Strain Name:
C57BL/6J-MtgxR4036Btlr/Mmmh
Stock Number:
040963-MU
Citation ID:
RRID:MMRRC_040963-MU
Other Names:
R4036 (G1), C57BL/6J-MtgxR4036Btlr
Major Collection:

Gene Information

Nsd1
Name: nuclear receptor-binding SET-domain protein 1
Synonyms: KMT3B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 18193
VEGA: 13
Homologene: 32543
Cyp39a1
Name: cytochrome P450, family 39, subfamily a, polypeptide 1
Synonyms: oxysterol 7-alpha-hydroxylase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 56050
VEGA: 17
Homologene: 9580
Map4
Name: microtubule-associated protein 4
Synonyms: MAP 4, Mtap4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 17758
HGNC: HGNC:6862
Homologene: 1780
Ahctf1
Name: AT hook containing transcription factor 1
Synonyms: 6230412P20Rik, Elys
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226747
Homologene: 9142
Urb1
Name: URB1 ribosome biogenesis 1 homolog (S. cerevisiae)
Synonyms: 4921511H13Rik, 5730405K23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 207932
Homologene: 45941
Ndc1
Name: NDC1 transmembrane nucleoporin
Synonyms: Tmem48, 2810475A17Rik, sks
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 72787
Homologene: 41224
Fanci
Name: Fanconi anemia, complementation group I
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 208836
Homologene: 49530
Bcan
Name: brevican
Synonyms: Cspg7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 12032
Homologene: 7244
Anxa2
Name: annexin A2
Synonyms: 36-kDa calelectrin, annexin II, Cal1h, lipocortin II
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 12306
HGNC: HGNC:537
Homologene: 20857
Klk8
Name: kallikrein related-peptidase 8
Synonyms: Prss19, Nrpn, BSP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 259277
HGNC: HGNC:6369
Homologene: 21410
Pomt2
Name: protein-O-mannosyltransferase 2
Synonyms: A830009D15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217734
VEGA: 12
Homologene: 5297
Scn4a
Name: sodium channel, voltage-gated, type IV, alpha
Synonyms: mH2, Nav1.4, SkM1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 110880
Homologene: 283
Dennd1c
Name: DENN/MADD domain containing 1C
Synonyms: 4432409M07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 70785
VEGA: 17
Homologene: 11773
Ttn
Name: titin
Synonyms: mdm, 2310036G12Rik, D830007G01Rik, connectin, 1100001C23Rik, shru, D330041I19Rik, 2310057K23Rik, 2310074I15Rik, L56
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22138
Homologene: 130650
Txnip
Name: thioredoxin interacting protein
Synonyms: Hyplip1, VDUP1, THIF, mVDUP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 56338
Homologene: 38186
Slc46a2
Name: solute carrier family 46, member 2
Synonyms: Ly110, Tscot, TSO-1C12, 5430429N04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 30936
Homologene: 23273
Metrn
Name: meteorin, glial cell differentiation regulator
Synonyms: 1810034B16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 70083
VEGA: 17
Homologene: 11432
Zfp575
Name: zinc finger protein 575
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 101544
Homologene: 45485
Rfx6
Name: regulatory factor X, 6
Synonyms: 4930572O07Rik, Rfxdc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 320995
Homologene: 18318
Gns
Name: glucosamine (N-acetyl)-6-sulfatase
Synonyms: 2610016K11Rik, G6S
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 75612
VEGA: 10
HGNC: HGNC:4422
Homologene: 1568
St18
Name: suppression of tumorigenicity 18
Synonyms: Myt3, Nzf3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 240690
Homologene: 8792
Prrt3
Name: proline-rich transmembrane protein 3
Synonyms: B230206N24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 210673
Homologene: 52099
Cntln
Name: centlein, centrosomal protein
Synonyms: B430108F07Rik, D530005L17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 338349
Homologene: 9805
Sntb1
Name: syntrophin, basic 1
Synonyms: beta1-Syntrophin, 59-1 DAP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 20649
Homologene: 9618
Drc1
Name: dynein regulatory complex subunit 1
Synonyms: Gm1060, Ccdc164, b2b1654Clo, LOC381738
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 381738
Homologene: 35977
Olfr204
Name: olfactory receptor 204
Synonyms: MOR182-3, GA_x54KRFPKG5P-55529713-55528796
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 258994
Homologene: 79425
Glb1l3
Name: galactosidase, beta 1 like 3
Synonyms: 4921509F24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 70893
Homologene: 72240
Hspa2
Name: heat shock protein 2
Synonyms: 70kDa, Hsp70-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 15512
VEGA: 12
HGNC: HGNC:5235
Homologene: 68564
Vmn1r219
Name: vomeronasal 1 receptor 219
Synonyms: V1rh13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 171272
Homologene: 110880
Slc16a9
Name: solute carrier family 16 (monocarboxylic acid transporters), member 9
Synonyms: 4930425B13Rik, 1200003C15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 66859
Homologene: 32642
4930544M13Rik
Name: RIKEN cDNA 4930544M13 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 75161
Eef2kmt
Name: eukaryotic elongation factor 2 lysine methyltransferase
Synonyms: Fam86, 5730409G15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 70511
Homologene: 45719
AC151712.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: Y
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 6,827,786 bp
  • T to C, chromosome 1 at 179,762,616 bp
  • A to G, chromosome 2 at 76,718,153 bp
  • A to G, chromosome 3 at 87,996,116 bp
  • C to G, chromosome 3 at 96,559,447 bp
  • A to T, chromosome 4 at 59,913,818 bp
  • A to G, chromosome 4 at 85,006,488 bp
  • G to A, chromosome 4 at 107,411,072 bp
  • A to G, chromosome 5 at 30,347,182 bp
  • AGGGGG to AGGGG, chromosome 6 at 113,497,680 bp
  • G to A, chromosome 7 at 24,586,015 bp
  • A to G, chromosome 7 at 43,798,087 bp
  • T to C, chromosome 7 at 79,444,822 bp
  • A to C, chromosome 9 at 26,829,047 bp
  • A to G, chromosome 9 at 69,488,070 bp
  • A to G, chromosome 9 at 110,032,215 bp
  • T to A, chromosome 10 at 51,726,746 bp
  • C to T, chromosome 10 at 70,274,956 bp
  • C to A, chromosome 10 at 121,371,190 bp
  • A to C, chromosome 11 at 106,322,057 bp
  • T to C, chromosome 12 at 76,405,768 bp
  • A to G, chromosome 12 at 87,111,522 bp
  • A to G, chromosome 13 at 23,163,102 bp
  • A to G, chromosome 13 at 55,213,711 bp
  • T to C, chromosome 13 at 114,607,669 bp
  • G to A, chromosome 15 at 55,792,020 bp
  • A to T, chromosome 16 at 5,245,271 bp
  • T to A, chromosome 16 at 59,314,750 bp
  • T to C, chromosome 16 at 90,788,086 bp
  • T to C, chromosome 17 at 25,795,010 bp
  • C to A, chromosome 17 at 43,676,940 bp
  • A to C, chromosome 17 at 57,070,638 bp
  • G to A, chromosome Y at 90,762,294 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4036 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040963-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.