Strain Name:
C57BL/6J-MtgxR3903Btlr/Mmmh
Stock Number:
040907-MU
Citation ID:
RRID:MMRRC_040907-MU
Other Names:
R3903 (G1), C57BL/6J-MtgxR3903Btlr
Major Collection:

Gene Information

Hyal1
Name: hyaluronoglucosaminidase 1
Synonyms: Hyal-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 15586
HGNC: HGNC:5320
Homologene: 5277
Col6a1
Name: collagen, type VI, alpha 1
Synonyms: Col6a-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 12833
HGNC: HGNC:2211
Homologene: 1391
Eif4a2
Name: eukaryotic translation initiation factor 4A2
Synonyms: Eif4, 4833432N07Rik, BM-010, Ddx2b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 13682
HGNC: HGNC:3284
Homologene: 1487
Wnk1
Name: WNK lysine deficient protein kinase 1
Synonyms: 6430573H23Rik, Prkwnk1, EG406236, Hsn2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232341
Homologene: 14253
Rorb
Name: RAR-related orphan receptor beta
Synonyms: RZR-beta, Nr1f2, Rorbeta, hstp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 225998
Homologene: 38250
Amt
Name: aminomethyltransferase
Synonyms: EG434437
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 434437
HGNC: HGNC:473
Homologene: 409
Lipc
Name: lipase, hepatic
Synonyms: HL, Hpl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 15450
VEGA: 9
HGNC: HGNC:6619
Homologene: 199
Lrrk2
Name: leucine-rich repeat kinase 2
Synonyms: cI-46, LOC381026, 9330188B09Rik, D630001M17Rik, 4921513O20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 66725
Homologene: 18982
Vps13d
Name: vacuolar protein sorting 13D
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230895
Homologene: 15583
Golm1
Name: golgi membrane protein 1
Synonyms: D030064E01Rik, PSEC0257, GP73, 2310001L02Rik, Golph2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 105348
VEGA: 13
Homologene: 12346
Ap3m1
Name: adaptor-related protein complex 3, mu 1 subunit
Synonyms: 1200013D09Rik, C78982
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 55946
HGNC: HGNC:569
Homologene: 22693
Cdh6
Name: cadherin 6
Synonyms: K-cadherin, cad6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 12563
VEGA: 15
HGNC: HGNC:1765
Homologene: 21027
Scn1a
Name: sodium channel, voltage-gated, type I, alpha
Synonyms: Nav1.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 20265
Homologene: 21375
Col1a2
Name: collagen, type I, alpha 2
Synonyms: Col1a-2, Cola2, Cola-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 12843
HGNC: HGNC:2198
Homologene: 69
Calcrl
Name: calcitonin receptor-like
Synonyms: CRLR
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 54598
Homologene: 21179
Xirp2
Name: xin actin-binding repeat containing 2
Synonyms: A530024P18Rik, 2310008C07Rik, 2310003D02Rik, mXin beta, myomaxin, Cmya3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241431
Homologene: 19388
Olfr1276
Name: olfactory receptor 1276
Synonyms: GA_x6K02T2Q125-72308574-72309512, MOR245-10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258390
Homologene: 133614
Pabpc6
Name: poly(A) binding protein, cytoplasmic 6
Synonyms: 4932702K14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 67543
VEGA: 17
Homologene: 129776
Cyp4f40
Name: cytochrome P450, family 4, subfamily f, polypeptide 40
Synonyms: EG631304
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 631304
VEGA: 17
Homologene: 117991
Obscn
Name: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Synonyms: LOC380698, OTTMUSG00000005786
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 380698
Homologene: 70869
Olfr898
Name: olfactory receptor 898
Synonyms: GA_x6K02T2PVTD-32037624-32038565, MOR170-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258871
VEGA: 9
Homologene: 133654
Samd9l
Name: sterile alpha motif domain containing 9-like
Synonyms: ESTM25
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 209086
HGNC: HGNC:1349
Homologene: 7707
Hormad2
Name: HORMA domain containing 2
Synonyms: 4930529M09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 75828
Homologene: 45130
Ccdc178
Name: coiled coil domain containing 178
Synonyms: 4921528I01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 70950
VEGA: 18
Homologene: 12373
Serpinb9
Name: serine (or cysteine) peptidase inhibitor, clade B, member 9
Synonyms: ovalbumin, PI-9, Spi6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 20723
HGNC: HGNC:8955
Homologene: 37888
Amd1
Name: S-adenosylmethionine decarboxylase 1
Synonyms: AdoMetDC, Amd-1, SAMDC
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 11702
VEGA: 10
HGNC: HGNC:457
Homologene: 1235
Kif12
Name: kinesin family member 12
Synonyms: N-9 kinesin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 16552
Homologene: 7796
Zfp39
Name: zinc finger protein 39
Synonyms: CTfin33, Zfp-39
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 22698
Homologene: 69102
Grap
Name: GRB2-related adaptor protein
Synonyms: 8430435N19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 71520
Homologene: 4822
Olfr1356
Name: olfactory receptor 1356
Synonyms: GA_x6K02T2QGN0-2962025-2962987, MOR142-2_p, MOR142-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 258305
HGNC: HGNC:8374
Homologene: 71958
Gm8180
Name: predicted gene 8180
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 105242437
Fsip2l
Name: fibrous sheath-interacting protein 2-like
Synonyms: LOC209005, Gm595
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 209005
Homologene: 83587
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 2 at 66,318,132 bp
  • C to T, chromosome 2 at 67,508,036 bp
  • T to A, chromosome 2 at 84,368,642 bp
  • A to T, chromosome 2 at 111,257,769 bp
  • A to G, chromosome 4 at 63,167,976 bp
  • A to G, chromosome 4 at 145,085,445 bp
  • T to A, chromosome 6 at 3,376,830 bp
  • G to A, chromosome 6 at 4,518,822 bp
  • A to G, chromosome 6 at 119,949,051 bp
  • C to T, chromosome 9 at 38,349,658 bp
  • A to C, chromosome 9 at 70,934,468 bp
  • T to C, chromosome 9 at 107,578,972 bp
  • C to T, chromosome 9 at 108,297,221 bp
  • C to T, chromosome 10 at 40,290,457 bp
  • C to T, chromosome 10 at 76,711,341 bp
  • T to G, chromosome 10 at 78,847,298 bp
  • A to G, chromosome 11 at 4,427,237 bp
  • T to C, chromosome 11 at 58,890,175 bp
  • T to C, chromosome 11 at 59,131,646 bp
  • T to G, chromosome 11 at 61,660,325 bp
  • T to C, chromosome 13 at 33,010,810 bp
  • T to C, chromosome 13 at 59,638,340 bp
  • T to C, chromosome 14 at 21,036,664 bp
  • T to A, chromosome 14 at 43,783,635 bp
  • T to C, chromosome 15 at 13,042,575 bp
  • A to T, chromosome 15 at 91,747,700 bp
  • G to A, chromosome 15 at 91,747,701 bp
  • AG to A, chromosome 16 at 23,110,640 bp
  • T to C, chromosome 17 at 9,669,154 bp
  • C to A, chromosome 17 at 32,659,624 bp
  • C to T, chromosome 18 at 22,023,095 bp
  • A to G, chromosome 19 at 18,962,099 bp
  • T to C, chromosome X at 48,841,544 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
(Deceased) Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3903 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040907-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.