Strain Name:
C57BL/6J-MtgxR3846Btlr/Mmmh
Stock Number:
040894-MU
Citation ID:
RRID:MMRRC_040894-MU
Other Names:
R3846 (G1), C57BL/6J-MtgxR3846Btlr
Major Collection:

Strain Information

Iqgap2
Name: IQ motif containing GTPase activating protein 2
Synonyms: 4933417J23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 544963
VEGA: 13
HGNC: HGNC:6111
Homologene: 101543
Phip
Name: pleckstrin homology domain interacting protein
Synonyms: Wdr11, Ndrp, 2810004D21Rik, 4632404O06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 83946
Homologene: 41209
Gapvd1
Name: GTPase activating protein and VPS9 domains 1
Synonyms: 2010005B09Rik, 4432404J10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 66691
Homologene: 32637
Arhgap32
Name: Rho GTPase activating protein 32
Synonyms: p200RhoGAP, GC-GAP, PX-RICS, 3426406O18Rik, Grit
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 330914
Homologene: 8812
Ctnnd1
Name: catenin (cadherin associated protein), delta 1
Synonyms: P120, Ctnnd, p120-catenin, Catns
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 12388
HGNC: HGNC:2515
Homologene: 1017
Apool
Name: apolipoprotein O-like
Synonyms: 6720473G16Rik, E130106L15Rik, 9430083G14Rik, Micos27
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 68117
Homologene: 57144
Ccser2
Name: coiled-coil serine rich 2
Synonyms: 1700012P13Rik, 2900054P12Rik, Gcap14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 72972
Homologene: 10367
Hr
Name: lysine demethylase and nuclear receptor corepressor
Synonyms: N, ba, rh, rh-bmh, bldy
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 15460
HGNC: HGNC:5172
Homologene: 3774
Scyl2
Name: SCY1-like 2 (S. cerevisiae)
Synonyms: D10Ertd802e, CVAK104
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 213326
Homologene: 13349
Ctps
Name: cytidine 5'-triphosphate synthase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 51797
HGNC: HGNC:2519
Homologene: 20446
Ptger2
Name: prostaglandin E receptor 2 (subtype EP2)
Synonyms: EP2, Ptgerep2, EP2 receptor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 19217
HGNC: HGNC:9594
Homologene: 739
Dock2
Name: dedicator of cyto-kinesis 2
Synonyms: MBC, CED-5, Hch
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 94176
HGNC: HGNC:2988
Homologene: 37984
Mov10l1
Name: Mov10 like RISC complex RNA helicase 1
Synonyms: CHAMP, Csm
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 83456
HGNC: HGNC:7201
Homologene: 56835
Cubn
Name: cubilin (intrinsic factor-cobalamin receptor)
Synonyms: D2Wsu88e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 65969
HGNC: HGNC:2548
Homologene: 37434
Hmcn2
Name: hemicentin 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 665700
Homologene: 90772
Ano4
Name: anoctamin 4
Synonyms: A330096O15Rik, Tmem16d
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 320091
Homologene: 66599
Acad10
Name: acyl-Coenzyme A dehydrogenase family, member 10
Synonyms: 2410021P16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 71985
Homologene: 49825
Dnah12
Name: dynein, axonemal, heavy chain 12
Synonyms: Hdhc3, HL-19, DLP12, HL19, DHC3, LOC380889, 4921531P07Rik, Dnahc7l, Dnahc12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 110083
HGNC: HGNC:2943
Homologene: 56821
Lamc3
Name: laminin gamma 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 23928
HGNC: HGNC:6494
Homologene: 21222
Fsip2
Name: fibrous sheath-interacting protein 2
Synonyms: OTTMUSG00000013335
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241516
Homologene: 110349
Nlrp9c
Name: NLR family, pyrin domain containing 9C
Synonyms: Nalp9c, Nalp-zeta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 330490
Homologene: 116072
Ifi207
Name: interferon activated gene 207
Synonyms: AI607873, Pyhin-A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226691
HGNC: HGNC:5395
Homologene: 115929
Adgb
Name: androglobin
Synonyms: 9130014G24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 215772
Homologene: 100289
Adgrg3
Name: adhesion G protein-coupled receptor G3
Synonyms: Pb99, A030001G24Rik, Gpr97
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 54672
Homologene: 18129
4930568D16Rik
Name: RIKEN cDNA 4930568D16 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 75859
Homologene: 86865
Notch4
Name: notch 4
Synonyms: Int-3, Int3, N4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 18132
HGNC: HGNC:7884
Homologene: 3351
Hrnr
Name: hornerin
Synonyms: 1110033K19Rik, A530063N20Rik, S100a18
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 68723
Homologene: 138092
Tkt
Name: transketolase
Synonyms: p68
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 21881
Homologene: 68154
Vmn2r91
Name: vomeronasal 2, receptor 91
Synonyms: EG665210
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 665210
Homologene: 115024
Lgmn
Name: legumain
Synonyms: preprolegumain, Prsc1, AEP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 19141
HGNC: HGNC:9472
Homologene: 38075
Nudt15
Name: nudix hydrolase 15
Synonyms: MTH2, A730068G11Rik, nudix (nucleoside diphosphate linked moiety X)-type motif 15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 214254
VEGA: 14
Homologene: 10109
Vmn2r124
Name: vomeronasal 2, receptor 124
Synonyms: Gm7196, Vmn2r-ps113
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 637021
Homologene: 115024
Itgax
Name: integrin alpha X
Synonyms: CD11C (p150) alpha polypeptide, Cd11c, CR4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 16411
HGNC: HGNC:6152
Homologene: 55493
Or10ag56
Name: olfactory receptor family 10 subfamily AG member 56
Synonyms: GA_x6K02T2Q125-48795705-48796673, MOR264-22, Olfr1118-ps, Olfr1118
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 404328
Homologene: 134077
Gja3
Name: gap junction protein, alpha 3
Synonyms: connexin 46, alpha 3 connexin, Gja-3, Cx46
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 14611
VEGA: 14
HGNC: HGNC:4277
Homologene: 9670
Trpc4
Name: transient receptor potential cation channel, subfamily C, member 4
Synonyms: CCE1, Trp4, STRPC4, Trrp4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 22066
Homologene: 22955
AC155270.1
Name:
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Hdac1-ps
Name: histone deacetylase 1, pseudogene
Synonyms: EG15181, Gm10093
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 15181
VEGA: 17
Or52e7
Name: olfactory receptor family 52 subfamily E member 7
Synonyms: GA_x6K02T2PBJ9-7664016-7664969, MOR32-1, Olfr676
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 259099
Homologene: 64955
Tysnd1
Name: trypsin domain containing 1
Synonyms: 1300019N10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 71767
VEGA: 10
Homologene: 87946
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 173,735,303 bp
  • T to C, chromosome 2 at 13,283,008 bp
  • A to G, chromosome 2 at 31,430,350 bp
  • A to G, chromosome 2 at 31,924,592 bp
  • A to T, chromosome 2 at 34,729,072 bp
  • A to G, chromosome 2 at 35,354,558 bp
  • A to T, chromosome 2 at 82,986,415 bp
  • T to C, chromosome 2 at 84,616,927 bp
  • T to C, chromosome 2 at 87,309,182 bp
  • C to A, chromosome 3 at 54,318,012 bp
  • A to G, chromosome 3 at 93,332,157 bp
  • A to T, chromosome 4 at 120,542,636 bp
  • T to A, chromosome 5 at 121,634,686 bp
  • A to G, chromosome 7 at 26,382,276 bp
  • T to C, chromosome 7 at 105,035,689 bp
  • G to T, chromosome 7 at 128,133,767 bp
  • T to C, chromosome 8 at 95,040,421 bp
  • T to C, chromosome 9 at 32,190,024 bp
  • G to A, chromosome 9 at 82,876,126 bp
  • G to A, chromosome 10 at 10,382,721 bp
  • C to T, chromosome 10 at 61,696,088 bp
  • A to T, chromosome 10 at 88,995,252 bp
  • A to T, chromosome 10 at 89,640,541 bp
  • T to G, chromosome 11 at 34,732,371 bp
  • T to A, chromosome 12 at 27,160,302 bp
  • T to C, chromosome 12 at 102,404,329 bp
  • G to A, chromosome 13 at 95,673,678 bp
  • A to G, chromosome 14 at 26,710,211 bp
  • T to A, chromosome 14 at 30,568,367 bp
  • A to G, chromosome 14 at 36,940,288 bp
  • T to G, chromosome 14 at 44,989,327 bp
  • T to A, chromosome 14 at 57,035,704 bp
  • C to T, chromosome 14 at 70,571,453 bp
  • T to A, chromosome 14 at 73,523,471 bp
  • A to G, chromosome 15 at 89,012,142 bp
  • T to A, chromosome 17 at 18,073,691 bp
  • G to A, chromosome 17 at 18,107,598 bp
  • A to G, chromosome 17 at 34,578,097 bp
  • A to G, chromosome 17 at 78,492,972 bp
  • A to T, chromosome X at 112,364,458 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3846 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040894-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.