Strain Name:
C57BL/6J-MtgxR4010Btlr/Mmmh
Stock Number:
040947-MU
Citation ID:
RRID:MMRRC_040947-MU
Other Names:
R4010 (G1), C57BL/6J-MtgxR4010Btlr
Major Collection:

Gene Information

Adsl
Name: adenylosuccinate lyase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 11564
HGNC: HGNC:291
Homologene: 12
Setd2
Name: SET domain containing 2
Synonyms: 4921524K10Rik, KMT3A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235626
Homologene: 56493
Safb
Name: scaffold attachment factor B
Synonyms: 5330423C17Rik, SAFB1, 3110021E02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224903
Homologene: 2229
Fxr1
Name: fragile X mental retardation gene 1, autosomal homolog
Synonyms: 1110050J02Rik, Fxr1p, 9530073J07Rik, Fxr1h
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 14359
HGNC: HGNC:4023
Homologene: 3573
Map2k2
Name: mitogen-activated protein kinase kinase 2
Synonyms: MEK2, MAP kinase/Erk kinase, Prkmk2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 26396
HGNC: HGNC:6842
Homologene: 48591
Rpa2
Name: replication protein A2
Synonyms: 30-kDa protein, Rf-A2, RPA34
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 19891
Homologene: 37712
Grb10
Name: growth factor receptor bound protein 10
Synonyms: Meg1, maternally expressed gene 1, 5730571D09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 14783
HGNC: HGNC:4564
Homologene: 3882
Supt16
Name: SPT16, facilitates chromatin remodeling subunit
Synonyms: Cdc68, Fact140, Spt16, Supt16h
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 114741
VEGA: 14
Homologene: 5207
Slc19a2
Name: solute carrier family 19 (thiamine transporter), member 2
Synonyms: TRMA, THTR1, DDA1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 116914
Homologene: 38258
Slc30a5
Name: solute carrier family 30 (zinc transporter), member 5
Synonyms: Zntl1, ZnT-5, ZTL1, 1810010K08Rik, Znt5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 69048
VEGA: 13
Homologene: 41503
Pdcl
Name: phosducin-like
Synonyms: 1200011E13Rik, PhLP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 67466
HGNC: HGNC:8770
Homologene: 38043
Pggt1b
Name: protein geranylgeranyltransferase type I, beta subunit
Synonyms: GGT1, BGG1, 2010207C17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 225467
VEGA: 18
HGNC: HGNC:8895
Homologene: 3685
Strip2
Name: striatin interacting protein 2
Synonyms: Myoscape, D330017J20Rik, Fam40b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 320609
Homologene: 66198
Adamts12
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 239337
VEGA: 15
Homologene: 12808
Usp39
Name: ubiquitin specific peptidase 39
Synonyms: D6Wsu157e, CGI-21, SAD1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 28035
Homologene: 13183
Frmd6
Name: FERM domain containing 6
Synonyms: 2610019M19Rik, 4930488L10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 319710
VEGA: 12
Homologene: 12449
Ryr1
Name: ryanodine receptor 1, skeletal muscle
Synonyms: calcium release channel isoform 1, Ryr, skrr
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 20190
Homologene: 68069
Itgae
Name: integrin alpha E, epithelial-associated
Synonyms: CD103, alpha-E1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 16407
HGNC: HGNC:6147
Homologene: 113560
Marveld2
Name: MARVEL (membrane-associating) domain containing 2
Synonyms: Mrvldc2, Tricellulin, Tric, Tric-c, Tric-b, Tric-a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218518
VEGA: 13
Homologene: 27037
Abca13
Name: ATP-binding cassette, sub-family A (ABC1), member 13
Synonyms: A930002G16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 268379
Homologene: 27991
Rel
Name: reticuloendotheliosis oncogene
Synonyms: c-Rel
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 19696
HGNC: HGNC:9954
Homologene: 2182
Pkhd1l1
Name: polycystic kidney and hepatic disease 1-like 1
Synonyms: D86 mRNA, PKHDL1, fibrocystin L
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 192190
Homologene: 16332
Ifit2
Name: interferon-induced protein with tetratricopeptide repeats 2
Synonyms: Ifi54
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 15958
HGNC: HGNC:5409
Homologene: 1187
Kif1a
Name: kinesin family member 1A
Synonyms: Kns1, ATSV, N-3 kinesin, LOC381283, C630002N23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 16560
HGNC: HGNC:888
Homologene: 99729
Sh2d4a
Name: SH2 domain containing 4A
Synonyms: SH2A, 2210402M20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 72281
Homologene: 11117
Erich6
Name: glutamate rich 6
Synonyms: 4932431H17Rik, Fam194a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 545527
Homologene: 65043
Impdh1
Name: inosine monophosphate dehydrogenase 1
Synonyms: B930086D20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 23917
HGNC: HGNC:6052
Homologene: 68096
Ddx60
Name: DExD/H box helicase 60
Synonyms: DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234311
Homologene: 23031
Olfr512
Name: olfactory receptor 512
Synonyms: GA_x6K02T2PBJ9-11043421-11044365, MOR268-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258719
Homologene: 138316
Pde6c
Name: phosphodiesterase 6C, cGMP specific, cone, alpha prime
Synonyms: cpfl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 110855
VEGA: 19
HGNC: HGNC:8787
Homologene: 4521
Gm1110
Name: predicted gene 1110
Synonyms: LOC382064
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 382064
VEGA: 9
Homologene: 78608
Abcc2
Name: ATP-binding cassette, sub-family C (CFTR/MRP), member 2
Synonyms: multidrug resistance protein 2, Mrp2, Cmoat
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 12780
HGNC: HGNC:53
Homologene: 68052
Vmn1r185
Name: vomeronasal 1 receptor 185
Synonyms: V1re12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 171265
Homologene: 74353
Rpain
Name: RPA interacting protein
Synonyms: 2400006N03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 69723
Homologene: 13006
Zfp618
Name: zinc finger protein 618
Synonyms: D430033D05Rik, 2810040O04Rik, 2810031P15Rik, Nedd10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 72701
Homologene: 18975
Zfp354c
Name: zinc finger protein 354C
Synonyms: Kid3, AJ18, 5330421P20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 30944
Homologene: 56606
Gm5592
Name: predicted gene 5592
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 434172
Homologene: 45597
AC156643.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Tekt4
Name: tektin 4
Synonyms: 1700010L19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 71840
Homologene: 25745
Acss2
Name: acyl-CoA synthetase short-chain family member 2
Synonyms: acetyl-CoA synthetase 1, ACAS, AceCS1, Acas1, Acs1, Acas2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 60525
Homologene: 6469
Serpina3a
Name: serine (or cysteine) peptidase inhibitor, clade A, member 3A
Synonyms: 4933406L18Rik, antitrypsin, alpha-1 antiproteinase,
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 74069
HGNC: HGNC:16
2310003L06Rik
Name: RIKEN cDNA 2310003L06 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
AC153874.3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Gm2000
Name: predicted gene 2000
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 100038991
Zfp213
Name: zinc finger protein 213
Synonyms: D17Ertd197e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 449521
VEGA: 17
Homologene: 55809
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 93,022,409 bp
  • T to C, chromosome 1 at 156,366,154 bp
  • T to G, chromosome 1 at 164,260,882 bp
  • T to C, chromosome 2 at 37,352,111 bp
  • T to A, chromosome 2 at 155,557,628 bp
  • G to T, chromosome 3 at 34,065,022 bp
  • T to A, chromosome 3 at 58,636,052 bp
  • G to A, chromosome 4 at 63,133,564 bp
  • T to A, chromosome 4 at 132,770,649 bp
  • T to C, chromosome 5 at 87,972,277 bp
  • A to G, chromosome 6 at 29,206,054 bp
  • A to G, chromosome 6 at 29,955,585 bp
  • C to A, chromosome 6 at 72,336,485 bp
  • T to A, chromosome 7 at 26,612,025 bp
  • T to C, chromosome 7 at 29,095,124 bp
  • C to T, chromosome 7 at 41,286,628 bp
  • A to T, chromosome 7 at 108,714,159 bp
  • A to T, chromosome 8 at 61,954,535 bp
  • A to T, chromosome 8 at 61,956,144 bp
  • C to T, chromosome 8 at 68,335,147 bp
  • A to G, chromosome 9 at 26,879,971 bp
  • A to G, chromosome 9 at 110,599,195 bp
  • T to C, chromosome 10 at 77,836,476 bp
  • T to C, chromosome 10 at 81,108,935 bp
  • G to A, chromosome 11 at 9,622,013 bp
  • A to G, chromosome 11 at 11,933,624 bp
  • C to T, chromosome 11 at 23,761,138 bp
  • T to A, chromosome 11 at 50,814,944 bp
  • T to G, chromosome 11 at 70,973,007 bp
  • T to A, chromosome 11 at 73,111,339 bp
  • A to G, chromosome 12 at 70,899,553 bp
  • G to A, chromosome 12 at 82,496,315 bp
  • A to T, chromosome 12 at 104,118,643 bp
  • C to A, chromosome 13 at 100,611,428 bp
  • G to A, chromosome 13 at 100,809,233 bp
  • A to C, chromosome 14 at 52,164,441 bp
  • A to G, chromosome 15 at 11,286,083 bp
  • T to A, chromosome 15 at 44,529,100 bp
  • T to C, chromosome 15 at 80,966,156 bp
  • T to C, chromosome 17 at 23,558,090 bp
  • T to G, chromosome 17 at 25,476,486 bp
  • T to C, chromosome 17 at 56,603,765 bp
  • A to G, chromosome 18 at 46,248,936 bp
  • G to T, chromosome 19 at 34,574,045 bp
  • A to G, chromosome 19 at 38,169,436 bp
  • A to G, chromosome 19 at 43,829,864 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4010 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040947-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.