Strain Name:
C57BL/6J-MtgxR3849Btlr/Mmmh
Stock Number:
040897-MU
Citation ID:
RRID:MMRRC_040897-MU
Other Names:
R3849 (G1), C57BL/6J-MtgxR3849Btlr
Major Collection:

Strain Information

Foxp4
Name: forkhead box P4
Synonyms: 1200010K03Rik, 2310007G05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 74123
Homologene: 12536
Col3a1
Name: collagen, type III, alpha 1
Synonyms: Col3a-1, Tsk-2, Tsk2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12825
HGNC: HGNC:2201
Homologene: 55433
Dst
Name: dystonin
Synonyms: bullous pemphigoid antigen 1, BPAG1-n, BPAG1, Bpag1, Bpag, ah, bullous pemphigoid antigen 1, athetoid, Macf2, 2310001O04Rik, nmf203, A830042E19Rik, nmf339
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 13518
HGNC: HGNC:1090
Homologene: 136716
Nsd1
Name: nuclear receptor-binding SET-domain protein 1
Synonyms: KMT3B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 18193
VEGA: 13
Homologene: 32543
Chd1
Name: chromodomain helicase DNA binding protein 1
Synonyms: 4930525N21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 12648
HGNC: HGNC:1915
Homologene: 68174
Axin1
Name: axin 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 12005
HGNC: HGNC:903
Homologene: 2614
Plxna1
Name: plexin A1
Synonyms: NOV, Plxn1, 2600013D04Rik, PlexA1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 18844
HGNC: HGNC:9099
Homologene: 56426
Aspm
Name: abnormal spindle microtubule assembly
Synonyms: Sha1, Aspm, D330028K02Rik, MCPH5, Calmbp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12316
Homologene: 7650
Cep170
Name: centrosomal protein 170
Synonyms: 4933426L22Rik, A330004A13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 545389
Homologene: 22844
Abca1
Name: ATP-binding cassette, sub-family A (ABC1), member 1
Synonyms: ABC1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 11303
HGNC: HGNC:29
Homologene: 21130
Nek1
Name: NIMA (never in mitosis gene a)-related expressed kinase 1
Synonyms: kat, kidney, anemia and testis, D8Ertd790e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 18004
HGNC: HGNC:7744
Homologene: 14376
Rnf17
Name: ring finger protein 17
Synonyms: MMIP-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 30054
VEGA: 14
Homologene: 23727
Cul5
Name: cullin 5
Synonyms: 4921514I20Rik, C330021I08Rik, C030032G03Rik, VACM-1, 8430423K24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 75717
HGNC: HGNC:2556
Homologene: 2597
Cacna2d3
Name: calcium channel, voltage-dependent, alpha2/delta subunit 3
Synonyms: alpha 2 delta-3, alpha2delta3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 12294
Homologene: 74929
Lmo7
Name: LIM domain only 7
Synonyms: LOC380928, FBXO20
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 380928
HGNC: HGNC:6646
Homologene: 83924
Fan1
Name: FANCD2/FANCI-associated nuclease 1
Synonyms: 6030441H18Rik, Mtmr15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 330554
Homologene: 45598
Rnf103
Name: ring finger protein 103
Synonyms: kf-1, Zfp103
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 22644
Homologene: 4146
Adamtsl1
Name: ADAMTS-like 1
Synonyms: punctin-1, 6720426B09Rik, 5930437A14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 77739
Homologene: 64642
Cpa4
Name: carboxypeptidase A4
Synonyms: 1110019K20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 71791
Homologene: 56753
Mtr
Name: 5-methyltetrahydrofolate-homocysteine methyltransferase
Synonyms: methionine synthase, MS, D830038K18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 238505
VEGA: 13
HGNC: HGNC:7468
Homologene: 37280
Kif24
Name: kinesin family member 24
Synonyms: 4933425J19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 109242
Homologene: 52346
Prol1
Name: proline rich, lacrimal 1
Synonyms: Muc10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 17830
Syne2
Name: spectrin repeat containing, nuclear envelope 2
Synonyms: nesprin-2, syne-2, D12Ertd777e, 6820443O06Rik, Nesp2g, Cpfl8, diminished cone electroretinogram, dice
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 319565
Homologene: 56700
Zbtb41
Name: zinc finger and BTB domain containing 41
Synonyms: 8430415N23Rik, 9830132G07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226470
Homologene: 27795
Dusp8
Name: dual specificity phosphatase 8
Synonyms: Nttp1, 5530400B01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 18218
HGNC: HGNC:3074
Homologene: 31239
Naip2
Name: NLR family, apoptosis inhibitory protein 2
Synonyms: Naip2, Naip-rs6, Birc1b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 17948
HGNC: HGNC:7634
Homologene: 136092
Efr3b
Name: EFR3 homolog B
Synonyms: C030014M07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 668212
VEGA: 12
Homologene: 66195
Sik1
Name: salt inducible kinase 1
Synonyms: Msk, Snf1lk
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 17691
VEGA: 17
Homologene: 7847
Vwa3a
Name: von Willebrand factor A domain containing 3A
Synonyms: E030013G06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233813
Homologene: 18607
Lrguk
Name: leucine-rich repeats and guanylate kinase domain containing
Synonyms: 4921528H16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 74354
Homologene: 34923
Vwce
Name: von Willebrand factor C and EGF domains
Synonyms: 1300015B04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 71768
VEGA: 19
Homologene: 17651
Tas2r110
Name: taste receptor, type 2, member 110
Synonyms: T2R10, Tas2r10, STC 9-1, mt2r57
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 387344
Homologene: 130069
Hpx
Name: hemopexin
Synonyms: hx, Hpxn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 15458
HGNC: HGNC:5171
Homologene: 511
Plxnc1
Name: plexin C1
Synonyms: vespr, 2510048K12Rik, CD232
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 54712
HGNC: HGNC:9106
Homologene: 4211
Mrc2
Name: mannose receptor, C type 2
Synonyms: novel lectin, Endo180, uPARAP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 17534
Homologene: 4408
Rimbp3
Name: RIMS binding protein 3
Synonyms: LOC239731, LOC385766, RIM-BP3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 239731
Homologene: 77940
Grip1
Name: glutamate receptor interacting protein 1
Synonyms: 4931400F03Rik, eb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 74053
Homologene: 12938
Klk1b1
Name: kallikrein 1-related peptidase b1
Synonyms: mGK-1, TK, tissue kallikrein, mK1, Klk1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 16623
Homologene: 68141
Tead2
Name: TEA domain family member 2
Synonyms: TEF-4, TEAD-2, Etdf
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 21677
Homologene: 19662
Rusf1
Name: RUS family member 1
Synonyms: BC017158
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233913
Homologene: 11232
Adamts17
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 17
Synonyms: AU023434
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233332
Homologene: 16373
Prss23
Name: protease, serine 23
Synonyms: 2310046G15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 76453
Homologene: 5191
Zfp385a
Name: zinc finger protein 385A
Synonyms: Hzf, Zfp385
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 29813
VEGA: 15
Homologene: 8479
Hoxc10
Name: homeobox C10
Synonyms: Hox-3.6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 209448
HGNC: HGNC:5122
Homologene: 9680
Or7d10
Name: olfactory receptor family 7 subfamily D member 10
Synonyms: 18A, MOR143-1, GA_x6K02T2PVTD-13660026-13660964, Olfr77
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258336
HGNC: HGNC:8380
Homologene: 133688
Car8
Name: carbonic anhydrase 8
Synonyms: Carp, Cals1, CA-RP VIII, wdl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 12319
HGNC: HGNC:1382
Homologene: 20861
Fcgr2b
Name: Fc receptor, IgG, low affinity IIb
Synonyms: CD32, FcgRII, Fc[g]RII, Fc gamma RIIB, FcgammaRIIB, Fcgr2, Ly-m20, Ly-17, LyM-1, Fcr-3, Fcgr2a, Fcr-2, F630109E10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 14130
Homologene: 2974
Rnase2b
Name: ribonuclease, RNase A family, 2B (liver, eosinophil-derived neurotoxin)
Synonyms: murine ribonuclease 5, mR5, Ear5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 54159
VEGA: 14
Homologene: 121614
Prdx5
Name: peroxiredoxin 5
Synonyms: peroxiredoxin V, PrxV, PrxV, PMP20, Prdx6, AOPP, AOEB166
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 54683
HGNC: HGNC:9355
Homologene: 8076
Mpnd
Name: MPN domain containing
Synonyms: E130307M08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 68047
Homologene: 12231
Lysmd1
Name: LysM, putative peptidoglycan-binding, domain containing 1
Synonyms: 2610022K04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 217779
Homologene: 41742
Ndufa13
Name: NADH:ubiquinone oxidoreductase subunit A13
Synonyms: GRIM-19, CDA016, CGI-39, 2700054G14Rik, Grim19
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 67184
Homologene: 41083
Gp9
Name: glycoprotein 9 (platelet)
Synonyms: GPIX, Cd42
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 54368
HGNC: HGNC:4444
Homologene: 144
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 34,212,319 bp
  • C to A, chromosome 1 at 45,321,990 bp
  • T to A, chromosome 1 at 139,423,996 bp
  • T to A, chromosome 1 at 139,458,286 bp
  • T to C, chromosome 1 at 170,968,135 bp
  • G to A, chromosome 1 at 176,755,843 bp
  • G to A, chromosome 3 at 95,138,461 bp
  • T to A, chromosome 4 at 8,189,353 bp
  • C to T, chromosome 4 at 41,404,734 bp
  • C to T, chromosome 4 at 53,061,481 bp
  • A to T, chromosome 4 at 86,418,546 bp
  • A to T, chromosome 5 at 88,328,617 bp
  • T to C, chromosome 6 at 30,590,873 bp
  • A to G, chromosome 6 at 34,073,768 bp
  • C to G, chromosome 6 at 71,508,875 bp
  • A to G, chromosome 6 at 87,779,151 bp
  • C to A, chromosome 6 at 89,356,519 bp
  • T to A, chromosome 6 at 132,868,675 bp
  • T to C, chromosome 7 at 43,969,327 bp
  • T to A, chromosome 7 at 45,232,328 bp
  • T to C, chromosome 7 at 64,372,371 bp
  • T to A, chromosome 7 at 66,840,467 bp
  • T to C, chromosome 7 at 89,509,751 bp
  • A to G, chromosome 7 at 105,596,291 bp
  • A to T, chromosome 7 at 120,762,464 bp
  • C to T, chromosome 7 at 128,285,208 bp
  • T to C, chromosome 7 at 142,090,065 bp
  • T to A, chromosome 8 at 61,072,315 bp
  • T to C, chromosome 8 at 69,901,610 bp
  • A to T, chromosome 9 at 19,920,809 bp
  • T to G, chromosome 9 at 53,617,986 bp
  • A to G, chromosome 10 at 94,794,432 bp
  • G to A, chromosome 10 at 119,929,958 bp
  • T to C, chromosome 11 at 105,292,903 bp
  • T to C, chromosome 12 at 3,983,414 bp
  • C to T, chromosome 12 at 76,046,065 bp
  • A to G, chromosome 13 at 12,247,365 bp
  • A to G, chromosome 13 at 55,246,691 bp
  • A to T, chromosome 13 at 100,179,432 bp
  • G to C, chromosome 13 at 100,179,433 bp
  • A to G, chromosome 14 at 29,347,120 bp
  • T to A, chromosome 14 at 51,162,748 bp
  • T to C, chromosome 14 at 56,512,296 bp
  • A to G, chromosome 14 at 101,922,095 bp
  • T to C, chromosome 15 at 102,967,444 bp
  • A to T, chromosome 15 at 103,315,810 bp
  • A to T, chromosome 16 at 17,210,299 bp
  • A to T, chromosome 17 at 15,731,871 bp
  • T to A, chromosome 17 at 26,187,797 bp
  • A to G, chromosome 17 at 31,851,605 bp
  • A to G, chromosome 17 at 47,875,528 bp
  • T to C, chromosome 17 at 56,011,692 bp
  • A to G, chromosome 19 at 6,906,850 bp
  • T to C, chromosome 19 at 10,646,905 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3849 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040897-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.