Strain Name:
C57BL/6J-MtgxR4019Btlr/Mmmh
Stock Number:
040953-MU
Citation ID:
RRID:MMRRC_040953-MU
Other Names:
R4019 (G1), C57BL/6J-MtgxR4019Btlr
Major Collection:

Gene Information

Ap4e1
Name: adaptor-related protein complex AP-4, epsilon 1
Synonyms: 2310033A20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 108011
HGNC: HGNC:573
Homologene: 22397
Ghitm
Name: growth hormone inducible transmembrane protein
Synonyms: 1010001P14Rik, C77840, PTD010, Tmbim5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 66092
VEGA: 14
Homologene: 8667
Dip2c
Name: disco interacting protein 2 homolog C
Synonyms: 2900024P20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 208440
Homologene: 40996
Nr2c1
Name: nuclear receptor subfamily 2, group C, member 1
Synonyms: Eenr, TR2, 4831444H07Rik, Tr2-11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 22025
HGNC: HGNC:7971
Homologene: 55731
Brpf1
Name: bromodomain and PHD finger containing, 1
Synonyms: 4930540D11Rik, 4833438B11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 78783
Homologene: 31251
Tenm2
Name: teneurin transmembrane protein 2
Synonyms: 9330187F13Rik, 2610040L17Rik, D3Bwg1534e, Ten-m2, Odz2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 23964
Homologene: 22672
Ctnnd1
Name: catenin (cadherin associated protein), delta 1
Synonyms: p120-catenin, Catns, P120, Ctnnd
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 12388
HGNC: HGNC:2515
Homologene: 1017
Acy1
Name: aminoacylase 1
Synonyms: Acy-1, 1110014J22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 109652
HGNC: HGNC:177
Homologene: 110440
Sox8
Name: SRY (sex determining region Y)-box 8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 20681
Homologene: 7950
Ptprc
Name: protein tyrosine phosphatase, receptor type, C
Synonyms: CD45, Ly-5, T200, Lyt-4, B220
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 19264
HGNC: HGNC:9666
Homologene: 2126
Epg5
Name: ectopic P-granules autophagy protein 5 homolog (C. elegans)
Synonyms: 5430411K18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 100502841
VEGA: 18
Homologene: 14575
Zfp335
Name: zinc finger protein 335
Synonyms: 1810045J01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 329559
Homologene: 11129
Casz1
Name: castor zinc finger 1
Synonyms: 2410019P08Rik, D4Ertd432e, Cst, castor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 69743
Homologene: 9824
Canx
Name: calnexin
Synonyms: 1110069N15Rik, CNX
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 12330
HGNC: HGNC:1473
Homologene: 1324
Notch1
Name: notch 1
Synonyms: Tan1, 9930111A19Rik, lin-12, Motch A, N1, Mis6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 18128
HGNC: HGNC:7881
Homologene: 32049
Ift81
Name: intraflagellar transport 81
Synonyms: Cdv1, CDV-1R
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 12589
Homologene: 7664
Ikbkb
Name: inhibitor of kappaB kinase beta
Synonyms: IKK2, IKK-2, IKK-beta, IKK[b], IKKbeta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 16150
HGNC: HGNC:5960
Homologene: 7782
Tbl3
Name: transducin (beta)-like 3
Synonyms: 9430070M15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 213773
Homologene: 4711
Nbas
Name: neuroblastoma amplified sequence
Synonyms: 4933425L03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 71169
VEGA: 12
Homologene: 41073
Lct
Name: lactase
Synonyms: LOC226413, Lphl, LPH
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226413
HGNC: HGNC:6530
Homologene: 124204
Naip5
Name: NLR family, apoptosis inhibitory protein 5
Synonyms: Naip-rs3, Birc1e, Lgn1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 17951
HGNC: HGNC:7634
Homologene: 113589
Rubcnl
Name: RUN and cysteine rich domain containing beclin 1 interacting protein like
Synonyms: LOC380917, 5031414D18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 271221
VEGA: 14
Homologene: 57021
Vmn2r115
Name: vomeronasal 2, receptor 115
Synonyms: V2Rp4, EG638102
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 638102
Homologene: 86604
Rin2
Name: Ras and Rab interactor 2
Synonyms: 4632403N06Rik, 2010003K16Rik, RASSF4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 74030
Homologene: 32430
Oplah
Name: 5-oxoprolinase (ATP-hydrolysing)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 75475
HGNC: HGNC:8149
Homologene: 90938
Gm884
Name: predicted gene 884
Synonyms: LOC380730
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 380730
Homologene: 134511
Pcnx
Name: pecanex homolog
Synonyms: 3526401J03Rik, 2900024E21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 54604
VEGA: 12
Homologene: 40997
Prpf40b
Name: pre-mRNA processing factor 40B
Synonyms: 2610317D23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 54614
Homologene: 81828
Spdya
Name: speedy/RINGO cell cycle regulator family, member A
Synonyms: Spdy1, 4921517J08Rik, 4930548B21Rik, speedy/ringo, speedy A1, speedy A2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 70891
Homologene: 16357
Lrrtm2
Name: leucine rich repeat transmembrane neuronal 2
Synonyms: C630011A14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 107065
VEGA: 18
Homologene: 65342
Olfr1211
Name: olfactory receptor 1211
Synonyms: MOR233-16P, MOR233-21, GA_x6K02T2Q125-50409367-50408432
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258025
Homologene: 81548
Zfp777
Name: zinc finger protein 777
Synonyms: 2500002G23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 72306
Homologene: 56721
Vmn2r45
Name: vomeronasal 2, receptor 45
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 100042810
Homologene: 113703
Vmn2r109
Name: vomeronasal 2, receptor 109
Synonyms: EG627814
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 627814
Homologene: 129678
Pdgfb
Name: platelet derived growth factor, B polypeptide
Synonyms: PDGF-B, Sis
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 18591
VEGA: 15
HGNC: HGNC:8800
Homologene: 74303
Gramd3
Name: GRAM domain containing 3
Synonyms: 9030613F08Rik, 9130427A09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 107022
VEGA: 18
Homologene: 32570
Pdzd3
Name: PDZ domain containing 3
Synonyms: NaPi-Cap2, sodium-phosphate cotransporter IIa C-terminal-associated protein 2, Pdzk2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 170761
VEGA: 9
Homologene: 11719
Lpar5
Name: lysophosphatidic acid receptor 5
Synonyms: GPR93, Gpr92, LPA5, LOC381810
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 381810
Homologene: 10696
Olfr552
Name: olfactory receptor 552
Synonyms: GA_x6K02T2PBJ9-5323062-5324015, MOR28-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 259106
Homologene: 73941
Ifitm3
Name: interferon induced transmembrane protein 3
Synonyms: IP15, Fgls, fragilis, mil-1, 1110004C05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 66141
HGNC: HGNC:5414
Homologene: 136199
Sytl3
Name: synaptotagmin-like 3
Synonyms: Slp3-a, Slp3-b, Slp3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 83672
Homologene: 12855
Slc25a10
Name: solute carrier family 25 (mitochondrial carrier, dicarboxylate transporter), member 10
Synonyms: Dic
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 27376
Homologene: 6519
Sco1
Name: SCO1 cytochrome c oxidase assembly protein
Synonyms: 2610001C07Rik, D11Bwg1310e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 52892
Homologene: 3374
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 128,304,226 bp
  • T to A, chromosome 1 at 138,078,516 bp
  • T to C, chromosome 2 at 26,481,142 bp
  • C to T, chromosome 2 at 84,619,958 bp
  • A to G, chromosome 2 at 88,929,736 bp
  • C to T, chromosome 2 at 127,061,926 bp
  • C to T, chromosome 2 at 145,860,446 bp
  • C to T, chromosome 2 at 164,901,460 bp
  • C to T, chromosome 4 at 148,932,878 bp
  • G to A, chromosome 5 at 122,593,129 bp
  • T to A, chromosome 6 at 48,042,112 bp
  • G to A, chromosome 6 at 113,310,282 bp
  • A to G, chromosome 6 at 125,081,675 bp
  • A to T, chromosome 7 at 8,471,581 bp
  • T to C, chromosome 7 at 102,604,642 bp
  • T to C, chromosome 7 at 141,009,859 bp
  • C to T, chromosome 8 at 22,671,712 bp
  • A to T, chromosome 9 at 44,250,820 bp
  • T to C, chromosome 9 at 106,436,779 bp
  • A to T, chromosome 10 at 94,162,240 bp
  • T to C, chromosome 11 at 36,047,074 bp
  • A to T, chromosome 11 at 50,299,245 bp
  • T to G, chromosome 11 at 67,064,020 bp
  • A to G, chromosome 11 at 103,615,293 bp
  • T to A, chromosome 11 at 120,497,439 bp
  • A to G, chromosome 12 at 13,482,519 bp
  • C to T, chromosome 12 at 81,918,244 bp
  • T to C, chromosome 13 at 9,614,365 bp
  • T to C, chromosome 13 at 100,223,375 bp
  • T to C, chromosome 13 at 100,223,394 bp
  • G to A, chromosome 14 at 37,130,694 bp
  • A to C, chromosome 14 at 75,040,794 bp
  • A to G, chromosome 15 at 76,297,276 bp
  • A to C, chromosome 15 at 80,001,722 bp
  • T to C, chromosome 15 at 99,316,476 bp
  • T to C, chromosome 17 at 6,736,493 bp
  • T to A, chromosome 17 at 20,553,812 bp
  • A to G, chromosome 17 at 23,360,043 bp
  • A to G, chromosome 17 at 24,704,721 bp
  • A to G, chromosome 17 at 25,570,297 bp
  • A to C, chromosome 17 at 71,556,314 bp
  • T to C, chromosome 18 at 35,212,870 bp
  • T to C, chromosome 18 at 56,478,954 bp
  • C to A, chromosome 18 at 78,030,450 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4019 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040953-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.