Strain Name:
C57BL/6J-MtgxR3835Btlr/Mmmh
Stock Number:
040890-MU
Citation ID:
RRID:MMRRC_040890-MU
Other Names:
R3835 (G1), C57BL/6J-MtgxR3835Btlr
Major Collection:

Strain Information

Eno1
Name: enolase 1, alpha non-neuron
Synonyms: MBP-1, alpha-enolase, Eno-1, 2-phospho-D-glycerate hydrolase, c-Myc promoter binding protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 13806
HGNC: HGNC:3350
Homologene: 134343
Apoa5
Name: apolipoprotein A-V
Synonyms: Apoav, 1300007O05Rik, RAP3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 66113
Homologene: 14197
Vldlr
Name: very low density lipoprotein receptor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 22359
Homologene: 443
Tagln
Name: transgelin
Synonyms: Sm22a, SM22, SM-22 alpha, SM22alpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 21345
VEGA: 9
Homologene: 2398
Prkdc
Name: protein kinase, DNA activated, catalytic polypeptide
Synonyms: XRCC7, DOXNPH, dxnph, DNAPDcs, slip, DNA-PKcs, DNA-PK
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 19090
HGNC: HGNC:9413
Homologene: 5037
Rad54l
Name: RAD54 like (S. cerevisiae)
Synonyms: RAD54
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 19366
HGNC: HGNC:9826
Homologene: 48227
Setx
Name: senataxin
Synonyms: A930037J23Rik, Als4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 269254
HGNC: HGNC:445
Homologene: 41003
Supt5
Name: suppressor of Ty 5, DSIF elongation factor subunit
Synonyms: Supt5h, Spt5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 20924
Homologene: 2384
Stag1
Name: STAG1 cohesin complex component
Synonyms: SA-1, Scc3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 20842
Homologene: 21191
Apaf1
Name: apoptotic peptidase activating factor 1
Synonyms: Apaf1l, 6230400I06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 11783
HGNC: HGNC:576
Homologene: 7626
Anapc7
Name: anaphase promoting complex subunit 7
Synonyms: APC7, prediabetic NOD sera-reactive autoantigen
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 56317
Homologene: 10512
Tasor2
Name: transcription activation suppressor family member 2
Synonyms: Fam208b, BC016423
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 105203
VEGA: 13
Homologene: 26435
Kcnh5
Name: potassium voltage-gated channel, subfamily H (eag-related), member 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 238271
VEGA: 12
HGNC: HGNC:6254
Homologene: 15858
Adgrl4
Name: adhesion G protein-coupled receptor L4
Synonyms: Eltd1, 1110033N21Rik, Etl, EGF-TM7 receptor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 170757
Homologene: 11170
Btnl9
Name: butyrophilin-like 9
Synonyms: D330012D11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 237754
Homologene: 68540
Qtrt2
Name: queuine tRNA-ribosyltransferase accessory subunit 2
Synonyms: Qrtr2, 4930470H18Rik, Qtrtd1, 3110012M05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 106248
Homologene: 41576
Gipc2
Name: GIPC PDZ domain containing family, member 2
Synonyms: Semcap2, 2200002N01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 54120
Homologene: 22994
Txnip
Name: thioredoxin interacting protein
Synonyms: THIF, mVDUP1, Hyplip1, VDUP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 56338
Homologene: 38186
Ttc16
Name: tetratricopeptide repeat domain 16
Synonyms: 1200002K10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 338348
Homologene: 17011
Bltp2
Name: bridge-like lipid transfer protein family member 2
Synonyms: 2610507B11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 72503
Homologene: 34730
Snrk
Name: SNF related kinase
Synonyms: 2010012F07Rik, SNRK
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 20623
Homologene: 9797
Nalcn
Name: sodium leak channel, non-selective
Synonyms: A530023G15Rik, Vgcnl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 338370
VEGA: 14
Homologene: 21832
Prmt6
Name: protein arginine N-methyltransferase 6
Synonyms: Hrmt1l6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 99890
Homologene: 10024
Lrrc37
Name: leucine rich repeat containing 37
Synonyms: LOC380730, Gm884
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 380730
Homologene: 134511
Muc5b
Name: mucin 5, subtype B, tracheobronchial
Synonyms: 2300002I04Rik, MUC5, MUC9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 74180
HGNC: HGNC:7516
Homologene: 136756
Rpgrip1
Name: retinitis pigmentosa GTPase regulator interacting protein 1
Synonyms: A930002K18Rik, 4930505G06Rik, 4930401L23Rik, nmf247
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 77945
Homologene: 10679
Dennd5a
Name: DENN domain containing 5A
Synonyms: ORF37, 1500012B19Rik, Rab6ip1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 19347
Homologene: 14584
Slc15a2
Name: solute carrier family 15 (H+/peptide transporter), member 2
Synonyms: 8430408C16Rik, Pept2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 57738
Homologene: 56912
Ptprt
Name: protein tyrosine phosphatase receptor type T
Synonyms: RPTPrho
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 19281
HGNC: HGNC:9682
Homologene: 56924
Lrrc10
Name: leucine rich repeat containing 10
Synonyms: Hrlrrp, Serdin1, D330003I11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 237560
VEGA: 10
Homologene: 17154
Dthd1
Name: death domain containing 1
Synonyms: Gm17384
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 100322896
Homologene: 123510
Nnt
Name: nicotinamide nucleotide transhydrogenase
Synonyms: 4930423F13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 18115
HGNC: HGNC:7863
Tbx18
Name: T-box18
Synonyms: 2810404D13Rik, 2810012F10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 76365
Homologene: 11384
St6galnac1
Name: ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1
Synonyms: Siat7a, ST6GalNAc I
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 20445
Homologene: 7937
Gm3486
Name: predicted gene 3486
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Ovgp1
Name: oviductal glycoprotein 1
Synonyms: MOGP, oviductin, muc9, mucin 9, OGP, Chit5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 12659
HGNC: HGNC:8524
Homologene: 74442
Nmt2
Name: N-myristoyltransferase 2
Synonyms: A930001K02Rik, hNMT-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 18108
HGNC: HGNC:7858
Homologene: 101539
Vmn2r24
Name: vomeronasal 2, receptor 24
Synonyms: EG243628
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 243628
Homologene: 135915
Meis2
Name: Meis homeobox 2
Synonyms: A430109D20Rik, Meis2, Stra10, Mrg1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 17536
HGNC: HGNC:7001
Homologene: 7846
Or4d6
Name: olfactory receptor family 4 subfamily D member 6
Synonyms: Olfr1428, MOR239-5, GA_x6K02T2RE5P-2468394-2467450
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 258673
Homologene: 17339
Or5b109
Name: olfactory receptor family 5 subfamily B member 109
Synonyms: Olfr1463, MOR202-29P, GA_x6K02T2RE5P-3560863-3561795
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 258120
HGNC: HGNC:8324
Homologene: 133886
Cimip3
Name: ciliary microtubule inner protein 3
Synonyms: 1700001C19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 75462
Homologene: 129540
Adh6a
Name: alcohol dehydrogenase 6A (class V)
Synonyms: Adh5a, 1810009C16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 69117
Homologene: 66291
Gpt
Name: glutamic pyruvic transaminase, soluble
Synonyms: ALT, Gpt1, 2310022B03Rik, Gpt-1, 1300007J06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 76282
VEGA: 15
HGNC: HGNC:4552
Homologene: 134231
Ap5b1
Name: adaptor-related protein complex 5, beta 1 subunit
Synonyms: Gm962
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 381201
VEGA: 19
Homologene: 16299
Or4a79
Name: olfactory receptor family 4 subfamily A member 79
Synonyms: Olfr1252, MOR231-22_p, GA_x6K02T2Q125-51162884-51161940
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 404331
Homologene: 128094
Rab9b
Name: RAB9B, member RAS oncogene family
Synonyms: 9330195C02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 319642
Homologene: 3136
Xlr3a
Name: X-linked lymphocyte-regulated 3A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 22445
Homologene: 40784
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 2 at 3,314,686 bp
  • C to T, chromosome 2 at 29,145,060 bp
  • T to C, chromosome 2 at 32,769,310 bp
  • T to G, chromosome 2 at 89,721,455 bp
  • T to C, chromosome 2 at 115,921,747 bp
  • A to G, chromosome 2 at 161,547,387 bp
  • C to G, chromosome 3 at 96,559,447 bp
  • A to G, chromosome 3 at 105,986,315 bp
  • T to C, chromosome 3 at 110,250,805 bp
  • G to A, chromosome 3 at 138,327,514 bp
  • T to C, chromosome 3 at 151,510,617 bp
  • C to A, chromosome 3 at 152,128,186 bp
  • A to T, chromosome 4 at 116,098,475 bp
  • T to C, chromosome 4 at 150,246,662 bp
  • A to T, chromosome 5 at 62,849,785 bp
  • A to G, chromosome 5 at 122,443,877 bp
  • G to T, chromosome 6 at 123,787,453 bp
  • A to G, chromosome 7 at 28,315,937 bp
  • T to C, chromosome 7 at 109,934,242 bp
  • A to T, chromosome 7 at 141,859,181 bp
  • T to C, chromosome 9 at 45,931,710 bp
  • A to T, chromosome 9 at 46,270,580 bp
  • C to A, chromosome 9 at 87,729,636 bp
  • C to T, chromosome 9 at 100,737,982 bp
  • T to C, chromosome 9 at 122,137,003 bp
  • G to A, chromosome 10 at 91,059,587 bp
  • A to G, chromosome 10 at 117,045,786 bp
  • T to G, chromosome 11 at 49,180,685 bp
  • A to G, chromosome 11 at 78,279,085 bp
  • C to A, chromosome 11 at 103,620,010 bp
  • T to C, chromosome 11 at 116,766,283 bp
  • T to A, chromosome 12 at 74,898,270 bp
  • T to C, chromosome 13 at 3,575,292 bp
  • C to T, chromosome 13 at 119,372,495 bp
  • A to G, chromosome 14 at 41,487,205 bp
  • A to G, chromosome 14 at 52,147,253 bp
  • A to T, chromosome 14 at 123,293,422 bp
  • A to G, chromosome 15 at 76,698,583 bp
  • A to G, chromosome 16 at 15,791,946 bp
  • A to T, chromosome 16 at 36,772,128 bp
  • A to G, chromosome 16 at 43,881,072 bp
  • AC to A, chromosome 17 at 47,433,423 bp
  • A to G, chromosome 19 at 5,568,890 bp
  • T to A, chromosome 19 at 12,109,400 bp
  • A to T, chromosome 19 at 13,234,739 bp
  • A to G, chromosome 19 at 27,234,814 bp
  • T to C, chromosome X at 73,095,038 bp
  • C to T, chromosome X at 136,861,510 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3835 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040890-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.