Strain Name:
C57BL/6J-MtgxR3945Btlr/Mmmh
Stock Number:
040926-MU
Citation ID:
RRID:MMRRC_040926-MU
Other Names:
R3945 (G1), C57BL/6J-MtgxR3945Btlr
Major Collection:

Gene Information

Trpc2
Name: transient receptor potential cation channel, subfamily C, member 2
Synonyms: TRPC2a, mTrp2, TRPC2b, Trrp2, trp2, 3010009O07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 22064
Homologene: 135989
Actn4
Name: actinin alpha 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 60595
HGNC: HGNC:166
Homologene: 55857
Spen
Name: spen family transcription repressor
Synonyms: Mint
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 56381
Homologene: 124461
Mast2
Name: microtubule associated serine/threonine kinase 2
Synonyms: Mtssk, MAST205
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 17776
Homologene: 7428
Trmt13
Name: tRNA methyltransferase 13
Synonyms: Ccdc76, A930028L21Rik, 4631408H19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 229780
Homologene: 6875
Sin3b
Name: transcriptional regulator, SIN3B (yeast)
Synonyms: 2810430C10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 20467
Homologene: 81810
Ankrd12
Name: ankyrin repeat domain 12
Synonyms: 2900001A12Rik, ANCO-2, GAC-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 106585
Homologene: 9059
Cabin1
Name: calcineurin binding protein 1
Synonyms: Cain, A330070M20Rik, Ppp3in
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 104248
VEGA: 10
Homologene: 49307
Rcbtb1
Name: regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1
Synonyms: 5430409I18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 71330
Homologene: 10061
Nr2c2
Name: nuclear receptor subfamily 2, group C, member 2
Synonyms: Tr4, TAK1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 22026
HGNC: HGNC:7972
Homologene: 2475
Ipo8
Name: importin 8
Synonyms: Om1, OM-1, C130009K11Rik, Ranbp8, 6230418K12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 320727
HGNC: HGNC:9853
Homologene: 48430
Trim66
Name: tripartite motif-containing 66
Synonyms: Tif1d, D7H11orf29
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 330627
Homologene: 28044
Vamp2
Name: vesicle-associated membrane protein 2
Synonyms: Syb2, synaptobrevin-2, sybII, synaptobrevin II, Syb-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 22318
Homologene: 7591
Coch
Name: cochlin
Synonyms: D12H14S564E, Coch-5B2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 12810
VEGA: 12
HGNC: HGNC:2180
Homologene: 20868
Efs
Name: embryonal Fyn-associated substrate
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 13644
VEGA: 14
Homologene: 4284
Fgfr2
Name: fibroblast growth factor receptor 2
Synonyms: Bek, Fgfr-2, KGFRTr, Fgfr-7, Fgfr7, svs
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 14183
HGNC: HGNC:3689
Homologene: 22566
Npc1
Name: NPC intracellular cholesterol transporter 1
Synonyms: lcsd, D18Ertd723e, nmf164, D18Ertd139e, A430089E03Rik, C85354
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 18145
HGNC: HGNC:7897
Homologene: 228
Creb3l1
Name: cAMP responsive element binding protein 3-like 1
Synonyms: BBF-2 (drosophila) homolog, Oasis
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 26427
Homologene: 8058
Kank4
Name: KN motif and ankyrin repeat domains 4
Synonyms: Ankrd38
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 242553
Homologene: 18244
Agr3
Name: anterior gradient 3
Synonyms: LOC380754, E030025L21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 403205
Homologene: 45551
Synrg
Name: synergin, gamma
Synonyms: L71-5, Ap1gbp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 217030
HGNC: HGNC:557
Homologene: 105680
Ssh2
Name: slingshot protein phosphatase 2
Synonyms: SSH-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 237860
Homologene: 14116
Csmd1
Name: CUB and Sushi multiple domains 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 94109
Homologene: 69536
Chrne
Name: cholinergic receptor, nicotinic, epsilon polypeptide
Synonyms: AChrepsilon, Acre
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 11448
HGNC: HGNC:1966
Homologene: 60
Ern2
Name: endoplasmic reticulum (ER) to nucleus signalling 2
Synonyms: Ire1b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 26918
Homologene: 22687
Ptprq
Name: protein tyrosine phosphatase, receptor type, Q
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 237523
HGNC: HGNC:9679
Homologene: 83557
2610507B11Rik
Name: RIKEN cDNA 2610507B11 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 72503
Homologene: 34730
Wdfy4
Name: WD repeat and FYVE domain containing 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 545030
Homologene: 83473
Atp7b
Name: ATPase, Cu++ transporting, beta polypeptide
Synonyms: Atp7a, Wilson protein, WND
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 11979
HGNC: HGNC:870
Homologene: 20063
C630050I24Rik
Name: RIKEN cDNA C630050I24 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
4930407I10Rik
Name: RIKEN cDNA 4930407I10 gene
Synonyms: LOC328573
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 328573
VEGA: 15
Homologene: 130065
Corin
Name: corin, serine peptidase
Synonyms: Lrp4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 53419
Homologene: 4804
Cpa3
Name: carboxypeptidase A3, mast cell
Synonyms: MC-CPA, mMC-CPA, mast cell carboxypeptidase A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 12873
HGNC: HGNC:2298
Homologene: 122138
Filip1
Name: filamin A interacting protein 1
Synonyms: FILIP, 5730485H21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 70598
Homologene: 6700
Samd9l
Name: sterile alpha motif domain containing 9-like
Synonyms: ESTM25
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 209086
HGNC: HGNC:1349
Homologene: 7707
Ddx59
Name: DEAD (Asp-Glu-Ala-Asp) box polypeptide 59
Synonyms: 4833411G06Rik, 1210002B07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 67997
Homologene: 12222
Slc22a23
Name: solute carrier family 22, member 23
Synonyms: 3110004L20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 73102
Homologene: 41457
Vmn1r181
Name: vomeronasal 1 receptor 181
Synonyms: V1rd20
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 404289
Homologene: 104166
Vmn1r113
Name: vomeronasal 1 receptor 113
Synonyms: Gm5748
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 436135
Homologene: 104166
Mst1
Name: macrophage stimulating 1 (hepatocyte growth factor-like)
Synonyms: DNF15S2h, Hgfl, D3F15S2h, D9H3F15S2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 15235
HGNC: HGNC:7380
Homologene: 7360
Pde11a
Name: phosphodiesterase 11A
Synonyms: 6330414F14Rik, A630086N24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 241489
HGNC: HGNC:8773
Homologene: 56763
Adamts17
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 17
Synonyms: AU023434
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 233332
Homologene: 16373
Tigd3
Name: tigger transposable element derived 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 332359
VEGA: 19
Homologene: 129795
Ascl2
Name: achaete-scute family bHLH transcription factor 2
Synonyms: Mash2, 2410083I15Rik, bHLHa45
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 17173
HGNC: HGNC:739
Homologene: 3789
Ugt3a2
Name: UDP glycosyltransferases 3 family, polypeptide A2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 223337
Homologene: 122787
Olfr1496
Name: olfactory receptor 1496
Synonyms: MOR127-1, GA_x6K02T2RE5P-4112771-4113718
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 258991
Homologene: 17458
Adck5
Name: aarF domain containing kinase 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 268822
Homologene: 34378
Vmn1r14
Name: vomeronasal 1 receptor 14
Synonyms: V1rc7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 113864
Homologene: 74373
Olfr1289
Name: olfactory receptor 1289
Synonyms: GA_x6K02T2Q125-72534883-72535821, MOR245-6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 258399
HGNC: HGNC:8301
Rpl37
Name: ribosomal protein L37
Synonyms: 3110005M08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 67281
VEGA: 15
Homologene: 68110
Defa25
Name: defensin, alpha, 25
Synonyms: Defcr25
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 13236
Homologene: 113382
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 136,434,618 bp
  • T to C, chromosome 2 at 76,075,931 bp
  • T to C, chromosome 2 at 91,991,211 bp
  • C to T, chromosome 2 at 111,483,687 bp
  • A to T, chromosome 3 at 20,225,117 bp
  • A to G, chromosome 3 at 116,581,518 bp
  • T to A, chromosome 4 at 98,771,280 bp
  • A to G, chromosome 4 at 116,463,729 bp
  • T to C, chromosome 4 at 141,477,353 bp
  • A to G, chromosome 5 at 72,358,424 bp
  • A to T, chromosome 6 at 3,377,029 bp
  • T to A, chromosome 6 at 57,234,269 bp
  • C to T, chromosome 6 at 92,163,138 bp
  • T to A, chromosome 6 at 148,818,117 bp
  • A to G, chromosome 7 at 20,787,712 bp
  • T to A, chromosome 7 at 23,984,152 bp
  • T to C, chromosome 7 at 28,912,236 bp
  • A to T, chromosome 7 at 67,120,939 bp
  • T to C, chromosome 7 at 102,088,279 bp
  • G to A, chromosome 7 at 109,472,268 bp
  • A to G, chromosome 7 at 122,176,530 bp
  • C to T, chromosome 7 at 130,177,755 bp
  • T to C, chromosome 7 at 142,967,971 bp
  • A to C, chromosome 8 at 15,910,619 bp
  • G to A, chromosome 8 at 21,084,490 bp
  • T to C, chromosome 8 at 22,020,864 bp
  • A to G, chromosome 8 at 72,733,439 bp
  • C to T, chromosome 8 at 107,119,262 bp
  • T to C, chromosome 9 at 79,818,367 bp
  • G to A, chromosome 9 at 108,084,853 bp
  • T to G, chromosome 10 at 75,745,259 bp
  • A to G, chromosome 10 at 107,686,392 bp
  • C to A, chromosome 11 at 69,089,174 bp
  • T to C, chromosome 11 at 70,617,043 bp
  • T to C, chromosome 11 at 77,454,668 bp
  • T to C, chromosome 11 at 78,289,964 bp
  • T to A, chromosome 11 at 84,023,406 bp
  • C to A, chromosome 12 at 35,947,513 bp
  • A to G, chromosome 12 at 51,601,812 bp
  • A to G, chromosome 13 at 34,183,126 bp
  • A to T, chromosome 14 at 32,966,395 bp
  • A to G, chromosome 14 at 54,920,651 bp
  • G to A, chromosome 14 at 59,224,776 bp
  • G to A, chromosome 15 at 5,117,694 bp
  • A to T, chromosome 15 at 9,370,098 bp
  • A to G, chromosome 15 at 76,595,200 bp
  • T to C, chromosome 15 at 82,065,400 bp
  • G to A, chromosome 17 at 65,976,103 bp
  • A to T, chromosome 18 at 12,201,551 bp
  • A to G, chromosome 19 at 5,892,433 bp
  • A to G, chromosome 19 at 13,781,422 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3945 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040926-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.