Strain Name:
C57BL/6J-MtgxR3941Btlr/Mmmh
Stock Number:
040923-MU
Citation ID:
RRID:MMRRC_040923-MU
Other Names:
R3941 (G1), C57BL/6J-MtgxR3941Btlr
Major Collection:

Gene Information

Kit
Name: KIT proto-oncogene receptor tyrosine kinase
Synonyms: CD117, Dominant white spotting, Tr-kit, Gsfsco1, Gsfsco5, Gsfsow3, SOW3, SCO5, SCO1, c-KIT, Steel Factor Receptor, belly-spot
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 16590
HGNC: HGNC:6342
Homologene: 187
Utrn
Name: utrophin
Synonyms: G-utrophin, DRP, Dmdl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 22288
VEGA: 10
Homologene: 21398
Cdon
Name: cell adhesion molecule-related/down-regulated by oncogenes
Synonyms: CDO, CAM-related/down-regulated by oncogenes
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 57810
Homologene: 22996
Strn
Name: striatin, calmodulin binding protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 268980
Homologene: 2380
Cd2ap
Name: CD2-associated protein
Synonyms: METS-1, Mets1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 12488
VEGA: 17
Homologene: 7663
Ticrr
Name: TOPBP1-interacting checkpoint and replication regulator
Synonyms: 5730590G19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 77011
Homologene: 67120
Zeb1
Name: zinc finger E-box binding homeobox 1
Synonyms: 3110032K11Rik, ZEB, Zfhx1a, Tcf18, Zfhep, Tcf8, [delta]EF1, Nil2, Zfx1a, Tw, AREB6, MEB1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 21417
Homologene: 31779
Depdc1b
Name: DEP domain containing 1B
Synonyms: XTP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 218581
Homologene: 10157
Tnfrsf21
Name: tumor necrosis factor receptor superfamily, member 21
Synonyms: DR6, Death receptor 6, TR7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 94185
VEGA: 17
Homologene: 8696
Ccdc80
Name: coiled-coil domain containing 80
Synonyms: DRO1, 2610001E17Rik, Ssg1, Urb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 67896
Homologene: 12206
Hey1
Name: hairy/enhancer-of-split related with YRPW motif 1
Synonyms: hesr-1, HRT1, CHF2, Hesr1, bHLHb31, Herp2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 15213
HGNC: HGNC:4880
Homologene: 7756
Gabrr3
Name: gamma-aminobutyric acid (GABA) receptor, rho 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 328699
VEGA: 16
Homologene: 26716
Crebbp
Name: CREB binding protein
Synonyms: KAT3A, CBP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 12914
HGNC: HGNC:2348
Homologene: 68393
Neto2
Name: neuropilin (NRP) and tolloid (TLL)-like 2
Synonyms: 5530601C23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 74513
Homologene: 32387
Dync2h1
Name: dynein cytoplasmic 2 heavy chain 1
Synonyms: 4432416O06Rik, DHC2, b2b414Clo, Dnchc2, m407Asp, m152Asp, D030010H02Rik, D330044F14Rik, DHC1b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 110350
HGNC: HGNC:2962
Homologene: 14468
Sorl1
Name: sortilin-related receptor, LDLR class A repeats-containing
Synonyms: LR11, 2900010L19Rik, Sorla, mSorLA
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 20660
Homologene: 2336
Zfp410
Name: zinc finger protein 410
Synonyms: D12Ertd748e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 52708
VEGA: 12
Homologene: 10918
Xrcc4
Name: X-ray repair complementing defective repair in Chinese hamster cells 4
Synonyms: 2310057B22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 108138
Homologene: 2555
Ttyh1
Name: tweety family member 1
Synonyms: 6330408P11Rik, 4930459B04Rik, tty
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 57776
Homologene: 10779
Lrp1
Name: low density lipoprotein receptor-related protein 1
Synonyms: A2mr, b2b1554Clo, CD91
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 16971
HGNC: HGNC:6692
Homologene: 1744
Tapbp
Name: TAP binding protein
Synonyms: TPN, D17Wsu91e, tapasin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 21356
Homologene: 2401
Cngb3
Name: cyclic nucleotide gated channel beta 3
Synonyms: Cngbeta2, CCNC2, CNG6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 30952
HGNC: HGNC:2153
Homologene: 40908
Brinp3
Name: bone morphogenetic protein/retinoic acid inducible neural specific 3
Synonyms: B830045N13Rik, Fam5c
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 215378
Homologene: 17786
Vmn1r73
Name: vomeronasal 1 receptor 73
Synonyms: V1rg2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 171237
HGNC: null
Homologene: 103842
Nlrp2
Name: NLR family, pyrin domain containing 2
Synonyms: Nalp2, PYPAF2, E330007A02Rik, Pan1, Nbs1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 232827
Homologene: 56789
Btn1a1
Name: butyrophilin, subfamily 1, member A1
Synonyms: Btn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 12231
HGNC: HGNC:1135
Homologene: 1312
Irf6
Name: interferon regulatory factor 6
Synonyms: E230028I05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 54139
HGNC: HGNC:6121
Homologene: 4479
Slc39a12
Name: solute carrier family 39 (zinc transporter), member 12
Synonyms: LOC277468
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 277468
Homologene: 17654
Mei4
Name: meiotic double-stranded break formation protein 4
Synonyms: 4930486G11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 75033
Homologene: 87251
Col6a5
Name: collagen, type VI, alpha 5
Synonyms: Gm7455, Col6a5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 665033
Homologene: 122792
Frem3
Name: Fras1 related extracellular matrix protein 3
Synonyms: LOC333315
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 333315
Homologene: 35388
Mpo
Name: myeloperoxidase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 17523
HGNC: HGNC:7218
Homologene: 55450
Mug2
Name: murinoglobulin 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 17837
HGNC: null
Homologene: 136663
Eml6
Name: echinoderm microtubule associated protein like 6
Synonyms: 2900083P10Rik, C230094A16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 237711
Homologene: 104282
AC139206.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
Cttnbp2
Name: cortactin binding protein 2
Synonyms: ORF4, 3010022N24Rik, Cortbp2, 9130022E09Rik, 4732477G22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 30785
Homologene: 14125
Mrrf
Name: mitochondrial ribosome recycling factor
Synonyms: 2400002D02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 67871
HGNC: HGNC:7234
Homologene: 12203
Nipal4
Name: NIPA-like domain containing 4
Synonyms: 9530066K23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 214112
Homologene: 133769
Washc1
Name: WASH complex subunit 1
Synonyms: 1110049F14Rik, Wash, ORF19, Wash1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 68767
VEGA: 17
Homologene: 45706
Tgm1
Name: transglutaminase 1, K polypeptide
Synonyms: protein-glutamine-gamma-glutamyltransferase, K polypeptide, TGase1, 2310004J08Rik, TG K, TGase 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 21816
VEGA: 14
Homologene: 306
Abcc1
Name: ATP-binding cassette, sub-family C (CFTR/MRP), member 1
Synonyms: Abcc1a, Mrp1, Mdrap, MRP, Abcc1b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 17250
HGNC: HGNC:51
Homologene: 133779
Fpr-rs3
Name: formyl peptide receptor, related sequence 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 14290
HGNC: null
Homologene: 130087
Fcgr1
Name: Fc receptor, IgG, high affinity I
Synonyms: FcgammaRI, CD64
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 14129
HGNC: HGNC:3613
Homologene: 475
Plekhg3
Name: pleckstrin homology domain containing, family G (with RhoGef domain) member 3
Synonyms: MGC40768
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 263406
VEGA: 12
Homologene: 77478
Wnt10a
Name: wingless-type MMTV integration site family, member 10A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 22409
Homologene: 22525
Arhgap11a
Name: Rho GTPase activating protein 11A
Synonyms: GAP (1-12), 6530401L14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 228482
Homologene: 8862
Phc2
Name: polyhomeotic 2
Synonyms: D4Ertd810e, D130050K19Rik, Edr2, Mph2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 54383
HGNC: HGNC:3183
Homologene: 75090
Slc25a54
Name: solute carrier family 25, member 54
Synonyms: 4930443G12Rik, SCaMC-1like
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 74686
HGNC: null
Homologene: 82464
Pcdh1
Name: protocadherin 1
Synonyms: 2010005A06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 75599
HGNC: HGNC:8655
Homologene: 12613
Cacnb4
Name: calcium channel, voltage-dependent, beta 4 subunit
Synonyms: Cchb4, 3110038O15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 12298
HGNC: HGNC:1404
Homologene: 20188
Bin1
Name: bridging integrator 1
Synonyms: Amphl, Amphiphysin 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 30948
VEGA: 18
HGNC: HGNC:1052
Homologene: 113707
2610203C20Rik
Name: RIKEN cDNA 2610203C20 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
Vmn1r175
Name: vomeronasal 1 receptor 175
Synonyms: Gm6299
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 622222
HGNC: null
Homologene: 128341
Eif2s3y
Name: eukaryotic translation initiation factor 2, subunit 3, structural gene Y-linked
Synonyms: Eif-2gy, Spy, Tfy
Type: Gene
Species: Mus musculus (mouse)
Chromosome: Y
Alteration at locus: Chemically Induced
NCBI: 26908
HGNC: null
Homologene: 99414
Psors1c2
Name: psoriasis susceptibility 1 candidate 2 (human)
Synonyms: Pcg, SPR1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 57390
Homologene: 105711
1700007J10Rik
Name: RIKEN cDNA 1700007J10 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 69320
HGNC: null
Homologene: null
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 74,803,497 bp
  • C to A, chromosome 1 at 146,751,861 bp
  • A to G, chromosome 1 at 193,168,549 bp
  • A to T, chromosome 1 at 195,165,814 bp
  • A to T, chromosome 2 at 14,396,181 bp
  • T to C, chromosome 2 at 36,147,343 bp
  • C to A, chromosome 2 at 52,469,489 bp
  • A to T, chromosome 2 at 113,836,897 bp
  • A to G, chromosome 3 at 8,664,578 bp
  • A to G, chromosome 3 at 96,286,033 bp
  • A to T, chromosome 3 at 109,112,163 bp
  • A to G, chromosome 4 at 19,396,786 bp
  • T to C, chromosome 4 at 128,747,244 bp
  • A to G, chromosome 5 at 75,609,318 bp
  • T to A, chromosome 6 at 18,427,453 bp
  • G to C, chromosome 6 at 122,063,563 bp
  • T to A, chromosome 7 at 4,129,318 bp
  • A to T, chromosome 7 at 5,327,552 bp
  • T to C, chromosome 7 at 11,756,755 bp
  • A to G, chromosome 7 at 23,808,968 bp
  • T to C, chromosome 7 at 79,693,697 bp
  • T to C, chromosome 8 at 80,615,020 bp
  • G to A, chromosome 8 at 85,674,118 bp
  • G to A, chromosome 9 at 7,124,825 bp
  • A to G, chromosome 9 at 35,464,171 bp
  • T to C, chromosome 9 at 41,590,274 bp
  • T to C, chromosome 9 at 41,989,468 bp
  • C to T, chromosome 9 at 81,927,283 bp
  • G to A, chromosome 9 at 105,939,834 bp
  • T to A, chromosome 10 at 12,711,585 bp
  • G to A, chromosome 10 at 127,553,396 bp
  • C to T, chromosome 11 at 29,803,167 bp
  • C to T, chromosome 11 at 46,150,646 bp
  • T to C, chromosome 11 at 59,731,502 bp
  • A to T, chromosome 11 at 87,797,349 bp
  • A to G, chromosome 12 at 76,573,359 bp
  • A to G, chromosome 12 at 84,338,753 bp
  • T to G, chromosome 13 at 23,459,264 bp
  • A to G, chromosome 13 at 90,071,633 bp
  • T to C, chromosome 13 at 108,368,836 bp
  • G to A, chromosome 14 at 55,712,424 bp
  • A to G, chromosome 16 at 4,126,987 bp
  • A to T, chromosome 16 at 14,396,399 bp
  • A to G, chromosome 16 at 45,096,092 bp
  • A to G, chromosome 16 at 59,433,501 bp
  • T to C, chromosome 17 at 20,624,849 bp
  • A to G, chromosome 17 at 33,920,483 bp
  • G to T, chromosome 17 at 35,533,928 bp
  • G to C, chromosome 17 at 42,808,799 bp
  • G to A, chromosome 17 at 43,038,010 bp
  • T to C, chromosome 17 at 66,118,128 bp
  • A to T, chromosome 17 at 78,657,940 bp
  • T to C, chromosome 18 at 5,767,799 bp
  • T to C, chromosome 18 at 32,406,158 bp
  • A to G, chromosome 18 at 38,199,458 bp
  • G to T, chromosome Y at 1,012,079 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3941 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040923-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.