Strain Name:
C57BL/6J-MtgxR3898Btlr/Mmmh
Stock Number:
040906-MU
Citation ID:
RRID:MMRRC_040906-MU
Other Names:
R3898 (G1), C57BL/6J-MtgxR3898Btlr
Major Collection:

Gene Information

Ptpn14
Name: protein tyrosine phosphatase, non-receptor type 14
Synonyms: C130080N23Rik, OTTMUSG00000022087, PTP36
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 19250
HGNC: HGNC:9647
Homologene: 3941
Thop1
Name: thimet oligopeptidase 1
Synonyms: EP24.15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 50492
Homologene: 55726
Ubr5
Name: ubiquitin protein ligase E3 component n-recognin 5
Synonyms: 4432411E13Rik, Edd, Edd1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 70790
VEGA: 15
Homologene: 9295
Kcnq2
Name: potassium voltage-gated channel, subfamily Q, member 2
Synonyms: Nmf134, KQT2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 16536
HGNC: HGNC:6296
Homologene: 26174
Vps53
Name: VPS53 GARP complex subunit
Synonyms: 2310040I21Rik, 3100002B05Rik, 2010002A08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 68299
Homologene: 6264
Cad
Name: carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
Synonyms: 2410008J01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 69719
HGNC: HGNC:1424
Homologene: 1412
Eif2ak4
Name: eukaryotic translation initiation factor 2 alpha kinase 4
Synonyms: GCN2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 27103
Homologene: 40891
Trip12
Name: thyroid hormone receptor interactor 12
Synonyms: 6720416K24Rik, 1110036I07Rik, Gtl6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 14897
Homologene: 44226
Wls
Name: wntless WNT ligand secretion mediator
Synonyms: 5031439A09Rik, Gpr177
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 68151
Homologene: 11779
Tbc1d5
Name: TBC1 domain family, member 5
Synonyms: 1600014N05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 72238
VEGA: 17
Homologene: 8834
Pou4f1
Name: POU domain, class 4, transcription factor 1
Synonyms: Brn-3.0, E130119J07Rik, Brn-3, Brn3, Brn3a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 18996
HGNC: HGNC:9218
Homologene: 21255
Drg2
Name: developmentally regulated GTP binding protein 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 13495
HGNC: HGNC:3030
Homologene: 1061
Dnah8
Name: dynein, axonemal, heavy chain 8
Synonyms: P1-Loop, Dnahc8, Hst6.7b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 13417
VEGA: 17
HGNC: HGNC:2952
Homologene: 1049
Ikbkb
Name: inhibitor of kappaB kinase beta
Synonyms: IKK[b], IKK-2, IKKbeta, IKK2, IKK-beta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 16150
HGNC: HGNC:5960
Homologene: 7782
Cul2
Name: cullin 2
Synonyms: 1300003D18Rik, 4932411N15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 71745
HGNC: HGNC:2552
Homologene: 2662
Fchsd2
Name: FCH and double SH3 domains 2
Synonyms: Sh3md3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 207278
Homologene: 8887
Elfn1
Name: leucine rich repeat and fibronectin type III, extracellular 1
Synonyms: A930017N06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 243312
Homologene: 18465
Anpep
Name: alanyl (membrane) aminopeptidase
Synonyms: Apn, Cd13, aminopeptidase N
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 16790
HGNC: HGNC:500
Homologene: 68163
Zkscan17
Name: zinc finger with KRAB and SCAN domains 17
Synonyms: Zfp496, Nizp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 268417
Homologene: 13108
Fli1
Name: Friend leukemia integration 1
Synonyms: Fli-1, EWSR2, SIC-1, Sic1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 14247
HGNC: HGNC:3749
Homologene: 55624
Lrp1
Name: low density lipoprotein receptor-related protein 1
Synonyms: b2b1554Clo, CD91, A2mr
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 16971
HGNC: HGNC:6692
Homologene: 1744
Mmrn2
Name: multimerin 2
Synonyms: Emilin3, EndoGlyx-1, ENDOGLYX1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 105450
VEGA: 14
Homologene: 11697
Dhx36
Name: DEAH (Asp-Glu-Ala-His) box polypeptide 36
Synonyms: Ddx36, 2810407E23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 72162
Homologene: 6356
Cdh8
Name: cadherin 8
Synonyms: cad8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 12564
HGNC: HGNC:1767
Homologene: 55604
D130043K22Rik
Name: RIKEN cDNA D130043K22 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 210108
Homologene: 8878
Megf10
Name: multiple EGF-like-domains 10
Synonyms: LOC240312, 3000002B06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 70417
Homologene: 23771
Lmntd1
Name: lamin tail domain containing 1
Synonyms: Lmna-rs1, Ifltd1, 4933403M22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 74071
Homologene: 69453
Nlrp1a
Name: NLR family, pyrin domain containing 1A
Synonyms: Nalp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 195046
Homologene: 133820
Trank1
Name: tetratricopeptide repeat and ankyrin repeat containing 1
Synonyms: LOC235639, C030048J01Rik, A230061D21Rik, Lba1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 320429
Homologene: 45845
1700028P14Rik
Name: RIKEN cDNA 1700028P14 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 67483
VEGA: 19
Homologene: 49850
Ccdc180
Name: coiled-coil domain containing 180
Synonyms: E230008N13Rik, LOC381522
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 381522
Homologene: 117988
Gpat2
Name: glycerol-3-phosphate acyltransferase 2, mitochondrial
Synonyms: A530057A03Rik, Gpat2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 215456
Homologene: 19037
Olfr1383
Name: olfactory receptor 1383
Synonyms: GA_x6K02T2QP88-5912627-5911692, MOR256-56
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 404337
Homologene: 105344
Zyg11a
Name: zyg-11 family member A, cell cycle regulator
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230590
Homologene: 66294
Rd3
Name: retinal degeneration 3
Synonyms: rd3, 3322402L07Rik, rd-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 74023
Homologene: 11373
Arfgef3
Name: ARFGEF family member 3
Synonyms: B930094H20Rik, BIG3, D10Bwg1379e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 215821
VEGA: 10
Homologene: 41366
Dnah7b
Name: dynein, axonemal, heavy chain 7B
Synonyms: Dnahc7b, LOC227058
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 227058
Homologene: 41287
H2-Q2
Name: histocompatibility 2, Q region locus 2
Synonyms: H-2Q2, Gm11132
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 15013
HGNC: HGNC:4931
Homologene: 128352
Cadps2
Name: Ca2+-dependent activator protein for secretion 2
Synonyms: cpd2, A230044C21Rik, Caps2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 320405
Homologene: 23060
Xirp1
Name: xin actin-binding repeat containing 1
Synonyms: Xin, mXin alpha, Cmya1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 22437
VEGA: 9
Homologene: 7998
Pyroxd2
Name: pyridine nucleotide-disulphide oxidoreductase domain 2
Synonyms: 3830409H07Rik, 4833409A17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 74580
VEGA: 19
Homologene: 13097
Vmn2r12
Name: vomeronasal 2, receptor 12
Synonyms: Gm6769
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 627569
Homologene: 129606
Ecscr
Name: endothelial cell surface expressed chemotaxis and apoptosis regulator
Synonyms: ARIA, 1110006O17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 68545
Homologene: 86811
Cyp2c69
Name: cytochrome P450, family 2, subfamily c, polypeptide 69
Synonyms: AI098658
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 100043108
VEGA: 19
Homologene: 74936
Cabyr
Name: calcium-binding tyrosine-(Y)-phosphorylation regulated (fibrousheathin 2)
Synonyms: 4933421A18Rik, FSP-2, 1700016C01Rik, CBP86
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 71132
Homologene: 49299
Trim30d
Name: tripartite motif-containing 30D
Synonyms: TRIM30-3, Trim79
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 209387
Homologene: 114426
Frmd3
Name: FERM domain containing 3
Synonyms: EPB41L4O, 4.1O, P410, 9430066I12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242506
Homologene: 16012
Cln6
Name: ceroid-lipofuscinosis, neuronal 6
Synonyms: D9Bwg1455e, 1810065L06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 76524
HGNC: HGNC:2077
Homologene: 9898
Alg1
Name: asparagine-linked glycosylation 1 (beta-1,4-mannosyltransferase)
Synonyms: HMAT1, HMT1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 208211
Homologene: 5387
AC151732.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 46,243,257 bp
  • A to T, chromosome 1 at 84,739,664 bp
  • C to T, chromosome 1 at 189,850,531 bp
  • T to C, chromosome 1 at 191,985,256 bp
  • T to C, chromosome 2 at 118,430,923 bp
  • T to C, chromosome 2 at 127,435,098 bp
  • C to T, chromosome 2 at 181,109,686 bp
  • T to C, chromosome 3 at 62,492,369 bp
  • A to T, chromosome 3 at 159,923,591 bp
  • A to G, chromosome 4 at 45,912,799 bp
  • A to G, chromosome 4 at 74,074,109 bp
  • T to A, chromosome 4 at 108,210,194 bp
  • G to T, chromosome 5 at 31,074,022 bp
  • C to T, chromosome 5 at 109,090,504 bp
  • G to A, chromosome 5 at 139,971,964 bp
  • G to A, chromosome 6 at 23,528,126 bp
  • G to A, chromosome 6 at 145,413,426 bp
  • A to G, chromosome 7 at 79,839,225 bp
  • A to G, chromosome 7 at 101,191,799 bp
  • T to A, chromosome 7 at 104,483,529 bp
  • C to T, chromosome 8 at 22,695,261 bp
  • TTCCTCCTCCTCCTCCTCCTCCTC to TTCCTCCTCCTCCTCCTCCTC, chromosome 8 at 89,146,861 bp
  • T to A, chromosome 8 at 99,171,373 bp
  • C to T, chromosome 9 at 32,476,722 bp
  • T to G, chromosome 9 at 62,850,652 bp
  • G to T, chromosome 9 at 111,393,862 bp
  • A to T, chromosome 9 at 120,019,340 bp
  • C to A, chromosome 10 at 18,664,879 bp
  • G to A, chromosome 10 at 81,080,444 bp
  • G to A, chromosome 10 at 127,592,100 bp
  • A to T, chromosome 11 at 49,524,559 bp
  • C to T, chromosome 11 at 59,503,437 bp
  • T to A, chromosome 11 at 60,456,634 bp
  • G to A, chromosome 11 at 71,122,874 bp
  • T to C, chromosome 11 at 76,117,810 bp
  • C to A, chromosome 13 at 24,879,585 bp
  • G to T, chromosome 14 at 34,399,560 bp
  • T to C, chromosome 14 at 104,465,729 bp
  • T to C, chromosome 15 at 37,997,739 bp
  • A to C, chromosome 16 at 5,236,389 bp
  • G to A, chromosome 17 at 30,854,898 bp
  • C to T, chromosome 17 at 35,342,767 bp
  • A to T, chromosome 17 at 50,963,744 bp
  • A to G, chromosome 18 at 3,434,033 bp
  • T to C, chromosome 18 at 12,751,523 bp
  • A to G, chromosome 18 at 35,713,652 bp
  • G to A, chromosome 18 at 57,262,162 bp
  • A to G, chromosome 19 at 23,593,102 bp
  • T to C, chromosome 19 at 39,876,390 bp
  • C to A, chromosome 19 at 42,740,392 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3898 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040906-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.