Strain Name:
C57BL/6J-MtgxR3783Btlr/Mmmh
Stock Number:
040875-MU
Citation ID:
RRID:MMRRC_040875-MU
Other Names:
R3783 (G1), C57BL/6J-MtgxR3783Btlr
Major Collection:

Strain Information

Sall4
Name: spalt like transcription factor 4
Synonyms: Tex20, 5730441M18Rik, C330011P20Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 99377
Homologene: 10716
Pdpk1
Name: 3-phosphoinositide dependent protein kinase 1
Synonyms: Pkb kinase, Pdk1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 18607
Homologene: 37643
Neurod1
Name: neurogenic differentiation 1
Synonyms: Neurod, Nd1, bHLHa3, BETA2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18012
HGNC: HGNC:7762
Homologene: 1871
Ptch1
Name: patched 1
Synonyms: wig, Ptc, A230106A15Rik, Ptc1, Patched 1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 19206
HGNC: HGNC:9585
Homologene: 223
Thbs4
Name: thrombospondin 4
Synonyms: TSP-4, TSP4
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 21828
Homologene: 20691
Kdm5b
Name: lysine demethylase 5B
Synonyms: Rb-Bp2, 2210016I17Rik, Jarid1b, 2010009J12Rik, D1Ertd202e, Plu1, PLU-1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 75605
Homologene: 48448
Xrn1
Name: 5'-3' exoribonuclease 1
Synonyms: Dhm2, mXrn1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 24127
Homologene: 5894
Fancd2
Name: Fanconi anemia, complementation group D2
Synonyms: 2410150O07Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 211651
HGNC: HGNC:3585
Homologene: 13212
Pmepa1
Name: prostate transmembrane protein, androgen induced 1
Synonyms: N4wbp4, STAG1, PMEPA1, Tmepai, 2210418I02Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 65112
Homologene: 10608
Fryl
Name: FRY like transcription coactivator
Synonyms: 2310004H21Rik, 9030227G01Rik, 2510002A14Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 72313
Homologene: 103956
Inpp5k
Name: inositol polyphosphate 5-phosphatase K
Synonyms: C62, Pps, putative PI-5-phosphatase, PI-5-phosphatase related
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 19062
Homologene: 75059
Ascc3
Name: activating signal cointegrator 1 complex subunit 3
Synonyms: B630009I04Rik, Helic1, ASC1p200
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 77987
VEGA: 10
Homologene: 4973
Flnb
Name: filamin, beta
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 286940
HGNC: HGNC:3755
Homologene: 37480
Ccdc93
Name: coiled-coil domain containing 93
Synonyms: 9230102M16Rik, 4633402D15Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 70829
Homologene: 10393
Heatr1
Name: HEAT repeat containing 1
Synonyms: B130016L12Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 217995
VEGA: 13
Homologene: 34562
Dmxl1
Name: Dmx-like 1
Synonyms: C630007L23Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 240283
HGNC: HGNC:2937
Homologene: 21136
Mdn1
Name: midasin AAA ATPase 1
Synonyms: 4833432B22Rik, LOC213784, D4Abb1e
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100019
Homologene: 39689
Xdh
Name: xanthine dehydrogenase
Synonyms: XO, Xox1, Xor, Xox-1, xanthine oxidase
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 22436
VEGA: 17
Homologene: 324
Wap
Name: whey acidic protein
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 22373
Homologene: 137242
Isy1
Name: ISY1 splicing factor homolog
Synonyms: 5830446M03Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 57905
Homologene: 6283
Usf2
Name: upstream transcription factor 2
Synonyms: bHLHb12, Usf-2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22282
Homologene: 2527
C6
Name: complement component 6
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 12274
HGNC: HGNC:1339
Homologene: 47
Scn10a
Name: sodium channel, voltage-gated, type X, alpha
Synonyms: Nav1.8
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20264
VEGA: 9
Homologene: 21300
Atp13a3
Name: ATPase type 13A3
Synonyms: LOC224087, LOC224088, LOC385637
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224088
Homologene: 23455
Map3k1
Name: mitogen-activated protein kinase kinase kinase 1
Synonyms: MEKK1, Mekk
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 26401
HGNC: HGNC:6848
Homologene: 8056
Rala
Name: v-ral simian leukemia viral oncogene A (ras related)
Synonyms: 3010001O15Rik, Ral, Rasl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 56044
HGNC: HGNC:9839
Homologene: 3942
Psmd4
Name: proteasome (prosome, macropain) 26S subunit, non-ATPase, 4
Synonyms: Mcb1, multiubiquitin-chain-binding protein, angiocidin, Af1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 19185
HGNC: HGNC:9561
Homologene: 55691
Synrg
Name: synergin, gamma
Synonyms: L71-5, Ap1gbp1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217030
HGNC: HGNC:557
Homologene: 105680
Plxna2
Name: plexin A2
Synonyms: OCT, Plxn2, 2810428A13Rik, PlexA2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18845
HGNC: HGNC:9100
Homologene: 56427
Myo15a
Name: myosin XVA
Synonyms: Myo15
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17910
HGNC: HGNC:7594
Homologene: 56504
Akap6
Name: A kinase anchor protein 6
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238161
VEGA: 12
HGNC: HGNC:376
Homologene: 3157
Magi2
Name: membrane associated guanylate kinase, WW and PDZ domain containing 2
Synonyms: S-SCAM, Acvrinp1, Magi-2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 50791
Homologene: 8189
Tro
Name: trophinin
Synonyms: Maged3, magphinin-gamma, Maged3l, magphinin-beta 2, magphinin, Trol, necdin and trophinin like, magphinin-alpha, Tnn, trophinin-2
Type: Gene
Species: Mouse
Chromosome: X
NCBI: 56191
Homologene: 75113
Carmil3
Name: capping protein regulator and myosin 1 linker 3
Synonyms: Lrrc16b
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 268747
VEGA: 14
Homologene: 74564
Aoc1
Name: amine oxidase, copper-containing 1
Synonyms: 1600012D06Rik, Abp1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 76507
HGNC: HGNC:80
Homologene: 68159
Tmprss9
Name: transmembrane protease, serine 9
Synonyms: Serase-1B
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 432478
VEGA: 10
Homologene: 115302
Niban1
Name: niban apoptosis regulator 1
Synonyms: Niban, Fam129a
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 63913
Homologene: 62170
Cpt1b
Name: carnitine palmitoyltransferase 1b, muscle
Synonyms: M-CPTI, Cpt1, M-CPT I
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 12895
HGNC: HGNC:2329
Homologene: 22548
Ttbk2
Name: tau tubulin kinase 2
Synonyms: 2610507N02Rik, B930008N24Rik, TTK
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 140810
Homologene: 62795
Thoc5
Name: THO complex 5
Synonyms: 1700060C24Rik, Fmip, PK1.3, A430085L24Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 107829
Homologene: 37836
Psg27
Name: pregnancy-specific beta-1-glycoprotein 27
Synonyms: cea15, EG545925
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 545925
Homologene: 110989
Tekt1
Name: tektin 1
Synonyms: MT14
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 21689
Homologene: 7973
1700012B07Rik
Name: RIKEN cDNA 1700012B07 gene
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 69324
Homologene: 78000
Abraxas1
Name: BRCA1 A complex subunit
Synonyms: Fam175a, 5630400M01Rik, 3830405G04Rik, Ccdc98
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 70681
Homologene: 16376
Gml
Name: glycosylphosphatidylinositol anchored molecule like
Synonyms: EG625599
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 625599
HGNC: HGNC:4375
Homologene: 48071
Cyp4f14
Name: cytochrome P450, family 4, subfamily f, polypeptide 14
Synonyms: 1300014O15Rik, leukotriene B4 omega hydroxylase
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 64385
VEGA: 17
Homologene: 81872
Nsa2
Name: NSA2 ribosome biogenesis homolog
Synonyms: Yr29, LNR42, 5730427N09Rik, Nsa2p
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 59050
VEGA: 13
Homologene: 5844
Gpr174
Name: G protein-coupled receptor 174
Synonyms: LOC213439
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 213439
Homologene: 13059
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 121,437,869 bp
  • A to G, chromosome 1 at 134,630,542 bp
  • C to T, chromosome 1 at 151,689,648 bp
  • T to A, chromosome 1 at 194,807,521 bp
  • T to A, chromosome 2 at 79,454,595 bp
  • A to T, chromosome 2 at 120,773,815 bp
  • A to G, chromosome 2 at 168,756,123 bp
  • G to A, chromosome 2 at 173,228,133 bp
  • T to C, chromosome 3 at 95,035,251 bp
  • A to T, chromosome 4 at 32,720,818 bp
  • C to T, chromosome 5 at 20,465,909 bp
  • T to C, chromosome 5 at 73,101,476 bp
  • A to G, chromosome 5 at 100,806,902 bp
  • T to C, chromosome 6 at 48,905,655 bp
  • T to C, chromosome 6 at 87,821,545 bp
  • T to G, chromosome 6 at 113,565,204 bp
  • T to A, chromosome 7 at 18,560,354 bp
  • A to G, chromosome 7 at 30,955,831 bp
  • G to T, chromosome 9 at 95,969,285 bp
  • T to C, chromosome 9 at 119,691,562 bp
  • A to G, chromosome 10 at 50,728,254 bp
  • G to T, chromosome 10 at 80,887,467 bp
  • A to G, chromosome 11 at 4,920,372 bp
  • G to A, chromosome 11 at 6,638,550 bp
  • A to T, chromosome 11 at 60,477,572 bp
  • A to G, chromosome 11 at 72,344,894 bp
  • T to C, chromosome 11 at 75,647,686 bp
  • T to C, chromosome 11 at 84,001,920 bp
  • G to T, chromosome 11 at 109,794,154 bp
  • A to G, chromosome 12 at 52,880,769 bp
  • G to T, chromosome 13 at 12,434,460 bp
  • T to A, chromosome 13 at 17,882,446 bp
  • T to G, chromosome 13 at 63,524,959 bp
  • T to C, chromosome 13 at 92,773,164 bp
  • G to T, chromosome 13 at 97,135,534 bp
  • C to T, chromosome 13 at 111,756,220 bp
  • T to G, chromosome 14 at 7,889,236 bp
  • T to C, chromosome 14 at 55,496,976 bp
  • A to G, chromosome 15 at 4,808,207 bp
  • C to T, chromosome 15 at 74,813,672 bp
  • T to C, chromosome 15 at 89,425,189 bp
  • A to T, chromosome 16 at 30,354,249 bp
  • T to C, chromosome 17 at 24,110,850 bp
  • A to G, chromosome 17 at 32,916,762 bp
  • C to T, chromosome 17 at 73,893,595 bp
  • G to A, chromosome 18 at 49,865,122 bp
  • A to G, chromosome X at 107,293,064 bp
  • G to A, chromosome X at 150,655,052 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3783 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040875-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.