Strain Name:
C57BL/6J-MtgxR3912Btlr/Mmmh
Stock Number:
040910-MU
Citation ID:
RRID:MMRRC_040910-MU
Other Names:
R3912 (G1), C57BL/6J-MtgxR3912Btlr
Major Collection:

Strain Information

Mrps18b
Name: mitochondrial ribosomal protein S18B
Synonyms: 2400002C15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 66973
Homologene: 32205
Aopep
Name: aminopeptidase O
Synonyms: ApO, 2010111I01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 72061
HGNC: HGNC:1361
Homologene: 66273
Vps35l
Name: VPS35 endosomal protein sorting factor like
Synonyms: 9030624J02Rik, Vsp35l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 71517
Homologene: 10659
Erbin
Name: Erbb2 interacting protein
Synonyms: 1700028E05Rik, Erbin, Erbb2ip
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 59079
Homologene: 41282
Ilf3
Name: interleukin enhancer binding factor 3
Synonyms: NF90
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 16201
VEGA: 9
HGNC: HGNC:6038
Homologene: 7785
Sec16a
Name: SEC16 homolog A, endoplasmic reticulum export factor
Synonyms: C230052J16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 227648
Homologene: 10533
Herc2
Name: HECT and RLD domain containing E3 ubiquitin protein ligase 2
Synonyms: D7H15F32S1, D15F32S1h, D7H15F37S1, rjs, jdf2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 15204
HGNC: HGNC:4868
Homologene: 3430
Tbl1xr1
Name: transducin (beta)-like 1X-linked receptor 1
Synonyms: Ira1, DC42, C21, TBLR1, C230089I12Rik, A630076E03Rik, 8030499H02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 81004
Homologene: 69382
Pvr
Name: poliovirus receptor
Synonyms: mE4, 3830421F03Rik, Taa1, CD155, Tage4, necl-5, D7Ertd458e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 52118
HGNC: HGNC:9705
Homologene: 79541
Ryr2
Name: ryanodine receptor 2, cardiac
Synonyms: 9330127I20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 20191
VEGA: 13
Homologene: 37423
Snap91
Name: synaptosomal-associated protein 91
Synonyms: F1-20, 91kDa, AP180
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 20616
Homologene: 8429
Ilf2
Name: interleukin enhancer binding factor 2
Synonyms: TEG-267, 6230405A16Rik, Tex261, Tex267
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 67781
HGNC: HGNC:6037
Homologene: 26894
Tmtc3
Name: transmembrane and tetratricopeptide repeat containing 3
Synonyms: 9130014E20Rik, B130008E12Rik, mSmile
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 237500
Homologene: 27616
Epg5
Name: ectopic P-granules autophagy protein 5 homolog (C. elegans)
Synonyms: 5430411K18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 100502841
VEGA: 18
Homologene: 14575
Wnt3a
Name: wingless-type MMTV integration site family, member 3A
Synonyms: Wnt-3a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 22416
Homologene: 22528
Gab2
Name: growth factor receptor bound protein 2-associated protein 2
Synonyms: p97, D130058I17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 14389
Homologene: 69067
Cndp1
Name: carnosine dipeptidase 1 (metallopeptidase M20 family)
Synonyms: Cn1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 338403
Homologene: 57178
Fcrl2
Name: Fc receptor like 2
Synonyms: 2810439C17Rik, IFGP2, Fcrh2, moFcRH2sc, Msr2, Fcrls
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 80891
Homologene: 57117
Cdhr5
Name: cadherin-related family member 5
Synonyms: 1810074H01Rik, Mucdhl, Mupcdh
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 72040
HGNC: HGNC:7521
Homologene: 69345
Kirrel
Name: kirre like nephrin family adhesion molecule 1
Synonyms: Neph1, Kirrel1, 6720469N11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 170643
Homologene: 10089
Susd4
Name: sushi domain containing 4
Synonyms: E430021N18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 96935
Homologene: 23062
Camkk1
Name: calcium/calmodulin-dependent protein kinase kinase 1, alpha
Synonyms: CaMKKalpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 55984
HGNC: HGNC:1469
Homologene: 10327
Id2
Name: inhibitor of DNA binding 2
Synonyms: inhibitor of differentiation 2, C78922, Idb2, bHLHb26
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 15902
VEGA: 12
HGNC: HGNC:5361
Homologene: 1632
Ppp1r12b
Name: protein phosphatase 1, regulatory subunit 12B
Synonyms: 1810037O03Rik, 9530009M10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 329251
HGNC: HGNC:7619
Homologene: 135710
Pax7
Name: paired box 7
Synonyms: Pax-7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 18509
HGNC: HGNC:8621
Homologene: 55665
Scn4a
Name: sodium channel, voltage-gated, type IV, alpha
Synonyms: Nav1.4, mH2, SkM1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 110880
Homologene: 283
Nutm2
Name: NUT family member 2
Synonyms: LOC328250, Gm806
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 328250
Homologene: 128615
Tnfrsf11b
Name: tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)
Synonyms: osteoclastogenesis inhibitory factor, OCIF, OPG, Opg, TR1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 18383
VEGA: 15
Homologene: 1912
Ints10
Name: integrator complex subunit 10
Synonyms: 4921521J11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 70885
Homologene: 10029
Ermap
Name: erythroblast membrane-associated protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 27028
Homologene: 22782
Lrrc7
Name: leucine rich repeat containing 7
Synonyms: densin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 242274
Homologene: 10817
Atp2c2
Name: ATPase, Ca++ transporting, type 2C, member 2
Synonyms: 1810010G06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 69047
Homologene: 73463
Prg4
Name: proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein)
Synonyms: MSF, DOL54, lubricin, SZP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 96875
HGNC: HGNC:9364
Homologene: 137352
4921528O07Rik
Name:
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Trim30a
Name: tripartite motif-containing 30A
Synonyms: Rpt-1, Rpt1, Trim30
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 20128
Homologene: 114426
Vmn2r59
Name: vomeronasal 2, receptor 59
Synonyms: EG628444
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 628444
Homologene: 129683
Rev3l
Name: REV3 like, DNA directed polymerase zeta catalytic subunit
Synonyms: Sez4, Rev
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 19714
HGNC: HGNC:9968
Homologene: 48147
Acot12
Name: acyl-CoA thioesterase 12
Synonyms: 1300004O04Rik, 4930449F15Rik, Cach
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 74156
Homologene: 12540
Acot1
Name: acyl-CoA thioesterase 1
Synonyms: D12Ucla1, CTE-1, ACH2, CTE-I, Cte1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 26897
VEGA: 12
Homologene: 22686
Pate4
Name: prostate and testis expressed 4
Synonyms: 9530004K16Rik, SVS VII, Svs7, Pate-B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 56872
Homologene: 49624
Vwa5a
Name: von Willebrand factor A domain containing 5A
Synonyms: BCSC-1, 5830475I06Rik, Loh11cr2a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 67776
HGNC: HGNC:6658
Homologene: 18222
Gbp3
Name: guanylate binding protein 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 55932
Homologene: 137329
Vmn1r39
Name: vomeronasal 1 receptor 39
Synonyms: Gm5993
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 546903
Homologene: 110800
Ccdc158
Name: coiled-coil domain containing 158
Synonyms: 4932413O14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 320696
Homologene: 18560
Fnip2
Name: folliculin interacting protein 2
Synonyms: D630023B12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 329679
Homologene: 46417
Slc19a3
Name: solute carrier family 19, member 3
Synonyms: ThTr2, A230084E24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 80721
Homologene: 23530
Myrip
Name: myosin VIIA and Rab interacting protein
Synonyms: Slac2-c, A230081N12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 245049
Homologene: 9150
Or2ag18
Name: olfactory receptor family 2 subfamily AG member 18
Synonyms: GA_x6K02T2PBJ9-9184187-9183237, MOR283-4, Olfr700
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258593
Homologene: 64895
Adgra1
Name: adhesion G protein-coupled receptor A1
Synonyms: 2900059M17Rik, D7Ertd680e, Gpr123
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 52389
Homologene: 18582
Gm5724
Name: predicted gene 5724
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 435927
Shisa7
Name: shisa family member 7
Synonyms: D430041B17Rik, CKAMP59
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 232813
Homologene: 122129
Eepd1
Name: endonuclease/exonuclease/phosphatase family domain containing 1
Synonyms: 2310005P05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 67484
Homologene: 12144
Slc26a8
Name: solute carrier family 26, member 8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224661
Homologene: 27095
Adh7
Name: alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
Synonyms: IV ADH, Adh-3, Adt-1, Adh-3t, Adh3-t, Adh3-e, Adh3, Adh4, Adh-3e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 11529
HGNC: HGNC:256
Homologene: 37333
Tas1r1
Name: taste receptor, type 1, member 1
Synonyms: TR1, T1r1, Gpr70, T1R1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 110326
Homologene: 12888
Gm14326
Name: predicted gene 14326
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 665211
Homologene: 134324
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 83,022,703 bp
  • C to T, chromosome 1 at 134,887,318 bp
  • T to C, chromosome 1 at 150,451,868 bp
  • C to T, chromosome 1 at 163,066,069 bp
  • A to T, chromosome 1 at 182,887,466 bp
  • C to T, chromosome 2 at 26,414,387 bp
  • T to C, chromosome 2 at 177,945,865 bp
  • A to G, chromosome 3 at 22,200,576 bp
  • A to T, chromosome 3 at 79,479,505 bp
  • C to T, chromosome 3 at 87,089,151 bp
  • A to T, chromosome 3 at 87,259,351 bp
  • A to G, chromosome 3 at 90,487,060 bp
  • T to A, chromosome 3 at 138,221,780 bp
  • C to T, chromosome 3 at 142,566,338 bp
  • G to A, chromosome 3 at 158,291,952 bp
  • T to C, chromosome 4 at 119,188,165 bp
  • C to A, chromosome 4 at 139,780,898 bp
  • A to T, chromosome 4 at 152,031,924 bp
  • G to C, chromosome 5 at 92,648,935 bp
  • C to T, chromosome 6 at 66,805,141 bp
  • A to G, chromosome 6 at 141,727,636 bp
  • T to A, chromosome 7 at 4,830,240 bp
  • T to C, chromosome 7 at 19,909,292 bp
  • T to C, chromosome 7 at 42,046,320 bp
  • T to C, chromosome 7 at 56,098,437 bp
  • A to G, chromosome 7 at 97,299,073 bp
  • A to G, chromosome 7 at 104,411,141 bp
  • A to T, chromosome 7 at 106,805,865 bp
  • A to G, chromosome 7 at 118,746,390 bp
  • T to C, chromosome 7 at 139,845,714 bp
  • T to A, chromosome 7 at 141,273,857 bp
  • T to A, chromosome 8 at 68,813,620 bp
  • A to G, chromosome 8 at 119,721,276 bp
  • C to T, chromosome 9 at 21,398,126 bp
  • C to T, chromosome 9 at 25,483,304 bp
  • C to A, chromosome 9 at 35,611,844 bp
  • T to C, chromosome 9 at 38,734,743 bp
  • T to C, chromosome 9 at 86,792,557 bp
  • A to G, chromosome 9 at 120,432,616 bp
  • A to G, chromosome 10 at 39,820,556 bp
  • A to C, chromosome 10 at 100,449,026 bp
  • A to C, chromosome 11 at 59,250,002 bp
  • A to G, chromosome 11 at 73,033,816 bp
  • T to A, chromosome 11 at 106,320,716 bp
  • T to A, chromosome 12 at 25,095,872 bp
  • A to G, chromosome 12 at 84,017,032 bp
  • A to G, chromosome 13 at 11,772,427 bp
  • C to T, chromosome 13 at 50,472,940 bp
  • G to T, chromosome 13 at 63,156,706 bp
  • A to G, chromosome 13 at 91,770,089 bp
  • G to T, chromosome 13 at 103,862,287 bp
  • G to A, chromosome 13 at 103,886,338 bp
  • G to A, chromosome 15 at 54,256,182 bp
  • T to A, chromosome 17 at 28,644,779 bp
  • C to T, chromosome 17 at 35,910,939 bp
  • T to C, chromosome 18 at 77,997,384 bp
  • C to T, chromosome 18 at 84,631,999 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3912 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040910-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.