Strain Name:
C57BL/6J-MtgxR4033Btlr/Mmmh
Stock Number:
040961-MU
Citation ID:
RRID:MMRRC_040961-MU
Other Names:
R4033 (G1), C57BL/6J-MtgxR4033Btlr
Major Collection:

Gene Information

Dnmt1
Name: DNA methyltransferase (cytosine-5) 1
Synonyms: MTase, Cxxc9, MommeD2, Dnmt1o
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 13433
VEGA: 9
HGNC: HGNC:2976
Homologene: 124071
Hsp90aa1
Name: heat shock protein 90, alpha (cytosolic), class A member 1
Synonyms: Hsp89, Hsp86-1, hsp4, Hsp90, Hspca
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 15519
HGNC: HGNC:5253
Homologene: 68464
Rlf
Name: rearranged L-myc fusion sequence
Synonyms: MommeD8, 9230110M18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 109263
Homologene: 8243
Unk
Name: unkempt family zinc finger
Synonyms: B230379M23Rik, Zc3h5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 217331
Homologene: 18194
Rbm28
Name: RNA binding motif protein 28
Synonyms: 2810480G15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 68272
Homologene: 135952
Dmxl1
Name: Dmx-like 1
Synonyms: C630007L23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 240283
HGNC: HGNC:2937
Homologene: 21136
Als2
Name: alsin Rho guanine nucleotide exchange factor
Synonyms: Als2cr6, Alsin, 3222402C23Rik, 9430073A21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 74018
HGNC: HGNC:443
Homologene: 23264
Nop14
Name: NOP14 nucleolar protein
Synonyms: Nol14, 2610033H07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 75416
Homologene: 41773
Ubn1
Name: ubinuclein 1
Synonyms: 1110029L11Rik, 2610108L02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 170644
VEGA: 16
Homologene: 9656
Car9
Name: carbonic anhydrase 9
Synonyms: MN/CA9, CAIX
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 230099
HGNC: HGNC:1383
Homologene: 20325
Lnx1
Name: ligand of numb-protein X 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 16924
HGNC: HGNC:6657
Homologene: 7819
Grhl3
Name: grainyhead like transcription factor 3
Synonyms: ct, Som, Get1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 230824
Homologene: 18864
Fnip1
Name: folliculin interacting protein 1
Synonyms: A730024A03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 216742
Homologene: 28173
Kalrn
Name: kalirin, RhoGEF kinase
Synonyms: 2210407G14Rik, Hapip, E530005C20Rik, LOC224126
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 545156
HGNC: HGNC:4814
Homologene: 57160
Fgf17
Name: fibroblast growth factor 17
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 14171
VEGA: 14
HGNC: HGNC:3673
Homologene: 2872
Reg3b
Name: regenerating islet-derived 3 beta
Synonyms: REG-III, Pap, RegIII (beta), PAP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 18489
HGNC: HGNC:8601
Homologene: 130506
Slc16a12
Name: solute carrier family 16 (monocarboxylic acid transporters), member 12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 240638
Homologene: 130007
Nalcn
Name: sodium leak channel, non-selective
Synonyms: A530023G15Rik, Vgcnl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 338370
VEGA: 14
Homologene: 21832
Zan
Name: zonadhesin
Synonyms: Zan
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 22635
Homologene: 124417
Cfap69
Name: cilia and flagella associated protein 69
Synonyms: A330021E22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 207686
Homologene: 11718
Tshz3
Name: teashirt zinc finger family member 3
Synonyms: Zfp537, Tsh3, teashirt3, A630038G13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 243931
Homologene: 10835
Gm5346
Name: predicted gene 5346
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 384813
Homologene: 78104
Sorbs2
Name: sorbin and SH3 domain containing 2
Synonyms: 2010203O03Rik, 9430041O17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 234214
Homologene: 83295
Pxdn
Name: peroxidasin
Synonyms: 2310075M15Rik, VPO1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 69675
Homologene: 33907
CAAA01180111.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
Nrxn3
Name: neurexin III
Synonyms: neurexin III beta, D12Bwg0831e, neurexin III alpha, neurexin III beta, neurexin III alpha, 9330112C09Rik, 4933401A11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 18191
HGNC: HGNC:8010
Homologene: 83225
Brf1
Name: BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit
Synonyms: TAF3C, TAFIII90, 2510002F24Rik, TFIIIB90, GTF3B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 72308
VEGA: 12
Homologene: 1161
Nfatc2ip
Name: nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2 interacting protein
Synonyms: NIP45, D7Ertd304e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 18020
Homologene: 7862
Olfr558
Name: olfactory receptor 558
Synonyms: GA_x6K02T2PBJ9-5425951-5426904, MOR18-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 259097
Homologene: 17503
Cerk
Name: ceramide kinase
Synonyms: D330016D08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 223753
Homologene: 11247
Tctn3
Name: tectonic family member 3
Synonyms: Tect3, 4930521E07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 67590
Homologene: 9221
Mtnr1b
Name: melatonin receptor 1B
Synonyms: Mt2, Mel1b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 244701
HGNC: HGNC:7464
Homologene: 4350
Mical1
Name: microtubule associated monooxygenase, calponin and LIM domain containing 1
Synonyms: Nical
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 171580
Homologene: 11246
Tdrd9
Name: tudor domain containing 9
Synonyms: 4930441E05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 74691
Homologene: 14311
Smyd4
Name: SET and MYND domain containing 4
Synonyms: G430029E23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 319822
Homologene: 35098
Ifih1
Name: interferon induced with helicase C domain 1
Synonyms: MDA-5, Helicard, MDA5, 9130009C22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 71586
Homologene: 32535
Prr27
Name: proline rich 27
Synonyms: 4930432K09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 73779
Homologene: 136277
Iqck
Name: IQ motif containing K
Synonyms: A230094G09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 434232
Homologene: 45162
Fhit
Name: fragile histidine triad gene
Synonyms: Fra14A2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 14198
HGNC: HGNC:3701
Homologene: 21661
Smo
Name: smoothened, frizzled class receptor
Synonyms: E130215L21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 319757
Homologene: 4115
Erich6b
Name: glutamate rich 6B
Synonyms: Gm46471, 4930564B18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 108168181
VEGA: 14
Homologene: 67175
Ankrd63
Name: ankyrin repeat domain 63
Synonyms: Gm1337, LOC383787
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 383787
Homologene: 19774
C530008M17Rik
Name: RIKEN cDNA C530008M17 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 320827
Homologene: 136278
Lsm14b
Name: LSM family member 14B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 241846
Homologene: 100207
Chil4
Name: chitinase-like 4
Synonyms: Ym2, Chi3l4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 104183
Homologene: 74931
Gprin2
Name: G protein regulated inducer of neurite outgrowth 2
Synonyms: C130040D06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 432839
VEGA: 14
Homologene: 40975
Gm17641
Name: predicted gene, 17641
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
Psmg3
Name: proteasome (prosome, macropain) assembly chaperone 3
Synonyms: 4930403H09Rik, 1810042K04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 66506
Homologene: 11980
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to T, chromosome 1 at 59,196,241 bp
  • G to A, chromosome 2 at 62,635,190 bp
  • C to A, chromosome 2 at 118,702,931 bp
  • A to G, chromosome 2 at 180,031,516 bp
  • C to T, chromosome 3 at 68,869,813 bp
  • T to C, chromosome 3 at 106,214,449 bp
  • T to C, chromosome 4 at 43,508,624 bp
  • T to G, chromosome 4 at 121,147,343 bp
  • T to A, chromosome 4 at 135,573,424 bp
  • A to T, chromosome 5 at 5,604,389 bp
  • T to C, chromosome 5 at 34,650,517 bp
  • A to T, chromosome 5 at 74,620,360 bp
  • A to G, chromosome 5 at 76,858,465 bp
  • G to T, chromosome 5 at 87,843,305 bp
  • A to T, chromosome 5 at 137,437,860 bp
  • G to A, chromosome 5 at 139,826,331 bp
  • T to C, chromosome 6 at 29,159,669 bp
  • G to A, chromosome 6 at 29,759,918 bp
  • A to T, chromosome 6 at 78,373,209 bp
  • G to A, chromosome 7 at 36,770,584 bp
  • C to T, chromosome 7 at 102,709,490 bp
  • T to C, chromosome 7 at 118,941,604 bp
  • G to T, chromosome 7 at 126,396,421 bp
  • C to G, chromosome 8 at 43,626,673 bp
  • C to G, chromosome 8 at 45,775,595 bp
  • A to T, chromosome 9 at 15,863,534 bp
  • G to T, chromosome 9 at 20,919,827 bp
  • T to A, chromosome 9 at 124,295,086 bp
  • G to A, chromosome 10 at 41,481,176 bp
  • A to T, chromosome 11 at 54,502,471 bp
  • A to G, chromosome 11 at 75,349,754 bp
  • A to T, chromosome 11 at 116,053,527 bp
  • A to G, chromosome 12 at 30,003,225 bp
  • T to C, chromosome 12 at 89,533,001 bp
  • T to A, chromosome 12 at 110,695,680 bp
  • C to A, chromosome 12 at 110,695,681 bp
  • A to T, chromosome 12 at 111,992,539 bp
  • G to A, chromosome 12 at 112,979,732 bp
  • A to T, chromosome 14 at 10,751,671 bp
  • A to T, chromosome 14 at 34,194,678 bp
  • G to T, chromosome 14 at 70,641,526 bp
  • A to T, chromosome 14 at 75,658,767 bp
  • T to C, chromosome 14 at 123,599,989 bp
  • T to G, chromosome 15 at 86,155,027 bp
  • C to T, chromosome 16 at 5,064,611 bp
  • C to T, chromosome 16 at 33,989,810 bp
  • A to G, chromosome 18 at 49,851,431 bp
  • A to T, chromosome 19 at 34,675,167 bp
  • G to T, chromosome 19 at 40,597,323 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4033 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040961-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.