Strain Name:
C57BL/6J-MtgxR3784Btlr/Mmmh
Stock Number:
040876-MU
Citation ID:
RRID:MMRRC_040876-MU
Other Names:
R3784 (G1), C57BL/6J-MtgxR3784Btlr
Major Collection:

Gene Information

Sall4
Name: spalt like transcription factor 4
Synonyms: 5730441M18Rik, Tex20, C330011P20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 99377
Homologene: 10716
Ptprz1
Name: protein tyrosine phosphatase, receptor type Z, polypeptide 1
Synonyms: DSD-1-PG, phosphacan, PTPzeta, PTPbeta, Rptpbeta, Ptpz, Ptprz, RPTPz
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 19283
HGNC: HGNC:9685
Homologene: 2136
Ank2
Name: ankyrin 2, brain
Synonyms: ankyrin B, Ank-2, Ankyrin-2, Ankyrin-B, Gm4392
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 109676
HGNC: HGNC:493
Col3a1
Name: collagen, type III, alpha 1
Synonyms: Col3a-1, Tsk-2, Tsk2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12825
HGNC: HGNC:2201
Homologene: 55433
Ptch1
Name: patched 1
Synonyms: Ptc, Patched 1, Ptc1, A230106A15Rik, wig
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 19206
HGNC: HGNC:9585
Homologene: 223
Thbs4
Name: thrombospondin 4
Synonyms: TSP-4, TSP4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 21828
Homologene: 20691
Pmepa1
Name: prostate transmembrane protein, androgen induced 1
Synonyms: N4wbp4, 2210418I02Rik, PMEPA1, STAG1, Tmepai
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 65112
Homologene: 10608
Inpp5k
Name: inositol polyphosphate 5-phosphatase K
Synonyms: C62, PI-5-phosphatase related, putative PI-5-phosphatase, Pps
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 19062
Homologene: 75059
Prtg
Name: protogenin
Synonyms: A230098A12Rik, Igdcc5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235472
Homologene: 54453
Senp6
Name: SUMO/sentrin specific peptidase 6
Synonyms: E130319N12Rik, 2810017C20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 215351
Homologene: 9196
Taf15
Name: TATA-box binding protein associated factor 15
Synonyms: TAFII68, 2610111C21Rik, Taf2n, 68kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 70439
Homologene: 131088
Prmt7
Name: protein arginine N-methyltransferase 7
Synonyms: 4933402B05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 214572
Homologene: 10382
Drosha
Name: drosha, ribonuclease type III
Synonyms: 1110013A17Rik, Etohi2, Rnasen
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 14000
Homologene: 8293
Prrc2c
Name: proline-rich coiled-coil 2C
Synonyms: 9630039I18Rik, 1810043M20Rik, Bat2d, Bat2l2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226562
Homologene: 41015
Mical3
Name: microtubule associated monooxygenase, calponin and LIM domain containing 3
Synonyms: MICAL-3, C130040D16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 194401
Homologene: 85288
Heatr1
Name: HEAT repeat containing 1
Synonyms: B130016L12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 217995
VEGA: 13
Homologene: 34562
Rad51b
Name: RAD51 paralog B
Synonyms: mREC2, R51H2, Rad51b, Rad51l1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 19363
VEGA: 12
HGNC: HGNC:9822
Homologene: 50190
3110082I17Rik
Name: RIKEN cDNA 3110082I17 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 73212
Homologene: 49901
Hook1
Name: hook microtubule tethering protein 1
Synonyms: azh, abnormal spermatozoon head shape, A930033L17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 77963
Homologene: 9289
Iars2
Name: isoleucine-tRNA synthetase 2, mitochondrial
Synonyms: 2010002H18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 381314
Homologene: 7118
Adam11
Name: a disintegrin and metallopeptidase domain 11
Synonyms: Mdc
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 11488
HGNC: HGNC:189
Homologene: 7614
Rala
Name: v-ral simian leukemia viral oncogene A (ras related)
Synonyms: Ral, 3010001O15Rik, Rasl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 56044
HGNC: HGNC:9839
Homologene: 3942
C3
Name: complement component 3
Synonyms: complement factor 3, acylation stimulating protein, Plp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 12266
HGNC: HGNC:1318
Homologene: 68031
Inpp5b
Name: inositol polyphosphate-5-phosphatase B
Synonyms: 75kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 16330
HGNC: HGNC:6077
Homologene: 69021
Synrg
Name: synergin, gamma
Synonyms: L71-5, Ap1gbp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217030
HGNC: HGNC:557
Homologene: 105680
Tubb6
Name: tubulin, beta 6 class V
Synonyms: 2310057H16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 67951
VEGA: 18
Homologene: 69414
Plxna2
Name: plexin A2
Synonyms: OCT, Plxn2, 2810428A13Rik, PlexA2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 18845
HGNC: HGNC:9100
Homologene: 56427
Olfml2b
Name: olfactomedin-like 2B
Synonyms: 1110018N05Rik, 4832415H08Rik, photomedin-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 320078
Homologene: 18546
Myo15
Name: myosin XV
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 17910
HGNC: HGNC:7594
Homologene: 56504
Spats2l
Name: spermatogenesis associated, serine-rich 2-like
Synonyms: A230104H11Rik, 2810022L02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 67198
Homologene: 56711
Fat2
Name: FAT atypical cadherin 2
Synonyms: LOC245827, mKIAA0811, Fath2, EMI2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 245827
HGNC: HGNC:3596
Homologene: 1110
Eif3f
Name: eukaryotic translation initiation factor 3, subunit F
Synonyms: 0610037M02Rik, Eif3s5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 66085
HGNC: HGNC:3275
Homologene: 2783
Ncoa6
Name: nuclear receptor coactivator 6
Synonyms: PRIP, ASC2, RAP250, AIB3, NRC, ASC-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 56406
Homologene: 137337
Cfap206
Name: cilia and flagella associated protein 206
Synonyms: 1700003M02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 69329
Homologene: 18713
Klra8
Name: killer cell lectin-like receptor, subfamily A, member 8
Synonyms: Ly49h, Cmv-1, Cmv1, Ly49u129
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 16639
Homologene: 110821
Armc2
Name: armadillo repeat containing 2
Synonyms: 2610018I05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 213402
Homologene: 41848
Foxg1
Name: forkhead box G1
Synonyms: BF-1, Hfh9, Hfhbf1, Bf1, 2900064B05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 15228
HGNC: HGNC:3811
Homologene: 3843
Atp8a2
Name: ATPase, aminophospholipid transporter-like, class I, type 8A, member 2
Synonyms: Ib, wl, agil
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 50769
Homologene: 4443
Plekhg3
Name: pleckstrin homology domain containing, family G (with RhoGef domain) member 3
Synonyms: MGC40768
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 263406
VEGA: 12
Homologene: 77478
Psg27
Name: pregnancy-specific glycoprotein 27
Synonyms: cea15, EG545925
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 545925
Homologene: 110989
Tekt1
Name: tektin 1
Synonyms: MT14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 21689
Homologene: 7973
Vmn1r200
Name: vomeronasal 1 receptor 200
Synonyms: V1rh3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 171246
Homologene: 110880
Fam161b
Name: family with sequence similarity 161, member B
Synonyms: 9830169C18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217705
Homologene: 17581
1700012B07Rik
Name: RIKEN cDNA 1700012B07 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 69324
Homologene: 78000
Txndc16
Name: thioredoxin domain containing 16
Synonyms: 5730420B22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 70561
Homologene: 18197
Nsa2
Name: NSA2 ribosome biogenesis homolog
Synonyms: LNR42, Yr29, Nsa2p, 5730427N09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 59050
VEGA: 13
Homologene: 5844
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 45,347,135 bp
  • A to G, chromosome 1 at 57,885,779 bp
  • T to C, chromosome 1 at 162,709,669 bp
  • A to G, chromosome 1 at 170,681,982 bp
  • T to C, chromosome 1 at 185,287,131 bp
  • T to A, chromosome 1 at 194,644,617 bp
  • G to A, chromosome 2 at 155,407,757 bp
  • A to G, chromosome 2 at 168,756,123 bp
  • G to A, chromosome 2 at 173,228,133 bp
  • A to G, chromosome 3 at 126,953,193 bp
  • A to T, chromosome 4 at 34,716,445 bp
  • T to C, chromosome 4 at 95,989,651 bp
  • G to A, chromosome 4 at 124,743,748 bp
  • G to T, chromosome 5 at 139,455,442 bp
  • T to C, chromosome 6 at 23,016,243 bp
  • T to C, chromosome 6 at 121,021,337 bp
  • T to A, chromosome 6 at 130,125,055 bp
  • T to A, chromosome 7 at 18,560,354 bp
  • G to A, chromosome 7 at 108,941,017 bp
  • C to A, chromosome 8 at 106,242,136 bp
  • A to G, chromosome 9 at 72,854,942 bp
  • T to G, chromosome 9 at 80,092,286 bp
  • T to C, chromosome 10 at 41,922,194 bp
  • C to T, chromosome 11 at 55,256,186 bp
  • A to T, chromosome 11 at 60,477,572 bp
  • A to G, chromosome 11 at 72,344,894 bp
  • T to C, chromosome 11 at 75,647,686 bp
  • G to A, chromosome 11 at 83,506,422 bp
  • T to C, chromosome 11 at 84,001,920 bp
  • T to C, chromosome 11 at 102,774,367 bp
  • G to T, chromosome 11 at 109,794,154 bp
  • A to G, chromosome 12 at 49,385,599 bp
  • T to C, chromosome 12 at 76,560,520 bp
  • C to T, chromosome 12 at 79,300,645 bp
  • A to T, chromosome 12 at 84,361,690 bp
  • G to T, chromosome 13 at 12,434,460 bp
  • T to A, chromosome 13 at 17,882,446 bp
  • A to T, chromosome 13 at 22,395,855 bp
  • T to G, chromosome 13 at 63,524,959 bp
  • T to C, chromosome 13 at 92,773,164 bp
  • G to T, chromosome 13 at 97,135,534 bp
  • A to T, chromosome 14 at 45,165,886 bp
  • A to T, chromosome 14 at 59,773,966 bp
  • A to G, chromosome 15 at 12,890,529 bp
  • A to G, chromosome 17 at 57,226,067 bp
  • A to G, chromosome 18 at 67,392,993 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3784 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040876-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.