Strain Name:
C57BL/6J-MtgxR3851Btlr/Mmmh
Stock Number:
040899-MU
Citation ID:
RRID:MMRRC_040899-MU
Other Names:
R3851 (G1), C57BL/6J-MtgxR3851Btlr
Major Collection:

Gene Information

Kmt2c
Name: lysine (K)-specific methyltransferase 2C
Synonyms: E330008K23Rik, HALR, Mll3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 231051
Homologene: 46480
Rgs14
Name: regulator of G-protein signaling 14
Synonyms: Rap1/rap2 interacting protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 51791
HGNC: HGNC:9996
Homologene: 4735
Tmem59l
Name: transmembrane protein 59-like
Synonyms: 5330410G16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 67937
Homologene: 8104
Lrp2
Name: low density lipoprotein receptor-related protein 2
Synonyms: D230004K18Rik, b2b1625.2Clo, Gp330, Megalin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 14725
HGNC: HGNC:6694
Homologene: 20952
Vps13c
Name: vacuolar protein sorting 13C
Synonyms: C230055H22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 320528
VEGA: 9
Homologene: 41188
Shroom3
Name: shroom family member 3
Synonyms: Shrm3, Shrm, D5Ertd287e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 27428
Homologene: 9263
Dock9
Name: dedicator of cytokinesis 9
Synonyms: Zizimin1, B230309H04Rik, D14Wsu89e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 105445
Homologene: 41026
Cry1
Name: cryptochrome 1 (photolyase-like)
Synonyms: Phll1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 12952
VEGA: 10
HGNC: HGNC:2384
Homologene: 7042
Slc38a10
Name: solute carrier family 38, member 10
Synonyms: 1810073N04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 72055
Homologene: 41556
Calcr
Name: calcitonin receptor
Synonyms: Clr
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 12311
HGNC: HGNC:1440
Homologene: 1320
Ntn1
Name: netrin 1
Synonyms: Netrin-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 18208
HGNC: HGNC:8029
Homologene: 21008
Dzip3
Name: DAZ interacting protein 3, zinc finger
Synonyms: 6430549P11Rik, 2A-HUB, 2310047C04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 224170
Homologene: 8771
Arap1
Name: ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
Synonyms: Centd2, 2410002L19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 69710
Homologene: 12326
Bcl9
Name: B cell CLL/lymphoma 9
Synonyms: A330041G23Rik, 2610202E01Rik, 8030475K17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 77578
HGNC: HGNC:1008
Homologene: 3191
Golga2
Name: golgi autoantigen, golgin subfamily a, 2
Synonyms: GM130
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 99412
HGNC: HGNC:4425
Homologene: 3300
Map4k3
Name: mitogen-activated protein kinase kinase kinase kinase 3
Synonyms: 9530052P13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 225028
VEGA: 17
HGNC: HGNC:6865
Homologene: 2683
Itpkc
Name: inositol 1,4,5-trisphosphate 3-kinase C
Synonyms: 9130023N17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 233011
Homologene: 11868
Rbp3
Name: retinol binding protein 3, interstitial
Synonyms: Rbp-3, Irbp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 19661
VEGA: 14
HGNC: HGNC:9921
Homologene: 9261
Pcdh15
Name: protocadherin 15
Synonyms: roda, nmf19, Ush1f, Gm9815
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 11994
Homologene: 23401
Ttn
Name: titin
Synonyms: shru, connectin, mdm, 2310057K23Rik, D330041I19Rik, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, L56, 2310074I15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 22138
Homologene: 130650
Pgm5
Name: phosphoglucomutase 5
Synonyms: aciculin, 9530034F03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 226041
HGNC: HGNC:8908
Homologene: 74881
Dpysl4
Name: dihydropyrimidinase-like 4
Synonyms: Drp-4, Ulip4, CRMP-3, Crmp3, DPY4, unc-33-like phosphoprotein 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 26757
HGNC: HGNC:3016
Homologene: 4691
Drc7
Name: dynein regulatory complex subunit 7
Synonyms: Ccdc135, SRG-L, LOC330830
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 330830
Homologene: 12996
Nubpl
Name: nucleotide binding protein-like
Synonyms: 2410170E07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 76826
Homologene: 11854
Dnm3
Name: dynamin 3
Synonyms: 9630020E24Rik, B230343F03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 103967
Homologene: 22906
Dclre1a
Name: DNA cross-link repair 1A
Synonyms: 2810043H12Rik, mSNM1, SMN1a, SNM1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 55947
Homologene: 8920
Fmo9
Name: flavin containing monooxygenase 9
Synonyms: 4831428F09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 240894
Homologene: 134192
Flnc
Name: filamin C, gamma
Synonyms: actin binding protein 280, Fln2, 1110055E19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 68794
HGNC: HGNC:3756
Homologene: 37481
Zfp521
Name: zinc finger protein 521
Synonyms: B930086A16Rik, Evi3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 225207
VEGA: 18
Homologene: 9151
AY358078
Name: cDNA sequence AY358078
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 278676
Homologene: 115686
Olfr813
Name: olfactory receptor 813
Synonyms: MOR108-3, GA_x6K02T2PULF-11535078-11536010
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 258252
Homologene: 138308
Parp14
Name: poly (ADP-ribose) polymerase family, member 14
Synonyms: CoaSt6, collaborator of Stat6, 1600029O10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 547253
Homologene: 19697
Fnip2
Name: folliculin interacting protein 2
Synonyms: D630023B12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 329679
Homologene: 46417
Radil
Name: Ras association and DIL domains
Synonyms: D930005D10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 231858
Homologene: 77648
Sult2b1
Name: sulfotransferase family, cytosolic, 2B, member 1
Synonyms: SULT2B, Gm5897
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 54200
Homologene: 49487
Insyn2a
Name: inhibitory synaptic factor 2A
Synonyms: Fam196a, B830028B13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 627214
Homologene: 85469
Mas1
Name: MAS1 oncogene
Synonyms: Mas-1, Mas receptor, MasR
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 17171
HGNC: HGNC:6899
Homologene: 1782
Slco4a1
Name: solute carrier organic anion transporter family, member 4a1
Synonyms: Slc21a12, OATP-E
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 108115
Homologene: 9482
Rrm2
Name: ribonucleotide reductase M2
Synonyms: R2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 20135
Homologene: 20277
AC123661.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 162,321,127 bp
  • A to G, chromosome 1 at 166,663,367 bp
  • A to G, chromosome 2 at 32,305,611 bp
  • A to G, chromosome 2 at 69,442,734 bp
  • G to T, chromosome 2 at 76,751,334 bp
  • C to T, chromosome 2 at 180,464,091 bp
  • G to C, chromosome 3 at 79,462,157 bp
  • G to A, chromosome 3 at 97,209,653 bp
  • G to A, chromosome 5 at 22,775,987 bp
  • A to G, chromosome 5 at 25,287,693 bp
  • G to T, chromosome 5 at 92,943,086 bp
  • T to C, chromosome 5 at 142,506,997 bp
  • T to C, chromosome 6 at 3,693,735 bp
  • T to A, chromosome 6 at 29,453,719 bp
  • A to T, chromosome 7 at 27,227,612 bp
  • G to T, chromosome 7 at 45,730,037 bp
  • G to A, chromosome 7 at 101,390,165 bp
  • A to G, chromosome 7 at 134,884,526 bp
  • C to T, chromosome 7 at 139,100,935 bp
  • A to G, chromosome 8 at 70,487,301 bp
  • C to T, chromosome 8 at 95,061,836 bp
  • A to G, chromosome 9 at 67,914,124 bp
  • C to A, chromosome 10 at 74,631,686 bp
  • C to A, chromosome 10 at 85,146,499 bp
  • A to C, chromosome 10 at 129,857,147 bp
  • C to G, chromosome 11 at 68,385,793 bp
  • A to G, chromosome 11 at 120,106,624 bp
  • G to T, chromosome 12 at 24,708,599 bp
  • T to C, chromosome 12 at 52,144,027 bp
  • T to A, chromosome 13 at 55,379,614 bp
  • C to A, chromosome 14 at 33,955,507 bp
  • A to G, chromosome 14 at 51,805,553 bp
  • A to T, chromosome 14 at 121,629,086 bp
  • A to G, chromosome 16 at 35,853,748 bp
  • T to C, chromosome 16 at 48,950,013 bp
  • C to G, chromosome 17 at 12,841,993 bp
  • A to G, chromosome 17 at 80,644,323 bp
  • T to C, chromosome 18 at 13,717,751 bp
  • C to T, chromosome 19 at 24,820,203 bp
  • A to T, chromosome 19 at 56,541,507 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3851 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040899-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.