Strain Name:
C57BL/6J-MtgxR3914Btlr/Mmmh
Stock Number:
040912-MU
Citation ID:
RRID:MMRRC_040912-MU
Other Names:
R3914 (G1), C57BL/6J-MtgxR3914Btlr
Major Collection:

Gene Information

Hps5
Name: HPS5, biogenesis of lysosomal organelles complex 2 subunit 2
Synonyms: Hermansky-Pudlak syndrome 5, ruby eye 2, ru-2, ru2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 246694
Homologene: 35333
Slc32a1
Name: solute carrier family 32 (GABA vesicular transporter), member 1
Synonyms: Viaat, R75019, VGAT
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 22348
Homologene: 56451
Ranbp17
Name: RAN binding protein 17
Synonyms: 4932704E15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 66011
Homologene: 36409
Mast4
Name: microtubule associated serine/threonine kinase family member 4
Synonyms: 4930420O11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 328329
Homologene: 42094
Rrm1
Name: ribonucleotide reductase M1
Synonyms: RnrM1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 20133
Homologene: 806
Sipa1l3
Name: signal-induced proliferation-associated 1 like 3
Synonyms: 2610511M17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 74206
Homologene: 77938
Islr2
Name: immunoglobulin superfamily containing leucine-rich repeat 2
Synonyms: Linx, mbu-3, B930052A04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 320563
VEGA: 9
Homologene: 10833
Xpot
Name: exportin, tRNA (nuclear export receptor for tRNAs)
Synonyms: EXPORTIN-T, 1110004L07Rik, C79645
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 73192
VEGA: 10
Homologene: 38291
Hdc
Name: histidine decarboxylase
Synonyms: Hdc-c, Hdc-e, Hdc-s, L-histidine decarboxylase, Hdc-a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 15186
HGNC: HGNC:4855
Homologene: 20490
Plaa
Name: phospholipase A2, activating protein
Synonyms: D4Ertd618e, Ufd3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 18786
HGNC: HGNC:9043
Homologene: 3138
Myo19
Name: myosin XIX
Synonyms: Myohd1, 1110055A02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 66196
Homologene: 49819
Riok3
Name: RIO kinase 3
Synonyms: D18Ertd331e, Sudd, E130306C24Rik, 1200013N13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 66878
VEGA: 18
Homologene: 2843
Nupl1
Name: nucleoporin like 1
Synonyms: 1700017F11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 71844
VEGA: 14
Homologene: 40924
AU041133
Name: expressed sequence AU041133
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 216177
Homologene: 87560
Ice1
Name: interactor of little elongation complex ELL subunit 1
Synonyms: BC018507
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 218333
VEGA: 13
Homologene: 18902
D230025D16Rik
Name: RIKEN cDNA D230025D16 gene
Synonyms: Lin10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 234678
Homologene: 11864
Tarsl2
Name: threonyl-tRNA synthetase-like 2
Synonyms: A530046H20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 272396
Homologene: 65036
Ccdc174
Name: coiled-coil domain containing 174
Synonyms: C130022K22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 232236
Homologene: 9523
Exoc1
Name: exocyst complex component 1
Synonyms: Sec3p, Sec3l1, 2810407P21Rik, SEC3, A730011E05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 69940
Homologene: 41241
Ttn
Name: titin
Synonyms: shru, connectin, mdm, 2310057K23Rik, D330041I19Rik, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, L56, 2310074I15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 22138
Homologene: 130650
Rabl6
Name: RAB, member RAS oncogene family-like 6
Synonyms: Rbel1a, Rbel1b, Rbel1, B230208H17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 227624
Homologene: 11674
Gprc6a
Name: G protein-coupled receptor, family C, group 6, member A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 210198
VEGA: 10
Homologene: 17529
Entpd7
Name: ectonucleoside triphosphate diphosphohydrolase 7
Synonyms: 2810003F23Rik, Lysal2, 1810012B13Rik, LALP1, 1810020C02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 93685
Homologene: 122202
Ubqlnl
Name: ubiquilin-like
Synonyms: 4922504M18Rik, LOC244179
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 244179
Homologene: 17034
Shoc1
Name: shortage in chiasmata 1
Synonyms: LOC242489, Gm426, AI481877, Mzip2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 100155
Homologene: 79783
Fam234b
Name: family with sequence similarity 234, member B
Synonyms: 8430419L09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 74525
Homologene: 12572
Phldb2
Name: pleckstrin homology like domain, family B, member 2
Synonyms: LL5beta, LL5b, C820004H04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 208177
Homologene: 17100
Col20a1
Name: collagen, type XX, alpha 1
Synonyms: 1700051I12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 73368
Homologene: 75138
Wnt7b
Name: wingless-type MMTV integration site family, member 7B
Synonyms: Wnt-7b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 22422
VEGA: 15
Homologene: 22531
Mrc2
Name: mannose receptor, C type 2
Synonyms: Endo180, novel lectin, uPARAP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 17534
Homologene: 4408
Cdh18
Name: cadherin 18
Synonyms: B230220E17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 320865
HGNC: HGNC:1757
Homologene: 55858
Slc22a8
Name: solute carrier family 22 (organic anion transporter), member 8
Synonyms: mOat3, Roct, OAT3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 19879
VEGA: 19
Homologene: 20901
Slc26a3
Name: solute carrier family 26, member 3
Synonyms: 9030623B18Rik, Dra, 9130013M11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 13487
HGNC: HGNC:3018
Homologene: 55435
Atp8b2
Name: ATPase, class I, type 8B, member 2
Synonyms: Id
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 54667
Homologene: 23226
AC147806.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
Disp1
Name: dispatched RND transporter family member 1
Synonyms: 1190008H24Rik, DispA
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 68897
Homologene: 14133
4732440D04Rik
Name: RIKEN cDNA 4732440D04 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 654788
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 6,214,676 bp
  • CAGAGAGA to CAGAGAGAGA, chromosome 1 at 85,577,224 bp
  • A to G, chromosome 1 at 183,089,102 bp
  • T to C, chromosome 2 at 25,588,706 bp
  • T to A, chromosome 2 at 76,754,824 bp
  • T to C, chromosome 2 at 126,603,006 bp
  • C to T, chromosome 2 at 158,611,232 bp
  • A to G, chromosome 2 at 180,998,492 bp
  • A to T, chromosome 3 at 89,954,448 bp
  • T to A, chromosome 4 at 59,094,201 bp
  • A to G, chromosome 4 at 94,571,677 bp
  • G to A, chromosome 5 at 76,543,561 bp
  • G to T, chromosome 6 at 91,899,357 bp
  • A to G, chromosome 6 at 135,225,683 bp
  • T to C, chromosome 7 at 29,400,085 bp
  • T to C, chromosome 7 at 46,783,526 bp
  • C to A, chromosome 7 at 65,683,808 bp
  • A to G, chromosome 7 at 102,457,174 bp
  • A to G, chromosome 7 at 104,149,606 bp
  • A to G, chromosome 8 at 105,239,983 bp
  • A to T, chromosome 9 at 58,198,383 bp
  • T to A, chromosome 10 at 51,628,275 bp
  • G to A, chromosome 10 at 82,151,815 bp
  • A to T, chromosome 10 at 121,604,538 bp
  • G to A, chromosome 11 at 33,479,189 bp
  • G to A, chromosome 11 at 84,894,603 bp
  • T to C, chromosome 11 at 105,347,232 bp
  • A to T, chromosome 12 at 31,453,906 bp
  • A to G, chromosome 13 at 70,606,084 bp
  • G to A, chromosome 13 at 102,739,321 bp
  • A to G, chromosome 14 at 60,232,147 bp
  • T to C, chromosome 15 at 23,410,685 bp
  • T to A, chromosome 15 at 85,537,858 bp
  • T to C, chromosome 16 at 45,757,163 bp
  • A to G, chromosome 18 at 12,148,822 bp
  • T to A, chromosome 19 at 8,608,186 bp
  • G to A, chromosome 19 at 43,691,158 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3914 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040912-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.