Strain Name:
C57BL/6J-MtgxR3877Btlr/Mmmh
Stock Number:
040904-MU
Citation ID:
RRID:MMRRC_040904-MU
Other Names:
R3877 (G1), C57BL/6J-MtgxR3877Btlr
Major Collection:

Gene Information

Sall4
Name: spalt like transcription factor 4
Synonyms: Tex20, C330011P20Rik, 5730441M18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 99377
Homologene: 10716
Sh3gl2
Name: SH3-domain GRB2-like 2
Synonyms: endophilin I, Sh3d2a, B930049H17Rik, 9530001L19Rik, endophilin A1, EEN-B1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 20404
Homologene: 20652
Lrp2
Name: low density lipoprotein receptor-related protein 2
Synonyms: D230004K18Rik, b2b1625.2Clo, Gp330, Megalin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 14725
HGNC: HGNC:6694
Homologene: 20952
Ckap5
Name: cytoskeleton associated protein 5
Synonyms: D730027C18Rik, 3110043H24Rik, 4930432B04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 75786
Homologene: 8844
Arhgap21
Name: Rho GTPase activating protein 21
Synonyms: ARHGAP10, 5530401C11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 71435
Homologene: 10822
Mapre1
Name: microtubule-associated protein, RP/EB family, member 1
Synonyms: BIM1p, D2Ertd459e, Eb1, 5530600P05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 13589
HGNC: HGNC:6890
Homologene: 56129
Idh3a
Name: isocitrate dehydrogenase 3 (NAD+) alpha
Synonyms: 1500012E04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 67834
VEGA: 9
HGNC: HGNC:5384
Homologene: 4037
Mms19
Name: MMS19 cytosolic iron-sulfur assembly component
Synonyms: Mms19l, 2610042O15Rik, C86341, Mms19
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 72199
Homologene: 41480
Dmxl1
Name: Dmx-like 1
Synonyms: C630007L23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 240283
HGNC: HGNC:2937
Homologene: 21136
Tram1
Name: translocating chain-associating membrane protein 1
Synonyms: TRAMP, 1810049E02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 72265
Homologene: 8621
Angptl4
Name: angiopoietin-like 4
Synonyms: HFARP, FIAF, BK89, NG27
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 57875
Homologene: 10755
Cd200r1
Name: CD200 receptor 1
Synonyms: CD200R, OX2R, Mox2r
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 57781
Homologene: 10957
Gmds
Name: GDP-mannose 4, 6-dehydratase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 218138
HGNC: HGNC:4369
Homologene: 75968
Kirrel
Name: kirre like nephrin family adhesion molecule 1
Synonyms: Neph1, Kirrel1, 6720469N11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 170643
Homologene: 10089
Vrk3
Name: vaccinia related kinase 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 101568
Homologene: 9509
Trpv5
Name: transient receptor potential cation channel, subfamily V, member 5
Synonyms: ECaC1, CaT2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 194352
HGNC: HGNC:3145
Homologene: 10520
Rpl5
Name: ribosomal protein L5
Synonyms: U21RNA
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 100503670
Homologene: 110649
Adam20
Name: a disintegrin and metallopeptidase domain 20
Synonyms: 4930529F22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 384806
HGNC: HGNC:199
Homologene: 128364
Zfhx4
Name: zinc finger homeodomain 4
Synonyms: Zfh-4, C130041O22Rik, Zfh4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 80892
Homologene: 23477
Kidins220
Name: kinase D-interacting substrate 220
Synonyms: 3110039L19Rik, C330002I19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 77480
VEGA: 12
Homologene: 14254
Dnah17
Name: dynein, axonemal, heavy chain 17
Synonyms: LOC382552, 2810003K23Rik, Dnahcl1, Dnahc17
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 69926
HGNC: HGNC:2946
Homologene: 72102
Adgrb3
Name: adhesion G protein-coupled receptor B3
Synonyms: Bai3, A830096D10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 210933
HGNC: HGNC:945
Homologene: 1289
Wdr93
Name: WD repeat domain 93
Synonyms: EG626359
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 626359
Homologene: 56878
Cplane1
Name: ciliogenesis and planar polarity effector 1
Synonyms: Hug, Jbts17, b2b012Clo, 2410089E03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 73692
Homologene: 11315
Reg3b
Name: regenerating islet-derived 3 beta
Synonyms: REG-III, Pap, RegIII (beta), PAP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 18489
HGNC: HGNC:8601
Homologene: 130506
Lrp1b
Name: low density lipoprotein-related protein 1B
Synonyms: 9630004P12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 94217
HGNC: HGNC:6693
Homologene: 56810
Lrpap1
Name: low density lipoprotein receptor-related protein associated protein 1
Synonyms: RAP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 16976
HGNC: HGNC:6701
Homologene: 37612
Muc5b
Name: mucin 5, subtype B, tracheobronchial
Synonyms: MUC5, MUC9, 2300002I04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 74180
HGNC: HGNC:7516
Homologene: 136756
Tnxb
Name: tenascin XB
Synonyms: Tnx, TN-MHC
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 81877
Homologene: 49589
Tyro3
Name: TYRO3 protein tyrosine kinase 3
Synonyms: Dtk, Tif, Etk-2, Brt, Sky, Rse, Sky
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 22174
Homologene: 4585
Adgb
Name: androglobin
Synonyms: 9130014G24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 215772
Homologene: 100289
Myh4
Name: myosin, heavy polypeptide 4, skeletal muscle
Synonyms: MYH-2B, Minmus, Minimsc, Myhsf, MM, MyHC-IIb, MHC2B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 17884
HGNC: HGNC:7574
Homologene: 123880
Shank1
Name: SH3 and multiple ankyrin repeat domains 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 243961
Homologene: 22949
1110012J17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
Tnfaip6
Name: tumor necrosis factor alpha induced protein 6
Synonyms: TSG-6, Tnfip6, Tsg6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 21930
Homologene: 5162
Vmn1r68
Name: vomeronasal 1 receptor 68
Synonyms: Gm6898
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 628580
Homologene: 120153
Thsd7b
Name: thrombospondin, type I, domain containing 7B
Synonyms: D130067I03Rik, 1700074E13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 210417
Homologene: 18180
Rimbp2
Name: RIMS binding protein 2
Synonyms: A930033C01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 231760
Homologene: 14672
Arhgef40
Name: Rho guanine nucleotide exchange factor (GEF) 40
Synonyms: E130112L23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 268739
Homologene: 19560
Pga5
Name: pepsinogen 5, group I
Synonyms: Pepf, 1110035E17Rik, pepsinogen A5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 58803
VEGA: 19
Homologene: 105932
Hyal5
Name: hyaluronoglucosaminidase 5
Synonyms: 4933439A12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 74468
Homologene: 50610
Dhx34
Name: DEAH (Asp-Glu-Ala-His) box polypeptide 34
Synonyms: 1810012L18Rik, 1200013B07Rik, Ddx34
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 71723
Homologene: 69171
Vmn2r28
Name: vomeronasal 2, receptor 28
Synonyms: EG665255
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 665255
Homologene: 129605
Inf2
Name: inverted formin, FH2 and WH2 domain containing
Synonyms: EG629699, 2610204M08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 70435
VEGA: 12
Homologene: 82406
Zfp512b
Name: zinc finger protein 512B
Synonyms: LOC269401, Znf512b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 269401
Homologene: 69314
Kcnd3
Name: potassium voltage-gated channel, Shal-related family, member 3
Synonyms: potassium channel Kv4.3M, Kv4.3, potassium channel Kv4.3L
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 56543
HGNC: HGNC:6239
Homologene: 21036
Dpm2
Name: dolichol-phosphate (beta-D) mannosyltransferase 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 13481
HGNC: HGNC:3006
Homologene: 99726
Olfr384
Name: olfactory receptor 384
Synonyms: Olfr386, GA_x6K02T2P1NL-3739520-3740032, GA_x6K02T2P1NL-3773152-3774090, MOR135-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 193053
Homologene: 105206
C4bp
Name: complement component 4 binding protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 12269
Olfr12
Name: olfactory receptor 12
Synonyms: MOR208-5, GA_x6K02T2R7CC-81134096-81133095
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 257890
Homologene: 114777
Cldn19
Name: claudin 19
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 242653
HGNC: HGNC:2040
Homologene: 17528
Eef1a2
Name: eukaryotic translation elongation factor 1 alpha 2
Synonyms: S1, Eef1a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 13628
HGNC: HGNC:3192
Homologene: 121568
Rcvrn
Name: recoverin
Synonyms: guanylate cyclase activator, S-modulin, cancer associated retinopathy protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 19674
HGNC: HGNC:9937
Homologene: 2177
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 13,569,603 bp
  • A to C, chromosome 1 at 25,111,825 bp
  • A to T, chromosome 1 at 92,620,083 bp
  • A to G, chromosome 1 at 130,190,182 bp
  • A to G, chromosome 1 at 130,648,027 bp
  • A to T, chromosome 2 at 20,859,906 bp
  • G to A, chromosome 2 at 32,572,400 bp
  • A to G, chromosome 2 at 41,445,194 bp
  • A to G, chromosome 2 at 52,052,327 bp
  • A to G, chromosome 2 at 69,459,472 bp
  • G to A, chromosome 2 at 69,549,047 bp
  • A to G, chromosome 2 at 91,615,150 bp
  • A to G, chromosome 2 at 119,813,293 bp
  • C to T, chromosome 2 at 153,746,281 bp
  • A to C, chromosome 2 at 168,756,242 bp
  • A to T, chromosome 2 at 181,152,833 bp
  • AG to AGG, chromosome 2 at 181,588,763 bp
  • T to C, chromosome 3 at 5,400,785 bp
  • C to T, chromosome 3 at 87,089,151 bp
  • C to T, chromosome 3 at 105,658,766 bp
  • T to C, chromosome 4 at 85,379,381 bp
  • T to C, chromosome 4 at 119,256,897 bp
  • T to C, chromosome 5 at 35,098,203 bp
  • A to G, chromosome 5 at 107,903,801 bp
  • T to A, chromosome 5 at 128,773,465 bp
  • A to T, chromosome 6 at 24,876,631 bp
  • A to G, chromosome 6 at 41,660,343 bp
  • T to A, chromosome 6 at 78,371,233 bp
  • A to T, chromosome 7 at 5,488,358 bp
  • A to T, chromosome 7 at 10,527,481 bp
  • G to A, chromosome 7 at 16,205,384 bp
  • G to T, chromosome 7 at 44,344,992 bp
  • A to T, chromosome 7 at 44,763,036 bp
  • G to T, chromosome 7 at 79,776,796 bp
  • A to G, chromosome 7 at 141,857,552 bp
  • G to A, chromosome 8 at 40,796,634 bp
  • T to C, chromosome 9 at 54,592,395 bp
  • A to T, chromosome 10 at 10,442,483 bp
  • A to T, chromosome 11 at 67,257,183 bp
  • A to T, chromosome 11 at 67,699,976 bp
  • A to T, chromosome 11 at 73,603,153 bp
  • T to G, chromosome 11 at 118,024,707 bp
  • T to A, chromosome 12 at 25,001,565 bp
  • C to A, chromosome 12 at 112,610,830 bp
  • G to A, chromosome 13 at 32,227,265 bp
  • A to G, chromosome 14 at 52,002,285 bp
  • T to C, chromosome 15 at 8,221,943 bp
  • T to C, chromosome 16 at 44,790,011 bp
  • G to A, chromosome 17 at 33,777,034 bp
  • A to G, chromosome 17 at 34,711,033 bp
  • T to C, chromosome 17 at 66,342,954 bp
  • T to C, chromosome 18 at 49,894,311 bp
  • A to G, chromosome 19 at 10,669,346 bp
  • G to A, chromosome 19 at 41,966,256 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3877 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040904-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.