Strain Name:
C57BL/6J-MtgxR3862Btlr/Mmmh
Stock Number:
040903-MU
Citation ID:
RRID:MMRRC_040903-MU
Other Names:
R3862 (G1), C57BL/6J-MtgxR3862Btlr
Major Collection:

Gene Information

Hapln1
Name: hyaluronan and proteoglycan link protein 1
Synonyms: CLP, Crtl1l, link protein, cartilage linking protein 1, LP-1, Crtl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 12950
VEGA: 13
HGNC: HGNC:2380
Homologene: 1420
Sptbn1
Name: spectrin beta, non-erythrocytic 1
Synonyms: non-erythrocytic, spectrin G, Spnb-2, Spnb2, beta fodrin, brain spectrin, elf3, elf1, 9930031C03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 20742
Homologene: 2354
Cdk8
Name: cyclin-dependent kinase 8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 264064
HGNC: HGNC:1779
Homologene: 55565
Fkbp9
Name: FK506 binding protein 9
Synonyms: FKBP60, FKBP63
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 27055
HGNC: HGNC:3725
Homologene: 31434
Snrnp200
Name: small nuclear ribonucleoprotein 200 (U5)
Synonyms: HELIC2, A330064G03Rik, Ascc3l1, U5-200KD
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 320632
Homologene: 5859
Gtpbp4
Name: GTP binding protein 4
Synonyms: Crfg, Nog1, 2610028C09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 69237
VEGA: 13
Homologene: 7100
4932438A13Rik
Name: RIKEN cDNA 4932438A13 gene
Synonyms: FSA, Tweek
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 229227
Homologene: 52105
Bub1
Name: BUB1, mitotic checkpoint serine/threonine kinase
Synonyms: Bub1a, D2Xrf87
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 12235
HGNC: HGNC:1148
Homologene: 37910
Stag1
Name: stromal antigen 1
Synonyms: SA-1, Scc3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 20842
Homologene: 21191
Nsmaf
Name: neutral sphingomyelinase (N-SMase) activation associated factor
Synonyms: factor associated with N-SMase activation, Fan
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 18201
HGNC: HGNC:8017
Homologene: 2652
Eri1
Name: exoribonuclease 1
Synonyms: 3110010F15Rik, Eri1, Thex1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 67276
Homologene: 32651
Kif26a
Name: kinesin family member 26A
Synonyms: N-11 kinesin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 668303
Homologene: 18970
Enpp6
Name: ectonucleotide pyrophosphatase/phosphodiesterase 6
Synonyms: 4833421B01Rik, Npp6, D8Ertd514e, B830047L21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 320981
Homologene: 62657
March11
Name: membrane-associated ring finger (C3HC4) 11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 211147
Homologene: 45584
Zc3h12a
Name: zinc finger CCCH type containing 12A
Synonyms: Mcpip1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 230738
Homologene: 11824
Mep1b
Name: meprin 1 beta
Synonyms: Mep-1b, meprin beta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 17288
VEGA: 18
HGNC: HGNC:7020
Homologene: 48382
Fat3
Name: FAT atypical cadherin 3
Synonyms: LOC382129, 9430076A06Rik, LOC234973, D430038H04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 270120
VEGA: 9
Homologene: 82252
Zfand4
Name: zinc finger, AN1-type domain 4
Synonyms: Anubl1, 2810002D23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 67492
VEGA: 6
Homologene: 18373
D430041D05Rik
Name: RIKEN cDNA D430041D05 gene
Synonyms: G2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 241589
Homologene: 115928
Obscn
Name: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Synonyms: LOC380698, OTTMUSG00000005786
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 380698
Homologene: 70869
Helt
Name: helt bHLH transcription factor
Synonyms: megane, Heslike
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 234219
Homologene: 18357
Lrrd1
Name: leucine rich repeats and death domain containing 1
Synonyms: 4932412H11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 242838
Homologene: 18247
Sgcz
Name: sarcoglycan zeta
Synonyms: C230085N17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 244431
Homologene: 26726
Itga1
Name: integrin alpha 1
Synonyms: CD49A, E130012M19Rik, Vla1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 109700
VEGA: 13
HGNC: HGNC:6134
Homologene: 57137
Ppp4r4
Name: protein phosphatase 4, regulatory subunit 4
Synonyms: 8430415E04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 74521
Homologene: 12571
Olfr652
Name: olfactory receptor 652
Synonyms: GA_x6K02T2PBJ9-7191524-7192471, MOR31-8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 259050
Homologene: 17477
Cttnbp2
Name: cortactin binding protein 2
Synonyms: ORF4, 3010022N24Rik, Cortbp2, 9130022E09Rik, 4732477G22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 30785
Homologene: 14125
Apc2
Name: adenomatosis polyposis coli 2
Synonyms: APCL
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 23805
Homologene: 4299
Slc25a21
Name: solute carrier family 25 (mitochondrial oxodicarboxylate carrier), member 21
Synonyms: 9930033G19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 217593
Homologene: 6988
Gm597
Name: predicted gene 597
Synonyms: LOC210962
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 210962
Veph1
Name: ventricular zone expressed PH domain-containing 1
Synonyms: Veph, 2810471M23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 72789
Homologene: 11624
Hint2
Name: histidine triad nucleotide binding protein 2
Synonyms: 1190005L05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 68917
Homologene: 13072
Pcdhb3
Name: protocadherin beta 3
Synonyms: PcdhbC
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 93874
HGNC: HGNC:8688
Homologene: 115665
Naif1
Name: nuclear apoptosis inducing factor 1
Synonyms: 2310007O20Rik, 4933440H19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 71254
Homologene: 45669
Slc15a1
Name: solute carrier family 15 (oligopeptide transporter), member 1
Synonyms: PECT1, PEPT1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 56643
VEGA: 14
Homologene: 38006
Evi2b
Name: ecotropic viral integration site 2b
Synonyms: Evi2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 216984
HGNC: HGNC:3500
Homologene: 48438
Scgb2b3
Name: secretoglobin, family 2B, member 3
Synonyms: Gm4362, Abpbg3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 100043326
Homologene: 83171
Olfr968
Name: olfactory receptor 968
Synonyms: GA_x6K02T2PVTD-33470347-33469403, MOR171-15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 258605
VEGA: 9
Homologene: 121532
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 28,777,641 bp
  • A to G, chromosome 2 at 32,452,625 bp
  • T to C, chromosome 2 at 104,214,177 bp
  • C to A, chromosome 2 at 127,233,099 bp
  • A to G, chromosome 2 at 127,814,756 bp
  • T to A, chromosome 3 at 36,885,398 bp
  • C to T, chromosome 3 at 66,254,892 bp
  • A to G, chromosome 4 at 6,435,064 bp
  • A to G, chromosome 4 at 43,654,771 bp
  • T to C, chromosome 4 at 125,126,939 bp
  • G to A, chromosome 5 at 3,851,248 bp
  • A to T, chromosome 5 at 146,295,154 bp
  • C to T, chromosome 6 at 18,434,906 bp
  • A to G, chromosome 6 at 56,868,905 bp
  • A to T, chromosome 6 at 116,293,815 bp
  • C to T, chromosome 7 at 31,362,005 bp
  • G to A, chromosome 7 at 104,564,938 bp
  • A to G, chromosome 8 at 35,491,294 bp
  • T to C, chromosome 8 at 37,523,411 bp
  • G to T, chromosome 8 at 46,292,278 bp
  • A to G, chromosome 8 at 47,065,992 bp
  • G to A, chromosome 9 at 15,998,271 bp
  • T to A, chromosome 9 at 39,772,624 bp
  • T to A, chromosome 9 at 100,944,785 bp
  • G to A, chromosome 10 at 80,307,559 bp
  • G to T, chromosome 11 at 30,142,329 bp
  • T to C, chromosome 11 at 59,131,646 bp
  • T to A, chromosome 11 at 79,515,646 bp
  • G to T, chromosome 12 at 56,718,135 bp
  • C to T, chromosome 12 at 103,596,421 bp
  • A to G, chromosome 12 at 112,179,889 bp
  • A to G, chromosome 13 at 8,990,798 bp
  • C to T, chromosome 13 at 89,605,299 bp
  • T to A, chromosome 13 at 114,992,256 bp
  • C to T, chromosome 14 at 121,484,857 bp
  • C to T, chromosome 15 at 26,387,866 bp
  • A to G, chromosome 18 at 21,084,169 bp
  • A to G, chromosome 18 at 37,303,276 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3862 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040903-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.