tut4
Name: terminal uridylyl transferase 4
Synonyms: 6030404K05Rik, 9230115F04Rik, Tent3a, Zcchc11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230594
Homologene: 35279
Prmt3
Name: protein arginine N-methyltransferase 3
Synonyms: 2410018A17Rik, 2010005E20Rik, Hrmt1l3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 71974
Homologene: 24255
Rttn
Name: rotatin
Synonyms: 4921538A15Rik, C530033I08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 246102
VEGA: 18
Homologene: 65275
Dock7
Name: dedicator of cytokinesis 7
Synonyms: 3110056M06Rik, LOC242555, m
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 67299
Homologene: 23566
Sox2
Name: SRY (sex determining region Y)-box 2
Synonyms: Sox-2, lcc, ysb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 20674
Homologene: 68298
Acsbg2
Name: acyl-CoA synthetase bubblegum family member 2
Synonyms: Bgr
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 328845
Homologene: 57133
Smarcd1
Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
Synonyms: Baf60a, D15Kz1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 83797
VEGA: 15
Homologene: 20670
Man2c1
Name: mannosidase, alpha, class 2C, member 1
Synonyms: 1110025H24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 73744
HGNC: HGNC:6827
Homologene: 4887
Gzmn
Name: granzyme N
Synonyms: GrN
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 245839
VEGA: 14
HGNC: HGNC:4709
Homologene: 87221
Zfp804a
Name: zinc finger protein 804A
Synonyms: C630007C17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241514
Homologene: 18461
Cacna1s
Name: calcium channel, voltage-dependent, L type, alpha 1S subunit
Synonyms: Cchl1a3, fmd, mdg, sj, muscle dysgenesis, Cav1.1, DHPR alpha1s
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12292
HGNC: HGNC:1397
Homologene: 37257
Mmp23
Name: matrix metallopeptidase 23
Synonyms: cysteine array matrix metalloproteinase, CA-MMP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 26561
HGNC: HGNC:7171
Homologene: 3424
Tm6sf1
Name: transmembrane 6 superfamily member 1
Synonyms: C630016D09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 107769
Homologene: 11305
Krt81
Name: keratin 81
Synonyms: Krt2-19
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 64818
VEGA: 15
HGNC: HGNC:6458
Homologene: 55645
Or1j17
Name: olfactory receptor family 1 subfamily J member 17
Synonyms: GA_x6K02T2NLDC-33382467-33383396, MOR136-11, Olfr346
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258940
Homologene: 133616
Zbtb46
Name: zinc finger and BTB domain containing 46
Synonyms: 4933406L05Rik, 2610019F01Rik, Btbd4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 72147
Homologene: 81908
Slc5a7
Name: solute carrier family 5 (choline transporter), member 7
Synonyms: CHT1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 63993
VEGA: 17
Homologene: 32516
Ptpru
Name: protein tyrosine phosphatase, receptor type, U
Synonyms: Ptprl, RPTPlambda
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 19273
HGNC: HGNC:9683
Homologene: 4168
Slc9a9
Name: solute carrier family 9 (sodium/hydrogen exchanger), member 9
Synonyms: 5730527A11Rik, Nhe9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 331004
Homologene: 69753
Elk3
Name: ELK3, member of ETS oncogene family
Synonyms: Erp, Sap-2, Net, D430049E23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 13713
HGNC: HGNC:3325
Homologene: 3833
Rexo5
Name: RNA exonuclease 5
Synonyms: 2610020H08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 434234
Homologene: 12803
Or5p58
Name: olfactory receptor family 5 subfamily P member 58
Synonyms: GA_x6K02T2PBJ9-10424354-10423383, MOR204-14, Olfr482
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258728
Homologene: 133604
Hook3
Name: hook microtubule tethering protein 3
Synonyms: E330005F07Rik, 5830454D03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 320191
Homologene: 13022
Get1
Name: guided entry of tail-anchored proteins factor 1
Synonyms: C030018G21Rik, Chd5, 5530402J05Rik, Wrb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 71446
Homologene: 37945
Abhd16a
Name: abhydrolase domain containing 16A
Synonyms: Bat5, NG26, D17H6S82E
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 193742
Homologene: 10904
Lysmd3
Name: LysM, putative peptidoglycan-binding, domain containing 3
Synonyms: 1110030H10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 80289
VEGA: 13
Homologene: 12722
Rtkn
Name: rhotekin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 20166
Homologene: 7522
4930486I03Rik
Name: RIKEN cDNA 4930486I03 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 75028
Trav16n
Name: T cell receptor alpha variable 16n
Synonyms: Gm16837
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 100126459
Ndufa11b
Name: NADH:ubiquinone oxidoreductase subunit A11B
Synonyms: Gm4943
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 239760
Homologene: 17926
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 20,392,236 bp
  • G to A, chromosome 1 at 30,816,458 bp
  • A to G, chromosome 1 at 136,108,195 bp
  • C to T, chromosome 2 at 19,447,008 bp
  • T to C, chromosome 2 at 30,030,025 bp
  • C to A, chromosome 2 at 36,688,722 bp
  • T to A, chromosome 2 at 82,253,488 bp
  • T to C, chromosome 2 at 181,424,355 bp
  • A to T, chromosome 3 at 34,650,554 bp
  • A to G, chromosome 4 at 9,859,650 bp
  • T to A, chromosome 4 at 98,966,401 bp
  • A to G, chromosome 4 at 108,548,059 bp
  • A to T, chromosome 4 at 131,776,348 bp
  • C to T, chromosome 4 at 155,651,310 bp
  • T to G, chromosome 6 at 83,142,395 bp
  • G to T, chromosome 7 at 49,826,776 bp
  • A to G, chromosome 7 at 81,871,448 bp
  • T to A, chromosome 7 at 108,095,073 bp
  • A to G, chromosome 7 at 119,827,398 bp
  • T to A, chromosome 8 at 26,095,787 bp
  • A to G, chromosome 9 at 57,138,026 bp
  • A to G, chromosome 9 at 95,228,899 bp
  • A to G, chromosome 10 at 93,265,335 bp
  • C to T, chromosome 13 at 81,669,410 bp
  • T to C, chromosome 14 at 32,566,797 bp
  • A to T, chromosome 14 at 53,346,418 bp
  • T to C, chromosome 14 at 56,166,804 bp
  • T to C, chromosome 14 at 86,985,707 bp
  • T to A, chromosome 15 at 65,845,982 bp
  • T to C, chromosome 15 at 76,891,618 bp
  • T to A, chromosome 15 at 80,916,787 bp
  • T to C, chromosome 15 at 99,707,931 bp
  • T to A, chromosome 15 at 101,461,312 bp
  • A to T, chromosome 16 at 22,053,775 bp
  • G to A, chromosome 16 at 96,152,976 bp
  • A to G, chromosome 17 at 35,100,361 bp
  • T to C, chromosome 17 at 54,276,858 bp
  • G to A, chromosome 17 at 56,853,846 bp
  • T to A, chromosome 18 at 88,975,723 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4170 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040863-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.