Strain Name:
C57BL/6J-MtgxR4014Btlr/Mmmh
Stock Number:
040951-MU
Citation ID:
RRID:MMRRC_040951-MU
Other Names:
R4014 (G1), C57BL/6J-MtgxR4014Btlr
Major Collection:

Gene Information

Tyr
Name: tyrosinase
Synonyms: Oca1, skc35
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 22173
Homologene: 30969
Frem2
Name: Fras1 related extracellular matrix protein 2
Synonyms: 6030440P17Rik, ne, my, 8430406N05Rik, b2b1562Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 242022
Homologene: 18454
Dst
Name: dystonin
Synonyms: Bpag1, Bpag, 2310001O04Rik, nmf339, BPAG1, BPAG1-n, bullous pemphigoid antigen 1, Macf2, nmf203, bullous pemphigoid antigen 1, athetoid, A830042E19Rik, ah
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 13518
HGNC: HGNC:1090
Homologene: 136716
Wwp2
Name: WW domain containing E3 ubiquitin protein ligase 2
Synonyms: AIP2, 1300010O06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 66894
Homologene: 48490
Pdia3
Name: protein disulfide isomerase associated 3
Synonyms: Plca, PDI, Grp58, ERp61, ERp60, ERp57, PDI-Q2, Erp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 14827
HGNC: HGNC:4606
Homologene: 68454
Igf2bp2
Name: insulin-like growth factor 2 mRNA binding protein 2
Synonyms: IMP-2, C330012H03Rik, IMP2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 319765
Homologene: 4774
Herc4
Name: hect domain and RLD 4
Synonyms: 1700056O17Rik, 4921531D01Rik, 9530080M15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 67345
VEGA: 10
Homologene: 56715
Clcn6
Name: chloride channel, voltage-sensitive 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 26372
HGNC: HGNC:2024
Homologene: 985
Usp1
Name: ubiquitin specific peptidase 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230484
Homologene: 2528
Setx
Name: senataxin
Synonyms: Als4, A930037J23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 269254
HGNC: HGNC:445
Homologene: 41003
Atr
Name: ataxia telangiectasia and Rad3 related
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 245000
HGNC: HGNC:882
Homologene: 96916
Epb41
Name: erythrocyte membrane protein band 4.1
Synonyms: Elp-1, 4.1R, Epb4.1, D4Ertd442e, Elp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 269587
HGNC: HGNC:3377
Homologene: 44324
Dmxl1
Name: Dmx-like 1
Synonyms: C630007L23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 240283
HGNC: HGNC:2937
Homologene: 21136
Urb1
Name: URB1 ribosome biogenesis 1 homolog (S. cerevisiae)
Synonyms: 5730405K23Rik, 4921511H13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 207932
Homologene: 45941
Cenpf
Name: centromere protein F
Synonyms: mitosin, Lek1, 6530404A22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 108000
HGNC: HGNC:1857
Homologene: 22969
Chek1
Name: checkpoint kinase 1
Synonyms: Chk1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 12649
HGNC: HGNC:1925
Homologene: 975
Dmxl2
Name: Dmx-like 2
Synonyms: 6430411K14Rik, E130119P06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235380
HGNC: HGNC:2938
Homologene: 41022
Alms1
Name: ALMS1, centrosome and basal body associated
Synonyms: Alstrom syndrome 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 236266
HGNC: HGNC:428
Homologene: 49406
Dnhd1
Name: dynein heavy chain domain 1
Synonyms: 8030491N06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 77505
Homologene: 131117
Lama2
Name: laminin, alpha 2
Synonyms: mer, merosin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 16773
HGNC: HGNC:6482
Homologene: 37306
Muc4
Name: mucin 4
Synonyms: 4933405I11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 140474
HGNC: HGNC:7514
Homologene: 124469
Dnah11
Name: dynein, axonemal, heavy chain 11
Synonyms: Dnahc11, b2b1727Clo, b2b1289Clo, b2b1203Clo, b2b1279Clo, avc4, b2b598Clo, lrd
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 13411
HGNC: HGNC:2942
Homologene: 2801
Slc22a4
Name: solute carrier family 22 (organic cation transporter), member 4
Synonyms: Octn1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 30805
Homologene: 81701
Gabra5
Name: gamma-aminobutyric acid (GABA) A receptor, subunit alpha 5
Synonyms: A230018I05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 110886
HGNC: HGNC:4079
Homologene: 20219
Vmn2r103
Name: vomeronasal 2, receptor 103
Synonyms: EG627636
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 627636
Homologene: 115024
Myo3a
Name: myosin IIIA
Synonyms: 9030416P08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 667663
HGNC: HGNC:7601
Homologene: 49486
Rnf213
Name: ring finger protein 213
Synonyms: D11Ertd759e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 672511
Homologene: 45439
Fsip2
Name: fibrous sheath-interacting protein 2
Synonyms: OTTMUSG00000013335
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241516
Homologene: 110349
Lrp1b
Name: low density lipoprotein-related protein 1B
Synonyms: 9630004P12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 94217
HGNC: HGNC:6693
Homologene: 56810
Ciz1
Name: CDKN1A interacting zinc finger protein 1
Synonyms: 2900056O04Rik, 0610038H21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 68379
Homologene: 8112
Muc5b
Name: mucin 5, subtype B, tracheobronchial
Synonyms: MUC9, MUC5, 2300002I04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 74180
HGNC: HGNC:7516
Homologene: 136756
4932441B19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Dennd5a
Name: DENN/MADD domain containing 5A
Synonyms: Rab6ip1, ORF37, 1500012B19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 19347
Homologene: 14584
Lmbrd2
Name: LMBR1 domain containing 2
Synonyms: 9930036E21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 320506
VEGA: 15
Homologene: 44696
Vmn1r214
Name: vomeronasal 1 receptor 214
Synonyms: V1rh5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 171248
Homologene: 110880
Krt26
Name: keratin 26
Synonyms: 4732407F15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 320864
Homologene: 37118
Smarca2
Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
Synonyms: brm, 2610209L14Rik, Snf2l2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 67155
Homologene: 2308
Olfr1016
Name: olfactory receptor 1016
Synonyms: MOR213-9, GA_x6K02T2Q125-47278889-47277960
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 257915
Homologene: 83133
Matn1
Name: matrilin 1, cartilage matrix protein
Synonyms: Mat1, CMP, matrilin-1, Crtm
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 17180
HGNC: HGNC:6907
Homologene: 1783
Ano3
Name: anoctamin 3
Synonyms: B230324K02Rik, Tmem16c
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228432
Homologene: 57147
Habp2
Name: hyaluronic acid binding protein 2
Synonyms: FSAP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 226243
HGNC: HGNC:4798
Homologene: 3050
Olfr834
Name: olfactory receptor 834
Synonyms: GA_x6K02T2PVTD-12724921-12725859, MOR153-4_p, MOR153-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258074
HGNC: HGNC:8467
Homologene: 128143
Hace1
Name: HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1
Synonyms: 1700042J16Rik, A730034A22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 209462
Homologene: 10807
Dctpp1
Name: dCTP pyrophosphatase 1
Synonyms: RS21-C6, 2410015N17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 66422
Homologene: 11329
Adgrg7
Name: adhesion G protein-coupled receptor G7
Synonyms: Gpr128, 9130020O16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 239853
Homologene: 13115
Mzf1
Name: myeloid zinc finger 1
Synonyms: Znf42, Mzf2, Zfp98, Zfp121
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 109889
Homologene: 9633
Cdk20
Name: cyclin-dependent kinase 20
Synonyms: 4932702G04Rik, Ccrk
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 105278
VEGA: 13
Homologene: 8109
Map2k7
Name: mitogen-activated protein kinase kinase 7
Synonyms: 5930412N11Rik, MKK7, Jnkk2, sek2, MAP kinase kinase 7, Prkmk7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 26400
HGNC: HGNC:6847
Homologene: 56548
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 34,191,282 bp
  • A to G, chromosome 1 at 189,653,159 bp
  • A to G, chromosome 2 at 22,578,170 bp
  • GTGGCT to GT, chromosome 2 at 29,154,061 bp
  • G to T, chromosome 2 at 32,374,344 bp
  • A to G, chromosome 2 at 40,802,984 bp
  • A to G, chromosome 2 at 82,983,518 bp
  • A to T, chromosome 2 at 85,799,476 bp
  • A to G, chromosome 2 at 110,774,976 bp
  • A to G, chromosome 2 at 121,426,585 bp
  • C to T, chromosome 3 at 53,652,353 bp
  • A to G, chromosome 4 at 98,934,702 bp
  • A to G, chromosome 4 at 130,951,947 bp
  • A to T, chromosome 4 at 131,982,445 bp
  • A to G, chromosome 4 at 148,017,610 bp
  • T to A, chromosome 6 at 85,678,352 bp
  • A to G, chromosome 7 at 13,043,956 bp
  • C to T, chromosome 7 at 57,489,010 bp
  • A to G, chromosome 7 at 87,437,940 bp
  • T to A, chromosome 7 at 105,714,838 bp
  • C to T, chromosome 7 at 109,935,481 bp
  • G to A, chromosome 7 at 127,257,113 bp
  • G to A, chromosome 7 at 141,863,630 bp
  • T to A, chromosome 8 at 4,247,663 bp
  • A to G, chromosome 8 at 107,485,621 bp
  • T to C, chromosome 9 at 18,988,882 bp
  • T to C, chromosome 9 at 36,722,754 bp
  • C to A, chromosome 9 at 54,378,709 bp
  • T to C, chromosome 9 at 95,951,441 bp
  • A to T, chromosome 10 at 26,984,376 bp
  • A to G, chromosome 10 at 45,588,374 bp
  • T to C, chromosome 10 at 63,287,544 bp
  • C to G, chromosome 11 at 53,997,392 bp
  • C to T, chromosome 11 at 99,335,302 bp
  • C to T, chromosome 11 at 119,445,729 bp
  • A to G, chromosome 12 at 117,974,914 bp
  • G to A, chromosome 13 at 23,035,350 bp
  • T to A, chromosome 13 at 64,437,505 bp
  • T to C, chromosome 13 at 65,035,399 bp
  • T to C, chromosome 15 at 9,151,585 bp
  • T to C, chromosome 16 at 22,063,676 bp
  • C to T, chromosome 16 at 32,755,273 bp
  • A to G, chromosome 16 at 56,742,288 bp
  • A to T, chromosome 16 at 90,769,465 bp
  • A to G, chromosome 17 at 19,793,604 bp
  • G to A, chromosome 18 at 49,863,962 bp
  • G to A, chromosome 19 at 26,683,927 bp
  • A to G, chromosome 19 at 56,319,622 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4014 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040951-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.