Strain Name:
C57BL/6J-MtgxR3850Btlr/Mmmh
Stock Number:
040898-MU
Citation ID:
RRID:MMRRC_040898-MU
Other Names:
R3850 (G1), C57BL/6J-MtgxR3850Btlr
Major Collection:

Strain Information

Dst
Name: dystonin
Synonyms: BPAG1-n, bullous pemphigoid antigen 1, Macf2, nmf203, 2310001O04Rik, BPAG1, nmf339, athetoid, A830042E19Rik, Bpag, Bpag1, bullous pemphigoid antigen 1, ah
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13518
HGNC: HGNC:1090
Homologene: 136716
Wfs1
Name: wolframin ER transmembrane glycoprotein
Synonyms: wolframin, Wolfram syndrome 1 homolog (human)
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 22393
Homologene: 4380
Smchd1
Name: SMC hinge domain containing 1
Synonyms: MommeD1, 4931400A14Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 74355
Homologene: 23665
Picalm
Name: phosphatidylinositol binding clathrin assembly protein
Synonyms: fit-1, fit1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233489
Homologene: 111783
Abca1
Name: ATP-binding cassette, sub-family A member 1
Synonyms: ABC1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11303
HGNC: HGNC:29
Homologene: 21130
Nek1
Name: NIMA (never in mitosis gene a)-related expressed kinase 1
Synonyms: kat, D8Ertd790e, kidney, anemia and testis
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 18004
HGNC: HGNC:7744
Homologene: 14376
Rnf17
Name: ring finger protein 17
Synonyms: MMIP-2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 30054
VEGA: 14
Homologene: 23727
Abcc5
Name: ATP-binding cassette, sub-family C member 5
Synonyms: 2900011L11Rik, Abcc5b, Abcc5a, Mrp5
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 27416
HGNC: HGNC:56
Homologene: 21164
Pikfyve
Name: phosphoinositide kinase, FYVE type zinc finger containing
Synonyms: PipkIII, Pip5k3, 5230400C17Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18711
Homologene: 32115
Cul5
Name: cullin 5
Synonyms: 8430423K24Rik, 4921514I20Rik, C030032G03Rik, VACM-1, C330021I08Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 75717
HGNC: HGNC:2556
Homologene: 2597
Ror1
Name: receptor tyrosine kinase-like orphan receptor 1
Synonyms: 2810404D04Rik, Ntrkr1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 26563
Homologene: 3675
Cacna2d3
Name: calcium channel, voltage-dependent, alpha2/delta subunit 3
Synonyms: alpha 2 delta-3, alpha2delta3
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 12294
Homologene: 74929
Fan1
Name: FANCD2/FANCI-associated nuclease 1
Synonyms: Mtmr15, 6030441H18Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330554
Homologene: 45598
Adamtsl1
Name: ADAMTS-like 1
Synonyms: 5930437A14Rik, 6720426B09Rik, punctin-1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 77739
Homologene: 64642
Rmdn3
Name: regulator of microtubule dynamics 3
Synonyms: Fam82a2, 1200015F23Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 67809
Homologene: 34926
Plod2
Name: procollagen lysine, 2-oxoglutarate 5-dioxygenase 2
Synonyms: LH2, D530025C14Rik, Plod-2, lysyl hydroxylase 2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 26432
HGNC: HGNC:9082
Homologene: 22681
Cwf19l1
Name: CWF19 like cell cycle control factor 1
Synonyms: 2610528C06Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 72502
VEGA: 19
Homologene: 41244
Snx27
Name: sorting nexin family member 27
Synonyms: 5730552M22Rik, ESTM47
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 76742
Homologene: 12797
Csmd1
Name: CUB and Sushi multiple domains 1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 94109
Homologene: 69536
Mov10l1
Name: Mov10 like RISC complex RNA helicase 1
Synonyms: CHAMP, Csm
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 83456
HGNC: HGNC:7201
Homologene: 56835
Hydin
Name: HYDIN, axonemal central pair apparatus protein
Synonyms: 4930545D19Rik, hy-3, hyrh, 1700034M11Rik, hy3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244653
Homologene: 52118
Syne2
Name: spectrin repeat containing, nuclear envelope 2
Synonyms: dice, syne-2, 6820443O06Rik, diminished cone electroretinogram, Cpfl8, D12Ertd777e, Nesp2g, nesprin-2
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 319565
Homologene: 56700
Naip2
Name: NLR family, apoptosis inhibitory protein 2
Synonyms: Naip2, Naip-rs6, Birc1b
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17948
HGNC: HGNC:7634
Homologene: 136092
Fat4
Name: FAT atypical cadherin 4
Synonyms: 6030410K14Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 329628
Homologene: 14377
Rb1cc1
Name: RB1-inducible coiled-coil 1
Synonyms: 2900055E04Rik, 5930404L04Rik, Cc1, Fip200, LaXp180
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12421
Homologene: 7659
Scn2a
Name: sodium channel, voltage-gated, type II, alpha
Synonyms: Scn2a1, Nav1.2, A230052E19Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 110876
Homologene: 75001
Or4a72
Name: olfactory receptor family 4 subfamily A member 72
Synonyms: GA_x6K02T2Q125-51020951-51020028, MOR231-12, Olfr1245
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258784
Homologene: 121560
Muc5b
Name: mucin 5, subtype B, tracheobronchial
Synonyms: MUC5, 2300002I04Rik, MUC9
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 74180
HGNC: HGNC:7516
Homologene: 136756
Cdh17
Name: cadherin 17
Synonyms: BILL-cadherin, LI-cadherin, HPT-1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12557
HGNC: HGNC:1756
Homologene: 56859
Golgb1
Name: golgin B1
Synonyms: F730017E11Rik, Gm6840, 6330407A06Rik, C130074L01Rik, Giantin
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224139
HGNC: HGNC:4429
Homologene: 68401
Sspo
Name: SCO-spondin
Synonyms: C79529, Scospondin
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243369
Homologene: 45453
Thap12
Name: THAP domain containing 12
Synonyms: 2900052B10Rik, Prkrir, Dap4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 72981
HGNC: HGNC:9440
Homologene: 37952
Sh3pxd2b
Name: SH3 and PX domains 2B
Synonyms: G431001E03Rik, Tks4, Fad49
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 268396
Homologene: 27952
Tas2r110
Name: taste receptor, type 2, member 110
Synonyms: Tas2r10, mt2r57, T2R10, STC 9-1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 387344
Homologene: 130069
Hsf4
Name: heat shock transcription factor 4
Synonyms: ldis1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 26386
HGNC: HGNC:5227
Homologene: 100128
Als2cl
Name: ALS2 C-terminal like
Synonyms: D930044G19Rik, mRn.49018
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235633
Homologene: 17152
Proz
Name: protein Z, vitamin K-dependent plasma glycoprotein
Synonyms: 1300015B06Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 66901
HGNC: HGNC:9460
Homologene: 2890
Zfp687
Name: zinc finger protein 687
Synonyms: 4931408L03Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 78266
Homologene: 10827
Mrc2
Name: mannose receptor, C type 2
Synonyms: uPARAP, Endo180, novel lectin
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17534
Homologene: 4408
Zfp229
Name: zinc finger protein 229
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 381067
Homologene: 136287
Rimbp3
Name: RIMS binding protein 3
Synonyms: LOC385766, LOC239731, RIM-BP3
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 239731
Homologene: 77940
Ap1g2
Name: adaptor protein complex AP-1, gamma 2 subunit
Synonyms: gamma 2-adaptin, Adtg2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 11766
HGNC: HGNC:556
Homologene: 49141
Vmn2r65
Name: vomeronasal 2, receptor 65
Synonyms: ENSMUSG00000070600
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100009609
Tead2
Name: TEA domain family member 2
Synonyms: Etdf, TEF-4, TEAD-2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 21677
Homologene: 19662
Adamts17
Name: ADAM metallopeptidase with thrombospondin type 1 motif 17
Synonyms: AU023434
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233332
Homologene: 16373
Pm20d2
Name: peptidase M20 domain containing 2
Synonyms: Acy1l2, LOC242377
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242377
Homologene: 19025
Zfp385a
Name: zinc finger protein 385A
Synonyms: Zfp385, Hzf
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 29813
VEGA: 15
Homologene: 8479
Hoxc10
Name: homeobox C10
Synonyms: Hox-3.6
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 209448
HGNC: HGNC:5122
Homologene: 9680
Antxrl
Name: anthrax toxin receptor-like
Synonyms: 1700112N15Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 239029
VEGA: 14
Homologene: 52111
Or7d10
Name: olfactory receptor family 7 subfamily D member 10
Synonyms: 18A, Olfr77, GA_x6K02T2PVTD-13660026-13660964, MOR143-1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258336
HGNC: HGNC:8380
Homologene: 133688
Or5aq1b
Name: olfactory receptor family 5 subfamily AQ member 1B
Synonyms: MOR172-2, Olfr1107, GA_x6K02T2Q125-48565383-48564445
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258841
Homologene: 131138
Fbxl8
Name: F-box and leucine-rich repeat protein 8
Synonyms: FBL8
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 50788
Homologene: 9279
Igfbpl1
Name: insulin-like growth factor binding protein-like 1
Synonyms: IGFBP-like protein, 2810011G06Rik, 2810453O06Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 75426
Homologene: 10292
Smim33
Name: small integral membrane protein 33
Synonyms: 1700066B19Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 73449
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 6,250,113 bp
  • C to T, chromosome 1 at 34,189,274 bp
  • C to T, chromosome 1 at 34,212,319 bp
  • T to C, chromosome 1 at 65,230,845 bp
  • T to C, chromosome 1 at 132,631,733 bp
  • C to T, chromosome 2 at 65,682,031 bp
  • T to A, chromosome 2 at 87,071,966 bp
  • T to C, chromosome 2 at 89,575,034 bp
  • A to T, chromosome 2 at 119,156,422 bp
  • T to A, chromosome 3 at 39,007,261 bp
  • G to T, chromosome 3 at 94,520,235 bp
  • T to C, chromosome 3 at 95,007,914 bp
  • A to G, chromosome 4 at 11,785,201 bp
  • A to G, chromosome 4 at 33,174,414 bp
  • C to T, chromosome 4 at 45,826,426 bp
  • C to T, chromosome 4 at 53,061,481 bp
  • A to T, chromosome 4 at 86,418,546 bp
  • A to G, chromosome 4 at 100,442,160 bp
  • C to A, chromosome 5 at 36,968,624 bp
  • T to A, chromosome 6 at 48,492,490 bp
  • T to A, chromosome 6 at 132,868,675 bp
  • T to A, chromosome 7 at 45,232,328 bp
  • T to C, chromosome 7 at 64,372,371 bp
  • T to A, chromosome 7 at 66,840,467 bp
  • T to A, chromosome 7 at 84,946,651 bp
  • A to G, chromosome 7 at 90,191,704 bp
  • G to T, chromosome 7 at 98,716,663 bp
  • G to A, chromosome 7 at 141,862,638 bp
  • A to G, chromosome 8 at 13,073,533 bp
  • C to G, chromosome 8 at 16,079,922 bp
  • T to A, chromosome 8 at 61,072,315 bp
  • T to C, chromosome 8 at 104,617,841 bp
  • T to C, chromosome 8 at 105,267,149 bp
  • T to C, chromosome 8 at 105,270,837 bp
  • T to C, chromosome 8 at 110,563,929 bp
  • A to T, chromosome 9 at 19,920,809 bp
  • T to G, chromosome 9 at 53,617,986 bp
  • A to G, chromosome 9 at 92,542,545 bp
  • A to G, chromosome 9 at 110,889,309 bp
  • A to G, chromosome 11 at 32,411,505 bp
  • T to C, chromosome 11 at 105,292,903 bp
  • T to C, chromosome 12 at 76,048,622 bp
  • A to T, chromosome 13 at 100,179,432 bp
  • G to C, chromosome 13 at 100,179,433 bp
  • A to G, chromosome 14 at 29,347,120 bp
  • C to A, chromosome 14 at 34,067,381 bp
  • T to C, chromosome 14 at 55,104,906 bp
  • T to C, chromosome 14 at 56,512,296 bp
  • A to T, chromosome 15 at 89,005,695 bp
  • T to C, chromosome 15 at 102,967,444 bp
  • A to T, chromosome 15 at 103,315,810 bp
  • A to T, chromosome 16 at 17,210,299 bp
  • A to T, chromosome 16 at 20,372,156 bp
  • C to A, chromosome 16 at 36,898,733 bp
  • C to A, chromosome 17 at 21,745,862 bp
  • A to G, chromosome 17 at 71,400,049 bp
  • G to A, chromosome 18 at 35,728,714 bp
  • T to C, chromosome 19 at 44,131,498 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3850 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040898-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.