Strain Name:
C57BL/6J-MtgxR3978Btlr/Mmmh
Stock Number:
040941-MU
Citation ID:
RRID:MMRRC_040941-MU
Other Names:
R3978 (G1), C57BL/6J-MtgxR3978Btlr
Major Collection:

Gene Information

Gene Symbol: Fga (Mus musculus (mouse))
Name: fibrinogen alpha chain
Synonyms: Fib, ENSMUSG00000059807
Chromosome: 3
Alteration at locus: Chemically Induced
Monarch Initiative (Disease and Phenotype Associations): MGI:1316726
Gene Symbol: Sbf2 (Mus musculus (mouse))
Name: SET binding factor 2
Synonyms: SBF2, B430219L04Rik, mMTMH1, 4833411B01Rik, Mtmr13
Chromosome: 7
Alteration at locus: Chemically Induced
Monarch Initiative (Disease and Phenotype Associations): MGI:1921831
Gene Symbol: Slc6a6 (Mus musculus (mouse))
Name: solute carrier family 6 (neurotransmitter transporter, taurine), member 6
Synonyms: Taut
Chromosome: 6
Alteration at locus: Chemically Induced
Monarch Initiative (Disease and Phenotype Associations): MGI:98488
Gene Symbol: Lyst (Mus musculus (mouse))
Name: lysosomal trafficking regulator
Synonyms: D13Sfk13
Chromosome: 13
Alteration at locus: Chemically Induced
Monarch Initiative (Disease and Phenotype Associations): MGI:107448
Gene Symbol: Itk (Mus musculus (mouse))
Name: IL2 inducible T cell kinase
Synonyms: Tsk, Tcsk, Emt
Chromosome: 11
Alteration at locus: Chemically Induced
Monarch Initiative (Disease and Phenotype Associations): MGI:96621
Gene Symbol: Ubp1 (Mus musculus (mouse))
Name: upstream binding protein 1
Synonyms: LBP-1b, NF2d9, LBP-1a
Chromosome: 9
Alteration at locus: Chemically Induced
Monarch Initiative (Disease and Phenotype Associations): MGI:104889
Gene Symbol: Zmym6 (Mus musculus (mouse))
Name: zinc finger, MYM-type 6
Synonyms: D4Wsu24e, Zfp258, 9330177P20Rik
Chromosome: 4
Alteration at locus: Chemically Induced
Monarch Initiative (Disease and Phenotype Associations): MGI:106505
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 10,209,634 bp
  • T to C, chromosome 1 at 86,128,187 bp
  • T to C, chromosome 1 at 93,421,351 bp
  • T to A, chromosome 1 at 180,668,792 bp
  • A to C, chromosome 2 at 3,225,035 bp
  • C to T, chromosome 2 at 37,517,850 bp
  • T to A, chromosome 2 at 52,116,747 bp
  • A to T, chromosome 3 at 83,030,183 bp
  • AAAT to AAATGTATATAAAT, chromosome 3 at 118,897,088 bp
  • AAT to AATGTATATATAT, chromosome 3 at 118,897,089 bp
  • T to C, chromosome 3 at 138,183,674 bp
  • C to T, chromosome 3 at 142,629,986 bp
  • T to C, chromosome 4 at 127,123,555 bp
  • T to C, chromosome 4 at 129,592,336 bp
  • T to C, chromosome 5 at 4,069,218 bp
  • T to A, chromosome 5 at 24,377,931 bp
  • T to C, chromosome 5 at 32,926,875 bp
  • C to T, chromosome 5 at 114,932,898 bp
  • A to T, chromosome 6 at 91,755,052 bp
  • A to G, chromosome 6 at 127,967,247 bp
  • G to A, chromosome 7 at 51,587,806 bp
  • T to C, chromosome 7 at 79,617,399 bp
  • T to A, chromosome 7 at 85,232,462 bp
  • G to T, chromosome 7 at 110,124,555 bp
  • G to T, chromosome 7 at 110,329,885 bp
  • C to T, chromosome 7 at 118,984,131 bp
  • A to G, chromosome 8 at 70,889,395 bp
  • G to A, chromosome 8 at 84,040,684 bp
  • T to A, chromosome 8 at 107,053,037 bp
  • C to T, chromosome 9 at 8,004,284 bp
  • A to G, chromosome 9 at 72,615,111 bp
  • T to C, chromosome 9 at 105,698,879 bp
  • A to T, chromosome 9 at 113,956,705 bp
  • T to C, chromosome 10 at 7,752,754 bp
  • C to A, chromosome 10 at 51,621,101 bp
  • T to C, chromosome 10 at 92,962,412 bp
  • C to A, chromosome 10 at 98,996,933 bp
  • A to G, chromosome 10 at 106,830,629 bp
  • A to G, chromosome 10 at 120,089,625 bp
  • A to T, chromosome 10 at 127,850,075 bp
  • T to G, chromosome 11 at 46,340,643 bp
  • A to G, chromosome 11 at 121,943,568 bp
  • T to A, chromosome 12 at 31,465,860 bp
  • T to C, chromosome 12 at 55,600,838 bp
  • A to T, chromosome 12 at 108,157,942 bp
  • G to A, chromosome 13 at 13,634,168 bp
  • A to G, chromosome 13 at 65,035,160 bp
  • T to A, chromosome 14 at 34,223,104 bp
  • G to T, chromosome 14 at 57,017,188 bp
  • A to G, chromosome 14 at 68,610,994 bp
  • A to G, chromosome 14 at 70,563,584 bp
  • C to T, chromosome 14 at 121,489,827 bp
  • A to G, chromosome 15 at 6,435,163 bp
  • A to T, chromosome 15 at 38,498,713 bp
  • A to T, chromosome 15 at 91,860,348 bp
  • A to G, chromosome 15 at 96,363,622 bp
  • T to C, chromosome 15 at 102,921,240 bp
  • G to A, chromosome 17 at 33,935,162 bp
  • C to T, chromosome 17 at 34,036,326 bp
  • A to T, chromosome 18 at 36,647,613 bp
  • A to T, chromosome 18 at 61,073,685 bp
  • A to G, chromosome 18 at 89,081,881 bp
  • T to C, chromosome 19 at 4,192,254 bp
  • A to G, chromosome 19 at 18,937,890 bp
  • T to A, chromosome 19 at 46,653,957 bp
  • A to G, chromosome 19 at 56,866,634 bp
  • T to C, chromosome X at 9,444,588 bp
Genotype Determination
ES Cell Line
N/A
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
MeSH Terms
    Strain Development
    C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
    Suggested Control Mice
    Wild-type littermates or C57BL/6J mice
    Primary Reference
    MUTAGENETIX record for R3978 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

    Colony and Husbandry Informationon

    Colony Surveillance Program and Current Health Reports

    Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
    Coat Color
    Black
    MMRRC Breeding System
    Random intra-strain mating
    Breeding Scheme(s)
    When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
    Overall Breeding Performance
    Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
    Average litter size
    Undetermined
    Recommended wean age
    3 weeks

    Order Request Information

    Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

    Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

    The donor or their institution limits the distribution to non-profit institutions only.

    Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

    Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
    MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
    040941-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.

    Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

    1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

    2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

    3 An aliquot contains a sufficient number of embryos (in one or more vials and based on the transfer success rate of the MMRRC facility) to transfer to at least two recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

    To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.